Author: "Lindquist A" / Publisher: springer nature - Searchworks@Jio Institute Digital Library Search Results

788 results on '"Lindquist A"'

1. Spaced recall reduces forgetting of fundamental mathematical concepts in a post high school precalculus course.

Author: Lindquist, Diane S., Sparrow, Brenda E., and Lindquist, Joseph M.
Subjects: UNITED States armed forces, TEACHING methods, HIGH school curriculum, SCHOOL dropout prevention, PREPARATORY schools
Abstract: The retention of fundamental mathematical skills is imperative to provide a foundation on which new skills are developed. Educators often lament about student retention. Cognitive scientists and educators have explored teaching methods that produce learning which endures over time. We wanted to know if using spaced recall quizzes would prevent our students from forgetting fundamental mathematical concepts at a post high school preparatory school where students attend for 1 year preparing to enter the United States Military Academy (USMA). This approach was implemented in a Precalculus course to determine if it would improve students' long-term retention. Our goal was to identify an effective classroom strategy that led to student recall of fundamental mathematical concepts through the end of the academic year. The concepts that were considered for long-term retention were 12 concepts identified by USMA's mathematics department as being fundamental for entering students. These concepts are taught during quarter one of the Precalculus with Introduction to Calculus course at the United States Military Academy Preparatory School. It is expected that students will remember the concepts when they take the post-test 6 months later. Our research shows that spaced recall in the form of quizzing had a statistically significant impact on reducing the forgetting of the fundamental concepts while not adversely effecting performance on current instructional concepts. Additionally, these results persisted across multiple sections of the course taught at different times of the day by six instructors with varying teaching styles and years of teaching experience. [ABSTRACT FROM AUTHOR]
Published: 2024
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2. Slowly getting there: a review of country experience on estimating emissions and removals from forest degradation.

Author: Neeff, Till, Gamarra, Javier G. P., Vollrath, Andreas, Lindquist, Erik, Gill, Ghislaine, Fox, Julian, Smith, Jennifer, Dyson, Karen, Tenneson, Karis, Sandker, Marieke, and Nakalema, Teopista
Subjects: GREENHOUSE gas mitigation, FOREST degradation, GOVERNMENT policy on climate change, DATA analysis
Abstract: Estimating emissions and removals from forest degradation is important, yet challenging, for many countries. This paper reports results from analysis of country reporting (to the United Nations Framework Convention on Climate Change and also to several climate finance initiatives) and key take-aways from a south-south exchange workshop among 17 countries with forest mitigation programmes. During the workshop discussions it became clear that, where forest degradation is a major source of emissions, governments want to include it when reporting on their mitigation efforts. However, challenges to accurately estimating emissions from degradation relate to defining forest degradation and setting the scope for estimating carbon stock changes; to detecting and monitoring degradation using earth observation data; and to estimating associated emissions and removals from field observation results. The paper concludes that recent and ongoing investments into data and analysis methods have helped improve forest degradation estimation, but further methodological work and continued effort will be needed. [ABSTRACT FROM AUTHOR]
Published: 2024
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3. A non-classical parameterization for density estimation using sample moments.

Author: Wu, Guangyu and Lindquist, Anders
Subjects: MOMENTS method (Statistics), DATA science, PARAMETERIZATION, DENSITY, PROBABILITY theory, NONPARAMETRIC estimation
Abstract: Probability density estimation is a core problem in statistics and data science. Moment methods are an important means of density estimation, but they are generally strongly dependent on the choice of feasible functions, which severely affects the performance. In this paper, we propose a non-classical parametrization for density estimation using sample moments, which does not require the choice of such functions. The parametrization is induced by the squared Hellinger distance, and the solution minimizing it, which is proved to exist and be unique subject to a simple prior that does not depend on data, and which can be obtained by convex optimization. Statistical properties of the density estimator, together with an asymptotic error upper bound, are proposed for the estimator by power moments. Simulation results validate the performance of the estimator by a comparison to several prevailing methods. The convergence rate of the proposed estimator is proved to be m - 1 / 2 (m being the number of data samples), which is the optimal convergence rate for parametric estimators and exceeds that of the nonparametric estimators. To the best of our knowledge, the proposed estimator is the first one in the literature for which the power moments up to an arbitrary even order exactly match the sample moments, while the true density is not assumed to fall within specific function classes. [ABSTRACT FROM AUTHOR]
Published: 2024
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4. Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery.

Author: Krueger, Johanna, Krauth, Richard, Reichert, Christoph, Perdikis, Serafeim, Vogt, Susanne, Huchtemann, Tessa, Dürschmid, Stefan, Sickert, Almut, Lamprecht, Juliane, Huremovic, Almir, Görtler, Michael, Nasuto, Slawomir J., Tsai, I.-Chin, Knight, Robert T., Hinrichs, Hermann, Heinze, Hans-Jochen, Lindquist, Sabine, Sailer, Michael, Millán, Jose del R., and Sweeney-Reed, Catherine M.
Subjects: ELECTRIC stimulation, EVOKED potentials (Electrophysiology), NEUROPLASTICITY, STROKE, FUNCTIONAL assessment, TRANSCRANIAL magnetic stimulation
Abstract: Functional electrical stimulation (FES) can support functional restoration of a paretic limb post-stroke. Hebbian plasticity depends on temporally coinciding pre- and post-synaptic activity. A tight temporal relationship between motor cortical (MC) activity associated with attempted movement and FES-generated visuo-proprioceptive feedback is hypothesized to enhance motor recovery. Using a brain–computer interface (BCI) to classify MC spectral power in electroencephalographic (EEG) signals to trigger FES-delivery with detection of movement attempts improved motor outcomes in chronic stroke patients. We hypothesized that heightened neural plasticity earlier post-stroke would further enhance corticomuscular functional connectivity and motor recovery. We compared subcortical non-dominant hemisphere stroke patients in BCI-FES and Random-FES (FES temporally independent of MC movement attempt detection) groups. The primary outcome measure was the Fugl-Meyer Assessment, Upper Extremity (FMA-UE). We recorded high-density EEG and transcranial magnetic stimulation-induced motor evoked potentials before and after treatment. The BCI group showed greater: FMA-UE improvement; motor evoked potential amplitude; beta oscillatory power and long-range temporal correlation reduction over contralateral MC; and corticomuscular coherence with contralateral MC. These changes are consistent with enhanced post-stroke motor improvement when movement is synchronized with MC activity reflecting attempted movement. [ABSTRACT FROM AUTHOR]
Published: 2024
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5. Causal inference on human behaviour.

Author: Bailey, Drew H., Jung, Alexander J., Beltz, Adriene M., Eronen, Markus I., Gische, Christian, Hamaker, Ellen L., Kording, Konrad P., Lebel, Catherine, Lindquist, Martin A., Moeller, Julia, Razi, Adeel, Rohrer, Julia M., Zhang, Baobao, and Murayama, Kou
Published: 2024
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6. Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain.

Author: Botvinik-Nezer, Rotem, Petre, Bogdan, Ceko, Marta, Lindquist, Martin A., Friedman, Naomi P., and Wager, Tor D.
Subjects: NOCICEPTIVE pain, AFFECTIVE neuroscience, PLACEBOS, STIMULUS intensity, AFFECT (Psychology), PAIN management
Abstract: Drug treatments for pain often do not outperform placebo, and a better understanding of placebo mechanisms is needed to improve treatment development and clinical practice. In a large-scale fMRI study (N = 392) with pre-registered analyses, we tested whether placebo analgesic treatment modulates nociceptive processes, and whether its effects generalize from conditioned to unconditioned pain modalities. Placebo treatment caused robust analgesia in conditioned thermal pain that generalized to unconditioned mechanical pain. However, placebo did not decrease pain-related fMRI activity in brain measures linked to nociceptive pain, including the Neurologic Pain Signature (NPS) and spinothalamic pathway regions, with strong support for null effects in Bayes Factor analyses. In addition, surprisingly, placebo increased activity in some spinothalamic regions for unconditioned mechanical pain. In contrast, placebo reduced activity in a neuromarker associated with higher-level contributions to pain, the Stimulus Intensity Independent Pain Signature (SIIPS), and affected activity in brain regions related to motivation and value, in both pain modalities. Individual differences in behavioral analgesia were correlated with neural changes in both modalities. Our results indicate that cognitive and affective processes primarily drive placebo analgesia, and show the potential of neuromarkers for separating treatment influences on nociception from influences on evaluative processes. The mechanisms underlying placebo analgesia are not fully understood. Here the authors show that a placebo treatment inducing analgesia in healthy participants reduced fMRI activity in systems related to evaluative and affective processes, but not systems related to nociceptive pain processing. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. Reprising Materials Science in the Additive Manufacturing Classroom.

Author: Noe, C., Brim, K., Sparks, R., Lindquist, N., and Bhate, D.
Subjects: MATERIALS science, CLASSROOMS
Published: 2024
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8. Pelvic Floor Muscle Training on Stress Urinary Incontinence in Power- and Weightlifters: a Pilot Study.

Author: Bø, Kari, Lillegård, Ragnhild Haug, and Skaug, Kristina Lindquist
Subjects: KEGEL exercises, URINARY stress incontinence, PELVIC floor, WEIGHT lifters, SPORTS participation, PILOT projects
Abstract: Introduction and hypothesis: Stress urinary incontinence (SUI) is defined as involuntary leakage of urine on physical effort and is prevalent among power- and weightlifters. However, there is scant knowledge on treatment options for this population. The aim of this pilot study was to evaluate the potential outcomes and feasibility of a pelvic floor muscle training (PFMT) program on SUI in nulliparous female power- and weightlifters. Methods: This was a case-series study, including one weightlifter and two powerlifters aged 21–32 years. The participants conducted 12 weeks of PFMT at home, with weekly follow-up by a physiotherapist. Change in total score of the International Consensus of Incontinence Questionnaire Urinary Incontinence Short Form (ICIQ-UI-SF) was the primary outcome. Secondary outcome was perceived change assessed by the Patient Global Impression of Improvement (PGI-I) Scale and impact on sport participation. PFM strength, endurance, and resting pressure was measured using vaginal manometry. Feasibility was evaluated as adherence to training and self-efficacy (Self Efficacy Scale for Practicing Pelvic Floor Exercises). Results: One athlete reduced their ICIQ-UI-SF score and experienced improvement in symptoms. One athlete reported no change, and one reported a worsening of symptoms. All three participants improved PFM strength and endurance, completed the testing, and 12 weeks of PFMT, but adherence varied between 40 and 80%. Participants reported a lack of time and energy and forgetting to perform the exercises, as reasons for low adherence. Conclusion: There were varying effects of a 12-week PFMT program on SUI in three strength athletes. The results can create the basis for a future randomized controlled trial. [ABSTRACT FROM AUTHOR]
Published: 2024
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9. Short Term Coping-Behaviors and Postpartum Health in a Population-Based Study of Women with a Live Birth, Stillbirth, or Neonatal Death.

Author: Stanhope, Kaitlyn K., Temple, Jeff R., Christiansen-Lindquist, Lauren, Dudley, Donald, Stoll, Barbara J., Varner, Michael, and Hogue, Carol J. R.
Subjects: BEHAVIORAL assessment, EDINBURGH Postnatal Depression Scale, SUPPORT groups, RESEARCH funding, CHILD health services, LOGISTIC regression analysis, SMOKING, PSYCHOLOGY of women, PERINATAL death, PSYCHOLOGICAL adaptation, POSTNATAL care, DESCRIPTIVE statistics, PREGNANCY outcomes, THEMATIC analysis, ODDS ratio, SPIRITUALITY, CONFIDENCE intervals, ALCOHOL drinking, MENTAL depression
Abstract: Objective: Responding to the National Institutes of Health Working Group's call for research on the psychological impact of stillbirth, we compared coping-related behaviors by outcome of an index birth (surviving live birth or perinatal loss – stillbirth or neonatal death) and, among individuals with loss, characterized coping strategies and their association with depressive symptoms 6–36 months postpartum. Methods: We used data from the Stillbirth Collaborative Research Network follow-up study (2006–2008) of 285 individuals who experienced a stillbirth, 691 a livebirth, and 49 a neonatal death. We conducted a thematic analysis of coping strategies individuals recommended following their loss. We fit logistic regression models, accounting for sampling and inverse probability of follow-up weights to estimate associations between pregnancy outcomes and coping-related behaviors and, separately, coping strategies and probable depression (Edinburgh Postnatal Depression Scale > 12) for those with loss. Results: Compared to those with a surviving live birth and adjusting for pre-pregnancy drinking and smoking, history of stillbirth, and age, individuals who experienced a loss were more likely to report increased drinking or smoking in the two months postpartum (adjusted OR: 2.7, 95% CI = 1.4–5.4). Those who smoked or drank more had greater odds of probable depression at 6 to 36 months postpartum (adjusted OR 6.4, 95% CI = 2.5–16.4). Among those with loss, recommended coping strategies commonly included communication, support groups, memorializing the loss, and spirituality. Discussion: Access to a variety of evidence-based and culturally-appropriate positive coping strategies may help individuals experiencing perinatal loss avoid adverse health consequences. Significance: What Is Already Known on this Subject?: Experiencing a perinatal loss (stillbirth or neonatal death) is a traumatic event with potential long term psychologic consequences. Effective coping strategies can prevent complicated grief; yet little is known about current practices and preferences among parents who experience perinatal loss. What this Study Adds?: In a population-based study, individuals who experienced perinatal loss reported higher maladaptive coping (increased smoking and drinking) compared to those with healthy live birth. Individuals who experienced perinatal loss recommended a wide range of coping including communication, memorializing the loss, spirituality, and support groups. [ABSTRACT FROM AUTHOR]
Published: 2024
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10. Radiation therapy for cancer is potentially associated with reduced growth of concomitant abdominal aortic aneurysm.

Author: Becker von Rose, Aaron, Kobus, Kathrin, Bohmann, Bianca, Lindquist-Lilljequist, Moritz, Eilenberg, Wolf, Kapalla, Marvin, Bassermann, Florian, Reeps, Christian, Eckstein, Hans-Henning, Neumayer, Christoph, Brostjan, Christine, Roy, Joy, von Heckel, Korbinian, Hultgren, Rebecka, Schwaiger, Benedikt J., Combs, Stephanie E., Busch, Albert, and Schiller, Kilian
Abstract: Purpose: Co-prevalence of abdominal aortic aneurysm (AAA) and cancer poses a unique challenge in medical care since both diseases and their respective therapies might interact. Recently, reduced AAA growth rates were observed in cancer patients that received radiation therapy (RT). The purpose of this study was to perform a fine-grained analysis of the effects of RT on AAA growth with respect to direct (infield) and out-of-field (outfield) radiation exposure, and radiation dose-dependency. Methods: A retrospective single-center analysis identified patients with AAA, cancer, and RT. Clinical data, radiation plans, and aneurysm diameters were analyzed. The total dose of radiation to each aneurysm was computed. AAA growth under infield and outfield exposure was compared to patients with AAA and cancer that did not receive RT (no-RT control) and to an external noncancer AAA reference cohort. Results: Between 2003 and 2020, a total of 38 AAA patients who had received well-documented RT for their malignancy were identified. AAA growth was considerably reduced for infield patients (n = 18) compared to outfield patients (n = 20), albeit not significantly (0.8 ± 1.0 vs. 1.3 ± 1.6 mm/year, p = 0.28). Overall, annual AAA growth in RT patients was lower compared to no-RT control patients (1.1 ± 1.5 vs. 1.8 ± 2.2 mm/year, p = 0.06) and significantly reduced compared to the reference cohort (1.1 ± 1.5 vs. 2.7 ± 2.1 mm/year, p < 0.001). The pattern of AAA growth reduction due to RT was corroborated in linear regression analyses correcting for initial AAA diameter. A further investigation with respect to dose-dependency of radiation effects on AAA growth, however, revealed no apparent association. Conclusion: In this study, both infield and outfield radiation exposure were associated with reduced AAA growth. This finding warrants further investigation, both in a larger scale clinical cohort and on a molecular level. [ABSTRACT FROM AUTHOR]
Published: 2024
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11. Type I interferon shapes brain distribution and tropism of tick-borne flavivirus

