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Equivalent constraint method (ECM) is an efficient method for safety life analysis under target time-dependent failure possibility (TDFP) constraint. However, the efficiency of existing ECM still needs to be improved for problems with complex performance functions. In this paper, an efficient method based on equivalent constraint and sequential Kriging model with fuzzy simulation (EC-SK-FS) is proposed to improve the efficiency of solving safety life. In EC-SK-FS, the TDFP constraint is first equivalently transformed into performance function constraint with respect to target TDFP, which can avoid performance function evaluations under unnecessary membership level. Second, based on the EC of the lower bound of extremum performance function being equal to zero, the traditional dichotomy method is embedded to search for the safety life. For each possible life searched by dichotomy, the Kriging model of time-dependent performance function is sequentially trained in the corresponding candidate sample pool (CSP) for estimating the lower bound of extremum performance function, in which a new stopping criterion is established to improve the efficiency of training Kriging model. The new stopping criterion only requires at least one failure sample point accurately identified by the current Kriging model, which reduces the computational cost while ensuring the accuracy of estimating the lower bound of extremum performance function. In addition, the strategy of reducing CSP is adopted to further improve the efficiency of the proposed method. Compared with the existing ECM, the results of examples fully prove that the proposed EC-SK-FS method is more efficient under acceptable accuracy. [ABSTRACT FROM AUTHOR]

Qunf Cave oxygen isotope (δ18Oc) record from southern Oman is one of the most significant of few Holocene Indian summer monsoon cave records. However, the interpretation of the Qunf δ18Oc remains in dispute. Here we provide a multi-proxy record from Qunf Cave and climate model simulations to reconstruct the Holocene local and regional hydroclimate changes. The results indicate that besides the Indian summer monsoon, the North African summer monsoon also contributes water vapor to southern Oman during the early to middle Holocene. In principle, Qunf δ18Oc values reflect integrated oxygen-isotope fractionations over a broad moisture transport swath from moisture sources to the cave site, rather than local precipitation amount alone, and thus the Qunf δ18Oc record characterizes primary changes in the Afro-Asian monsoon regime across the Holocene. In contrast, local climate proxies appear to suggest an overall slightly increased or unchanged wetness over the Holocene at the cave site. Southern Oman speleothem oxygen isotope and multi-proxy data reveal diverse changes in the Afro-Indian summer monsoon circulations and local hydroclimate conditions during the Holocene, confirming climate model simulations. [ABSTRACT FROM AUTHOR]

Excessive exposure of fluoride not only leads to damage on bone, but also has an adverse effect on soft tissues. Oxidative DNA damage induced by fluoride is thought to be one of the toxic mechanisms of fluoride effect. However, the dose–response of fluoride on oxidative DNA damage is barely studied in organisms. This study investigated the concentration of fluoride in rat blood, kidney, liver, and brain as well as the dose-time effect of fluoride on the expression of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the above tissues. Rats were exposed to 0 mg/L, 25 mg/L, 50 mg/L, and 100 mg/L of fluorine ion and treated for one and three months. The results showed that the accumulation of fluoride in soft tissues was very different. At the first month, blood fluoride was increased, liver and brain fluoride showed a U-shaped change, and kidney fluoride was not significant. At the third month, blood fluoride was altered with an inverted U-shaped change, kidney and brain fluoride increased, but liver fluoride decreased. Both the exposure concentration and the time of exposure had a significant effect on the expression of 8-OHdG in the above tissues. However, the effect patterns of fluoride on these tissues were notably different at different times. At the first month of fluoride treatment, blood, kidney, and liver 8-OHdG decreased with the increasing fluoride concentration. At the third month, blood 8-OHdG showed a U-shaped change, but kidney 8-OHdG altered with an inverted U-shaped change. Liver 8-OHdG increased, while brain 8-OHdG decreased at the third month. Correlation analysis showed that only blood 8-OHdG was significantly inversely correlated with blood fluoride and dental fluorosis grade in both the first and third months. Liver 8-OHdG was negatively and significantly correlated with liver fluoride. There was a weak but nonsignificant correlation between kidney and brain 8-OHdG and fluoride in both tissues. Additionally, blood 8-OHdG was positively correlated with kidney and liver 8-OHdG at the first month and positively correlated with brain 8-OHdG at the third month. Taken together, our data suggests that concentration and time of fluoride exposure had a significant effect on 8-OHdG, but the effect patterns of fluoride on 8-OHdG were different in the tissues, which suggests that the impact of fluoride on 8-OHdG may be a tissue-specific, as well as a non-monotonic positive correlation. [ABSTRACT FROM AUTHOR]

