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A method for the "Dissolution" test was developed and validated for tablets of the new bisphosphonate sodium prodronate and was compliant with the general normative requirements. Dissolution was carried out on an instrument with paddles rotating at a rate of 50 rpm. The quantity of drug entering solution over 45 min was assed by UV spectrophotometry via formation of complexes with copper ions, with an absorption peak at 237 nm. [ABSTRACT FROM AUTHOR]

A spectrophotometric method for determining sodium prodronate in tablets by measuring the absorption at 237 ± 2 nm of a Cu(II)—prodronate complex in acetate buffer was developed and validated. The method met applicable requirements of the SP RB for quantitative analysis methods for drugs and could be recommended for use by the State Drug Quality Control Inspection and technical control departments of chemical and pharmaceutical plants. [ABSTRACT FROM AUTHOR]

We synthesized chalcopyrite (CuFeS2) nanoparticles by methods involving laser ablation and electrical discharge in water. The nanoparticles obtained were exposed to an oxygen/argon plasma of a microwave discharge. The synthesized material was studied by photometry, x-ray diffraction (XRD), and energy dispersive x-ray elemental analysis (EDX), IR spectroscopy, and atomic force electron microscopy (AFM). We have established that the nanoparticles are morphologically stable relative to exposure to plasma fluxes of power ≤1 kW, and can be used as a model system to study processes of interaction between a plasma and minerals. [ABSTRACT FROM AUTHOR]

The synthesis of L-ornithine L-aspartate that involved basic hydrolysis of L-arginine by barium hydroxide, precipitation of barium cations as barium carbonate, addition of L-aspartic acid, and direct precipitation of L-ornithine L-aspartate was described. The obtained compound could be used as a hepatoprotective drug. [ABSTRACT FROM AUTHOR]

N-acetyl derivatives of L-glutamine, L-proline, and 4-hydroxy-L-proline were synthesized in aqueous solutions with acetic anhydride as the acetylating agent. The resulting compounds were used as medicinal substances. [ABSTRACT FROM AUTHOR]

Taurine (2-aminoethanesulfonic acid) has been synthesized via reaction of 2-aminoethylsulfuric acid (prepared from monoethanolamine and sulfuric acid) with sodium sulfite. The target compound was separated from the excess of sodium sulfite by extraction with conc. aqueous ammonia (25%). [ABSTRACT FROM AUTHOR]

A series of selenium-containing complex salts of L-lysine and L-arginine has been synthesized. Some physicochemical characteristics of selenium-containing amino acids are reported. [ABSTRACT FROM AUTHOR]

The synthesis of iron(II) di- DL-aspartate is described. Tests on rabbits with a model of acute and chronic anemia showed that the administration of the synthesized compound led to an increase in the hemoglobin level and in the numbers of erythrocytes and thrombocytes. [ABSTRACT FROM AUTHOR]