Author: Chotiwan, Nunya, Rosendal, Ebba, Willekens, Stefanie M. A., Schexnaydre, Erin, Nilsson, Emma, Lindquist, Richard, Hahn, Max, Mihai, Ionut Sebastian, Morini, Federico, Zhang, Jianguo, Ebel, Gregory D., Carlson, Lars-Anders, Henriksson, Johan, Ahlgren, Ulf, Marcellino, Daniel, Överby, Anna K., Chotiwan, Nunya, Rosendal, Ebba, Willekens, Stefanie M. A., Schexnaydre, Erin, Nilsson, Emma, Lindquist, Richard, Hahn, Max, Mihai, Ionut Sebastian, Morini, Federico, Zhang, Jianguo, Ebel, Gregory D., Carlson, Lars-Anders, Henriksson, Johan, Ahlgren, Ulf, Marcellino, Daniel, and Överby, Anna K.
Abstract: Viral tropism within the brain and the role(s) of vertebrate immune response to neurotropic flaviviruses infection is largely understudied. We combine multimodal imaging (cm-nm scale) with single nuclei RNA-sequencing to study Langat virus in wildtype and interferon alpha/beta receptor knockout (Ifnar-/-) mice to visualize viral pathogenesis and define molecular mechanisms. Whole brain viral infection is imaged by Optical Projection Tomography coregistered to ex vivo MRI. Infection is limited to grey matter of sensory systems in wildtype mice, but extends into white matter, meninges and choroid plexus in Ifnar-/- mice. Cells in wildtype display strong type I and II IFN responses, likely due to Ifnb expressing astrocytes, infiltration of macrophages and Ifng-expressing CD8+ NK cells, whereas in Ifnar-/-, the absence of this response contributes to a shift in cellular tropism towards non-activated resident microglia. Multimodal imaging-transcriptomics exemplifies a powerful way to characterize mechanisms of viral pathogenesis and tropism.
Published: 2023
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12. Three-dimensional growth and biomechanical risk progression of abdominal aortic aneurysms under serial computed tomography assessment

Author: Siika, Antti, Bogdanovic, Marko, Liljeqvist, Moritz Lindquist, Gasser, T. Christian, Hultgren, Rebecka, Roy, Joy, Siika, Antti, Bogdanovic, Marko, Liljeqvist, Moritz Lindquist, Gasser, T. Christian, Hultgren, Rebecka, and Roy, Joy
Abstract: Growth of abdominal aortic aneurysms (AAAs) is often described as erratic and discontinuous. This study aimed at describing growth patterns of AAAs with respect to maximal aneurysm diameter (Dmax) and aneurysm volume, and to characterize changes in the intraluminal thrombus (ILT) and biomechanical indices as AAAs grow. 384 computed tomography angiographies (CTAs) from 100 patients (mean age 70.0, standard deviation, SD = 8.5 years, 22 women), who had undergone at least three CTAs, were included. The mean follow-up was 5.2 (SD = 2.5) years. Growth of Dmax was 2.64 mm/year (SD = 1.18), volume 13.73 cm3/year (SD = 10.24) and PWS 7.3 kPa/year (SD = 4.95). For Dmax and volume, individual patients exhibited linear growth in 87% and 77% of cases. In the tertile of patients with the slowest Dmax-growth (< 2.1 mm/year), only 67% belonged to the slowest tertile for volume-growth, and 52% and 55% to the lowest tertile of PWS- and PWRI-increase, respectively. The ILT-ratio (ILT-volume/aneurysm volume) increased with time (2.6%/year, p < 0.001), but when adjusted for volume, the ILT-ratio was inversely associated with biomechanical stress. In contrast to the notion that AAAs grow in an erratic fashion most AAAs displayed continuous and linear growth. Considering only change in Dmax, however, fails to capture the biomechanical risk progression, and parameters such as volume and the ILT-ratio need to be considered., QC 20230711
Published: 2023
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13. Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis.

Author: Rudman-Melnick, Valeria, Adam, Mike, Stowers, Kaitlynn, Potter, Andrew, Ma, Qing, Chokshi, Saagar M., Vanhoutte, Davy, Valiente-Alandi, Iñigo, Lindquist, Diana M., Nieman, Michelle L., Kofron, J. Matthew, Chung, Eunah, Park, Joo-Seop, Potter, S. Steven, and Devarajan, Prasad
Subjects: RENAL fibrosis, KIDNEY injuries, KIDNEYS, HOMEOBOX genes, FIBROBLASTS, CHRONIC kidney failure
Abstract: Examining kidney fibrosis is crucial for mechanistic understanding and developing targeted strategies against chronic kidney disease (CKD). Persistent fibroblast activation and tubular epithelial cell (TEC) injury are key CKD contributors. However, cellular and transcriptional landscapes of CKD and specific activated kidney fibroblast clusters remain elusive. Here, we analyzed single cell transcriptomic profiles of two clinically relevant kidney fibrosis models which induced robust kidney parenchymal remodeling. We dissected the molecular and cellular landscapes of kidney stroma and newly identified three distinctive fibroblast clusters with "secretory", "contractile" and "vascular" transcriptional enrichments. Also, both injuries generated failed repair TECs (frTECs) characterized by decline of mature epithelial markers and elevation of stromal and injury markers. Notably, frTECs shared transcriptional identity with distal nephron segments of the embryonic kidney. Moreover, we identified that both models exhibited robust and previously unrecognized distal spatial pattern of TEC injury, outlined by persistent elevation of renal TEC injury markers including Krt8 and Vcam1, while the surviving proximal tubules (PTs) showed restored transcriptional signature. We also found that long-term kidney injuries activated a prominent nephrogenic signature, including Sox4 and Hox gene elevation, which prevailed in the distal tubular segments. Our findings might advance understanding of and targeted intervention in fibrotic kidney disease. [ABSTRACT FROM AUTHOR]
Published: 2024
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14. Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets.

Author: Hovhannisyan, Anahit H., Lindquist, Karen A., Belugin, Sergei, Mecklenburg, Jennifer, Ibrahim, Tarek, Tram, Meilinn, Corey, Tatiana M., Salmon, Adam B., Perez, Daniel, Ruparel, Shivani, and Akopian, Armen N.
Abstract: Myogenous temporomandibular disorders is associated with an increased responsiveness of nerves innervating the masseter (MM), temporal (TM), and lateral pterygoid muscles (LPM). This study aimed to examine sensory nerve types innervating MM, TM and LPM of adult non-human primate—common marmosets. Sensory nerves were localized in specific regions of these muscles. Pgp9.5, marker for all nerves, and NFH, a marker for A-fibers, showed that masticatory muscles were primarily innervated with A-fibers. The proportion of C- to A-fibers was highest in LPM, and lowest in MM. All C-fibers (pgp9.5+/NFH-) observed in masticatory muscles were peptidergic (CGRP+) and lacked mrgprD and CHRNA3, a silent nociceptive marker. TrpV1 was register in 17% of LPM nerves. All fibers in masticatory muscles were labeled with GFAP+, a myelin sheath marker. There were substantially more peptidergic A-fibers (CGRP+/NFH+) in TM and LPM compared to MM. MM, TM and LPM NFH+ fibers contained different percentages of trkC+ and parvalbumin+, but not trkB+ fibers. Tyrosine hydroxylase antibodies, which did not label TG, highlighted sympathetic fibers around blood vessels of the masticatory muscles. Overall, masticatory muscle types of marmosets have similarities and differences in innervation patterns. [ABSTRACT FROM AUTHOR]
Published: 2023
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15. Evaluating the prediction performance of objective physical activity measures for incident Parkinson's disease in the UK Biobank.

Author: Zhao, Angela, Cui, Erjia, Leroux, Andrew, Lindquist, Martin A., and Crainiceanu, Ciprian M.
Subjects: PARKINSON'S disease, PHYSICAL activity, PHYSICAL mobility, NEUROLOGICAL disorders, REGRESSION analysis
Abstract: Background: Parkinson's disease (PD) is the fastest-growing neurological condition with over 10 million cases worldwide. While age and sex are known predictors of incident PD, there is a need to identify other predictors. This study compares the prediction performance of accelerometry-derived physical activity (PA) measures and traditional risk factors for incident PD in the UK Biobank. Methods: The study population consisted of 92,352 UK Biobank participants without PD at baseline (43.8% male, median age 63 years with interquartile range 43–69). 245 participants were diagnosed with PD by April 1, 2021 (586,604 person-years of follow-up). The incident PD prediction performances of 10 traditional predictors and 8 objective PA measures were compared using single- and multi-variable Cox models. Prediction performance was assessed using a novel, stable statistic: the repeated cross-validated concordance (rcvC). Sensitivity analyses were conducted where PD cases diagnosed within the first six months, one year, and two years were deleted. Results: Single-predictor Cox regression models indicated that all PA measures were statistically significant (p-values < 0.0001). The highest-performing individual predictors were total acceleration (TA) (rcvC = 0.813) among PA measures, and age (rcvC = 0.757) among traditional predictors. The two-step forward-selection process produced a model containing age, sex, and TA (rcvC = 0.851). Adding TA to the model increased the rcvC by 9.8% (p-value < 0.0001). Results were largely unchanged in sensitivity analyses. Conclusions: Objective PA summaries have better single-predictor model performance than known risk factors and increase the prediction performance substantially when added to models with age and sex. [ABSTRACT FROM AUTHOR]
Published: 2023
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16. Digital Health Technologies in Clinical Trials: An Ontology-Driven Analysis to Inform Digital Sustainability Policies.

Author: Hey, Spencer Phillips, Dellapina, Maria, Lindquist, Kristin, Hartog, Bert, and LaRoche, Jason
Subjects: HEALTH policy, SUSTAINABILITY, CLINICAL trials, DIGITAL technology, BLOOD sugar monitoring, DIGITAL health, ACQUISITION of data, PRIVATE sector, WEARABLE technology, WASTE products, MEDICAL records, PUBLIC sector, ONTOLOGIES (Information retrieval), CLINICAL trial registries
Abstract: Background: Digital health technologies (DHTs) can facilitate the execution of de-centralized trials that can offer opportunities to reduce the burden on participants, collect outcome data in a real-world setting, and potentially make trial populations more diverse and inclusive. However, DHTs can also be a significant source of electronic waste (e-waste). In recognition of the potential health and environmental impact from DHT use in trials, private and public institutions have recently launched initiatives to help measure and manage this e-waste. But in order to develop sound e-waste management policies, it will be necessary to first estimate the current volume of e-waste that results from the use of DHTs in trials. Materials and Methods: A Web Ontology Language (OWL)-compliant ontology of DHTs was created using a list of 500 DHT device names derived from a mixture of public and private sources. The U.S. clinical trials registry, ClinicalTrials.gov, was then queried to identify and classify trials using any of the devices in the ontology. The ClinicalTrials.gov records from this search were then analyzed to characterize the volume and properties of trials using DHTs, as well as estimating the total volume of individual DHT units that have been provisioned (or are planned to be provisioned) for clinical research. Results: Our ontology-driven search identified 2326 unique clinical trials with a reported "actual" enrollment of 200,947 participants and a "planned" enrollment of an additional 4,094,748 participants. The most-used class of DHTs in our ontology was "wearables," (1852 trials), largely driven by the use of smart watches and other wrist-worn sensors (estimated to involve 149,391 provisioned devices). The most-used subtype of DHTs in trials was "subcutaneous" devices (367 trials), driven by the prevalent use and testing of glucose monitors (estimated to involve 17,666 provisioned devices). Conclusion: Thousands of trials, involving hundreds of thousands of devices, have already been completed, and many more trials (potentially involving millions more devices) are planned. Despite the great opportunities that are afforded by DHTs to the clinical trial enterprise, if the industry lacks the ability to track DHT use with sufficient resolution, the result is likely to be a great deal of e-waste. A new ontology of DHTs, combined with rigorous data science methods like those described in this paper, can be used to provide better information across the industry, and in turn, help create a more sustainable and equitable clinical trials enterprise. [ABSTRACT FROM AUTHOR]
Published: 2023
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17. Six-Month Outcomes of Mechanical Thrombectomy for Treating Deep Vein Thrombosis: Analysis from the 500-Patient CLOUT Registry.

Author: Shaikh, Abdullah, Zybulewski, Adam, Paulisin, Joseph, Bisharat, Mohannad, Mouawad, Nicolas J., Raskin, Adam, Ichinose, Eugene, Abramowitz, Steven, Lindquist, Jonathan, Azene, Ezana, Shah, Neil, Nguyen, James, Cockrell, Josh, Khalsa, Bhavraj, Khetarpaul, Vipul, Murrey Jr., Douglas A., Veerina, Kalyan, Skripochnik, Edvard, Maldonado, Thomas S., and Bunte, Matthew C.
Subjects: VENOUS thrombosis, THROMBECTOMY, POSTTHROMBOTIC syndrome
Abstract: Purpose: Mechanical thrombectomy for the treatment of deep vein thrombosis (DVT) is being increasingly utilized to reduce symptoms and prevent postthrombotic syndrome (PTS), but more data on clinical outcomes are needed. Mechanical thrombectomy was studied in the ClotTriever Outcomes (CLOUT) registry with 6-month full analysis outcomes reported herein. Materials and Methods: The CLOUT registry is a prospective, all-comer study that enrolled 500 lower extremity DVT patients across 43 US sites treated with mechanical thrombectomy using the ClotTriever System. Core-lab assessed Marder scores and physician-assessed venous patency by duplex ultrasound, PTS assessment using Villalta score, venous symptom severity, pain, and quality of life scores through 6 months were analyzed. Adverse events were identified and independently adjudicated. Results: All-cause mortality at 30 days was 0.9%, and 8.6% of subjects experienced a serious adverse event (SAE) within the first 30 days, 1 of which (0.2%) was device related. SAE rethrombosis/residual thrombus incidence was 4.8% at 30 days and 8.0% at 6 months. Between baseline and 6 months, venous flow increased from 27.2% to 92.5% of limbs (P < 0.0001), and venous compressibility improved from 28.0% to 91.8% (P < 0.0001), while median Villalta scores improved from 9.0 at baseline to 1.0 at 6 months (P < 0.0001). Significant improvements in venous symptom severity, pain, and quality of life were also demonstrated. Outcomes from iliofemoral and isolated femoral-popliteal segments showed similar improvements. Conclusion: Outcomes from the CLOUT study, a large prospective registry for DVT, indicate that mechanical thrombectomy is safe and demonstrates significant improvement in symptoms and health status through 6 months. Level of Evidence 3: Non-randomized controlled cohort/follow-up study. [ABSTRACT FROM AUTHOR]
Published: 2023
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18. An inter‐species protein–protein interaction network across vast evolutionary distance

Author: Quan Zhong, Samuel J Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang, Patrick Haley, Ryan R Murray, Flora Mer, Fana Gebreab, Stanley Tam, Andrew MacWilliams, Amélie Dricot, Patrick Reichert, Balaji Santhanam, Lila Ghamsari, Michael A Calderwood, Thomas Rolland, Benoit Charloteaux, Susan Lindquist, Albert‐László Barabási, David E Hill, Patrick Aloy, Michael E Cusick, Yu Xia, Frederick P Roth, and Marc Vidal
Subjects: Cross‐species complementation, Network evolution, Selection, Biology (General), QH301-705.5, Medicine (General), R5-920
Abstract: Abstract In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and how such biophysical‐versus‐functional network coordination is shaped by evolutionary forces are all largely unanswered questions. Here, we investigate these questions using an “inter‐interactome” approach. We systematically probed the yeast and human proteomes for interactions between proteins from these two species and functionally characterized the resulting inter‐interactome network. After a billion years of evolutionary divergence, the yeast and human proteomes are still capable of forming a biophysical network with properties that resemble those of intra‐species networks. Although substantially reduced relative to intra‐species networks, the levels of functional overlap in the yeast–human inter‐interactome network uncover significant remnants of co‐functionality widely preserved in the two proteomes beyond human–yeast homologs. Our data support evolutionary selection against biophysical interactions between proteins with little or no co‐functionality. Such non‐functional interactions, however, represent a reservoir from which nascent functional interactions may arise.
Published: 2016
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19. Are Geriatrics-Focused Primary Care Clinics Better at Diagnosing Dementia Than Traditional Clinics? A Matched Cohort Study.

Author: Perfect, Chelsea R., Lindquist, J., Smith, V. A., Stanwyck, C., Seidenfeld, J., Van Houtven, C. H., and Hastings, S. N.
Subjects: *PRIMARY care, *DEMENTIA, *DIAGNOSIS, *MILD cognitive impairment, *COHORT analysis
Abstract: Background: Dementia and mild cognitive impairment (MCI) are prevalent but underdiagnosed. Objective: To compare new dementia/MCI diagnosis rates in geriatrics-focused primary care clinics and traditional primary care clinics. Design: Secondary analysis of a prospective matched cohort study that spanned 2017–2021. Participants: Community-dwelling Veterans over 65 receiving primary care in a geriatrics-focused medical home (GeriPACT) or traditional primary care home (PACT) at one of 57 Veterans Affairs sites. We excluded individuals with a documented diagnosis of dementia or MCI in the year prior to enrollment. Main Measures: Diagnoses obtained from EHR. Cognitive status was assessed using modified Telephone Interview for Cognitive Status (mTICS) tool. Key Results: The 470 participants included in this analysis were predominantly white, non-Hispanic males with an average age of 80.3 years. 9.4% of participants received a diagnosis of dementia/MCI after 24 months: 11.5% in GeriPACT and 7.2% in PACT. Adjusted OR for dementia/MCI diagnosis based on GeriPACT exposure was 1.47 (95% CI 0.65–3.29). Low mTICS score (≤ 27) (OR 4.89, 95% CI 2.36–10.13) and marital status (married/partnered) (OR 1.89, CI 0.99–3.59) were independent predictors of dementia/MCI diagnosis. When stratified by cognitive status: diagnosis rates were 20.8% in GeriPACT and 16.7% in PACT among those who scored lower on the cognitive assessment (mTICS ≤ 27); 7.4% in GeriPACT and 3.6% in PACT among those who scored higher (mTICS > 27). The OR for new dementia/MCI diagnosis in GeriPACT was 1.19 (95% CI 0.49–2.91) among those with a low mTICS score and 1.85 (95% CI 0.70–4.88) among those with a higher mTICS score. Conclusions: Observed rates of new dementia/MCI diagnosis were higher in GeriPACT, but with considerable uncertainty around estimates. Geriatrics-focused primary care clinics may be a promising avenue for improving the detection of dementia in older adults, but further larger studies are needed to confirm this relationship. [ABSTRACT FROM AUTHOR]
Published: 2023
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20. Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes.

Author: Bogaerts, Katleen, Van Den Houte, Maaike, Jongen, Daniëlle, Ly, Huynh Giao, Coppens, Eline, Schruers, Koen, Van Diest, Ilse, Jan, Tack, Van Wambeke, Peter, Petre, Bogdan, Kragel, Philip A., Lindquist, Martin A., Wager, Tor D., Van Oudenhove, Lukas, and Van den Bergh, Omer
Published: 2023
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21. A qualitative analysis describing attrition from bariatric surgery to identify strategies for improving retention in patients who desire treatment.

Author: Chao, Grace F., Lindquist, Kerry, Vitous, Crystal A., Tolentino, Dante A., Delaney, Lia, Alimi, Yewande, Jafri, Sara M., and Telem, Dana A.
Subjects: *BARIATRIC surgery, *SOCIAL role, *GROUP identity, *DESIRE, *SEMI-structured interviews
Abstract: Background: Among patients who express interest in bariatric surgery, dropout rates from bariatric surgery programs are reported as high as 60%. There is a lack of understanding how we can better support patients to obtain treatment of this serious chronic disease. Methods: Semi-structured interviews with individuals who dropped out of bariatric surgery programs from three clinical sites were conducted. Transcripts were iteratively analyzed to understand patterns clustering around codes. We mapped these codes to domains of the Theoretical Domains Framework (TDF) which will serve as the basis of future theory-based interventions. Results: Twenty patients who self-identified as 60% female and 85% as non-Hispanic White were included. The results clustered around codes of "perceptions of bariatric surgery," "reasons for not undergoing surgery," and "factors for re-considering surgery." Major drivers of attrition were burden of pre-operative workup requirements, stigma against bariatric surgery, fear of surgery, and anticipated regret. The number and time for requirements led patients to lose their initial optimism about improving health. Perceptions regarding being seen as weak for choosing bariatric surgery, fear of surgery itself, and possible regret over surgery grew as time passed. These drivers mapped to four TDF domains: environmental context and resources, social role and identity, emotion, and beliefs about consequences, respectively. Conclusions: This study uses the TDF to identify areas of greatest concern for patients to be used for intervention design. This is the first step in understanding how we best support patients who express interest in bariatric surgery achieve their goals and live healthier lives. [ABSTRACT FROM AUTHOR]
Published: 2023
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22. A dorsomedial prefrontal cortex-based dynamic functional connectivity model of rumination.

Author: Kim, Jungwoo, Andrews-Hanna, Jessica R., Eisenbarth, Hedwig, Lux, Byeol Kim, Kim, Hong Ji, Lee, Eunjin, Lindquist, Martin A., Losin, Elizabeth A. Reynolds, Wager, Tor D., and Woo, Choong-Wan
Subjects: PREFRONTAL cortex, FUNCTIONAL connectivity, RUMINATION (Cognition), DEFAULT mode network, MENTAL depression, COGNITIVE styles
Abstract: Rumination is a cognitive style characterized by repetitive thoughts about one's negative internal states and is a common symptom of depression. Previous studies have linked trait rumination to alterations in the default mode network, but predictive brain markers of rumination are lacking. Here, we adopt a predictive modeling approach to develop a neuroimaging marker of rumination based on the variance of dynamic resting-state functional connectivity and test it across 5 diverse subclinical and clinical samples (total n = 288). A whole-brain marker based on dynamic connectivity with the dorsomedial prefrontal cortex (dmPFC) emerges as generalizable across the subclinical datasets. A refined marker consisting of the most important features from a virtual lesion analysis further predicts depression scores of adults with major depressive disorder (n = 35). This study highlights the role of the dmPFC in trait rumination and provides a dynamic functional connectivity marker for rumination. Rumination, which is the tendency to dwell on negative internal states repetitively, is a well-known cognitive style associated with depression. The authors developed a predictive model of rumination and observed that the dorsomedial prefrontal cortex plays an important role in rumination. [ABSTRACT FROM AUTHOR]
Published: 2023
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23. Detecting Changes in Correlation Networks with Application to Functional Connectivity of fMRI Data.

Author: Baek, Changryong, Leinwand, Benjamin, Lindquist, Kristen A., Jeong, Seok-Oh, Hopfinger, Joseph, Gates, Katheleen M., and Pipiras, Vladas
Subjects: FUNCTIONAL connectivity, FUNCTIONAL magnetic resonance imaging, RESEARCH questions, ANTHROPOSOPHY, STATISTICAL hypothesis testing
Abstract: Research questions in the human sciences often seek to answer if and when a process changes across time. In functional MRI studies, for instance, researchers may seek to assess the onset of a shift in brain state. For daily diary studies, the researcher may seek to identify when a person's psychological process shifts following treatment. The timing and presence of such a change may be meaningful in terms of understanding state changes. Currently, dynamic processes are typically quantified as static networks where edges indicate temporal relations among nodes, which may be variables reflecting emotions, behaviors, or brain activity. Here we describe three methods for detecting changes in such correlation networks from a data-driven perspective. Networks here are quantified using the lag-0 pair-wise correlation (or covariance) estimates as the representation of the dynamic relations among variables. We present three methods for change point detection: dynamic connectivity regression, max-type method, and a PCA-based method. The change point detection methods each include different ways to test if two given correlation network patterns from different segments in time are significantly different. These tests can also be used outside of the change point detection approaches to test any two given blocks of data. We compare the three methods for change point detection as well as the complementary significance testing approaches on simulated and empirical functional connectivity fMRI data examples. [ABSTRACT FROM AUTHOR]
Published: 2023
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24. Gangs, violence, and fear: punitive Darwinism in El Salvador.

Author: Rosen, Jonathan D., Cutrona, Sebastián, and Lindquist, Katy
Subjects: PUBLIC opinion, GANG violence, BIOLOGICAL evolution, MULTIPLE regression analysis, HUMAN rights violations, GANGS, VIOLENCE
Abstract: This article evaluates the factors impacting support for tough on crime policies in El Salvador. Examining theoretical and empirical scholarly work, we look at how fear, together with social and political contexts drive public appetite for punitive policies towards criminals. We show that President Nayib Bukele is responding to public opinion and has implemented tough on crime policies at the expense of human rights violations and democratic institutions. Society favors candidates who are the "toughest" against criminal actors. Political candidates from all sides of the ideological spectrum tap into the fear of the populace to win votes, leading to punitive Darwinism. We provide an empirical assessment of which theoretically relevant factors are statistically associated with punitivism in the Salvadoran context, using multiple regression analysis of high-quality public opinion survey data from LAPOP. [ABSTRACT FROM AUTHOR]
Published: 2023
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25. Culture and gender modulate dlPFC integration in the emotional brain: evidence from dynamic causal modeling.

Author: Pugh, Zachary H., Huang, Jiali, Leshin, Joseph, Lindquist, Kristen A., and Nam, Chang S.
Abstract: Past research has recognized culture and gender variation in the experience of emotion, yet this has not been examined on a level of effective connectivity. To determine culture and gender differences in effective connectivity during emotional experiences, we applied dynamic causal modeling (DCM) to electroencephalography (EEG) measures of brain activity obtained from Chinese and American participants while they watched emotion-evoking images. Relative to US participants, Chinese participants favored a model bearing a more integrated dorsolateral prefrontal cortex (dlPFC) during fear v. neutral experiences. Meanwhile, relative to males, females favored a model bearing a less integrated dlPFC during fear v. neutral experiences. A culture-gender interaction for winning models was also observed; only US participants showed an effect of gender, with US females favoring a model bearing a less integrated dlPFC compared to the other groups. These findings suggest that emotion and its neural correlates depend in part on the cultural background and gender of an individual. To our knowledge, this is also the first study to apply both DCM and EEG measures in examining culture-gender interaction and emotion. [ABSTRACT FROM AUTHOR]
Published: 2023
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26. Valence-dependent mutation in lexical evolution.

Author: Jackson, Joshua Conrad, Lindquist, Kristen, Drabble, Ryan, Atkinson, Quentin, and Watts, Joseph
Published: 2023
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27. Enhanced Understanding of Elements Influencing Tribal College Math Students’ Post-Secondary Persistence: Student Voices.

Author: Conway, Pat, Lindquist, Cynthia, Olimb, Sarah, Parker, Michael, Saari, Karen, and Voels, Brent
Subjects: *NATIVE American universities & colleges, *SCHOOL attendance, *COMMUNITY college students, *SCHOOL schedules, *MATHEMATICS students, *ALASKA Natives
Abstract: Individuals who are American Indian and Alaskan Native (AI/AN) are less likely to enroll in and complete post-high school educational programs and to enter STEM careers than White students. Completion of math courses is a common barrier to academic persistence for many students, including students who are AI/AN. This qualitative study interviewed 40 students from one rural, tribal college; the students articulated elements that supported them in math and led to academic persistence and those that were barriers to success in math and subsequent graduation. About one-third had attended college intermittently, some for more than 20 years. Most said that flexible class schedules, the ability to complete math coursework in settings other than the math classroom, and using technology allowed them to complete math courses successfully. Students more frequently commented on individual, family, and community elements that influenced their academic progress, especially non-academic barriers such as health and work. The students’ words informed development of a more robust description of elements influencing student academic persistence among tribal community college math students to guide future research and program development leading to higher rates of academic success. [ABSTRACT FROM AUTHOR]
Published: 2024
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28. Directed assembly of layered perovskite heterostructures as single crystals

Author: Marina R. Filip, Hemamala I. Karunadasa, Abraham Saldivar Valdes, Bridget A. Connor, Kurt P. Lindquist, Jeffrey B. Neaton, and Michael L. Aubrey
Subjects: Solid-state chemistry, Multidisciplinary, Materials science, Graphene, Stacking, Heterojunction, law.invention, chemistry.chemical_compound, chemistry, law, Chemical physics, Monolayer, Electronic band structure, Bifunctional, Perovskite (structure)
Abstract: The precise stacking of different two-dimensional (2D) structures such as graphene and MoS2 has reinvigorated the field of 2D materials, revealing exotic phenomena at their interfaces1,2. These unique interfaces are typically constructed using mechanical or deposition-based methods to build a heterostructure one monolayer at a time2,3. By contrast, self-assembly is a scalable technique, where complex materials can selectively form in solution4–6. Here we show a synthetic strategy for the self-assembly of layered perovskite–non-perovskite heterostructures into large single crystals in aqueous solution. Using bifunctional organic molecules as directing groups, we have isolated six layered heterostructures that form as an interleaving of perovskite slabs with a different inorganic lattice, previously unknown to crystallize with perovskites. In many cases, these intergrown lattices are 2D congeners of canonical inorganic structure types. To our knowledge, these compounds are the first layered perovskite heterostructures formed using organic templates and characterized by single-crystal X-ray diffraction. Notably, this interleaving of inorganic structures can markedly transform the band structure. Optical data and first principles calculations show that substantive coupling between perovskite and intergrowth layers leads to new electronic transitions distributed across both sublattices. Given the technological promise of halide perovskites4, this intuitive synthetic route sets a foundation for the directed synthesis of richly structured complex semiconductors that self-assemble in water. Using organic molecules as directing groups, a wide range of perovskite heterostructures are shown to self-assemble in solution to yield single crystals.
Published: 2021
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29. Parental post-traumatic stress and psychiatric care utilisation among refugee adolescents.

Author: Berg, Lisa, de Montgomery, Edith, Brendler-Lindquist, Monica, Mittendorfer-Rutz, Ellenor, and Hjern, Anders
Subjects: BIRTHPLACES, PSYCHOLOGY of parents, CONFIDENCE intervals, PSYCHOLOGY of refugees, POST-traumatic stress disorder, CHILDREN of parents with disabilities, REGRESSION analysis, MEDICAL care use, SEX distribution, CHILD psychopathology, PSYCHOSOCIAL factors, DESCRIPTIVE statistics, MENTAL depression, PARENT-child relationships, RESIDENTIAL patterns, SOCIODEMOGRAPHIC factors, ANXIETY, PSYCHIATRIC treatment, PROPORTIONAL hazards models, MOTHER-child relationship, FATHER-child relationship, CHILDREN, ADOLESCENCE
Abstract: Parental psychiatric morbidity related to experiences of war and trauma has been associated with adverse psychological outcomes for children. The aim of this study was to investigate parental post-traumatic stress in relation to psychiatric care utilization among children of refugees with particular attention on the child's own refugee status, sex of both child and parents, and specific psychiatric diagnoses. This was a register study in a population of 16 143 adolescents from refugee families in Stockholm County born 1995–2000 and followed between 2011 and 2017 (11–18 years old). Parental post-traumatic stress, identified in three levels of care, was analysed in relation to child and adolescent psychiatric care use. Cox regression analysis was used to estimate hazard ratios (HR) and 95% confidence intervals (CI), adjusted for duration of residence and demographic and socioeconomic variables. Having a mother with post-traumatic stress was associated with higher psychiatric care utilization, with adjusted HR 2.44 (95% CI 1.90–3.14) among foreign-born refugee children and HR 1.77 (1.33–2.36) among Swedish-born children with refugee parents, with particularly high risks for children with less than five years of residence (HR 4.03; 2.29–7.10) and for diagnoses of anxiety and depression (HR 2.71; 2.11–3.48). Having a father with post-traumatic stress was not associated with increased HRs of psychiatric care utilization. Similar results were seen for boys and girls. Treatment for post-traumatic stress should be made available in refugee reception programmes. These programmes should use a family approach that targets both parents and children. [ABSTRACT FROM AUTHOR]
Published: 2022
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30. Search for top-quark decays t→Hq with 36 fb−1 of pp collision data at s√=13 TeV with the ATLAS detector

