1. Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging.
- Author
-
Li, Benhao, Zhao, Mengyao, Feng, Lishuai, Dou, Chaoran, Ding, Suwan, Zhou, Gang, Lu, Lingfei, Zhang, Hongxin, Chen, Feiya, Li, Xiaomin, Li, Guangfeng, Zhao, Shichang, Jiang, Chunyu, Wang, Yan, Zhao, Dongyuan, Cheng, Yingsheng, and Zhang, Fan
- Subjects
BLOOD circulation ,BLOOD-brain barrier ,CAROTID artery ,MOLECULES ,BLOOD ,REPERFUSION - Abstract
Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties. Optical bioimaging in the second near-infrared (NIR-II, 1000–1700 nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule with long blood circulation half-life time for continuous real-time monitoring of dynamic vascular processes. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF