1. Association of high LDL concentrations with erectile dysfunction from a Mendelian randomization study.
- Author
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Zhu, Quan, Tan, Yao, Zou, Xuyan, and Lu, Liqing
- Subjects
IMPOTENCE ,ANTILIPEMIC agents ,LIPID metabolism ,ODDS ratio ,CONFIDENCE intervals - Abstract
Lipid metabolism plays a key role in erectile dysfunction. Our purpose was to evaluate the influence of lipid-lowering drugs on erectile dysfunction employing a two-sample Mendelian randomization (MR) study. Genetic instruments were employed to represent the exposure of lipid-lowering drugs. Inverse variance-weighted MR (IVWMR) was employed to calculate the estimation of effects. IVW-MR analysis showed that the positive relationship between the expression of HMGCR and the risk of erectile dysfunction (odds ratio [OR] = 1.27, 95% confidence interval [CI] 1.03–1.57; p = 0.028). No significant relationship was detected between NPC1L1, PSK9 expression and erectile dysfunction. This MR study suggested that HMGCR inhibitors are a more desirable treatment modality for patients with ED. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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