Author: The ATLAS collaboration, M. Aaboud, G. Aad, B. Abbott, D. C. Abbott, O. Abdinov, B. Abeloos, D. K. Abhayasinghe, S. H. Abidi, O. S. AbouZeid, N. L. Abraham, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, S. Adachi, L. Adam, L. Adamczyk, L. Adamek, J. Adelman, M. Adersberger, A. Adiguzel, T. Adye, A. A. Affolder, Y. Afik, C. Agheorghiesei, J. A. Aguilar-Saavedra, F. Ahmadov, G. Aielli, S. Akatsuka, T. P. A. Åkesson, E. Akilli, A. V. Akimov, G. L. Alberghi, J. Albert, P. Albicocco, M. J. Alconada Verzini, S. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, D. Alexandre, T. Alexopoulos, M. Alhroob, B. Ali, G. Alimonti, J. Alison, S. P. Alkire, C. Allaire, B. M. M. Allbrooke, B. W. Allen, P. P. Allport, A. Aloisio, A. Alonso, F. Alonso, C. Alpigiani, A. A. Alshehri, M. I. Alstaty, B. Alvarez Gonzalez, D. Álvarez Piqueras, M. G. Alviggi, B. T. Amadio, Y. Amaral Coutinho, A. Ambler, L. Ambroz, C. Amelung, D. Amidei, S. P. Amor Dos Santos, S. Amoroso, C. S. Amrouche, F. An, C. Anastopoulos, L. S. Ancu, N. Andari, T. Andeen, C. F. Anders, J. K. Anders, K. J. Anderson, A. Andreazza, V. Andrei, C. R. Anelli, S. Angelidakis, I. Angelozzi, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, M. Antonelli, D. J. A. Antrim, F. Anulli, M. Aoki, J. A. Aparisi Pozo, L. Aperio Bella, G. Arabidze, J. P. Araque, V. Araujo Ferraz, R. Araujo Pereira, A. T. H. Arce, R. E. Ardell, F. A. Arduh, J-F. Arguin, S. Argyropoulos, J.-H. Arling, A. J. Armbruster, L. J. Armitage, A. Armstrong, O. Arnaez, H. Arnold, M. Arratia, O. Arslan, A. Artamonov, G. Artoni, S. Artz, S. Asai, N. Asbah, E. M. Asimakopoulou, L. Asquith, K. Assamagan, R. Astalos, R. J. Atkin, M. Atkinson, N. B. Atlay, K. Augsten, G. Avolio, R. Avramidou, M. K. Ayoub, A. M. Azoulay, G. Azuelos, A. E. Baas, M. J. Baca, H. Bachacou, K. Bachas, M. Backes, P. Bagnaia, M. Bahmani, H. Bahrasemani, A. J. Bailey, V. R. Bailey, J. T. Baines, M. Bajic, C. Bakalis, O. K. Baker, P. J. Bakker, D. Bakshi Gupta, S. Balaji, E. M. Baldin, P. Balek, F. Balli, W. K. Balunas, J. Balz, E. Banas, A. Bandyopadhyay, S. Banerjee, A. A. E. Bannoura, L. Barak, W. M. Barbe, E. L. Barberio, D. Barberis, M. Barbero, T. Barillari, M-S. Barisits, J. Barkeloo, T. Barklow, R. Barnea, S. L. Barnes, B. M. Barnett, R. M. Barnett, Z. Barnovska-Blenessy, A. Baroncelli, G. Barone, A. J. Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, R. Bartoldus, A. E. Barton, P. Bartos, A. Basalaev, A. Bassalat, R. L. Bates, S. J. Batista, S. Batlamous, J. R. Batley, M. Battaglia, M. Bauce, F. Bauer, K. T. Bauer, H. S. Bawa, J. B. Beacham, T. Beau, P. H. Beauchemin, P. Bechtle, H. C. Beck, H. P. Beck, K. Becker, M. Becker, C. Becot, A. Beddall, A. J. Beddall, V. A. Bednyakov, M. Bedognetti, C. P. Bee, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, F. Beisiegel, A. S. Bell, G. Bella, L. Bellagamba, A. Bellerive, M. Bellomo, P. Bellos, K. Belotskiy, N. L. Belyaev, O. Benary, D. Benchekroun, M. Bender, N. Benekos, Y. Benhammou, E. Benhar Noccioli, J. Benitez, D. P. Benjamin, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, L. J. Bergsten, J. Beringer, S. Berlendis, N. R. Bernard, G. Bernardi, C. Bernius, F. U. Bernlochner, T. Berry, P. Berta, C. Bertella, G. Bertoli, I. A. Bertram, G. J. Besjes, O. Bessidskaia Bylund, M. Bessner, N. Besson, A. Bethani, S. Bethke, A. Betti, A. J. Bevan, J. Beyer, R. Bi, R. M. Bianchi, O. Biebel, D. Biedermann, R. Bielski, K. Bierwagen, N. V. Biesuz, M. Biglietti, T. R. V. Billoud, M. Bindi, A. Bingul, C. Bini, S. Biondi, M. Birman, T. Bisanz, J. P. Biswal, C. Bittrich, D. M. Bjergaard, J. E. Black, K. M. Black, T. Blazek, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, Dr. Blunier, G. J. Bobbink, V. S. Bobrovnikov, S. S. Bocchetta, A. Bocci, D. Boerner, D. Bogavac, A. G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, A. S. Boldyrev, A. E. Bolz, M. Bomben, M. Bona, J. S. Bonilla, M. Boonekamp, H. M. Borecka-Bielska, A. Borisov, G. Borissov, J. Bortfeldt, D. Bortoletto, V. Bortolotto, D. Boscherini, M. Bosman, J. D. Bossio Sola, K. Bouaouda, J. Boudreau, E. V. Bouhova-Thacker, D. Boumediene, C. Bourdarios, S. K. Boutle, A. Boveia, J. Boyd, D. Boye, I. R. Boyko, A. J. Bozson, J. Bracinik, N. Brahimi, A. Brandt, G. Brandt, O. Brandt, F. Braren, U. Bratzler, B. Brau, J. E. Brau, W. D. Breaden Madden, K. Brendlinger, L. Brenner, R. Brenner, S. Bressler, B. Brickwedde, D. L. Briglin, D. Britton, D. Britzger, I. Brock, R. Brock, G. Brooijmans, T. Brooks, W. K. Brooks, E. Brost, J. H Broughton, P. A. Bruckman de Renstrom, D. Bruncko, A. Bruni, G. Bruni, L. S. Bruni, S. Bruno, B. H. Brunt, M. Bruschi, N. Bruscino, P. Bryant, L. Bryngemark, T. Buanes, Q. Buat, P. Buchholz, A. G. Buckley, I. A. Budagov, M. K. Bugge, F. Bührer, O. Bulekov, D. Bullock, T. J. Burch, S. Burdin, C. D. Burgard, A. M. Burger, B. Burghgrave, K. Burka, S. Burke, I. Burmeister, J. T. P. Burr, V. Büscher, E. Buschmann, P. Bussey, J. M. Butler, C. M. Buttar, J. M. Butterworth, P. Butti, W. Buttinger, A. Buzatu, A. R. Buzykaev, G. Cabras, S. Cabrera Urbán, D. Caforio, H. Cai, V. M. M. Cairo, O. Cakir, N. Calace, P. Calafiura, A. Calandri, G. Calderini, P. Calfayan, G. Callea, L. P. Caloba, S. Calvente Lopez, D. Calvet, S. Calvet, T. P. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, D. Cameron, R. Caminal Armadans, C. Camincher, S. Campana, M. Campanelli, A. Camplani, A. Campoverde, V. Canale, M. Cano Bret, J. Cantero, T. Cao, Y. Cao, M. D. M. Capeans Garrido, I. Caprini, M. Caprini, M. Capua, R. M. Carbone, R. Cardarelli, F. C. Cardillo, I. Carli, T. Carli, G. Carlino, B. T. Carlson, L. Carminati, R. M. D. Carney, S. Caron, E. Carquin, S. Carrá, J. W. S. Carter, D. Casadei, M. P. Casado, A. F. Casha, D. W. Casper, R. Castelijn, F. L. Castillo, V. Castillo Gimenez, N. F. Castro, A. Catinaccio, J. R. Catmore, A. Cattai, J. Caudron, V. Cavaliere, E. Cavallaro, D. Cavalli, M. Cavalli-Sforza, V. Cavasinni, E. Celebi, F. Ceradini, L. Cerda Alberich, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, A. Cervelli, S. A. Cetin, A. Chafaq, D. Chakraborty, S. K. Chan, W. S. Chan, W. Y. Chan, J. D. Chapman, B. Chargeishvili, D. G. Charlton, C. C. Chau, C. A. Chavez Barajas, S. Che, A. Chegwidden, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, M. A. Chelstowska, B. Chen, C. Chen, C. H. Chen, H. Chen, J. Chen, S. Chen, S. J. Chen, X. Chen, Y. Chen, Y-H. Chen, H. C. Cheng, H. J. Cheng, A. Cheplakov, E. Cheremushkina, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, T. J. A. Chevalérias, L. Chevalier, V. Chiarella, G. Chiarelli, G. Chiodini, A. S. Chisholm, A. Chitan, I. Chiu, Y. H. Chiu, M. V. Chizhov, K. Choi, A. R. Chomont, S. Chouridou, Y. S. Chow, V. Christodoulou, M. C. Chu, J. Chudoba, A. J. Chuinard, J. J. Chwastowski, L. Chytka, D. Cinca, V. Cindro, I. A. Cioară, A. Ciocio, F. Cirotto, Z. H. 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Wagner, W. Wagner, J. Wagner-Kuhr, H. Wahlberg, S. Wahrmund, K. Wakamiya, V. M. Walbrecht, J. Walder, R. Walker, S. D. Walker, W. Walkowiak, V. Wallangen, A. M. Wang, C. Wang, F. Wang, H. Wang, J. Wang, P. Wang, Q. Wang, R.-J. Wang, R. Wang, S. M. Wang, W. T. Wang, W. Wang, W. X. Wang, Y. Wang, Z. Wang, C. Wanotayaroj, A. Warburton, C. P. Ward, D. R. Wardrope, A. Washbrook, P. M. Watkins, A. T. Watson, M. F. Watson, G. Watts, S. Watts, B. M. Waugh, A. F. Webb, S. Webb, C. Weber, M. S. Weber, S. A. Weber, S. M. Weber, A. R. Weidberg, J. Weingarten, M. Weirich, C. Weiser, P. S. Wells, T. Wenaus, T. Wengler, S. Wenig, N. Wermes, M. D. Werner, P. Werner, M. Wessels, T. D. Weston, K. Whalen, N. L. Whallon, A. M. Wharton, A. S. White, A. White, M. J. White, R. White, D. Whiteson, B. W. Whitmore, F. J. Wickens, W. Wiedenmann, M. Wielers, C. Wiglesworth, L. A. M. Wiik-Fuchs, F. Wilk, H. G. Wilkens, L. J. Wilkins, H. H. Williams, S. Williams, C. Willis, S. Willocq, J. A. Wilson, I. 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Zgubič, D. F. Zhang, D. Zhang, F. Zhang, G. Zhang, H. Zhang, J. Zhang, L. Zhang, M. Zhang, P. Zhang, R. Zhang, X. Zhang, Y. Zhang, Z. Zhang, P. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, Z. Zheng, D. Zhong, B. Zhou, C. Zhou, M. S. Zhou, M. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. L. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, A. Zibell, D. Zieminska, N. I. Zimine, S. Zimmermann, Z. Zinonos, M. Ziolkowski, G. Zobernig, A. Zoccoli, K. Zoch, T. G. Zorbas, R. Zou, M. Zur Nedden, L. Zwalinski, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Aaboud, M, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Mirto, A, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Aloisio, Alberto, Alviggi, Mariagrazia, Canal, Vincenzo, Pietra, Massimo, Merola, Leonardo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Massarotti, Paolo, Atlas, Collaboration, Fakülteler, Fen - Edebiyat Fakültesi, Fizik Bölümü, Aaboud, M., Aad, G., Abbott, B., Abbott, D. C., Abdinov, O., Abeloos, B., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Adachi, S., Adam, L., Adamczyk, L., Adamek, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Akatsuka, S., Åkesson, T. P. A., Akilli, E., Akimov, A. V., Alberghi, G. L., Albert, J., Albicocco, P., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexandre, D., Alexopoulos, T., Alhroob, M., Ali, B., Alimonti, G., Alison, J., Alkire, S. P., Allaire, C., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alshehri, A. A., Alstaty, M. I., Alvarez Gonzalez, B., Álvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., An, F., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angelozzi, I., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aperio Bella, L., Arabidze, G., Araque, J. P., Araujo Ferraz, V., Araujo Pereira, R., Arce, A. T. H., Ardell, R. E., Arduh, F. A., Arguin, J-F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armitage, L. J., Armstrong, A., Arnaez, O., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Artz, S., Asai, S., Asbah, N., Asimakopoulou, E. M., Asquith, L., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Augsten, K., Avolio, G., Avramidou, R., Ayoub, M. K., Azoulay, A. M., Azuelos, G., Baas, A. E., Baca, M. J., Bachacou, H., Bachas, K., Backes, M., Bagnaia, P., Bahmani, M., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bajic, M., Bakalis, C., Baker, O. K., Bakker, P. J., Bakshi Gupta, D., Balaji, S., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandyopadhyay, A., Banerjee, S., Bannoura, A. A. E., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barillari, T., Barisits, M-S., Barkeloo, J., Barklow, T., Barnea, R., Barnes, S. L., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Bartoldus, R., Barton, A. E., Bartos, P., Basalaev, A., Bassalat, A., Bates, R. L., Batista, S. J., Batlamous, S., Batley, J. R., Battaglia, M., Bauce, M., Bauer, F., Bauer, K. T., Bawa, H. S., Beacham, J. B., Beau, T., Beauchemin, P. H., Bechtle, P., Beck, H. C., Beck, H. P., Becker, K., Becker, M., Becot, C., Beddall, A., Beddall, A. J., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beisiegel, F., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellomo, M., Bellos, P., Belotskiy, K., Belyaev, N. L., Benary, O., Benchekroun, D., Bender, M., Benekos, N., Benhammou, Y., Benhar Noccioli, E., Benitez, J., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernard, N. R., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Bertella, C., Bertoli, G., Bertram, I. A., Besjes, G. J., Bessidskaia Bylund, O., Bessner, M., Besson, N., Bethani, A., Bethke, S., Betti, A., Bevan, A. J., Beyer, J., Bi, R., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birman, M., Bisanz, T., Biswal, J. P., Bittrich, C., Bjergaard, D. M., Black, J. E., Black, K. M., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Blunier, Dr., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bocci, A., Boerner, D., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Boldyrev, A. S., Bolz, A. E., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Borecka-Bielska, H. M., Borisov, A., Borissov, G., Bortfeldt, J., Bortoletto, D., Bortolotto, V., Boscherini, D., Bosman, M., Bossio Sola, J. D., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bourdarios, C., Boutle, S. K., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, A., Brandt, G., Brandt, O., Braren, F., Bratzler, U., Brau, B., Brau, J. E., Breaden Madden, W. D., Brendlinger, K., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, T., Brooks, W. K., Brost, E., Broughton, J. H, Bruckman de Renstrom, P. A., Bruncko, D., Bruni, A., Bruni, G., Bruni, L. S., Bruno, S., Brunt, B. H., Bruschi, M., Bruscino, N., Bryant, P., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Bührer, F., Bulekov, O., Bullock, D., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burka, K., Burke, S., Burmeister, I., Burr, J. T. P., Büscher, V., Buschmann, E., Bussey, P., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buzatu, A., Buzykaev, A. R., Cabras, G., Cabrera Urbán, S., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calandri, A., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Camacho Toro, R., Camarda, S., Camarero Munoz, D., Camarri, P., Cameron, D., Caminal Armadans, R., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Campoverde, A., Canale, V., Cano Bret, M., Cantero, J., Cao, T., Cao, Y., Capeans Garrido, M. D. M., Caprini, I., Caprini, M., Capua, M., Carbone, R. M., Cardarelli, R., Cardillo, F. C., Carli, I., Carli, T., Carlino, G., Carlson, B. T., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carrá, S., Carter, J. W. S., Casadei, D., Casado, M. P., Casha, A. F., Casper, D. W., Castelijn, R., Castillo, F. L., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Caudron, J., Cavaliere, V., Cavallaro, E., Cavalli, D., Cavalli-Sforza, M., Cavasinni, V., Celebi, E., Ceradini, F., Cerda Alberich, L., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chafaq, A., Chakraborty, D., Chan, S. K., Chan, W. S., Chan, W. Y., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Chau, C. C., Chavez Barajas, C. A., Che, S., Chegwidden, A., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chelstowska, M. A., Chen, B., Chen, C., Chen, C. H., Chen, H., Chen, J., Chen, S., Chen, S. J., Chen, X., Chen, Y., Chen, Y-H., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalérias, T. J. A., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chouridou, S., Chow, Y. S., Christodoulou, V., Chu, M. C., Chudoba, J., Chuinard, A. J., Chwastowski, J. J., Chytka, L., Cinca, D., Cindro, V., Cioară, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Clark, A., Clark, M. R., Clark, P. J., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Cohen, H., Coimbra, A. E. C., Colasurdo, L., Cole, B., Colijn, A. P., Collot, J., Conde Muiño, P., Coniavitis, E., Connell, S. H., Connelly, I. A., Constantinescu, S., Conventi, F., Cooper-Sarkar, A. M., Cormier, F., Cormier, K. J. R., Corpe, L. D., Corradi, M., Corrigan, E. E., Corriveau, F., Cortes-Gonzalez, A., Costa, M. J., Costanza, F., Costanzo, D., Cottin, G., Cowan, G., Cowley, J. W., Cox, B. E., Crane, J., Cranmer, K., Crawley, S. J., Creager, R. A., Cree, G., Crépé-Renaudin, S., Crescioli, F., Cristinziani, M., Croft, V., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cukierman, A. R., Czekierda, S., Czodrowski, P., Da Cunha Sargedas De Sousa, M. J., Da Via, C., Dabrowski, W., Dado, T., Dahbi, S., Dai, T., Dallaire, F., Dallapiccola, C., Dam, M., D’Amen, G., Damp, J., Dandoy, J. R., Daneri, M. F., Dang, N. P., Dann, N. D, Danninger, M., Dao, V., Darbo, G., Darmora, S., Dartsi, O., Dattagupta, A., Daubney, T., D’Auria, S., Davey, W., David, C., Davidek, T., Davis, D. R., Dawe, E., Dawson, I., De, K., De Asmundis, R., De Benedetti, A., De Beurs, M., De Castro, S., De Cecco, S., De Groot, N., de Jong, P., De la Torre, H., De Lorenzi, F., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santis, M., De Santo, A., De Vasconcelos Corga, K., De Vivie De Regie, J. B., Debenedetti, C., Dedovich, D. V., Dehghanian, N., Del Gaudio, M., Del Peso, J., Delabat Diaz, Y., Delgove, D., Deliot, F., Delitzsch, C. M., Della Pietra, M., Della Volpe, D., Dell’Acqua, A., Dell’Asta, L., Delmastro, M., Delporte, C., Delsart, P. A., Demarco, D. A., Demers, S., Demichev, M., Denisov, S. P., Denysiuk, D., D’Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Deterre, C., Dette, K., Devesa, M. R., Deviveiros, P. O., Dewhurst, A., Dhaliwal, S., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Clemente, W. K., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Micco, B., Di Nardo, R., Di Petrillo, K. 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G., Zou, R., Zur Nedden, M., Zwalinski, L., Akilli, Ece, Amrouche, Cherifa Sabrina, Ancu, Lucian Stefan, Benoit, Mathieu, Clark, Allan Geoffrey, Della Volpe, Domenico, Di Bello, Francesco Armando, Dubreuil, Arnaud, Ferrere, Didier, Gadatsch, Stefan, Golling, Tobias, Gonzalez Sevilla, Sergio, Iacobucci, Giuseppe, Iizawa, Tomoya, Jansky, Roland, Khoo, Teng Jian, Kiehn, Moritz, Lanfermann, Marie Christine, Lionti, Anthony Eric, March Ruiz, Luis, Mermod, Philippe, Nessi, Marzio, Nindhito, Herjuno Rah, Paolozzi, Lorenzo, Poggi, Riccardo, Raine, Johnny, Salamani, Dalila, Schramm, Steven, Sfyrla, Anna, Sultan, D M S, Valente, Marco, Vicente Barreto Pinto, Mateus, Wu, Xin, Zaffaroni, Ettore, Ministerio de Economía y Competitividad (España), Brandt, Oleg [0000-0001-5219-1417], Fawcett, William [0000-0003-2596-8264], Hill, John [0000-0002-8650-2807], Lester, Christopher [0000-0001-5770-4883], Parker, Andy [0000-0001-9798-8411], Potter, Christina [0000-0002-9815-5208], Apollo - University of Cambridge Repository, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), ATLAS (IHEF, IoP, FNWI), XENON (IHEF, IoP, FNWI), IHEF (IoP, FNWI), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Sultansoy, Saleh F., Aaboud M., Aad G., Abbott B., Abbott D.C., Abdinov O., Abeloos B., Abhayasinghe D.K., Abidi S.H., AbouZeid O.S., Abraham N.L., Abramowicz H., Abreu H., Abulaiti Y., Acharya B.S., Adachi S., Adam L., Adamczyk L., Adamek L., Adelman J., Adersberger M., Adiguzel A., Adye T., Affolder A.A., Afik Y., Agheorghiesei C., Aguilar-Saavedra J.A., Ahmadov F., Aielli G., Akatsuka S., Åkesson T.P.A., Akilli E., Akimov A.V., Alberghi G.L., Albert J., Albicocco P., Alconada Verzini M.J., Alderweireldt S., Aleksa M., Aleksandrov I.N., Alexa C., Alexandre D., Alexopoulos T., Alhroob M., Ali B., Alimonti G., Alison J., Alkire S.P., Allaire C., Allbrooke B.M.M., Allen B.W., Allport P.P., Aloisio A., Alonso A., Alonso F., Alpigiani C., Alshehri A.A., Alstaty M.I., Alvarez Gonzalez B., Álvarez Piqueras D., Alviggi M.G., Amadio B.T., Amaral Coutinho Y., Ambler A., Ambroz L., 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C., Baker O.K., Bakker P.J., Bakshi Gupta D., Balaji S., Baldin E.M., Balek P., Balli F., Balunas W.K., Balz J., Banas E., Bandyopadhyay A., Banerjee S., Bannoura A.A.E., Barak L., Barbe W.M., Barberio E.L., Barberis D., Barbero M., Barillari T., Barisits M.-S., Barkeloo J., Barklow T., Barnea R., Barnes S.L., Barnett B.M., Barnett R.M., Barnovska-Blenessy Z., Baroncelli A., Barone G., Barr A.J., Barranco Navarro L., Barreiro F., Barreiro Guimarães da Costa J., Bartoldus R., Barton A.E., Bartos P., Basalaev A., Bassalat A., Bates R.L., Batista S.J., Batlamous S., Batley J.R., Battaglia M., Bauce M., Bauer F., Bauer K.T., Bawa H.S., Beacham J.B., Beau T., Beauchemin P.H., Bechtle P., Beck H.C., Beck H.P., Becker K., Becker M., Becot C., Beddall A., Beddall A.J., Bednyakov V.A., Bedognetti M., Bee C.P., Beermann T.A., Begalli M., Begel M., Behera A., Behr J.K., Beisiegel F., Bell A.S., Bella G., Bellagamba L., Bellerive A., Bellomo M., Bellos P., Belotskiy K., Belyaev N.L., Benary O., Benchekroun D., Bender M., Benekos N., Benhammou Y., Benhar Noccioli E., Benitez J., Benjamin D.P., Benoit M., Bensinger J.R., Bentvelsen S., Beresford L., Beretta M., Berge D., Bergeaas Kuutmann E., Berger N., Bergmann B., Bergsten L.J., Beringer J., Berlendis S., Bernard N.R., Bernardi G., Bernius C., Bernlochner F.U., Berry T., Berta P., Bertella C., Bertoli G., Bertram I.A., Besjes G.J., Bessidskaia Bylund O., Bessner M., Besson N., Bethani A., Bethke S., Betti A., Bevan A.J., Beyer J., Bi R., Bianchi R.M., Biebel O., Biedermann D., Bielski R., Bierwagen K., Biesuz N.V., Biglietti M., Billoud T.R.V., Bindi M., Bingul A., Bini C., Biondi S., Birman M., Bisanz T., Biswal J.P., Bittrich C., Bjergaard D.M., Black J.E., Black K.M., Blazek T., Bloch I., Blocker C., Blue A., Blumenschein U., Blunier D., Bobbink G.J., Bobrovnikov V.S., Bocchetta S.S., Bocci A., Boerner D., Bogavac D., Bogdanchikov A.G., Bohm C., Boisvert V., Bokan P., Bold T., Boldyrev A.S., Bolz A.E., Bomben M., Bona M., 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Buschmann E., Bussey P., Butler J.M., Buttar C.M., Butterworth J.M., Butti P., Buttinger W., Buzatu A., Buzykaev A.R., Cabras G., Cabrera Urbán S., Caforio D., Cai H., Cairo V.M.M., Cakir O., Calace N., Calafiura P., Calandri A., Calderini G., Calfayan P., Callea G., Caloba L.P., Calvente Lopez S., Calvet D., Calvet S., Calvet T.P., Calvetti M., Camacho Toro R., Camarda S., Camarero Munoz D., Camarri P., Cameron D., Caminal Armadans R., Camincher C., Campana S., Campanelli M., Camplani A., Campoverde A., Canale V., Cano Bret M., Cantero J., Cao T., Cao Y., Capeans Garrido M.D.M., Caprini I., Caprini M., Capua M., Carbone R.M., Cardarelli R., Cardillo F.C., Carli I., Carli T., Carlino G., Carlson B.T., Carminati L., Carney R.M.D., Caron S., Carquin E., Carrá S., Carter J.W.S., Casadei D., Casado M.P., Casha A.F., Casper D.W., Castelijn R., Castillo F.L., Castillo Gimenez V., Castro N.F., Catinaccio A., Catmore J.R., Cattai A., Caudron J., Cavaliere V., Cavallaro E., Cavalli D., Cavalli-Sforza M., Cavasinni V., Celebi E., Ceradini F., Cerda Alberich L., Cerqueira A.S., Cerri A., Cerrito L., Cerutti F., Cervelli A., Cetin S.A., Chafaq A., Chakraborty D., Chan S.K., Chan W.S., Chan W.Y., Chapman J.D., Chargeishvili B., Charlton D.G., Chau C.C., Chavez Barajas C.A., Che S., Chegwidden A., Chekanov S., Chekulaev S.V., Chelkov G.A., Chelstowska M.A., Chen B., Chen C., Chen C.H., Chen H., Chen J., Chen J., Chen S., Chen S.J., Chen X., Chen Y., Chen Y.-H., Cheng H.C., Cheng H.J., Cheplakov A., Cheremushkina E., Cherkaoui El Moursli R., Cheu E., Cheung K., Chevalérias T.J.A., Chevalier L., Chiarella V., Chiarelli G., Chiodini G., Chisholm A.S., Chitan A., Chiu I., Chiu Y.H., Chizhov M.V., Choi K., Chomont A.R., Chouridou S., Chow Y.S., Christodoulou V., Chu M.C., Chudoba J., Chuinard A.J., Chwastowski J.J., Chytka L., Cinca D., Cindro V., Cioară I.A., Ciocio A., Cirotto F., Citron Z.H., Citterio M., Clark A., Clark M.R., Clark P.J., Clement C., Coadou Y., Cobal M., Coccaro A., Cochran J., Cohen H., Coimbra A.E.C., Colasurdo L., Cole B., Colijn A.P., Collot J., Conde Muiño P., Coniavitis E., Connell S.H., Connelly I.A., Constantinescu S., Conventi F., Cooper-Sarkar A.M., Cormier F., Cormier K.J.R., Corpe L.D., Corradi M., Corrigan E.E., Corriveau F., Cortes-Gonzalez A., Costa M.J., Costanza F., Costanzo D., Cottin G., Cowan G., Cowley J.W., Cox B.E., Crane J., Cranmer K., Crawley S.J., Creager R.A., Cree G., Crépé-Renaudin S., Crescioli F., Cristinziani M., Croft V., Crosetti G., Cueto A., Cuhadar Donszelmann T., Cukierman A.R., Czekierda S., Czodrowski P., Da Cunha Sargedas De Sousa M.J., Da Via C., Dabrowski W., Dado T., Dahbi S., Dai T., Dallaire F., Dallapiccola C., Dam M., D’amen G., Damp J., Dandoy J.R., Daneri M.F., Dang N.P., Dann N.D., Danninger M., Dao V., Darbo G., Darmora S., Dartsi O., Dattagupta A., Daubney T., D’Auria S., Davey W., David C., Davidek T., Davis D.R., Dawe E., Dawson I., De K., De Asmundis R., De Benedetti A., De Beurs 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A., Ezzi M., Fabbri F., Fabbri L., Fabiani V., Facini G., Faisca Rodrigues Pereira R.M., Fakhrutdinov R.M., Falciano S., Falke P.J., Falke S., Faltova J., Fang Y., Fanti M., Farbin A., Farilla A., Farina E.M., Farooque T., Farrell S., Farrington S.M., Farthouat P., Fassi F., Fassnacht P., Fassouliotis D., Faucci Giannelli M., Fawcett W.J., Fayard L., Fedin O.L., Fedorko W., Feickert M., Feigl S., Feligioni L., Feng C., Feng E.J., Feng M., Fenton M.J., Fenyuk A.B., Ferrando J., Ferrari A., Ferrari P., Ferrari R., Ferreira de Lima D.E., Ferrer A., Ferrere D., Ferretti C., Fiedler F., Filipčič A., Filthaut F., Finelli K.D., Fiolhais M.C.N., Fiorini L., Fischer C., Fisher W.C., Flaschel N., Fleck I., Fleischmann P., Fletcher R.R.M., Flick T., Flierl B.M., Flores L.M., Flores Castillo L.R., Follega F.M., Fomin N., Forcolin G.T., Formica A., Förster F.A., Forti A.C., Foster A.G., Fournier D., Fox H., Fracchia S., Francavilla P., Franchini M., Franchino S., Francis D., Franconi L., Franklin 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Heidegger K.K., Heilman J., Heim S., Heim T., Heinemann B., Heinrich J.J., Heinrich L., Heinz C., Hejbal J., Helary L., Held A., Hellesund S., Helling C.M., Hellman S., Helsens C., Henderson R.C.W., Heng Y., Henkelmann S., Henriques Correia A.M., Herbert G.H., Herde H., Herget V., Hernández Jiménez Y., Herr H., Herrmann M.G., Herrmann T., Herten G., Hertenberger R., Hervas L., Herwig T.C., Hesketh G.G., Hessey N.P., Higashida A., Higashino S., Higón-Rodriguez E., Hildebrand K., Hill E., Hill J.C., Hill K.K., Hiller K.H., Hillier S.J., Hils M., Hinchliffe I., Hinterkeuser F., Hirose M., Hirschbuehl D., Hiti B., Hladik O., Hlaluku D.R., Hoad X., Hobbs J., Hod N., Hodgkinson M.C., Hoecker A., Hoeferkamp M.R., Hoenig F., Hohn D., Hohov D., Holmes T.R., Holzbock M., Homann M., Hommels B.H., Honda S., Honda T., Hong T.M., Hönle A., Hooberman B.H., Hopkins W.H., Horii Y., Horn P., Horton A.J., Horyn L.A., Hostachy J.-Y., Hostiuc A., Hou S., Hoummada A., Howarth J., Hoya J., Hrabovsky M., 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Strizenec P., Ströhmer R., Strom D.M., Stroynowski R., Strubig A., Stucci S.A., Stugu B., Stupak J., Styles N.A., Su D., Su J., Suchek S., Sugaya Y., Suk M., Sulin V.V., Sullivan M.J., Sultan D.M.S., Sultansoy S., Sumida T., Sun S., Sun X., Suruliz K., Suster C.J.E., Sutton M.R., Suzuki S., Svatos M., Swiatlowski M., Swift S.P., Sydorenko A., Sykora I., Sykora M., Sykora T., Ta D., Tackmann K., Taenzer J., Taffard A., Tafirout R., Tahirovic E., Taiblum N., Takai H., Takashima R., Takasugi E.H., Takeda K., Takeshita T., Takubo Y., Talby M., Talyshev A.A., Tanaka J., Tanaka M., Tanaka R., Tannenwald B.B., Tapia Araya S., Tapprogge S., Tarek Abouelfadl Mohamed A., Tarem S., Tarna G., Tartarelli G.F., Tas P., Tasevsky M., Tashiro T., Tassi E., Tavares Delgado A., Tayalati Y., Taylor A.J., Taylor G.N., Taylor P.T.E., Taylor W., Tee A.S., Teixeira De Lima R., Teixeira-Dias P., Ten Kate H., Teoh J.J., Terada S., Terashi K., Terron J., Terzo S., Testa M., Teuscher R.J., Thais S.J., Theveneaux-Pelzer T., Thiele F., Thomas D.W., Thomas J.P., Thompson A.S., Thompson P.D., Thomsen L.A., Thomson E., Tian Y., Ticse Torres R.E., Tikhomirov V.O., Tikhonov Y.A., Timoshenko S., Tipton P., Tisserant S., Todome K., Todorova-Nova S., Todt S., Tojo J., Tokár S., Tokushuku K., Tolley E., Tomiwa K.G., Tomoto M., Tompkins L., Toms K., Tong B., Tornambe P., Torrence E., Torres H., Torró Pastor E., Tosciri C., Toth J., Touchard F., Tovey D.R., Treado C.J., Trefzger T., Tresoldi F., Tricoli A., Trigger I.M., Trincaz-Duvoid S., Trischuk W., Trocmé B., Trofymov A., Troncon C., Trovatelli M., Trovato F., Truong L., Trzebinski M., Trzupek A., Tsai F., Tseng J.C.-L., Tsiareshka P.V., Tsirigotis A., Tsirintanis N., Tsiskaridze V., Tskhadadze E.G., Tsukerman I.I., Tsulaia V., Tsuno S., Tsybychev D., Tu Y., Tudorache A., Tudorache V., Tulbure T.T., Tuna A.N., Turchikhin S., Turgeman D., Turk Cakir I., Turra R.T., Tuts P.M., Tzamarias S., Tzovara E., Ucchielli G., Ueda I., Ughetto M., Ukegawa F., Unal G., Undrus A., Unel G., Ungaro F.C., Unno Y., Uno K., Urban J., Urquijo P., Usai G., Usui J., Vacavant L., Vacek V., Vachon B., Vadla K.O.H., Vaidya A., Valderanis C., Valdes Santurio E., Valente M., Valentinetti S., Valero A., Valéry L., Vallance R.A., Vallier A., Valls Ferrer J.A., Van Daalen T.R., Van der Graaf H., Van Gemmeren P., Van Vulpen I., Vanadia M., Vandelli W., Vaniachine A., Vankov P., Vari R., Varnes E.W., Varni C., Varol T., Varouchas D., Varvell K.E., Vasquez G.A., Vasquez J.G., Vazeille F., Vazquez Furelos D., Vazquez Schroeder T., Veatch J., Vecchio V., Veloce L.M., Veloso F., Veneziano S., Ventura A., Venturi N., Vercesi V., Verducci M., Vergel Infante C.M., Vergis C., Verkerke W., Vermeulen A.T., Vermeulen J.C., Vetterli M.C., Viaux Maira N., Vicente Barreto Pinto M., Vichou I., Vickey T., Vickey Boeriu O.E., Viehhauser G.H.A., Viel S., Vigani L., Villa M., Villaplana Perez M., Vilucchi E., Vincter M.G., Vinogradov V.B., Vishwakarma A., Vittori C., Vivarelli I., Vlachos S., Vogel M., Vokac P., Volpi G., von Buddenbrock S.E., Von Toerne E., Vorobel V., Vorobev K., Vos M., Vossebeld J.H., Vranjes N., Vranjes Milosavljevic M., Vrba V., Vreeswijk M., Šfiligoj T., Vuillermet R., Vukotic I., Ženiš T., Živković L., Wagner P., Wagner W., Wagner-Kuhr J., Wahlberg H., Wahrmund S., Wakamiya K., Walbrecht V.M., Walder J., Walker R., Walker S.D., Walkowiak W., Wallangen V., Wang A.M., Wang C., Wang F., Wang H., Wang H., Wang J., Wang J., Wang P., Wang Q., Wang R.-J., Wang R., Wang R., Wang S.M., Wang W.T., Wang W., Wang W.X., Wang Y., Wang Z., Wanotayaroj C., Warburton A., Ward C.P., Wardrope D.R., Washbrook A., Watkins P.M., Watson A.T., Watson M.F., Watts G., Watts S., Waugh B.M., Webb A.F., Webb S., Weber C., Weber M.S., Weber S.A., Weber S.M., Weidberg A.R., Weingarten J., Weirich M., Weiser C., Wells P.S., Wenaus T., Wengler T., Wenig S., Wermes N., Werner M.D., Werner P., Wessels M., Weston T.D., Whalen K., Whallon N.L., Wharton A.M., White A.S., White A., White M.J., White R., Whiteson D., Whitmore B.W., Wickens F.J., Wiedenmann W., Wielers M., Wiglesworth C., Wiik-Fuchs L.A.M., Wilk F., Wilkens H.G., Wilkins L.J., Williams H.H., Williams S., Willis C., Willocq S., Wilson J.A., Wingerter-Seez I., Winkels E., Winklmeier F., Winston O.J., Winter B.T., Wittgen M., Wobisch M., Wolf A., Wolf T.M.H., Wolff R., Wollrath J., Wolter M.W., Wolters H., Wong V.W.S., Woods N.L., Worm S.D., Wosiek B.K., Wozniak K.W., Wraight K., Wu M., Wu S.L., Wu X., Wu Y., Wyatt T.R., Wynne B.M., Xella S., Xi Z., Xia L., Xu D., Xu H., Xu L., Xu T., Xu W., Xu Z., Yabsley B., Yacoob S., Yajima K., Yallup D.P., Yamaguchi D., Yamaguchi Y., Yamamoto A., Yamanaka T., Yamane F., Yamatani M., Yamazaki T., Yamazaki Y., Yan Z., Yang H.J., Yang H.T., Yang S., Yang Y., Yang Z., Yao W.-M., Yap Y.C., Yasu Y., Yatsenko E., Ye J., Ye S., Yeletskikh I., Yigitbasi E., Yildirim E., Yorita K., Yoshihara K., Young C.J.S., Young C., Yu J., Yu J., Yue X., Yuen S.P.Y., Zabinski B., Zacharis G., Zaffaroni E., Zaidan R., Zaitsev A.M., Zakareishvili T., Zakharchuk N., Zambito S., Zanzi D., Zaripovas D.R., Zeißner S.V., Zeitnitz C., Zemaityte G., Zeng J.C., Zeng Q., Zenin O., Zerwas D., Zgubič M., Zhang D.F., Zhang D., Zhang F., Zhang G., Zhang G., Zhang H., Zhang J., Zhang L., Zhang L., Zhang M., Zhang P., Zhang R., Zhang R., Zhang X., Zhang Y., Zhang Z., Zhao P., Zhao Y., Zhao Z., Zhemchugov A., Zheng Z., Zhong D., Zhou B., Zhou C., Zhou M.S., Zhou M., Zhou N., Zhou Y., Zhu C.G., Zhu H.L., Zhu H., Zhu J., Zhu Y., Zhuang X., Zhukov K., Zhulanov V., Zibell A., Zieminska D., Zimine N.I., Zimmermann S., Zinonos Z., Ziolkowski M., Zobernig G., Zoccoli A., Zoch K., Zorbas T.G., Zou R., Zur Nedden M., Zwalinski L., and Universidade do Minho
Subjects: associated production [Higgs particle], Hadron-Hadron scattering (experiments), Rare decay, Top physics, PAIR-PRODUCTION, CROSS-SECTION, STANDARD, HIGGS, BOSON, PROGRAM, MASS, 13000 GeV-cms, 7. Clean energy, 01 natural sciences, Subatomär fysik, Higgs particle: hadroproduction, scattering [p p], Collisions, QC, two-photon, Large Hadron Collider, Mathematics and natural scienses: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], CERN LHC Coll, Higgs boson, flavor changing [neutral current], colliding beams [p p], top: pair production, Higgs particle: decay modes, branching ratio: upper limit [top], Quark, p p: scattering, Ciências Naturais::Ciências Físicas, ddc:500.2, LHC, ATLAS, High Energy Physics, HIGH ENERGY PHYSICS, ddc:530, 010306 general physics, top quark, leptonic decay [Higgs particle], Science & Technology, +Higgs+particle+charm%22">top --> Higgs particle charm, Neutral current, 010308 nuclear & particles physics, hadronic decay [Higgs particle], Experimental High Energy Physics, lcsh:QC770-798, p p: colliding beams, Top quark, Atlas detector, Ciencias Físicas, pair production [top], High Energy Physics - Experiment, purl.org/becyt/ford/1 [https], High Energy Physics - Experiment (hep-ex), +Higgs+particle+up%22">top --> Higgs particle up, Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics, proton–proton collisions, tau: pair production, Settore FIS/01 - Fisica Sperimentale, ATLAS, pair production [bottom], Q007.13, Q007.12, pair production [tau], top: branching ratio: upper limit, top: rare decay, Particle Physics - Experiment, rare decay [top], CIENCIAS NATURALES Y EXACTAS, jets, data analysis method, Nuclear and High Energy Physics, Particle physics, CERN Lab, 530 Physics, Ciências Físicas [Ciências Naturais], high [multiplicity], decay modes [Higgs particle], FOS: Physical sciences, bottom: pair production, Física de Partículas y Campos, statistical analysis, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Higgs particle: leptonic decay, Q007:Desig=13, Q007:Desig=12, hep-ex, background, neutral current: flavor changing, High Energy Physics::Phenomenology, Matematikk og naturvitenskap: 400::Fysikk: 430::Kjerne- og elementærpartikkelfysikk: 431 [VDP], multiplicity: high, purl.org/becyt/ford/1.3 [https], Higgs particle: associated production, Collision, Pair production, Higgs particle: hadronic decay, hadroproduction [Higgs particle], High Energy Physics::Experiment, Hadron-hadron collisions, experimental results
Abstract: A search for flavour-changing neutral current decays of a top quark into an up-type quark (q = u, c) and the Standard Model Higgs boson, t → Hq, is presented. The search is based on a dataset of pp collisions at s√ = 13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider and corresponding to an integrated luminosity of 36.1 fb−1. Two complementary analyses are performed to search for top-quark pair events in which one top quark decays into Wb and the other top quark decays into Hq, and target the H→bb¯¯ and H → τ+τ− decay modes, respectively. The high multiplicity of b-quark jets, or the presence of hadronically decaying τ-leptons, is exploited in the two analyses respectively. Multivariate techniques are used to separate the signal from the background, which is dominated by top-quark pair production. No significant excess of events above the background expectation is found, and 95% CL upper limits on the t → Hq branching ratios are derived. The combination of these searches with ATLAS searches in diphoton and multilepton final states yields observed (expected) 95% CL upper limits on the t → Hc and t → Hu branching ratios of 1.1 × 10−3 (8.3 × 10−4) and 1.2 × 10−3 (8.3 × 10−4), respectively. The corresponding combined observed (expected) upper limits on the |λtcH| and |λtuH| couplings are 0.064 (0.055) and 0.066 (0.055), respectively., We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently.r We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CHerakleitosNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom.r The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major c, info:eu-repo/semantics/publishedVersion
Published: 2019
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31. Intrinsic connectivity within the affective salience network moderates adolescent susceptibility to negative and positive peer norms.

