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The aim of the study was to assess the involvement of submandibular gland in oral cancer patients undergoing neck dissection. This study reviewed the records and pathologic specimens of patients who were clinically and histopathologically diagnosed as having oral cavity squamous cell carcinoma, from the year 2018 to 2023. A total of 332 patients were included. These patients underwent surgery with primary tumor resection and neck dissection. Pathologic metastasis to submandibular gland was then evaluated. Histopathological data showed that submandibular gland was involved in only 10 cases. Out of these cases, involvement of level IA &B lymph nodes was found in 9 of the cases. Direct extension of primary tumor to submandibular gland was noted in advanced stages (stage IV). Most common primary site for involvement of SMG was buccal mucosa (six patients), with significant correlation with LVI, ENE, DOI and WPOI (p value < 0.05). This study demonstrates that the incidence of submandibular gland metastasis in oral cavity (SCC) is extremely rare. Its involvement is either through direct extension from a primary lesion or in advanced disease. Thus, patients with early-stage oral SCC with preoperative N0 neck, may be candidates for preservation of the submandibular gland. [ABSTRACT FROM AUTHOR]

In this transdisciplinary study, we investigated, using genomic tools and physico-chemical parameters, the effect of Moringa oleifera seed (MOS) on the removal of microorganisms and pharmaceutic residues (antibiotics), and also the development of antibiotic-resistant genes (ARGs) in water samples from a domestic wastewater treatment plant (WWTP) prototype. Water samples were analyzed with and without the addition of powder of MOS. The results showed that MOS addition reduced the total bacterial load from 1.73 × 1010 ± 3.21 × 109 to 6.67 × 106 ± 5.77 × 106 CFU/L, while fecal coliforms and Escherichia coli were removed with efficiencies of 99% and 57%, respectively. Furthermore, MOS treatment resulted in a reduction in fecal coliforms and E. coli resistant to ampicillin by about 100% and 96%, respectively. The results indicated that ciprofloxacin removal efficiencies at 29 °C were over 93% (fecal coliforms) and 68% (E. coli) with doxycycline. Adding MOS significantly reduced the copy number of the 16S rRNA gene and the genes conferring resistance to β-lactam (blaCTX-M, blaSHV, and blaTEM). However, MOS does not reveal real effectiveness on removal of pollutants (phosphorus and nitrates) contrary to what was expected. Additional studies are needed for confirmation from our observations. The findings of this study, whatever the functioning conditions (not optimal) of the prototype followed over 4 years, confirmed that MOS is potentially an effective natural and environmentally friendly coagulant that could be applied to wastewater treatment in low-income countries to remove or minimize multiple pollutants and control ARG spread. To promote sustainable development, this small-scale study provides guidance for designing infrastructure in resource-limited locations to take advantage of MOS effects in wastewater treatments. An individual WWTP prototype was installed in Senegal in 2018 and evaluated in 2020 and 2022. MOS powder addition is supposed to reduce bacterial loads and pharmaceutical residues in wastewater from the WWTP. Evaluation of treatment efficiency was carried out based on using chemistry, microbiology, genomics, physic-chemistry, and statistics analysis. [ABSTRACT FROM AUTHOR]

As part of an initiative aimed at reducing maternal and child mortality, Senegal implemented a policy of free Cesarean section (C-section) since 2005. Despite the implementation, C-section rates have remained low and significant large disparities in access, particularly in major cities such as Dakar. This paper aims to assess C-section rates and examines socioeconomic inequalities in C-section use in the Dakar region between 2005 and 2019. This study incorporates data from various sources, including the health routine data within District Health Information Software 2 (DHIS2) platform, government statistics on slum areas, and data from Demographic and Health Surveys (DHS). A geospatial analysis was conducted to identify locations of Comprehensive emergency obstetric and Newborn Care (CEmONC) services using the Direction des Travaux Géographiques et Cartographiques (DTGC) databases and satellite imagery from the Google Earth platform. The analytical approach encompassed univariate, bivariate, and multivariate analyses. The C-section rate fluctuated over the years, increasing from 11.1% in 2005 to 16.4% in 2011, declined to 9.8% in 2014, and then raised to 13.3% in 2019. The wealth tertile demonstrated a positive correlation with C-sections in urban areas of the Dakar region. Geospatial analyses revealed that women residing in slum areas were less likely to undergo C-section deliveries. These findings underscore the importance of public health policies extending beyond merely providing free C-section delivery services. Strategies that improve equitable access to C-section delivery services for women across all socioeconomic strata are needed, particularly targeting the poor women and those in urban slums. [ABSTRACT FROM AUTHOR]

Purpose: For the first time, three currently available 360° CZT-SPECT/CT cameras were compared under clinical conditions using phantom-based measurements. Methods: A 99mTc- and a 177Lu-customized NEMA IEC body phantom were imaged with three different cameras, StarGuide (GE Healthcare), VERITON-CT versions 200 (V200) and 400 (V400) (Spectrum Dynamics Medical) under the same clinical conditions. Energy resolution and volumetric sensitivity were evaluated from energy spectra. Vendors provided the best reconstruction parameters dedicated to visualization and/or quantification, based on their respective software developments. For both 99mTc- and 177Lu-phantoms, noise level, quantification accuracy, and recovery coefficient (RC) were performed with 3DSlicer. Image quality metrics from an approach called "task-based" were computed with iQMetrix-CT on 99mTc visual reconstructions to assess, through spatial frequencies, noise texture in the background (NPS) and contrast restitution of a hot insert (TTF). Spatial resolution indices were calculated from frequencies corresponding to TTF10% and TTF50%. Results: Despite the higher sensitivity of VERITON cameras and the enhanced energy resolution of the V400 (3.2% at 140 keV, 5.2% at 113 keV, and 3.6% at 208 keV), StarGuide presents comparable image quality. This highlights the need to differentiate sensitivity from count quality, which is influenced by hardware design (collimator, detector block) and conditions image quality as well as the reconstruction process (algorithms, scatter correction, noise regulation). For 99mTc imaging, the quantitative image optimization approach based on RCmean for StarGuide versus RCmax for V200 and V400 systems (RCmean/RCmax: 0.9/1.8; 0.5/0.9; 0.5/0.9 respectively—Ø37 mm). SRTB10/50 showed nearly equivalent spatial resolution performances across the different reconstructed images. For 177Lu imaging, the 113 keV imaging of the V200 and V400 systems demonstrated strong performances in both image quality and quantification, while StarGuide and V400 systems offer even better potential due to their ability to exploit signals from both the 113 and 208 keV peaks. 177Lu quantification was optimized according to RCmax for all cameras and reconstructions (1.07 ± 0.09—Ø37 mm). Conclusions: The three cameras have equivalent potential for 99mTc imaging, while StarGuide and V400 have demonstrated higher potential for 177Lu. Dedicated visual or quantitative reconstructions offer better specific performances compared to the unified visual/quantitative reconstruction. The task-based approach appears to be promising for in-depth comparison of images in the context of system characterization/comparison and protocol optimization. [ABSTRACT FROM AUTHOR]

Background: Roughly one in six patients receiving conventional transvenous pacemaker systems experience significant complications within 1 year of implant, mainly due to the transvenous lead and subcutaneous pocket. A new helix-fixation single-chamber ventricular leadless pacemaker (LP) system capable of pre-deployment exploratory electrical mapping is commercially available. Such an LP may mitigate complications while streamlining the implantation. In this study, the initial real-world implant experience of the helix-fixation LP was evaluated following its commercial release. Methods: In patients indicated for single-chamber right ventricular pacing, helix-fixation Aveir VR LPs (Abbott, Abbott Park, IL) were implanted using the dedicated loading tool, introducer, and delivery catheter. Implant procedural characteristics, electrical parameters, and any 30-day procedure-related adverse events of consecutive implant attempts were retrospectively evaluated. Results: A total of 167 patients with Class I indication for permanent pacing received implants in four North American centers (57% male, 70 years old). Pre-fixation electrical mapping of potential sites allowed repositioning to be avoided in 95.7% of patients. Median [interquartile range] LP procedure and fluoroscopy durations were 25.5 min [20.0, 35.0] and 5.7 min [4.0, 9.2], respectively. Pacing capture threshold, sensed R-wave amplitude, and impedance were 0.8 V [0.5, 1.3], 9.0 mV [6.0, 12.0], and 705 Ω [550, 910], respectively. Implantation was successful in 98.8% of patients, with 98.2% free from acute adverse events. Conclusions: The initial, real-world experience of the helix-fixation ventricular leadless pacemaker demonstrated safe and efficient implantation with minimal repositioning, viable electrical metrics, and limited acute complications. Helix-fixation single-chamber ventricular leadless pacemakers were implanted in 167 patients, with a median procedure time of 25.5 minutes, 98.8% implant success, and 98.2% freedom from acute adverse events. [ABSTRACT FROM AUTHOR]

Background: The zygomaticomaxillary complex (ZMC) functions as the main buttress for the lateral portion of the middle third of the facial skeleton and because of its prominent position & convex shape, it is frequently fractured, alone or along with other bones of the midface. The management of the ZMC fractures is debatable as the literature is saturated with various theories. A number of techniques, from closed reduction to open reduction and internal fixation can be effectively used to manage these fractures. Controversies lie right from the amount of fixation (mostly 2-, 3-point fixation) required to the ideal approach, and there is no conclusive view on its ideal line of management. Aim: To systematically review the existing scientific literature to determine whether two-point or three-point fixation is a better treatment alternative for the patients with zygomaticomaxillary fractures through a meta-analysis. Methods: Review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Electronic databases like PubMed, Google scholar and Ebsco Host were searched from January 2000 to November 2023 for studies reporting treatment of zygomaticomaxillary fractures through two-point and three-point fixation and reporting the outcome in terms of mean and standard deviation (SD). Quality assessment of included was evaluated using Cochrane risk of bias (ROB)-2 tool through its domains. The risk of bias summary graph and risk of bias summary applicability concern was plotted using RevMan software version 5.3. The standardized mean difference (SDM) was used as summary statistic measure with random effect model and p value < 0.05 as statistically significant. Results: Eleven studies fulfilled the eligibility criteria and were included in qualitative synthesis, of which only eight studies were suitable for meta-analysis. The pooled estimate through the standardized mean difference (SMD) of – 0.21 (– 0.83–0.41) favors two-point fixation employing random effect model with I2 (heterogeneity) value of 89% and p value 0.51. Publication bias through the funnel plot showed asymmetric distribution with systematic heterogeneity. Conclusion: In our systematic review, we aimed to evaluate which method of fixation is more effective in the treatment of zygomaticomaxillary complex fractures. Our pooled estimate using quantitative synthesis indicates that both two- and three-point fixation procedures are equally effective in the treatment of zygomaticomaxillary fractures. As a result, two-point fixation is as efficient as three-point fixation in treating zygomaticomaxillary complex fractures. [ABSTRACT FROM AUTHOR]

Natural spices play an essential role in human nutrition and well-being. However, their processing on different scales can expose them to potential sources of contamination. This study aimed to describe the bacterial community genomic footprint in spices sold in Senegal. Spice samples were collected in August 2022 in Saint-Louis, Senegal. The genomic region coding bacterial 16S rRNA was then amplified and sequenced using Oxford Nanopore Technology (ONT). Sequencing was carried out on two batches of samples, one containing part of the "Local Spices or Herbs" (n = 10), and the other, a mixture of 7 spices, Curcuma, Thyme and the other part of the "Local Spices or Herbs" (n = 39). Results showed high bacterial diversity and the predominance of Escherichia coli and Salmonella enterica in samples, with total reads of 65,744 and 165,325 for the two batches, respectively. The sample category "Homemade mixture of food condiments ", which includes all "Local Spices or Herbs" samples, showed remarkable bacterial diversity. These were followed by Curcuma, a blend of 7 spices and thyme. Also, the different categories of spices studied show similarities in their bacterial composition. These results highlight the microbial community's highly diverse genomic profile, including pathogenic bacteria, in spice samples. [ABSTRACT FROM AUTHOR]

The millet Head Miner (MHM), Heliocheilus albipunctella (Lepidoptera: Noctuidae), is the most important pest of the millet crop in the Sahel. Augmentative biological control was successfully tested in the Sahel for controlling the MHM with releases of the egg parasitoids, Trichogrammatoidea armigera Nagaraja (Hymenoptera: Trichogrammatidae). However, mass production of adult T. armigera at the proper moment to respond to the pest outbreak remains challenging. The aim of the study was to optimize the T. armigera mass rearing technique by determining the minimum sterilization time for Corcyra cephalonica Stainton (Lepidoptera: Pyralidae) eggs used as the fictitious host of the parasitoid. 24-h-old eggs of C. cephalonica were exposed to Ultraviolet (UV) radiation for 15 to 55 min and to cold (4 °C ± 0.5) for 24 to 120 h, to determine the minimum duration of egg abortion for each method. The results showed that C. cephalonica eggs can be sterilized using UV radiation (285–395 nm) and cold (4 °C) for 45 min and 96 h, respectively without any effect on the host suitability for parasitism. Sterilized eggs appeared to be more parasitized by T. armigera females than unsterilized eggs. The parasitism rate of T. armigera parents was influenced by sterilization. However, the hatching rate and the sex ratio were not significantly influenced. In the first generation (F1), the parasitism rate and hatching rate were not influenced by sterilization. However, cold-sterilized eggs produced more offspring with more females. This study contributed to the optimization of mass rearing of T. armigera and could make biological control of H. albipunctella more operational by using augmentative releases. [ABSTRACT FROM AUTHOR]

The present article deals with the modulation of electroosmotic flow (EOF) and transport of ionic species within soft nanochannels. The power-law model is adopted to consider the non-Newtonian nature of bulk electrolyte. The soft layer grafted along the rigid walls often bears ionizable functional groups, which in turn leads to the net volumetric charge. Besides, the dielectric permittivity of the soft layer is in general lower than that of the ambient electrolyte solution, which in turn leads to ion partitioning effect. The net volumetric charge within the soft polymeric layer coated along the channel walls may be moderate to large. For such a case, the ion steric effect may play a pivotal role on the modulation of electrostatic potential and thereby the flow field across the channel. In the present article, we aim to study the flow modulation across the soft nanochannels considering all such intrinsic effects. The mathematical model is based on modified Poisson−Boltzmann equations based on Carnahan−Striling model, Cauchy momentum equation for flow field. The governing equations are solved via a suitable numerical scheme based on finite difference method to calculate the electrostatic potential as well as flow velocity. We further analyze the impact of pertinent parameters on the flow modulation and ion selectivity parameter. [ABSTRACT FROM AUTHOR]

Chance constraints are a valuable tool for the design of safe decisions in uncertain environments; they are used to model satisfaction of a constraint with a target probability. However, because of possible non-convexity and non-smoothness, optimizing over a chance constrained set is challenging. In this paper, we consider chance constrained programs where the objective function and the constraints are convex with respect to the decision parameter. We establish an exact reformulation of such a problem as a bilevel problem with a convex lower-level. Then we leverage this bilevel formulation to propose a tractable penalty approach, in the setting of finitely supported random variables. The penalized objective is a difference-of-convex function that we minimize with a suitable bundle algorithm. We release an easy-to-use open-source python toolbox implementing the approach, with a special emphasis on fast computational subroutines. [ABSTRACT FROM AUTHOR]

Studying the pressing impacts of climate change on runoff is vital for the sustainable functioning of society and ecosystems. In Senegal, there is insufficient consideration given to the magnitude of the decrease in water resources caused by climate change and the potential impact of this decrease on both society and the environment. The objective of this study was to evaluate the hydrological effects of climate change in the Aga-Foua-Djilas basin by employing CWatM hydrological models inside the frameworks of ISIMIP and HMF-WA. Over the historical period (1981–2019) in the Aga-Foua-Djilas basin, the analysis of all hydrological parameters indicates positive trends, although not statistically significant (except for runoff). Over the future period, unlike temperatures and PET, which show an upward trend in all scenarios, precipitation and runoff show downward trends, which are more significant under SSP 585. For precipitation, Kendall's Tau shows a downward trend of − 0.157 mm/yr, − 0.321 mm/yr, and − 0.472 mm/yr under SSP 126, SSP 370 and SSP 585, respectively. For runoff, the trends are negative and of the order of − 0.207 m3/s/yr, − 0.44 m3/s/yr, and − 0.565 m3/s/yr, respectively, under SSP 126, SSP 370 and SSP 585 with CwatM and − 0.248 m3/s/yr (SSP 126), − 0.389 m3/s/yr (SSP 245) and − 0.579 m3/s/yr (SSP585) with HMF-WA. Compared with the decrease in precipitation toward the end of the century, the decrease in runoff noted for the distant future (2081–2100) will be of the order of − 32.8% (SSP 126), − 80.8% (SSP 370) and − 94.6% (SSP 585) with CwatM and − 22.3% (SSP 126), − 19.6% (SSP 245) and − 50.9% (SSP 585) with HMF-WA. This study could help policymakers and stakeholders to develop adaptation strategies for the Aga-Foua-Djilas basin. [ABSTRACT FROM AUTHOR]

Background: Mandibular fractures are frequent in facial trauma. Management of mandibular condylar fractures (MCF) remains an ongoing matter of controversy in maxillofacial injury. A number of techniques, from closed reduction (CR) to open reduction and internal fixation (ORIF), can be effectively used to manage these fractures. The best treatment strategy, that is, closed reduction or open reduction with internal fixation, remains controversial. Aim: The aim of this study is to systematically review the existing scientific literature to determine whether open reduction with internal fixation or closed reduction is a better treatment alternative for the patients with condylar fractures through a meta-analysis. Methods: A systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Electronic databases like PubMed, google scholar and Ebsco Host were searched from 2000 to December 2021 for studies reporting management of condylar fractures through open reduction with internal fixation against closed reduction and reporting the outcome in terms of mean and standard deviation (SD). Quality assessment of included case control and cohort studies was performed using Newcastle–Ottawa Scale, and randomized studies were evaluated using Cochrane risk-of-bias (ROB)-2 tool through its domains. The risk of bias summary graph and risk of bias summary applicability concern was plotted using RevMan software version 5.3. The standardized mean difference (SDM) was used as summary statistic measure with random effect model and p value <0.05 as statistically significant. Results: Seventeen studies fulfilled the eligibility criteria and were included in qualitative synthesis, of which only nine studies were suitable for meta-analysis. The pooled estimate through the Standardized Mean Difference (SMD) of 0.80, 0.36 and 0.42 for maximum inter incisal opening, laterotrusion and protrusion favours CR compared to ORIF for condylar fracture management. Also, most results of heterogeneity tests were poor and most of the funnel plots showed asymmetry, indicating the presence of possible publication bias. Conclusion: The results of our meta-analysis suggest that CR provides superior outcomes in terms of maximum inter incisal opening, laterotrusion and protrusion compared to ORIF in condylar fractures management. It is necessary to conduct more prospective randomized studies and properly control confounding factors to achieve effective results and gradually unify clinical guidelines. [ABSTRACT FROM AUTHOR]

We present a federated learning framework that is designed to robustly deliver good predictive performance across individual clients with heterogeneous data. The proposed approach hinges upon a superquantile-based learning objective that captures the tail statistics of the error distribution over heterogeneous clients. We present a stochastic training algorithm that interleaves differentially private client filtering with federated averaging steps. We prove finite time convergence guarantees for the algorithm: O (1 / T) in the nonconvex case in T communication rounds and O (exp (- T / κ 3 / 2) + κ / T) in the strongly convex case with local condition number κ . Experimental results on benchmark datasets for federated learning demonstrate that our approach is competitive with classical ones in terms of average error and outperforms them in terms of tail statistics of the error. [ABSTRACT FROM AUTHOR]

A combined Truck–drone system that delivers packages from a warehouse to multiple customers is investigated. The truck movements are restricted to the potential stops from which the drone with limited capacity takes off or lands. The aim is to determine both the best or 'optimal' sequence of the drone delivery trips and the best or 'optimal' trucks stops that will minimize the total combined truck drone delivery cost. This is an innovative delivery process which also falls under the umbrella of last mile delivery which is known to be one of the most challenging activities within logistics. The problem is first formulated as a 0–1 Linear programming model. A Variable Neighborhood Search (VNS) algorithm is then designed. The proposed metaheuristic is assessed on test problems from the online TSP library. A sensitivity analysis which examines the effect of a neighborhood removal, and the neighborhood sequencing is carried out. The metaheuristic has also shown to be reliable when tested against our mathematical model using the commercial optimizer CPLEX. Interesting overall results are discovered which demonstrate the robustness of the proposed VNS. [ABSTRACT FROM AUTHOR]

This work aims to use experimental data from thermal characterization and adsorption/desorption isotherms of two tropicals woods species (Ayous and Tali) to propose an empirical model of thermal conductivity as a function of air relative humidity. A static gravimetric method was used to determine the adsorption isotherms of Tali and Ayous at 30 °C, and 40 °C. The GAB, Henderson and Nelson models were used to predict the isotherms. Exponential models of thermal conductivity and volumetric heat capacity with air relative humidity were proposed. The influence of hysteresis phenomenum was studied on these properties. The reliability of the developed empirical correlation between thermal properties and air relative humidity was evaluated by comparing the experimental and predicted curves. The relative errors were less than 8% for both Ayous and Tali. The correlation coefficients obtained were greater than 99% for both species in adsorption and desorption. There was also an increase in the equilibrium water content of both species with the increase in water activity at constant temperature. The correlation coefficients between GAB model and sorption experimental data were lower than 99% when Ayous was subjected to a temperature of 40 °C in adsorption and Tali to a temperature of 40 °C in desorption. [ABSTRACT FROM AUTHOR]

We investigate the atmospheric response to seasonal variations in sea surface temperature (SST) in the eastern tropical Atlantic during the boreal summer, using the Weather Research and Forecasting (WRF) regional atmospheric model. Three ensembles of 11 simulations each are produced with different SST forcings: the control ensemble (CTL) uses the observed climatology of the SST in 2000–2009, while the Frozen North (FzN) and Frozen South (FzS) experiments block the seasonal warming or cooling of the SST from June onwards in a region confined to the eastern tropical Atlantic. The result is a cold SST anomaly in the northeastern tropical Atlantic off the coasts of Senegal and Mauritania in FzN, and a warm anomaly in the southeastern region (Gulf of Guinea and the cold tongue zone in the equatorial Atlantic) in FzS. Comparison with CTL reveals significant impacts of these SST anomalies on the position and intensity of the marine intertropical convergence zone (ITCZ) and on West African rainfall during July and August. Over the ocean, the cold anomaly in NETA suppresses convection on the northern side of the ITCZ (north of 10 ∘ N), while the warm anomaly in the Gulf of Guinea strengthens convection on its southern flank. The latter is also leading to a sharp increase in precipitation in the coastal regions to the northeast of the Gulf of Guinea. These changes are clearly due to variations in surface pressure gradients and the divergence of low-level moisture in response to SST anomalies, which in turn induce changes in deep atmospheric convection through thermodynamic feedback. On the continent, a substantial reduction in precipitation is observed in the western Sahel (particularly Senegal) following the cold anomaly in NETA, and in the eastern Sahel following the warm anomaly in the Gulf of Guinea: both are explained by a positive anomaly in the divergence of moisture transport in the upper troposphere, associated with an acceleration of the African easterly jet along its southern edge. However, the mechanism by which the SST anomalies create this acceleration in both experiments remains to be elucidated. [ABSTRACT FROM AUTHOR]

