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Background: Myricetin, a flavonoid, has anti-inflammation effects and can improve pancreatic β cells dysfunction. However, the role of myricetin in severe acute pancreatitis (SAP) and the precise mechanism remain unclear. Objectives: This study aimed to investigate how myricetin affects pancreatic damage induced by SAP. Results: Myricetin substantially reduced the expression of lipase and amylase, and ameliorated pancreatic damage induced by SAP. Moreover, myricetin inhibited the release of several inflammatory relevant cytokines including tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-10, alleviated apoptosis of pancreatic alveolar cells, and ameliorated microcirculatory dysfunction in SAP rats. Furthermore, myricetin inhibited the acetylation of forkhead box protein O1(FOXO1) and the phosphorylation of NF-kB. Conclusion: Myricetin improves SAP-induced pancreatic injury through suppressing microcirculation dysfunction, overactive inflammatory response, and cell apoptosis. In addition, myricetin deregulates acetylated FOXO1 and phosphorylated nuclear factor kappa B (NF-kB), which may be the potential mechanism for SAP alleviation. [ABSTRACT FROM AUTHOR]

Phase unwrapping is a crucial step in almost all Interferometric Synthetic Aperture Radar (InSAR) applications. However, the presence of noise often introduces phase inconsistencies, known as residues, which lead to ambiguous solutions. This paper builds upon the unscented Kalman filter phase unwrapping method and combines a modified phase gradient estimation algorithm, a pre-filtering step based on a neural network, and previous work to achieve higher precision in unwrapping the phase. The pre-filtering step aims to obtain a fringe-enhanced interferogram. The proposed method estimates the phase gradient of the pre-filtered interference phase and integrates it with the unscented Kalman filter phase unwrapping method. Additionally, it incorporates a strategy based on pixel reliability grades and introduces a new path-following strategy to obtain more accurate unwrapped phases. Unlike the traditional unscented Kalman filter phase unwrapping method, the proposed method can simultaneously unwrap multiple pixels, thereby improving the efficiency of the phase unwrapping process. Experimental results of simulated and real data demonstrate that the method proposed in this paper achieves better unwrapped results, especially when dealing with interferograms containing unclear fringes. [ABSTRACT FROM AUTHOR]

The development of high-performance lead-free K0.5Na0.5NbO3-based piezoceramics for replacing commercial lead-containing counterparts is crucial for achieving environmentally sustainable society. Although the proposed new phase boundaries (NPB) can effectively improve the piezoelectricity of KNN-based ceramics, the difficulty of achieving saturated poling and the underlying multiscale structures resolution of their complex microstructures are urgent issues. Here, we employ a medium entropy strategy to design NPB and utilize texture engineering to induce crystal orientation. The developed K0.5Na0.5NbO3-based ceramics enjoys both prominent piezoelectric performance and satisfactory Curie temperature, thus exhibiting an ultrahigh energy harvesting performance as well as excellent transducer performance, which is highly competitive in both lead-free and lead-based piezoceramics. Comprehensive structural analysis have ascertained that the field-induced efficient multiscale polarization configurations irreversible transitions greatly encourages high saturated poling. This study demonstrates a strategy for designing high-performance piezoceramics and establishes a close correlation between the piezoelectricty and the underlying multiscale structures. There are difficulty of achieving saturated poling and understanding of multi-scale structures in (K, Na)NbO3 ceramics. Here, the authors find atomic-scale polymorphic distortion and micrometer-scale high-density thin striped domains, which is key for high saturated poling. [ABSTRACT FROM AUTHOR]