Author: Do, Kathy T., McCormick, Ethan M., Prinstein, Mitchell J., Lindquist, Kristen A., and Telzer, Eva H.
Subjects: SALIENCE network, SOCIAL norms, FUNCTIONAL magnetic resonance imaging, CONTROL (Psychology), RISK-taking behavior, TEENAGE boys, TEENAGE girls
Abstract: Not all adolescents are equally susceptible to peer influence, and for some, peer influence exerts positive rather than negative effects. Using resting-state functional magnetic resonance imaging, the current study examined how intrinsic functional connectivity networks associated with processing social cognitive and affective stimuli predict adolescents' (n = 87, ages 11–14 years) prosocial tendencies and risky behaviors in the context of positive and negative peer norms. We tested the moderating role of four candidate intrinsic brain networks—associated with mentalizing, cognitive control, motivational relevance, and affective salience—in peer influence susceptibility. Only intrinsic connectivity within the affective salience network significantly moderated the association between peer norms and adolescent behavior above and beyond the other networks. Adolescents with high intrinsic connectivity within the affective salience network reported greater prosocial tendencies in contexts with more positive peer norms but greater risk-taking behavior in contexts with more negative peer norms. In contrast, peer norms were not associated with adolescent behavior for individuals with low affective salience within-network intrinsic connectivity. The mentalizing network, cognitive control network, and motivational relevance network were not associated with individual differences in peer influence susceptibility. This study identifies key neural mechanisms underlying differential susceptibility to positive and negative peer influence in early adolescence, with a particular emphasis on the role of affective salience over traditional mentalizing, regulatory, and motivational processes. [ABSTRACT FROM AUTHOR]
Published: 2022
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32. Tumors of the central nervous system among women treated with fertility drugs: a population-based cohort study.

