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It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy, lesion-targeted precision and mild accessibility. Compared to traditional treatment modalities, photodynamic therapy has been widely studied since the generation of reactive oxygen species (ROS) at cancerous lesions unprecedentedly offers a convenient approach for localized tumor eliminations. Nevertheless, the consumption of oxygen for ROS production in a hypoxic tumor micro-environment has dramatically limited its feasibility and efficacy. Herein, the engineered nanocomposites of BTO@PDA-ICG-HA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic treatments. The continuing ROS production derived from intracellular oxygen (O2) and water (H2O) by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth inhibition. Thus, this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses, facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives. [ABSTRACT FROM AUTHOR]

We aimed to identify the molecular biomarkers of MDD disease progression to uncover potential mechanisms of major depressive disorder (MDD). In this study, three microarray data sets, GSE44593, GSE12654, and GSE54563, were cited from the Gene Expression Omnibus database for performance evaluation. To perform molecular functional enrichment analyses, differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was configured using the Search Tool for the Retrieval of Interacting Genes/Proteins and Cytoscape. To assess multi-purpose functions and pathways, such as signal transduction, plasma membrane, protein binding, and cancer pathways, a total of 220 DEGs, including 143 upregulated and 77 downregulated genes, were selected. Additionally, six central genes were observed, including electron transport system variant transcription factor 6, FMS-related receptor tyrosine kinase 3, carnosine synthetase 1, solute carrier family 22 member 13, prostaglandin endoperoxide synthetase 2, and protein serine kinase H1, which had a significant impact on cell proliferation, extracellular exosome, protein binding, and hypoxia-inducible factor 1 signaling pathway. This study enhances our understanding of the molecular mechanism of the occurrence and progression of MDD and provides candidate targets for its diagnosis and treatment. [ABSTRACT FROM AUTHOR]

In a recently published report, Somak Bhattacharyya et al. 2016 presented a broadband metamaterial absorber based on a single split ring resonator. He proposed that such an absorber can achieve a broadband absorption which is from 6.70 GHz to 15.82 GHz with above 90% absorptivity. In this paper, the absorber proposed Somak Bhattacharyya et al. is recalculated again and justified that to have ignored the cross-polarization conversion. It is observed that this absorber has no absorption spectrum which is over 90%. Further, we propose two solutions to eliminate the cross-polarization conversion so that it can realize energy absorption again. [ABSTRACT FROM AUTHOR]

In this article, we demonstrate a tunable ultra-broadband metamaterial absorber (TUMA) in terahertz (THz) band which is based on the multilayered structure composed of an Au reflective layer, polyimide dielectric layers, and vanadium dioxide (VO2) periodic structures, respectively. We gain the tunable absorption spectra because of the room temperature phased-changed character of VO2. The relative bandwidth reaches to 81.2% and the absorption rate is over 90% at the frequency range of 1.63–3.86 THz when the temperature (t1) is 350 K, but when t1 = 300 K, the presented absorber is acted as a reflector whose absorption is small besides the frequency points of 9.75 THz and 9.81 THz. For the sake of comprehending the physical mechanism in-depth, the electric field (E-field) diagrams, the surface current distributions and the power loss density (PLD) of the TUMA are investigated. The influences of structural arguments and incident angle (θ) on the absorption are also analyzed. The emulated consequences show that the absorption spectrum can be regulated by changing structural parameters and incident angle and the tunable absorption regions can be obtained by altering the external temperature. [ABSTRACT FROM AUTHOR]

In recent days, we read a paper called "Design of a Quad-Band Wide-Angle Microwave Metamaterial Absorber", which was written by Ren et al. In such report, Ren et al. proposed a quad-band wide-angle absorber based on a metallic hexagonal patch layer. The absorption peaks are located at 6.8 GHz, 8.24 GHz, 11.24 GHz, and 12.7 GHz, whose absorptivity values are 97.2%, 95.2%, 97.7%, and 98.5%, respectively. However, we verified that the results which were given by Ren et al. are wrong because they ignored the polarization conversion. The proposed quad-band metamaterial absorber (QBMA) is not an absorber. [ABSTRACT FROM AUTHOR]