The Marine Isotope Stage (MIS5e) is characterized by a warmer climate than that of the pre-industrial period, and serves as an analog for the Current Warm Period (CWP). However, uncertainties persist regarding its climatic stability. Here, we retrieved a stalagmite (WXB075) from Wanxiang Cave in the eastern Qinghai-Tibetan Plateau, and employed absolute 230Th dating and relative annual layer data to establish a high-precision chronological framework for reconstructing the history of the Asian summer monsoon (ASM) and environmental evolution during early MIS5e with multiple proxies. The findings indicate that the annually laminated stalagmite was formed during Cooling Event 27 (C27). The deposition of WXB075 experienced a hiatus (∼125.58 ka BP) due to a significant cooling event in the North Atlantic, which may be linked to the unstable climate in the Northern Hemisphere. Additionally, the impact of meltwater discharge in high northern latitudes results in a two-phase evolution of the ASM, i.e., an initial weaker stage followed by a gradual increase (with the exception of deposition hiatus). The climatic instability of ASM is generally characterized by a quasi-60 year cycle that affects vegetation conditions, biological productivity, and karst hydroclimate dynamics. However, the increase in meltwater and decrease in temperature in the Northern Hemisphere have led to a weakened ASM and subsequent reduction in precipitation. Consequently, vegetation degradation above the cave has occurred along with a slowdown of karst hydroclimate. The vegetation conditions, organic matter content, and wet/drought of the karst hydroclimate were affected by both the large-scale monsoon circulation and local environment during extreme weakening (strengthening) of the monsoon when high-frequency climatic events of ASM occurred. A comparison of δ18O records between early MIS5e and the past 2000 years reveals that the climate during early MIS5e differed significantly from that of CWP, Medieval Warm Period (MWP), and Dark Age Cold Period (DACP) but was similar to Little Ice Age (LIA). Comparison with other geological records from the Northern Hemisphere indicates that climate instability was a widespread phenomenon during MIS5e. The power spectrum analysis of WXB075 δ18O reveals significant quasi-60 and 35 a cycles during the early MIS5e, which is consistent with the Atlantic Multidecadal Oscillation (AMO). The comprehensive results demonstrate that the ASM in the early MIS5e was closely linked to solar activity, Intertropical Convergence Zone (ITCZ) position, and Atlantic Meridional Overturning Circulation (AMOC). [ABSTRACT FROM AUTHOR]

Our understanding of climate dynamics during millennial-scale events is incomplete, partially due to the lack of their precise phase analyses under various boundary conditions. Here we present nine speleothem oxygen-isotope records from mid-to-low-latitude monsoon regimes with sub-centennial age precision and multi-annual resolution, spanning the Heinrich Stadial 2 (HS2) — a millennial-scale event that occurred at the Last Glacial Maximum. Our data suggests that the Greenland and Antarctic ice-core chronologies require +320- and +400-year adjustments, respectively, supported by extant volcanic evidence and radiocarbon ages. Our chronological framework shows a synchronous HS2 onset globally. Our records precisely characterize a centennial-scale abrupt "tropical atmospheric seesaw" superimposed on the conventional "bipolar seesaw" at the beginning of HS2, implying a unique response/feedback from low-latitude hydroclimate. Together with our observation of an early South American monsoon shift at the HS2 termination, we suggest a more active role of low-latitude hydroclimate dynamics underlying millennial events than previously thought. New cave records from monsoon regions improve the Greenland ice core chronological framework around the Heinrich Stadial 2 by an order of magnitude, suggesting a more active role of low-latitude hydroclimate in millennial-scale climate oscillations. [ABSTRACT FROM AUTHOR]

Fluoride is an environmental chemical that has adverse effects on articular cartilage, probably increasing osteoarthritis (OA) risk. However, this association still needs more epidemiological evidence to clarify. The aim of this study was to determine the relationships between chronic fluoride exposure and OA risk among the residents living in Tongyu County, China, 2019, with a frequency-matched case–control study (186 OA patients and 186 healthy participants). The results showed that urinary fluoride (UF) (2.73 ± 1.18 mg/L) was significantly higher in OA patients compared to the controls (2.35 ± 1.24 mg/L) (p < 0.002). After adjustment, the odds ratios (ORs) with 95% confidence intervals (95% CIs) between the OA risk and fluoride were calculated by the unconditional logistic regression. In full sample analysis, a 1 mg/L increase in UF level was associated with a 27% higher risk of OA (1.06–1.52, p = 0.008), and 4th quarter's participants were associated with higher risk when compared to 1st quarter (OR: 2.46, 95% CI: 1.34–4.57, p = 0.003). In stratified analysis, compared to 1st quarter, 4th quarter's participants were 4 times more likely to have OA (1.86–8.82, p < 0.001) in the non-obese group and 7.7 times more likely to have OA (2.58–25.05, p < 0.001) among adults ≤ 60 years. In conclusion, excessive exposure of water fluoride may increase OA risk, and could have more impact on the specific population such as non-obese, and adult aged ≤ 60 years. [ABSTRACT FROM AUTHOR]