Ligation of bilateral IJV causes interruption of major part of venous drainage from Dural venous sinuses that causes complications such as gross facial edema, increased intracranial pressure, brain compression, coma and even death increasing the morbidity and mortality post-operatively. This case report illustrates a case of normalcy noted in post-operative period in a patient after ligation of bilateral IJV in left lower alveolus cancer. [ABSTRACT FROM AUTHOR]

Studying the behaviour and trophic preferences of mosquitoes is an important step in understanding the exposure of vertebrate hosts to vector-borne diseases. In the case of human malaria, transmission increases when mosquitoes feed more on humans than on other animals. Therefore, understanding the spatio-temporal dynamics of vectors and their feeding preferences is essential for improving vector control measures. In this study, we investigated the feeding behaviour of Anopheles mosquitoes at two sites in the Sudanian areas of Senegal where transmission is low following the implementation of vector control measures. Blood-fed mosquitoes were collected monthly from July to November 2022 by pyrethrum spray catches in sleeping rooms of almost all houses in Dielmo and Ndiop villages, and blood meals were identified as from human, bovine, ovine, equine and chicken by ELISA. Species from the An. gambiae complex were identified by PCR. The types and numbers of potential domestic animal hosts were recorded in each village. The Human Blood Index (HBI) and the Manly Selection Ratio (MSR) were calculated to determine whether hosts were selected in proportion to their abundance. Spatio-temporal variation in HBI was examined using the Moran's index. A total of 1251 endophilic Anopheles females were collected in 115 bedrooms, including 864 blood fed females of 6 species. An. arabiensis and An. funestus were predominant in Dielmo and Ndiop, respectively. Of the 864 blood meals tested, 853 gave a single host positive result mainly on bovine, equine, human, ovine and chicken in decreasing order in both villages. Overall, these hosts were not selected in proportion to their abundance. The human host was under-selected, highlighting a marked zoophily for the vectors. Over time and space, the HBI were low with no obvious trend, with higher and lower values observed in each of the five months at different points in each village. These results highlight the zoophilic and exophagic behaviour of malaria vectors. This behaviour is likely to be a consequence of the distribution and use of LLINs in both villages and may increase risk of residual outdoor transmission. This underlines the need to study the feeding host profile of outdoor resting populations and how domestic animals may influence malaria epidemiology in order to tailor effective malaria vector control strategies in the two villages. [ABSTRACT FROM AUTHOR]

Health disparities are driven by underlying social disadvantage and psychosocial stressors. However, how social disadvantage and psychosocial stressors lead to adverse health outcomes is unclear, particularly when exposure begins prenatally. Variations in the gut microbiome and circulating proinflammatory cytokines offer potential mechanistic pathways. Here, we interrogate the gut microbiome of mother-child dyads to compare high-versus-low prenatal social disadvantage, psychosocial stressors and maternal circulating cytokine cohorts (prospective case-control study design using gut microbiomes from 121 dyads profiled with 16 S rRNA sequencing and 89 dyads with shotgun metagenomic sequencing). Gut microbiome characteristics significantly predictive of social disadvantage and psychosocial stressors in the mothers and children indicate that different discriminatory taxa and related pathways are involved, including many species of Bifidobacterium and related pathways across several comparisons. The lowest inter-individual gut microbiome similarity was observed among high-social disadvantage/high-psychosocial stressors mothers, suggesting distinct environmental exposures driving a diverging gut microbiome assembly compared to low-social disadvantage/low-psychosocial stressors controls (P = 3.5 × 10−5 for social disadvantage, P = 2.7 × 10−15 for psychosocial stressors). Children's gut metagenome profiles at 4 months also significantly predicted high/low maternal prenatal IL-6 (P = 0.029), with many bacterial species overlapping those identified by social disadvantage and psychosocial stressors. These differences, based on maternal social and psychological status during a critical developmental window early in life, offer potentially modifiable targets to mitigate health inequities. Here, in a cohort of mother-child dyads, the authors show that maternal prenatal social disadvantage and psychosocial stressors associate with distinct gut microbiome taxonomic and functional diversity in both the mothers and their four-month children. [ABSTRACT FROM AUTHOR]

Aim: To systematically review the existing scientific literature, to summarize and assess the efficacy of the nasal floor augmentation on the survival rate of dental implants by systematically reviewing the available literature. Methodology: Review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and registered in PROSPERO-CRD42027289143. Electronic databases like PubMed, google scholar and Ebsco Host were searched from 2000 to December 2021 for studies reporting efficacy of nasal floor augmentation and reporting outcomes in terms of survival rates of dental implants. Quality assessment of included comparative follow-up studies was done using the critical checklist put forward by the Joanna Briggs Institute (JBI) was used. Results: Only nine studies fulfilled the eligibility criteria and were included in the qualitative synthesis. Of those nine studies, five were case reports and four comparative follow-up studies. A total of 14 implants were placed in five patients with a survival rate of 100% in included case reports, while a total of 408 implants were placed in 130 patients with survival rates ranging from 89% to 100% in included comparative follow-up studies. No complications were observed during follow-ups, and the patients were satisfied with the functional and aesthetic results of the treatment. Quality assessment of included studies showed moderate to low risk of bias with overall high quality of studies. Conclusion: The results of this systematic review indicate that implant placement by nasal floor augmentation techniques can be considered as a predictable treatment modality. However, due to the scarcity of literature, more studies should be carried out on proving the efficacy of nasal floor augmentation on survival rate or success of dental Implants. [ABSTRACT FROM AUTHOR]