The family of rare-earth doped phosphors has drawn pronounced attention in technological of fingerprint visualization, anti-counterfeiting, and phosphor-converted light-emitting diodes applications. A series of NaSrGd(1–x–y)EuxDyy(WO4)3 powder luminescent materials were synthesized by a solid-state reaction. The emission color of NaSrGd(WO4)3:Dy3+ phosphor could be tunned via changing concentrations of Eu3+ ion. In addition, the phosphors exhibit narrow red-light emission at 610 nm caused by the electric dipole transition 5D0 → 7F2 of Eu3+. Especially, the phosphor exhibits superior thermal stability, its emission intensity of optimum sample remained ± 15% over the temperature range from 233 to 393 K. The Commission International de I'Eclairage (CIE) chromaticity coordinates of x = 0.4 are (0.6388, 0.3371) with a high color purity (92.84%). More importantly, prepared color-changing device of phosphors achieves a high level of optical safety. The results demonstrate that their materials can be potentially applied to the field of white light-emitting diodes (LEDs) and optical anti-counterfeiting. [ABSTRACT FROM AUTHOR]

Acute lung injury (ALI) is a life-threatening clinical condition associated with critically ill patients, and the construction of potential microRNA (miRNA) and messenger RNA (mRNA) regulatory networks will help to fully elucidate its underlying molecular mechanisms. First, we screened fifteen upregulated differentially expressed miRNAs (DE-miRNAs) and six downregulated DE-miRNAs from the Gene Expression Omnibus (GEO) database. Then, the predicted target genes of the upregulated and downregulated DE-miRNAs were identified from the miRNet database. Subsequently, differentially expressed mRNAs (DE-mRNAs) were identified from the GEO database and subjected to combined analysis with the predicted DE-miRNA target genes. Eleven target genes of the upregulated DE-miRNAs and one target gene of the downregulated DE-miRNAs were screened out. To further validate the prediction results, we randomly selected a dataset for subsequent analysis and found some accurate potential miRNA-mRNA regulatory axes, including mmu-mir-7b-5p-Gria1, mmu-mir-486a-5p-Shc4 and mmu-mir-486b-5p-Shc4 pairs. Finally, mir-7b and its target gene Gria1 and mir-486b and its target gene Shc4 were further validated in a bleomycin-induced ALI mouse model. We established a potential miRNA-mRNA regulatory network of ALI in mice, which may provide a basis for basic and clinical research on ALI and advance the available treatment options. [ABSTRACT FROM AUTHOR]

Software traceability links are established between diverse artifacts of the software development process in order to support tasks such as compliance analysis, safety assurance, and requirements validation. However, practice has shown that it is difficult and costly to create and maintain trace links in non-trivially sized projects. For this reason, many researchers have proposed and evaluated automated approaches based on information retrieval and deep-learning. Generating trace links automatically can also be challenging – especially in multi-national projects which include artifacts written in multiple languages. The intermingled language use can reduce the efficiency of automated tracing solutions. In this work, we analyze patterns of intermingled language that we observed in several different projects, and then comparatively evaluate different tracing algorithms. These include Information Retrieval techniques, such as the Vector Space Model (VSM), Latent Semantic Indexing (LSI), Latent Dirichlet Allocation (LDA), and various models that combine mono- and cross-lingual word embeddings with the Generative Vector Space Model (GVSM), and a deep-learning approach based on a BERT language model. Our experimental analysis of trace links generated for 14 Chinese-English projects indicates that our MultiLingual Trace-BERT approach performed best in large projects with close to 2-times the accuracy of the best IR approach, while the IR-based GVSM with neural machine translation and a monolingual word embedding performed best on small projects. [ABSTRACT FROM AUTHOR]

The rapid repair of gastric mucosa is critical upon exposure to injurious agents. Intestinal trefoil factor (ITF) is a member of the trefoil factor family domain peptides, which play an important role in the cytoprotection of gastric epithelium. However, the underlying molecular mechanisms that are responsible for ITF-induced gastric epithelial repair remain unclear. In the present study, we demonstrate that ITF enhances the proliferation and migration of GES-1 gastric endothelial cells in a dose- and time-dependent manner through the activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Furthermore, the ITF-mediated protection of GES-1 cells from a NS398 (nonsteroidal anti-inflammatory drug) was dependent on the ERK1/2 signaling pathway. Taken together, the results provide a mechanistic explanation for ITF-mediated protection of gastric epithelial mucosa cells, suggesting that activation of the ERK1/2 signaling pathway may provide a new therapeutic strategy for repairing gastric injury. [ABSTRACT FROM AUTHOR]