Located at the southern boundary of the tropical rainfall belt within the South Africa monsoon regime, Rodrigues Island, ∼2500 km east of East Africa, is ideally located to investigate climatic changes over the southwest Indian Ocean (SWIO). In this study, we investigate the climatic controls of its modern interannual rainfall variability in terms of teleconnection and local effects. We find that increased rainfall over the SWIO tends to occur in association with anomalously warm (cold) SSTs over the equatorial central Pacific (Maritime Continent), resembling the central Pacific El Niño, closely linked with the Victoria mode in the North Pacific. Our analyses show that the low-level convergence induced by warm SST over the equatorial central Pacific leads to anomalous low-level divergence over the Maritime Continent and convergence over a large area surrounding the Rodrigues Island, which leads to increased rainfall over the SWIO during the rainy season. Meanwhile, the excited Rossby wave along the tropical Indian Ocean transports more water vapor from the tropical convergence zone into the SWIO via intensified northwest wind. Furthermore, positive feedback induced by the Rossby wave response to the increased rainfall in the region contributes to the large interannual variations over the SWIO. [ABSTRACT FROM AUTHOR]

The Asian summer monsoon (ASM) is a vast climate system, whose variability is critical to the livelihoods of billions of people across the Asian continent. During the past half-century, much progress has been made in understanding variations on a wide range of timescales, yet several significant issues remain unresolved. Of note are two long-standing problems concerning orbital-scale variations of the ASM. (1) Chinese loess magnetic susceptibility records show a persistent glacial-interglacial dominated ~100 kyr (thousand years) periodicity, while the cave oxygen-isotope (δ18O) records reveal periodicity in an almost pure precession band (~20 kyr periodicity)—the "Chinese 100 kyr problem". (2) ASM records from the Arabian Sea and other oceans surrounding the Asian continent show a significant lag of 8–10 kyr to Northern Hemisphere summer insolation (NHSI), whereas the Asian cave δ18O records follow NHSI without a significant lag—a discrepancy termed the "sea-land precession-phase paradox". How can we reconcile these differences? Recent and more refined model simulations now provide spatial patterns of rainfall and wind across the precession cycle, revealing distinct regional divergences in the ASM domain, which can well explain a large portion of the disparities between the loess, marine, and cave proxy records. Overall, we also find that the loess, marine, and cave records are indeed complementary rather than incompatible, with each record preferentially describing a certain aspect of ASM dynamics. Our study provides new insight into the understanding of different hydroclimatic proxies and largely reconciles the "Chinese 100 kyr problem" and "sea-land precession-phase paradox". [ABSTRACT FROM AUTHOR]

