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Radiogenic isotope dating of illitic clays has been widely used to reconstruct thermal and fluid flow events in siliciclastic sedimentary basins, the information of which is critical to investigate mechanisms of hydrocarbon maturation. This study carried out Rb−Sr and 40Ar−39Ar dating of authigenic illitic clay samples separated from the Palaeogene sandstone in the northern South China Sea. Our Rb−Sr data further confirm the previously reported three periods of fluid flow events (at 34.5 ± 0.9, 31.2 ± 0.6, and 23.6 ± 0.8 Ma, respectively) in the northern South China Sea, which are related to regional episodic tectonism. However, 40Ar−39Ar ages of illite obtained in this study are significantly younger than the corresponding Rb−Sr ages. The significantly younger 40Ar−39Ar ages were probably due to 40Ar loss caused by later dry heating events on the Hainan Island that have not affected the Rb−Sr isotopic systematics. The inconsistency between Rb−Sr and 40Ar−39Ar data should be attributed to different isotopic behaviors of K−Ar and Rb−Sr isotopic systematics in illite. Our results indicate that Rb−Sr isotopic dating method may be a preferential approach for clay dating in geological settings where exist younger dry heating events. [ABSTRACT FROM AUTHOR]

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were designated as variants of concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact on vaccine-mediated protection from disease. To ascertain and rank the risk of VOCs and VOIs, we analyze the ability of 14 variants (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron) to escape from mRNA vaccine-induced antibodies. The variants show differential reductions in neutralization and replication by post-vaccination sera. Although the Omicron variant (BA.1, BA.1.1, and BA.2) shows the most escape from neutralization, sera collected after a third dose of vaccine (booster sera) retain moderate neutralizing activity against that variant. Therefore, vaccination remains an effective strategy during the COVID-19 pandemic. Emerging SARS-CoV-2 variants raise concerns on immune evasion. Here, the authors evaluate the neutralization efficiency of COVID-19 mRNA vaccinee sera against representative viruses of 13 WHO-designated SARS-CoV-2 variants of concern/interest. [ABSTRACT FROM AUTHOR]

We consider a digital product seller who needs to determine the number of items to sell and its price over an infinite horizon. The seller indeed owns unlimited supply of the digital products like music or software. Each buyer is risk-neutral and needs one unit of the product. The number of buyers in each period and their private valuations are random. The seller conducts an auction to allocate the items in each period. The buyers who fail to gain one item in the previous periods will rebid in the subsequent auctions. Regarding the formulated dynamic program, we prove that the optimal allocation solution is a variant of the base-stock policy. Based on the known Revenue Equivalence Principle, we also prove that the generalized second-price auction and the first-price auction will result in the same expected revenue for the seller. Finally, with mild technical modifications, the results of the infinite-horizon case can be extended to the finite-horizon case even if the demand is time-varying stochastic and independent. [ABSTRACT FROM AUTHOR]

During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike glycoprotein (S) has emerged; virus containing this substitution has become the predominant circulating variant in the COVID-19 pandemic1. However, whether the increasing prevalence of this variant reflects a fitness advantage that improves replication and/or transmission in humans or is merely due to founder effects remains unknown. Here we use isogenic SARS-CoV-2 variants to demonstrate that the variant that contains S(D614G) has enhanced binding to the human cell-surface receptor angiotensin-converting enzyme 2 (ACE2), increased replication in primary human bronchial and nasal airway epithelial cultures as well as in a human ACE2 knock-in mouse model, and markedly increased replication and transmissibility in hamster and ferret models of SARS-CoV-2 infection. Our data show that the D614G substitution in S results in subtle increases in binding and replication in vitro, and provides a real competitive advantage in vivo—particularly during the transmission bottleneck. Our data therefore provide an explanation for the global predominance of the variant that contains S(D614G) among the SARS-CoV-2 viruses that are currently circulating. A SARS-CoV-2 variant containing a D614G substitution in the spike protein shows enhanced binding to human ACE2, increased replication in human cell cultures and a competitive advantage in animal models of infection. [ABSTRACT FROM AUTHOR]

oIn order to realize the application of continuous glass fibers (GFs) in polyvinyl chloride (PVC), the wet powder impregnation technology was introduced to the preparation of the PVC/GF composites to improve the mechanical properties of the PVC products. During the molding process, the PVC powder impregnated GFs tapes were prepared first and then hot pressed into the test samples. Besides, the effect of the processing conditions, such as molding temperature, molding pressure and dwelling time, on the mechanical properties of the samples were investigated. In addition, the coupling agents and the heat stabilizers were also applied to improve the bonding interface between GFs and PVC and the thermal stability of the composites. The experimental results indicated that the samples prepared with the molding temperature of 160 °C, the molding pressure of 6 MPa and the dwelling time of 10 min could achieve the best mechanical properties. Moreover, the addition of KH550 could greatly improve the bonding interface and the mechanical properties. The applied organotin heat stabilizer also caused a definite improvement in the Vicat softening temperature and the heat deflection temperature of the samples. [ABSTRACT FROM AUTHOR]

