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Background Preclinical results in rats have demonstrated anxiolytic-like effects of a tryptic bovine alpha[S1]-casein hydrolysate. Aim of the study We investigated the putative effects of this tryptic hydrolysate on systolic (SBP), diastolic (DBP) blood pressures, heart rate (HR) values and plasma cortisol concentrations (CC) in human healthy volunteers facing successive stress situations. Methods The subjects were (double blind) randomly allocated to ingest three times, 12 hours apart, two capsules containing either 200 mg of alpha[S1]-casein hydrolysate (TS) or bovine skimmed milk powder as a placebo (CS). On the morning of the test day, a first blood sample for baseline measurement of CC was taken before the subjects were submitted to the Stroop test (ST) and, after a 30-min rest, to a Cold Pressor test (CPT). SBP, DBP, and HR were continuously recorded for 5 min before the ST and during each stress situation. A second blood sample was taken 15 min after the end of the CPT condition. Results ST and ST + CPT combined test situations increased SBP, DBP and HR. The significant 'Treatment x SBP' and 'Treatment x DBP' interactions indicated the lower percentage changes in SBP and DBP of the TS. In addition, the results showed a significant decrease of the CC in the TS but not in the CS throughout the ST + CPT combined stress tests. HR remained stable in TS between the initial rest period and the CPT unlike what happened in CS. Conclusion On the basis of blood pressure and cortisol changes, these results suggest an antistress profile of this alpha[S1]-casein hydrolysate in human subjects. [ABSTRACT FROM AUTHOR]

Background Preclinical results in rats have demonstrated anxiolytic-like effects of a tryptic bovine