Tuberculosis, an airborne disease, is the deadliest human infectious disease caused by one single agent. The African region is among the most affected and most burdensome area in terms of tuberculosis cases. In this paper, we modeled the number of new cases of tuberculosis for 2000–2021 by integer time series. For each African country, we fitted twenty different models and selected the model that best fitted the data. The twenty models were mostly based on the number of new cases following either the Poisson or negative binomial distribution with the rate parameter allowed to vary linearly or quadratically with respect to year. The best fitted models were used to give predictions for 2022–2031. [ABSTRACT FROM AUTHOR]

Background: Diagnostic value of 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine ([18F]FDOPA) PET in patients with suspected recurrent gliomas is recognised. We conducted a multicentre prospective study to assess its added value in the practical management of patients suspected of recurrence of high grade gliomas (HGG). Methods: Patients with a proven HGG (WHO grade III and IV) were referred to the multidisciplinary neuro-oncology board (MNOB) during their follow-up after initial standard of care treatment and when MRI findings were not fully conclusive. Each case was discussed in 2 steps. For step 1, a diagnosis and a management proposal were made only based on the clinical and the MRI data. For step 2, the same process was repeated taking the [18F]FDOPA PET results into consideration. A level of confidence for the decisions was assigned to each step. Changes in diagnosis and management induced by [18F]FDOPA PET information were measured. When unchanged, the difference in the confidence of the decisions were assessed. The diagnostic performances of each step were measured. Results: 107 patients underwent a total of 138 MNOB assessments. The proposed diagnosis changed between step 1 and step 2 in 37 cases (26.8%) and the proposed management changed in 31 cases (22.5%). When the management did not change, the confidence in the MNOB final decision was increased in 87 cases (81.3%). Step 1 had a sensitivity, specificity and accuracy of 83%, 58% and 66% and step 2, 86%, 64% and 71% respectively. Conclusion: [18F]FDOPA PET adds significant information for the follow-up of HGG patients in clinical practice. When MRI findings are not straightforward, it can change the management for more than 20% of the patients and increases the confidence level of the multidisciplinary board decisions. [ABSTRACT FROM AUTHOR]

Proximal methods are known to identify the underlying substructure of nonsmooth optimization problems. Even more, in many interesting situations, the output of a proximity operator comes with its structure at no additional cost, and convergence is improved once it matches the structure of a minimizer. However, it is impossible in general to know whether the current structure is final or not; such highly valuable information has to be exploited adaptively. To do so, we place ourselves in the case where a proximal gradient method can identify manifolds of differentiability of the nonsmooth objective. Leveraging this manifold identification, we show that Riemannian Newton-like methods can be intertwined with the proximal gradient steps to drastically boost the convergence. We prove the superlinear convergence of the algorithm when solving some nondegenerated nonsmooth nonconvex optimization problems. We provide numerical illustrations on optimization problems regularized by ℓ 1 -norm or trace-norm. [ABSTRACT FROM AUTHOR]

Schwann cells are responsible for the production of the myelin sheath around the axons of the peripheral nervous system. Benign neoplasms which originate from Schwann cells are hence termed Schwannomas or Neurilemmomas. They present as slow-growing, solitary, encapsulated, benign masses usually in association with nerve trunks. Schwannomas are relatively rare tumors with 25–45% occurring in the head and neck region. These case reports aim to describe the presentations, work-up, and treatment of two patients with head and neck schwannoma in atypical locations. Both patients had a history of gradually increasing swelling, the first originating from the sino-nasal region and the second from the temporal/ infratemporal region. Complete surgical excision of the tumor was done in both cases with no reported recurrence at 18 months follow-up. The final diagnosis was made based on histopathology and immunohistochemistry findings. Schwannomas often present a diagnostic dilemma and should be considered a possibility in all head and neck tumors. Recurrence is rare. [ABSTRACT FROM AUTHOR]

Complex network analysis helps in finding hidden patterns within a graph network. This concept is extended for knowledge graphs to identify hidden concepts using state-of-the-art network analysis techniques. In this paper, a profiling knowledge graph is analyzed to identify hidden concepts which result in the identification of implicit communities within a campus network. The proposed work is verified with the interesting results achieved by applying different metrics using a state-of-the-art network analysis algorithm. The results of the proposed work are mapped in the domain of digital advertisement to answer intelligent semantic queries. Various factors of centrality measures identify the prospective influencers within a campus network. Moreover, bridge analysis determines amplifier nodes in the knowledge graph that will help in the digital advertisement. The proposed work concludes with a discussion on link prediction. It shows the future interactions to design digital advertising campaigns through billboards. [ABSTRACT FROM AUTHOR]

Sea surface temperature (SST) variability in the North Eastern Tropical Atlantic has its center of action in the Senegalese–Mauritanian upwelling system, where its drivers are wind-induced ocean dynamics and air–sea thermodynamic processes. Thus, a better understanding of the local wind variations, together with their predictability, contributes to a more comprehensive assessment of the SST variability in that region. In this study, we use monthly data from two ocean reanalyses, SODA and ORAS-5, and a regional forced-ocean simulation to characterize the interannual SST variability off the Senegalese Coast in the common period 1960–2008. Local indices of the mixed layer heat budget during the major upwelling season (February–March–April) exhibit pronounced interannual to decadal variability. We demonstrate that the local interannual SST variability undergoes inter-decadal fluctuation and concomitant changes in its local and remote drivers. Off-Senegal SST variability was largely controlled by wind-induced Ekman transport during the 1960s–1970s, acting under favorable thermocline and mixed layer conditions. However, from 1980s onwards, the drastically reduced Ekman impact observed on local SSTs is associated with a deeper thermocline. This shift in the effectiveness of the dynamic mechanisms coincides with a more active ENSO teleconnection with upwelling before the 1980s. An extended SODA record reveals that the multidecadal modulator of the ENSO impact on the North-eastern Tropical Atlantic resembles the negative phase of the Atlantic Multidecadal Variability. Our results bring to light the fundamental role played by the global decadal background state in the activation of the drivers and air-sea mechanisms responsible for generating the interannual off-Senegal SST variability. [ABSTRACT FROM AUTHOR]