Influenza A viruses pose a major public health threat by causing seasonal epidemics and sporadic pandemics. Their epidemiological success relies on airborne transmission from person to person; however, the viral properties governing airborne transmission of influenza A viruses are complex. Influenza A virus infection is mediated via binding of the viral haemagglutinin (HA) to terminally attached α2,3 or α2,6 sialic acids on cell surface glycoproteins. Human influenza A viruses preferentially bind α2,6-linked sialic acids whereas avian influenza A viruses bind α2,3-linked sialic acids on complex glycans on airway epithelial cells. Historically, influenza A viruses with preferential association with α2,3-linked sialic acids have not been transmitted efficiently by the airborne route in ferrets. Here we observe efficient airborne transmission of a 2009 pandemic H1N1 (H1N1pdm) virus (A/California/07/2009) engineered to preferentially bind α2,3-linked sialic acids. Airborne transmission was associated with rapid selection of virus with a change at a single HA site that conferred binding to long-chain α2,6-linked sialic acids, without loss of α2,3-linked sialic acid binding. The transmissible virus emerged in experimentally infected ferrets within 24 hours after infection and was remarkably enriched in the soft palate, where long-chain α2,6-linked sialic acids predominate on the nasopharyngeal surface. Notably, presence of long-chain α2,6-linked sialic acids is conserved in ferret, pig and human soft palate. Using a loss-of-function approach with this one virus, we demonstrate that the ferret soft palate, a tissue not normally sampled in animal models of influenza, rapidly selects for transmissible influenza A viruses with human receptor (α2,6-linked sialic acids) preference. [ABSTRACT FROM AUTHOR]

In this paper, with the application of satellite thermal infrared remote sensing technique, nine land surface temperature distribution maps of Changbaishan Tianchi volcano area are retrieved from nine thermal infrared images which are taken from 1999 to 2008. In terms of NDVI (Normalized Difference Vegetation Index), we classify the surface cover of the study area into three types, i.e. vegetation (forest), mixture of soil and vegetation (short grasses), and bare rock. The average temperature of each type of surface covers is calculated first, and then the average daily temperature record from Tianchi meteorological station is subtracted in order to reduce the effect of weather variation. Finally, thermal anomalies of three types of surface cover in Changbaishan Tianchi volcano area in the period of 1999 to 2008 are obtained, which is believed to reflect the magmatic activity in the magma chamber under Tianchi volcano caldera. Our results indicate that temperature of the study area increased with an intermittent tendency during 1999 to 2005, but dropped after 2005, and then maintained a relatively stable state from 2006 to 2008. Such a tendency of annual temperature variation possibly caused by magmatic activity is correlated with the results observed by means of seismic monitoring, ground deformation from GPS measurement, and volcanic gas geochemistry monitoring in the same area. It is implied that the upward intrusion of magma may cause temperature increase, and such temperature variation is great enough so that could be detected by using satellite thermal infrared remote sensing technology. [ABSTRACT FROM AUTHOR]

As a continuation of our previous work [Optics Express.25, 15229(2017)] in which we have verified the performance of a coherent free space optical communication (FSOC) system with a 97-element adaptive optics (AO) system, in this paper, we evaluated the performance improvement of the coherent FSOC system using a large-scale high-speed AO system with a 349-element continuous surface deformable mirror. The mixing efficiency (ME) and bit-error-rate (BER) under different Greenwood frequency (GF) were calculated as the performance metric of coherent FSOC system. The performance of FSOC system using such a large-scale AO system was quantitatively verified for the first time. The obtained results showed that the performance was obviously improved when a larger-scale high-speed AO system is employed in coherent FSOC system. This analysis result provides a performance verification for large-scale high-speed AO systems used in FSOC system which is beneficial for coherent FSOC system parameters design. [ABSTRACT FROM AUTHOR]

Technologies for mapping the spatial and temporal patterns of neural activity have advanced our understanding of brain function in both health and disease. An important application of these technologies is the discovery of next-generation neurotherapeutics for neurological and psychiatric disorders. Here, we describe an in vivo drug screening strategy that combines high-throughput technology to generate large-scale brain activity maps (BAMs) with machine learning for predictive analysis. This platform enables evaluation of compounds' mechanisms of action and potential therapeutic uses based on information-rich BAMs derived from drug-treated zebrafish larvae. From a screen of clinically used drugs, we found intrinsically coherent drug clusters that are associated with known therapeutic categories. Using BAM-based clusters as a functional classifier, we identify anti-seizure-like drug leads from non-clinical compounds and validate their therapeutic effects in the pentylenetetrazole zebrafish seizure model. Collectively, this study provides a framework to advance the field of systems neuropharmacology. A major goal in neuropharmacology is to develop new tools to effectively test the therapeutic potential of pharmacological agents to treat neurological and psychiatric conditions. Here, authors present an in vivo drug screening system that generates large-scale brain activity maps to be used with machine learning to predict the therapeutic potential of clinically relevant drug leads. [ABSTRACT FROM AUTHOR]