Author: Frandsen, Clarissa L. B., Jensen, Allan, Poulsen, Frantz R., Møller, Maria, Lindquist, Sofie, Albieri, Vanna, Nøhr, Bugge, and Kjær, Susanne K.
Abstract: Purpose: To investigate the association between fertility drugs and tumors of the central nervous system (CNS).Methods: This cohort study was based on The Danish Infertility Cohort and included 148,016 infertile women living in Denmark (1995-2017). The study cohort was linked to national registers to obtain information on use of specific fertility drugs, cancer diagnoses, covariates, emigration, and vital status. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all CNS tumors and separately for gliomas, meningiomas and diverse benign tumors of the brain and other parts of the CNS.Results: During a median 11.3 years of follow-up, 328 women were diagnosed with CNS tumors. No marked associations were observed between use of the fertility drugs clomiphene citrate, gonadotropins, gonadotropin-releasing hormone receptor modulators and progesterone and CNS tumors. However, use of human chorionic gonadotropin was associated with a decreased rate of meningiomas (HR 0.49 95% CI 0.28-0.87). No clear associations with CNS tumors were observed according to time since first use or cumulative dose for any of the fertility drugs.Conclusion: No associations between use of most types of fertility drugs and CNS tumors were observed. However, our findings only apply to premenopausal women and additional studies with longer follow-up time are necessary. [ABSTRACT FROM AUTHOR]
Published: 2022
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33. Evolution of Stronger SARS-CoV-2 Variants as Revealed Through the Lens of Molecular Dynamics Simulations.

Author: Wozney, Alec J., Smith, Macey A., Abdrabbo, Mobeen, Birch, Cole M., Cicigoi, Kelsey A., Dolan, Connor C., Gerzema, Audrey E. L., Hansen, Abby, Henseler, Ethan J., LaBerge, Ben, Leavens, Caterra M., Le, Christine N., Lindquist, Allison C., Ludwig, Rikaela K., O'Reilly, Maggie G., Reynolds, Jacob H., Sherman, Brandon A., Sillman, Hunter W., Smith, Michael A., and Snortheim, Marissa J.
Subjects: SARS-CoV-2, MOLECULAR dynamics, PEPTIDASE, SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, CORONAVIRUS spike protein
Abstract: Using molecular dynamics simulations, the protein–protein interactions of the receptor-binding domain of the wild-type and seven variants of the severe acute respiratory syndrome coronavirus 2 spike protein and the peptidase domain of human angiotensin-converting enzyme 2 were investigated. These variants are alpha, beta, gamma, delta, eta, kappa, and omicron. Using 100 ns simulation data, the residue interaction networks at the protein–protein interface were identified. Also, the impact of mutations on essential protein dynamics, backbone flexibility, and interaction energy of the simulated protein–protein complexes were studied. The protein–protein interface for the wild-type, delta, and omicron variants contained several stronger interactions, while the alpha, beta, gamma, eta, and kappa variants exhibited an opposite scenario as evident from the analysis of the inter-residue interaction distances and pair-wise interaction energies. The study reveals that two distinct residue networks at the central and right contact regions forge stronger binding affinity between the protein partners. The study provides a molecular-level insight into how enhanced transmissibility and infectivity by delta and omicron variants are most likely tied to a handful of interacting residues at the binding interface, which could potentially be utilized for future antibody constructs and structure-based antiviral drug design. [ABSTRACT FROM AUTHOR]
Published: 2022
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34. Midkine release during hemodialysis is predictive of hypervolemia and associates with excess (cardiovascular) mortality in patients with end-stage renal disease: a prospective study.