Key message: Improving crop resistance against insect pests is crucial for ensuring future food security. Integrating genomics with modern breeding methods holds enormous potential in dissecting the genetic architecture of this complex trait and accelerating crop improvement. Insect resistance in crops has been a major research objective in several crop improvement programs. However, the use of conventional breeding methods to develop high-yielding cultivars with sustainable and durable insect pest resistance has been largely unsuccessful. The use of molecular markers for identification and deployment of insect resistance quantitative trait loci (QTLs) can fastrack traditional breeding methods. Till date, several QTLs for insect pest resistance have been identified in field-grown crops, and a few of them have been cloned by positional cloning approaches. Genome editing technologies, such as CRISPR/Cas9, are paving the way to tailor insect pest resistance loci for designing crops for the future. Here, we provide an overview of diverse defense mechanisms exerted by plants in response to insect pest attack, and review recent advances in genomics research and genetic improvements for insect pest resistance in major field crops. Finally, we discuss the scope for genomic breeding strategies to develop more durable insect pest resistant crops. [ABSTRACT FROM AUTHOR]

Stem cell-based therapy is considered an attractive tool to overcome the burden of liver diseases. However, efficient hepatic differentiation is still a big challenge for the research community. In this study, we explored a novel method for differentiation of bone marrow-derived mesenchymal stem cells (MSCs) into hepatic-like cells using 3D culture conditions and histone deacetylase inhibitor, sodium butyrate (NaBu). MSCs were characterized by the presence of cell surface markers via immunocytochemistry, flow cytometry, and by their potential for osteogenic, adipogenic, and chondrogenic differentiation. MSCs were treated with 1mM NaBu in 2D and 3D environments for 21 days. The hepatic differentiation was confirmed by qPCR and immunostaining. According to qPCR data, the 3D culture of NaBu-treated MSCs has shown significant upregulation of hepatic gene, CK-18 (P < 0.01), and hepatic proteins, AFP (P < 0.01) and ALB (P < 0.01). In addition, immunocytochemistry analysis showed significant increase (P < 0.05) in the acetylation of histones (H3 and H4) in NaBu-pretreated cells. It can be concluded from the study that NaBu-treated MSCs in 3D culture conditions can induce hepatic differentiation without the use of additional cytokines and growth factors. The method shown in this study represents an improved protocol for hepatic differentiation and could contribute to improvement in future cell-based therapeutics. [ABSTRACT FROM AUTHOR]

Plant growth and development are regulated by phytohormones, such as abscisic acid, auxins, or gibberellins. Under drought stress, melatonin and the signaling calcium (Ca2+) are involved in plant defense and stress responses by controlling phytohormone and antioxidant machineries. Exogenous melatonin (MT) promotes drought stress tolerance in plants. As an essential second messenger, the signaling molecule Ca2+ is necessary in the stress tolerance of plants and might increase stress tolerance induced by exogenous melatonin. The present study elucidated the effects of Ca2+-MT on Dalbergia odorifera seedlings under drought stress. Results showed increases in growth traits and photosynthesis indexes (pigments, net photosynthetic rate, water use efficiency, stomatal conductance, and transpiration) by MT and Ca2+ under non stress and stress conditions. Under drought stress, the water status in leaves was slightly ameliorated by MT and Ca2+ treatments, whereas the Ca2+-MT combination strongly improved water status. Comparison between combined Ca2+-MT and single Ca2+/MT treatments showed that superoxide anion was significantly lower in Ca2+-MT-treated seedlings. Lipid peroxidation was lower in Ca2+-MT-treated seedlings under drought stress. Further, relative conductivity was significantly decreased by Ca2+ and MT treatments under stress compared with seedlings untreated with Ca2+ or MT under drought. The accumulation of proline decreased by Ca2+ and MT under stress, but the carbohydrates and protein contents were increased by exogenous MT and Ca2+. Under drought, antioxidant systems (peroxidase, superoxide dismutase, and catalase activities, and glutathione [GSH] and ascorbic acid [ASA] levels) were significantly increased by the Ca2+ and MT treatments. The combined treatment showed better performance in increasing GSH and ASA levels than single MT or Ca2+ treatment. The gibberellin GA3 and cytokine ZR increased significantly under non stress and stress conditions, but exogenous Ca2+ or MT did not increase their activities compared with those in the control groups. Exogenous Ca2+ and Ca2+-MT enhanced indole-3-acetic acid (IAA) content in D. odorifera leaves under stress compared with the control. Moreover, abscisic acid (ABA) level is downregulated by MT and Ca2+-MT treatments compared with the control. The seedlings treated with Ca2+ only showed increase in ABA concentration under drought stress. This study provides an insight into a possible coordination between Ca2+ and melatonin and into drought tolerance in woody plants. [ABSTRACT FROM AUTHOR]

The hydraulic model is a set of closed-form, deterministic equations used to predict average crowd speeds and movement times of evacuees exiting a building. The standard SFPE hydraulic model assumes that crowd speed is only influenced by crowd congestion and type of terrain, when in fact, it is also affected heavily influenced by smoke, which not only causes evacuees to slow down due to poorer visibility but may also force them to switch a different movement mode: crawling. This paper gathers and refines empirical data from various published experiments involving individuals and groups moving through smoke by walking upright and crawling, to establish two new variants of the hydraulic model describing the movement of crowds through smoke by the two movement modes. [ABSTRACT FROM AUTHOR]