Stalagmite is one kind of secondary carbonates formed in limestone caves (speleothem). After cave water droplets containing Ca2+ and H C O 3 − drip onto floor, carbonate in the water might become supersaturated due to CO2 degassing under certain conditions, resulting in the formation of stalagmite in a process year after year. Stalagmite is one of important geological archives for paleoclimate research. The advantages include wide spatial distribution, suitable for U-Th and U-Pb dating, enriched in climate proxies, continuity, long time span, comparability and lower sampling cost etc. These factors have propelled stalagmite paleoclimate research to the forefront of global paleoclimatology with an irreplaceable role. The stalagmite paleoclimate study started in the western countries, mainly in Europe and America in 1960s–1970s, while the relevant research in China was progressively developed in the 1980s–1990s after the Reform and Opening up. Although there was a huge gap between the overall research level in China and western countries, a solid research foundation, as well as a number of talent teams were established during the period. In the 21st century, starting from the publication of stalagmite records from Hulu Cave in Nanjing in 2001, the stalagmite paleoclimate research in China has ushered in a flourishing development and a real leap on the basis of international cooperation, resulting in significant international impacts. The landmark achievements, including establishment of the world's longest (640000 years) East Asian monsoon stalagmite record, as well as the longest Indian monsoon (280000 years), South American monsoon (250000 years), North American westerly climate (330000 years), Central Asian westerly climate (135000 years), and northwestern China westerly climate (500000 years), have laid a milestone in the paleoclimate study in these climate domains. Importantly, these stalagmite records have revealed the relationship of Asian monsoon variations with solar insolation climate change in polar regions, and the South American monsoon changes on orbital-suborbital timescales, which have provided new geological observations for the development of orbital-suborbital climate theory; elaborated coupling and differentiation relationships between the Asian monsoon and the westerly climate; reconstructed the history of Asian monsoon changes in the Holocene in detail, and thus the hydrological and climate variances behind Chinese and Indian civilization-cultural evolutions. Furthermore, a large number of high-resolution stalagmite records over the past 2000 years have been reconstructed, which are important for understanding short-term climate variability and magnitude, events, cycles, and thus the future climate projection. The achievements have also involved the improvements of a number of important techniques, such as U-Th dating method, the establishments of various hydroclimatic proxies, as well as the contributions to the reconstruction of the atmosphere 14C variation history over the past ∼54000 years. On the perspective of the future, the Chinese stalagmite community should continue to develop key techniques, further clarify the hydroclimatic significance of stalagmite proxies, impel the integration of related disciplines, and concentrate on key scientific issues in global climate change and major social demands. [ABSTRACT FROM AUTHOR]

Cave oxygen isotope (δ18O) records have been important in characterizing Asian Monsoon variations on a wide range of timescales. The climatic significance of the δ18O proxy of the cave records and its main control factors, however, remain hotly debated, especially with respect to annual to decadal timescales. In particular, while the spatial and intensity variations of the Western Pacific Subtropical High (WPSH) affects the East Asian Monsoon remarkably on annual to decadal timescales, cave records up to present do not show clear evidence of the WPSH signal. Here we report a new high-resolution (average of 1.5 months) δ18O record from Dongshiya Cave, Qinling Mountain, central China. The region is highly sensitive to variations in the position of the WPSH western boundary, which in turn regulates the alternation of dominant moisture sources between the proximal Pacific Ocean and the remote Indian Ocean. Together with another cave record near the WPSH western boundary, we established a new index to reconstruct variations of the WPSH western boundary over the past 200 years. Our new data revealed two significant periodicities, 12 and 2-7 years respectively, that can be causally linked to solar and ENSO variances correspondingly. [ABSTRACT FROM AUTHOR]

Contact resistance at the interface between metal electrodes and semiconductors can significantly limit the performance of organic field-effect transistors, leading to a distinct voltage drop at the interface. Here, we demonstrate enhanced performance of n-channel field-effect transistors based on solution-grown C single-crystalline ribbons by introducing an interlayer of a conjugated polyelectrolyte (CPE) composed of poly[(9,9-bis(3′-(( N, N-dimethyl)- N-ethylammonium)-propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)] dibromide (PFNBr). The PFNBr interlayer greatly improves the charge injection. Consequently, the electron mobility is promoted up to 5.60 cm V s and the threshold voltage decreased dramatically with the minimum of 4.90 V. [ABSTRACT FROM AUTHOR]

High-mobility organic field-effect transistors (OFETs) are the basic units for a variety of high-performance electronic applications. Here, we review recent progress in controlling molecular packing and crystal growth in high-mobility, small molecular organic FETs. Strategies to tune molecular packing of organic semiconductors and their impact on charge transport are described. Methods for the controlled growth of single-crystal organic semiconductors required for large-area device construction are reviewed. Furthermore, the advantages, limitations, and potential of these methods are also discussed. [ABSTRACT FROM PUBLISHER]

Organic-inorganic perovskite as a promising candidate for solar energy harvesting has attracted immense interest for its low-cost preparation and extremely high quantum efficiency. However, the fundamental understanding of the photophysics in perovskite remains elusive. In this work, we have revealed two distinct states in MAPbI3 thin films at low temperature through time-resolved photoluminescence spectroscopy (TRPL). In particular, we observed a photo-induced carrier injection from the high energy (HE) state to the low energy (LE) state which has a longer lifetime. The strong interaction between the two states, evidenced by the injection kinetics, can be sensitively controlled through the excitation power. Understanding of the interacting two-states not only sheds light on the long PL lifetime in perovskite but also helps to understand the different behavior of perovskite in response to different excitation power. Further efforts in modifying the low energy state could significantly improve the quantum efficiency and lead to novel application in optoelectronics based on perovskite. [ABSTRACT FROM AUTHOR]