Author: Brandt, Sabine, Fischer, Anja, Kreutze, Carla, Hempel, Dorothea, Gorny, Xenia, Scurt, Florian G., Şalaru, Delia L., Bartsch, Peter, Bernhardt, Anja, Bode-Böger, Stefanie M., Girndt, Matthias, Fiedler, Roman, Isermann, Berend, Lindquist, Jonathan A., and Mertens, Peter R.
Abstract: Background: In end-stage renal disease, a high cardiovascular risk profile and endothelial damage prevails. The heparin-binding growth factor midkine stimulates neo-angiogenesis in ischemic diseases, coordinates neutrophil influx, and raises blood pressure through stimulated angiotensin synthesis. Methods: We determined changes of midkine serum levels during hemodialysis sessions under the assumption that endothelial cell-derived midkine is released. Periprocedural differences (∆midkine) were calculated and correlated with cardiovacular biomarkers and fluid status (clinical assessment, V. cava collapse, comet tail phenomenon), cardiovascular morbidities, mortality rates. Blood was collected before and after dialysis from hemodialysis patients (n = 171; diabetes: n = 70; hypervolemia: n = 83; both: n = 32). Results: Baseline midkine levels were ~ fourfold elevated compared to healthy controls (n = 100). Further, on average a tenfold rise was detected during dialysis, the extent of which was partially related to non-fractionated heparin application (r2 = 0.17). Inter-individual differences were highly reproducible. Hypervolemic patients responded with a less than average rise in midkine levels during dialysis (p < 0.02), this difference became more obvious with co-existing diabetes (p < 0.001 for long dialysis-free interval) and was confirmed in an independently enrolled dialysis cohort (n = 88). In Kaplan Meier survival curves, low delta midkine levels correlated with cardiovascular/overall mortality rates, similar to elevated uPAR levels, whereas other markers (NTproANP, galectin, tenascin-C) were less predictive. Following intervention with successful fluid removal in hypervolemic dialysis patients to optimize fluid homeostasis, midkine values increased (p < 0.002), which was not observed in patients that failed to decrease weight. Conclusion: Thus, for dialysis patients inadequate periprocedural midkine upregulation is linked with hypervolemia and associates with cardiovascular events. [ABSTRACT FROM AUTHOR]
Published: 2022
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35. Design of simulator training : a comparative study of Swedish dynamic decision-making training facilities

Author: Aronsson, Sanna, Artman, Henrik, Brynielsson, Joel, Lindquist, Sinna, Ramberg, Robert, Aronsson, Sanna, Artman, Henrik, Brynielsson, Joel, Lindquist, Sinna, and Ramberg, Robert
Abstract: Simulator training is becoming increasingly important for training of time-critical and dynamic situations. Hence, how simulator training in such domains is planned, carried out and followed up becomes important. Based on a model prescribing such crucial aspects, ten decision-making training simulator facilities have been analyzed from an activity theoretical perspective. The analysis reveals several conflicts that exist between the training that is carried out and the defined training objectives. Although limitations in technology and organization are often alleviated by proficient instructors, it is concluded that there is a need for a structured approach to the design of training to be able to define the competencies and skills that ought to be trained along with relevant measurable training goals. Further, there is a need for a pedagogical model that takes the specifics of simulator training into account. Such a pedagogical model is needed to be able to evaluate the training, and would make it possible to share experiences and make comparisons between facilities in a structured manner., QC 20220405
Published: 2021
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36. Maternal lithium use and the risk of adverse pregnancy and neonatal outcomes : a Swedish population-based cohort study

Author: Hastie, Roxanne, Tong, Stephen, Hiscock, Richard, Lindquist, Anthea, Lindström, Linda, Wikström, Anna-Karin, Sundström Poromaa, Inger, Hastie, Roxanne, Tong, Stephen, Hiscock, Richard, Lindquist, Anthea, Lindström, Linda, Wikström, Anna-Karin, and Sundström Poromaa, Inger
Abstract: Background: Lithium is prescribed during pregnancy, but there is limited information about pregnancy and neonatal outcomes following in utero exposure. Thus, this study aimed to investigate the associations between lithium use and adverse pregnancy and neonatal outcomes. Methods: This population-based cohort study examined associations between maternal lithium use and major adverse pregnancy and neonatal outcomes via inverse probability weighted propensity score regression models. Results: Of 854,017 women included in this study, 434 (0.05%) used lithium during pregnancy. Among pre-specified primary outcomes, lithium use during pregnancy was associated with an increased risk of spontaneous preterm birth (8.7% vs 3.0%; adjusted relative risk [aRR] 2.64 95% CI 1.82, 3.82) and birth of a large for gestational age infant (9.0% vs 3.5%; aRR 2.64 95% CI 1.91, 3.66), but not preeclampsia nor birth of a small for gestational age infant. Among secondary outcomes, lithium use was associated with an increased risk of cardiac malformations (2.1% vs 0.8%; aRR 3.17 95% CI 1.64, 6.13). In an analysis restricted to pregnant women with a diagnosed psychiatric illness (n=9552), associations remained between lithium and spontaneous preterm birth, birth of a large for gestational age infant, and cardiovascular malformations; and a positive association with neonatal hypoglycaemia was also found. These associations were also apparent in a further analysis comparing women who continued lithium treatment during pregnancy to those who discontinued prior to pregnancy. Conclusions: Lithium use during pregnancy is associated with an increased risk of spontaneous preterm birth and other adverse neonatal outcomes. These potential risks must be balanced against the important benefit of treatment and should be used to guide shared decision-making.
Published: 2021
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37. COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19) : a structured summary of a study protocol for a randomised controlled trial

Author: Welen, Karin, Overby, Anna K., Ahlm, Clas, Freyhult, Eva, Robinsson, David, Henningsson, Anna Jonsson, Stranne, Johan, Bremell, Daniel, Angelin, Martin, Lindquist, Elisabeth, Buckland, Robert, Carlsson, Camilla Thellenberg, Pauksens, Karlis, Bill-Axelson, Anna, Akre, Olof, Ryden, Cecilia, Wagenius, Magnus, Bjartell, Anders, Nilsson, Anna C., Styrke, Johan, Repo, Johanna, Balkhed, Ase Osholm, Niward, Katarina, Gisslen, Magnus, Josefsson, Andreas, Welen, Karin, Overby, Anna K., Ahlm, Clas, Freyhult, Eva, Robinsson, David, Henningsson, Anna Jonsson, Stranne, Johan, Bremell, Daniel, Angelin, Martin, Lindquist, Elisabeth, Buckland, Robert, Carlsson, Camilla Thellenberg, Pauksens, Karlis, Bill-Axelson, Anna, Akre, Olof, Ryden, Cecilia, Wagenius, Magnus, Bjartell, Anders, Nilsson, Anna C., Styrke, Johan, Repo, Johanna, Balkhed, Ase Osholm, Niward, Katarina, Gisslen, Magnus, and Josefsson, Andreas
Abstract: Objectives: The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for SARS-CoV-2 host cell internalization. Trial design: Hospitalised COVID-19 patients will be randomised (2:1) to enzalutamide plus standard of care vs. standard of care designed to identify superiority. Participants: Included participants, men or women above 50 years of age, must be hospitalised for PCR confirmed COVID-19 symptoms and not in need of immediate mechanical ventilation. Major exclusion criteria are breast-feeding or pregnant women, hormonal treatment for prostate or breast cancer, treatment with immunosuppressive drugs, current symptomatic unstable cardiovascular disease (see Additional file 1 for further details). The trial is registered at Umea University Hospital, Region Vasterbotten, Sweden and 8 hospitals are approved for inclusion in Sweden. Intervention and comparator: Patients randomised to the treatment arm will be treated orally with 160 mg (4x40 mg) enzalutamide (Xtandi (R)) daily, for five consecutive days. The study is not placebo controlled. The comparator is standard of care treatment for patients hospitalised with COVID-19. Main outcomes: The primary endpoints of the study are (time to) need of mechanical ventilation or discharge from hospital as assessed by a clinical 7-point ordinal scale (up to 30 days after inclusion). Randomisation: Randomisation was stratified by center and sex. Each strata was randomized separately with block size six with a 2:1 allocation ratio (enzalutamide + "standard of care": "standard of care"). The randomisation list, with consecutive subject numbers, was generated by an independent statistician using the PROC PLAN p
Published: 2021
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38. Geometric and biomechanical modeling aided by machine learning improves the prediction of growth and rupture of small abdominal aortic aneurysms

Author: Liljeqvist, Moritz Lindquist, Bogdanovic, Marko, Siika, Antti, Gasser, T. Christian, Hultgren, Rebecka, Roy, Joy, Liljeqvist, Moritz Lindquist, Bogdanovic, Marko, Siika, Antti, Gasser, T. Christian, Hultgren, Rebecka, and Roy, Joy
Abstract: It remains difficult to predict when which patients with abdominal aortic aneurysm (AAA) will require surgery. The aim was to study the accuracy of geometric and biomechanical analysis of small AAAs to predict reaching the threshold for surgery, diameter growth rate and rupture or symptomatic aneurysm. 189 patients with AAAs of diameters 40-50 mm were included, 161 had undergone two CTAs. Geometric and biomechanical variables were used in prediction modelling. Classifications were evaluated with area under receiver operating characteristic curve (AUC) and regressions with correlation between observed and predicted growth rates. Compared with the baseline clinical diameter, geometric-biomechanical analysis improved prediction of reaching surgical threshold within four years (AUC 0.80 vs 0.85, p = 0.031) and prediction of diameter growth rate (r = 0.17 vs r = 0.38, p = 0.0031), mainly due to the addition of semiautomatic diameter measurements. There was a trend towards increased precision of volume growth rate prediction (r = 0.37 vs r = 0.45, p = 0.081). Lumen diameter and biomechanical indices were the only variables that could predict future rupture or symptomatic AAA (AUCs 0.65-0.67). Enhanced precision of diameter measurements improves the prediction of reaching the surgical threshold and diameter growth rate, while lumen diameter and biomechanical analysis predicts rupture or symptomatic AAA., QC 20211027
Published: 2021
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39. Erice Manifesto 2022: On the Surveillance of Potential Harms Caused by Food Supplements in Europe.

Author: Menniti-Ippolito, Francesca, Aiello, Eugenio, Arzenton, Elena, Assisi, Alessandro, Blaznik, Urška, Castenmiller, Jacqueline J. M., Crevani, Marta, de Clock, Dominique, Di Giacomo, Silvia, Emendi, Silvia, Gonella, Laura Augusta, Ippoliti, Ilaria, Lindquist, Marie, Magro, Lara, Mazzanti, Gabriela, Mores, Nadia, Moretti, Ugo, Moro, Paola Angela, Novakovic, Budimka, and Raschi, Emanuel
Subjects: SAFETY standards, DRUG-food interactions, DRUG side effects
Abstract: A very recent survey explored how and why EU consumers are using food supplements. The aim of this manifesto is: to enhance the awareness on a safe use of food supplements; to promote the creation of a common European monitoring system; to inform citizens and health professionals about the potential risks associated with the consumption of these products; to stimulate the reporting of possible harm (adverse events). [Extracted from the article]
Published: 2023
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40. Alternatives to classical option pricing.

Author: Lindquist, W. Brent and Rachev, Svetlozar T.
Subjects: *PRICES, *RATINGS & rankings of public debts, *FINANCIAL markets, *SOFR, *PROBABILITY theory
Abstract: We develop two alternate approaches to arbitrage-free, market-complete, option pricing. The first approach requires no riskless asset. We develop the general framework for this approach and illustrate it with two specific examples. The second approach does use a riskless asset. However, by ensuring equality between real-world and risk-neutral price-change probabilities, the second approach enables the computation of risk-neutral option prices utilizing expectations under the natural world probability P\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${\mathbb{P}}$$\end{document}. This produces the same option prices as the classical approach in which prices are computed under the risk neutral measure Q\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${\mathbb{Q}}$$\end{document}. The second approach and the two specific examples of the first approach require the introduction of new, marketable asset types, specifically perpetual derivatives of a stock, and a stock whose cumulative return (rather than price) is deflated. These two asset types are designed specifically for hedgers who don’t have access to sovereign riskless rates or may be hesitant to utilize interbank rates such as SOFR. [ABSTRACT FROM AUTHOR]
Published: 2024
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41. NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host.

Author: Liublin, Wjatscheslaw, Rausch, Sebastian, Leben, Ruth, Lindquist, Randall L., Fiedler, Alexander, Liebeskind, Juliane, Beckers, Ingeborg E., Hauser, Anja E., Hartmann, Susanne, and Niesner, Raluca A.
Subjects: PARASITES, NICOTINAMIDE adenine dinucleotide phosphate, NAD (Coenzyme), NEMATODES, NEMATODE infections, INTESTINAL infections, INTESTINES, PARASITIC diseases
Abstract: Infections with intestinal nematodes have an equivocal impact: they represent a burden for human health and animal husbandry, but, at the same time, may ameliorate auto-immune diseases due to the immunomodulatory effect of the parasites. Thus, it is key to understand how intestinal nematodes arrive and persist in their luminal niche and interact with the host over long periods of time. One basic mechanism governing parasite and host cellular and tissue functions, metabolism, has largely been neglected in the study of intestinal nematode infections. Here we use NADH (nicotinamide adenine dinucleotide) and NADPH (nicotinamide adenine dinucleotide phosphate) fluorescence lifetime imaging of explanted murine duodenum infected with the natural nematode Heligmosomoides polygyrus and define the link between general metabolic activity and possible metabolic pathways in parasite and host tissue, during acute infection. In both healthy and infected host intestine, energy is effectively produced, mainly via metabolic pathways resembling oxidative phosphorylation/aerobic glycolysis features. In contrast, the nematodes shift their energy production from balanced fast anaerobic glycolysis-like and effective oxidative phosphorylation-like metabolic pathways, towards mainly anaerobic glycolysis-like pathways, back to oxidative phosphorylation/aerobic glycolysis-like pathways during their different life cycle phases in the submucosa versus the intestinal lumen. Additionally, we found an increased NADPH oxidase (NOX) enzymes-dependent oxidative burst in infected intestinal host tissue as compared to healthy tissue, which was mirrored by a similar defense reaction in the parasites. We expect that, the here presented application of NAD(P)H-FLIM in live tissues constitutes a unique tool to study possible shifts between metabolic pathways in host-parasite crosstalk, in various parasitic intestinal infections. [ABSTRACT FROM AUTHOR]
Published: 2022
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42. Implementation of a synoptic operative note for abdominal wall hernia repair: a statewide pilot evaluating completeness and communication of intraoperative details.

Author: Delaney, Lia D., Lindquist, Kerry M., Howard, Ryan, Ehlers, Anne P., Ann Vitous, C., Englesbe, Michael, Dimick, Justin B., and Telem, Dana A.
Subjects: *HERNIA surgery, *HERNIA, *ABDOMINAL wall, *REPAIRING, *MISSING data (Statistics), *DATA transmission systems, *RESISTANCE to change
Abstract: Background: Variable approaches to intraoperative communication impede our understanding of surgical decision-making and best practices. This is critical among hernia repairs, where improved outcomes are reliant on understanding the impact of different patient characteristics and surgical approaches. In this context, a hernia-specific synoptic operative note was piloted as part of an effort to create a statewide hernia registry. We aimed to understand the impact of the synoptic operative note on variable missingness and evaluate barriers and facilitators to improved intraoperative communication and note adoption. Methods: In January 2020, the Michigan Surgical Quality Collaborative (MSQC) registry was expanded to capture hernia-specific intraoperative variables. A synoptic operative note for hernia repair was piloted at 8 hospitals. The primary outcome was change in hernia variable communication, measured by missingness. Using a sequential explanatory mixed-methods design, we performed semi-structured interviews with data abstractors (n = 4) and surgeons (n = 4) at 5 pilot sites to assess barriers and facilitators of implementation. Interviews were iteratively analyzed using content analysis with both deductive and inductive approaches. Results: From January to June 2020, 870 hernia repairs were performed across 8 pilot and 53 control sites. Pilot sites had significantly less missingness for all hernia-specific variables. At pilot sites, 46% of notes were fully complete in regard to hernia variables, compared to 21% at control sites (p value < 0.001). While collection of intraoperative variables improved after synoptic note implementation, low note adoption was reported. Facilitators of improved variable collection were (1) communication with data abstractors and (2) stakeholder acknowledgment of widespread benefit, while barriers included (1) surgeon resistance to practice change, (2) EMR/technology, and (3) interruptions to communication and implementation. Conclusion: This mixed-methods evaluation of a synoptic operative note implementation suggests that sustained communication, particularly with abstractors, was the most impactful intervention. Future implementation efforts may have improved effectiveness with interventions supplementary to surgeon-level direction. [ABSTRACT FROM AUTHOR]
Published: 2022
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43. Urinary and anal incontinence among female gymnasts and cheerleaders—bother and associated factors. A cross-sectional study.

Author: Skaug, Kristina Lindquist, Engh, Marie Ellström, Frawley, Helena, and Bø, Kari
Subjects: *ATHLETES, *URINARY incontinence, *URINARY stress incontinence, *CHEERLEADING, *GYMNASTS, *ARTISTIC gymnastics
Abstract: Introduction and hypothesis: Artistic gymnastics, team gymnastics and cheerleading are sports including high-impact activities. It is presumed that the athletes' pelvic floor must be functioning well to prevent urinary (UI) and anal incontinence (AI) during sports. The aim of this study was to investigate the prevalence and risk factors for UI and AI in female artistic gymnasts, team gymnasts and cheerleaders; the influence of UI and AI on daily living and sport performance; and the athletes' knowledge about the pelvic floor muscles (PFM). Methods: All female athletes ≥ 12 years of age competing in ≥ 1 National Championship in artistic gymnastics, team gymnastics or cheerleading in 2018/2019 were invited. International Consensus on Incontinence Questionnaires were used to assess the prevalence/bother of UI and AI. Results: Among the 319 gymnasts and cheerleaders who participated, the prevalence of UI and AI was 67% and 84%, respectively. Age, training ≥ 4 days/week and straining to void were significantly associated with stress urinary incontinence (SUI) and years of training with AI. Eighty-three percent of athletes with SUI reported a negative effect on sports performance, 22% would occasionally avoid training or specific exercises because of leakage, and 28% used pads for protection. Forty-one percent of the athletes had never heard about the PFM, and 74% reported an interest in PFM training to prevent/treat UI or AI. Conclusions: UI and AI were prevalent in female gymnasts and cheerleaders, and SUI negatively influenced sport performance. The athletes' knowledge about the PFM was limited. [ABSTRACT FROM AUTHOR]
Published: 2022
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44. Effects of rTMS and tDCS on neuropathic pain after brachial plexus injury: a randomized placebo-controlled pilot study.

Author: Bonifácio de Assis, Erickson Duarte, Martins, Wanessa Kallyne Nascimento, de Carvalho, Carolina Dias, Ferreira, Clarice Martins, Gomes, Ruth, de Almeida Rodrigues, Evelyn Thais, Meira, Ussânio Mororó, de Holanda, Ledycnarf Januário, Lindquist, Ana Raquel, Morya, Edgard, Mendes, Cristina Katya Torres Teixeira, de Assis, Thaís Castro Gomes, de Oliveira, Eliane Araújo, and Andrade, Suellen Marinho
Subjects: TRANSCRANIAL direct current stimulation, BRACHIAL plexus, NEURALGIA, MOTORCYCLING accidents, TRANSCRANIAL magnetic stimulation, BRAIN stimulation, DISABILITIES
Abstract: Neuropathic pain after brachial plexus injury (NPBPI) is a highly disabling clinical condition and is increasingly prevalent due to increased motorcycle accidents. Currently, no randomized controlled trials have evaluated the effectiveness of non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS) in patients suffering from NPBPI. In this study, we directly compare the efficacy of 10-Hz rTMS and anodal 2 mA tDCS techniques applied over the motor cortex (5 daily consecutive sessions) in 20 patients with NPBPI, allocated into 2 parallel groups (active or sham). The order of the sessions was randomised for each of these treatment groups according to a crossover design and separated by a 30-day interval. Scores for "continuous" and "paroxysmal" pain (primary outcome) were tabulated after the last stimulation day and 30 days after. Secondary outcomes included the improvement in multidimensional aspects of pain, anxiety state and quality of life from a qualitative and quantitative approach. Active rTMS and tDCS were both superior to sham in reducing continuous (p < 0.001) and paroxysmal (p = 0.002; p = 0.02) pain as well as in multidimensional aspects of pain (p = 0.001; p = 0.002) and anxiety state (p = < 0.001; p = 0.005). Our results suggest rTMS and tDCS are able to treat NPBPI with little distinction in pain and anxiety state, which may promote the use of tDCS in brachial plexus injury pain management, as it constitutes an easier and more available technique. Clinical Trial Registration: http://www.ensaiosclinicos.gov.br/, RBR-5xnjbc – Sep 3, 2018. [ABSTRACT FROM AUTHOR]
Published: 2022
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45. A bridge to relevance: on the history of the Academy of Marketing Science® (AMS).

Author: Babin, Barry J., Moulard, Julie Guidry, and Lindquist, Jay D.
Abstract: AMS has survived half a century. Originally envisioned by Harold W. Berkman, who survived nearly a full century, the association has grown in numbers and in prominence. While AMS is well-known for its two leading academic journals and for hosting well-attended annual conferences and the World Marketing Congress, relatively little has been written about AMS history. We contribute a brief history of AMS that emphasizes the organization's missions and values. In particular, AMS, along with its publications and conferences, has been, is, and will continue to aim to represent, a bridge between the academic and practicing marketing community. Further, that bridge should be built upon quality, service, and integrity. [ABSTRACT FROM AUTHOR]
Published: 2021
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46. Directed assembly of layered perovskite heterostructures as single crystals.

Author: Aubrey, Michael L., Saldivar Valdes, Abraham, Filip, Marina R., Connor, Bridget A., Lindquist, Kurt P., Neaton, Jeffrey B., and Karunadasa, Hemamala I.
Abstract: The precise stacking of different two-dimensional (2D) structures such as graphene and MoS2 has reinvigorated the field of 2D materials, revealing exotic phenomena at their interfaces1,2. These unique interfaces are typically constructed using mechanical or deposition-based methods to build a heterostructure one monolayer at a time2,3. By contrast, self-assembly is a scalable technique, where complex materials can selectively form in solution4–6. Here we show a synthetic strategy for the self-assembly of layered perovskite–non-perovskite heterostructures into large single crystals in aqueous solution. Using bifunctional organic molecules as directing groups, we have isolated six layered heterostructures that form as an interleaving of perovskite slabs with a different inorganic lattice, previously unknown to crystallize with perovskites. In many cases, these intergrown lattices are 2D congeners of canonical inorganic structure types. To our knowledge, these compounds are the first layered perovskite heterostructures formed using organic templates and characterized by single-crystal X-ray diffraction. Notably, this interleaving of inorganic structures can markedly transform the band structure. Optical data and first principles calculations show that substantive coupling between perovskite and intergrowth layers leads to new electronic transitions distributed across both sublattices. Given the technological promise of halide perovskites4, this intuitive synthetic route sets a foundation for the directed synthesis of richly structured complex semiconductors that self-assemble in water.Using organic molecules as directing groups, a wide range of perovskite heterostructures are shown to self-assemble in solution to yield single crystals. [ABSTRACT FROM AUTHOR]
Published: 2021
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47. The biogeographic differentiation of algal microbiomes in the upper ocean from pole to pole.

Author: Martin, Kara, Schmidt, Katrin, Toseland, Andrew, Boulton, Chris A., Barry, Kerrie, Beszteri, Bánk, Brussaard, Corina P. D., Clum, Alicia, Daum, Chris G., Eloe-Fadrosh, Emiley, Fong, Allison, Foster, Brian, Foster, Bryce, Ginzburg, Michael, Huntemann, Marcel, Ivanova, Natalia N., Kyrpides, Nikos C., Lindquist, Erika, Mukherjee, Supratim, and Palaniappan, Krishnaveni
Subjects: EFFECT of human beings on climate change, CARBON fixation, OCEAN temperature, ALGAL communities, GENE regulatory networks, SPECIES diversity, OCEAN
Abstract: Eukaryotic phytoplankton are responsible for at least 20% of annual global carbon fixation. Their diversity and activity are shaped by interactions with prokaryotes as part of complex microbiomes. Although differences in their local species diversity have been estimated, we still have a limited understanding of environmental conditions responsible for compositional differences between local species communities on a large scale from pole to pole. Here, we show, based on pole-to-pole phytoplankton metatranscriptomes and microbial rDNA sequencing, that environmental differences between polar and non-polar upper oceans most strongly impact the large-scale spatial pattern of biodiversity and gene activity in algal microbiomes. The geographic differentiation of co-occurring microbes in algal microbiomes can be well explained by the latitudinal temperature gradient and associated break points in their beta diversity, with an average breakpoint at 14 °C ± 4.3, separating cold and warm upper oceans. As global warming impacts upper ocean temperatures, we project that break points of beta diversity move markedly pole-wards. Hence, abrupt regime shifts in algal microbiomes could be caused by anthropogenic climate change. Latitudinal ecosystem boundaries in the global upper ocean may be driven by many factors. Here the authors investigate pole-to-pole eukaryotic phytoplankton metatranscriptomes, gene co-expression networks, and beta diversity, finding that geographic patterns are best explained by temperature gradients. [ABSTRACT FROM AUTHOR]
Published: 2021
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48. Geometric and biomechanical modeling aided by machine learning improves the prediction of growth and rupture of small abdominal aortic aneurysms.

Author: Lindquist Liljeqvist, Moritz, Bogdanovic, Marko, Siika, Antti, Gasser, T. Christian, Hultgren, Rebecka, and Roy, Joy
Subjects: *MACHINE learning, *ABDOMINAL aortic aneurysms, *SURGERY, *ANEURYSMS, *REGRESSION analysis
Abstract: It remains difficult to predict when which patients with abdominal aortic aneurysm (AAA) will require surgery. The aim was to study the accuracy of geometric and biomechanical analysis of small AAAs to predict reaching the threshold for surgery, diameter growth rate and rupture or symptomatic aneurysm. 189 patients with AAAs of diameters 40–50 mm were included, 161 had undergone two CTAs. Geometric and biomechanical variables were used in prediction modelling. Classifications were evaluated with area under receiver operating characteristic curve (AUC) and regressions with correlation between observed and predicted growth rates. Compared with the baseline clinical diameter, geometric-biomechanical analysis improved prediction of reaching surgical threshold within four years (AUC 0.80 vs 0.85, p = 0.031) and prediction of diameter growth rate (r = 0.17 vs r = 0.38, p = 0.0031), mainly due to the addition of semiautomatic diameter measurements. There was a trend towards increased precision of volume growth rate prediction (r = 0.37 vs r = 0.45, p = 0.081). Lumen diameter and biomechanical indices were the only variables that could predict future rupture or symptomatic AAA (AUCs 0.65–0.67). Enhanced precision of diameter measurements improves the prediction of reaching the surgical threshold and diameter growth rate, while lumen diameter and biomechanical analysis predicts rupture or symptomatic AAA. [ABSTRACT FROM AUTHOR]
Published: 2021
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49. Accuracy of echocardiographic estimates of pulmonary artery pressures in pulmonary hypertension: insights from the KARUM hemodynamic database.

Author: Venkateshvaran, Ashwin, Seidova, Natavan, Tureli, Hande Oktay, Kjellström, Barbro, Lund, Lars H., Tossavainen, Erik, and Lindquist, Per
Abstract: Accurate assessment of pulmonary artery (PA) pressures is integral to diagnosis, follow-up and therapy selection in pulmonary hypertension (PH). Despite wide utilization, the accuracy of echocardiography to estimate PA pressures has been debated. We aimed to evaluate echocardiographic accuracy to estimate right heart catheterization (RHC) based PA pressures in a large, dual-centre hemodynamic database. Consecutive PH referrals that underwent comprehensive echocardiography within 3 h of clinically indicated right heart catheterization were enrolled. Subjects with absent or severe, free-flowing tricuspid regurgitation (TR) were excluded. Accuracy was defined as mean bias between echocardiographic and invasive measurements on Bland–Altman analysis for the cohort and estimate difference within ± 10 mmHg of invasive measurements for individual diagnosis. In 419 subjects, echocardiographic PA systolic and mean pressures demonstrated minimal bias with invasive measurements (+ 2.4 and + 1.9 mmHg respectively) but displayed wide limits of agreement (− 20 to + 25 and − 14 to + 18 mmHg respectively) and frequently misclassified subjects. Recommendation-based right atrial pressure (RAP) demonstrated poor precision and was falsely elevated in 32% of individual cases. Applying a fixed, median RAP to echocardiographic estimates resulted in relatively lower bias between modalities when assessing PA systolic (+ 1.4 mmHg; 95% limits of agreement + 25 to − 22 mmHg) and PA mean pressures (+ 1.4 mmHg; 95% limits of agreement + 19 to − 16 mmHg). Echocardiography accurately represents invasive PA pressures for population studies but may be misleading for individual diagnosis owing to modest precision and frequent misclassification. Recommendation-based estimates of RAPmean may not necessarily contribute to greater accuracy of PA pressure estimates. [ABSTRACT FROM AUTHOR]
Published: 2021
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50. Effect of Delays in Maternal Access to Healthcare on Neonatal Mortality in Sierra Leone: A Social Autopsy Case–Control Study at a Child Health and Mortality Prevention Surveillance (CHAMPS) Site.

Author: Preslar, Jessica P., Worrell, Mary Claire, Kaiser, Reinhard, Cain, Carrie Jo, Samura, Solomon, Jambai, Amara, Raghunathan, Pratima L., Clarke, Kevin, Goodman, David, Christiansen-Lindquist, Lauren, Webb-Girard, Amy, Kramer, Michael, and Breiman, Robert
Subjects: PREGNANCY & psychology, HEALTH services accessibility, CONFIDENCE intervals, SELF-evaluation, AUTOPSY, INTERVIEWING, CASE-control method, PERINATAL death, QUESTIONNAIRES, DESCRIPTIVE statistics, RESEARCH funding, INFANT mortality, LOGISTIC regression analysis, ODDS ratio, DELIVERY (Obstetrics)
Abstract: Introduction: In low-resource settings, a social autopsy tool has been proposed to measure the effect of delays in access to healthcare on deaths, complementing verbal autopsy questionnaires routinely used to determine cause of death. This study estimates the contribution of various delays in maternal healthcare to subsequent neonatal mortality using a social autopsy case–control design. Methods: This study was conducted at the Child Health and Mortality Prevention Surveillance (CHAMPS) Sierra Leone site (Makeni City and surrounding rural areas). Cases were neonatal deaths in the catchment area, and controls were sex- and area-matched living neonates. Odds ratios for maternal barriers to care and neonatal death were estimated, and stratified models examined this association by neonatal age and medical complications. Results: Of 53 neonatal deaths, 26.4% of mothers experienced at least one delay during pregnancy or delivery compared to 46.9% of mothers of stillbirths and 18.6% of control mothers. The most commonly reported delay among neonatal deaths was receiving care at the facility (18.9%). Experiencing any barrier was weakly associated (OR 1.68, CI 0.77, 3.67) and a delay in receiving care at the facility was strongly associated (OR 19.15, CI 3.90, 94.19) with neonatal death. Discussion: Delays in healthcare are associated with neonatal death, particularly delays experienced at the healthcare facility. Heterogeneity exists in the prevalence of specific delays, which has implications for local public health policy. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. [ABSTRACT FROM AUTHOR]
Published: 2021
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