Miscanthus is a perennial C4 crop whose lignocellulose can be used as an alternative to the production of biosourced material. Miscanthus x giganteus (M. x giganteus) has demonstrated high maximum yields but also high yield variability across farmers' fields. Miscanthus sinensis (M. sinensis) can be an alternative to M. x giganteus because it is considered to be more tolerant to water stress and to produce more stable yields. This study aimed to identify the main factors explaining the variability of yields across site-years for M. x giganteus and M. sinensis. A multi-local and multi-year trial network was set up in France (Ile de France and Center regions). Four treatments were established on seven sites, from spring 2013 to winter 2019: at each site, two treatments of M. x giganteus (a treatment from rhizome and a treatment from rhizome-derived plantlets) and two treatments of M. sinensis (a treatment from seed-derived plantlets established in single density and a treatment from seed-derived plantlets established in double density). We experienced 5 years of harvest because miscanthus was not harvested in 2014. First, we characterized yield variations across site-years for both genotypes. Second, we defined and calculated a set of indicators (e.g., water stress indicator, sum of degree-days of the previous year, number of frost days) that could affect miscanthus yields. Finally, we performed a mixed model with re-sampling to identify the main indicators that explained yield variability for each genotype specifically. Results showed that water stress and crop age mainly explained yield variability for both genotypes. M. sinensis yields were also affected by the sum of degree-days of the previous year of growth. Hence, genotype choice must take into account environmental characteristics. M. sinensis could indeed achieve higher and more stable yields than those of M. x giganteus in shallow sandy soils or in locations with a higher risk of low rainfall. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study is to compare the surgical accuracy and efficiency of endo-osseous implant placement using a conventional method and when placed using a custom surgical guide. Materials and methods: The study was carried out in a case control design on 20 patients aged between 15 years and 60 years. In the study group (n = 10) the implants were placed with the help of a surgical stent, while in the control group (n = 10) implants were placed in a conventional manner (without surgical stent) planned only with CBCT scan. The same surgeon placed the implants in both the groups. Results: Each patient was considered in terms of the number of implants received. Each planned and actual implant was compared in terms of the 8 quantitative variables, which were used to observe and compare the accuracy of the surgical guides and conventionally placed implants. Data were analysed by a single blinded statistician using statistical software (Graphpad Prism (Version 5)). The Microsoft excel and Student T test for parametric data and Chi-square test for categorical data were used to observe significant differences between the 2 study groups. The nonparametric Chi-Square test revealed a statistically significant difference between surgical stent guided and conventional surgery in terms of buccal and lingual/palatal cortical plate to implant deviation, adjacent tooth to implant deviation, and mesiodistal angular deviation, whereas the differences between the marginal bone loss deviation, stability deviation, pain and swelling deviation, treatment time and number of sessions deviation, satisfaction deviation were not statistically significant. Conclusion: From our study, we can conclude that guided surgery is essential for insertion of the implants regardless of the surgical technique. The success of the guided surgery depends on accuracy of the clinical and/or laboratorial steps of the virtual planning. Despite all the limitations and probability of errors encountered in our study, the guided surgery is superior in better positioning of implants. [ABSTRACT FROM AUTHOR]

Background and Objectives: Trauma to the maxillofacial region is usually associated with varying degrees of disruption of the soft and hard tissues in the region and injuries to the neighbouring structures such as eyes, brain, nasal apparatus and paranasal sinuses. Injuries to the middle third of the face commonly destroys the integrity of the orbital skeleton, and are frequently complicated by injury to the eye, ranging between 2.7 and 67% as reported in the literature. These injuries may result in loss of vision or compromised ocular function. When these injuries are severe, they may be detected with ease by any medical or maxillofacial surgeon but many injuries appear minimal and may be missed by the non-ophthalmologist. Methods: A total of thirty patients were selected who were diagnosed with a zygomatic complex fracture, irrespective of sex predilection and in the age group of 18–70 years. All patients underwent a thorough ophthalmic examination by an Oral and Maxillofacial Surgeon and an Ophthalmologist preoperatively and on postoperative day 2, and 7 and all findings were documented separately by the surgeon and the ophthalmologist and the findings were later compared. Results: The statistical analysis was performed using SPSS VERSION 21.0, Shapiro–Wilk test which was used to assess the normality. Descriptive analysis was done for age and gender distribution of study subjects, which are expressed as number and frequency. Cochran's q test was used to determine if there are differences in various study factors among OMFS and ophthalmologists at three time intervals which are expressed as number and frequency. Kappa agreement was used to assess the measurement of agreement between OMFS and ophthalmologists for each factor at each time interval and these are expressed as number and frequency, and p ≤ 0.05 is considered as statistically significant. Upon examination by an OMFS periorbital oedema (p = 0.000), periorbital ecchymosis (p = 0.002), chemosis (p = 0.02) and exophthalmos (p = 0.03) were considered clinically significant. Upon examination by an ophthalmologist subconjunctival haemorrhage (p = 0.05), periorbital oedema (p = 0.05), periorbital ecchymosis (p = 0.00), ptosis (p = 0.006), enopthalmos (p = 0.05) and diplopia (p = 0.05) were considered to be clinically significant. Upon correlation of the findings of the surgeon and the ophthalmologist it was seen that certain parameters like corneal injury, Phthisis bulbing, examination of posterior segment can be better done by the ophthalmologist. Interpretation and Conclusion: In conclusion, it was determined that there is a significant correlation between ophthalmic injuries caused by zygomatic complex fractures. There are a wide array of injuries affecting the eye due to trauma to the middle third of the face, and the superficial injury can be well evaluated and documented by a surgeon; however due to the extensive nature of the injuries in trauma and the importance of the eye, an ophthalmic examination cannot be ruled out. The need for evaluation of such injures deem it pertinent for observation by an ophthalmologist. [ABSTRACT FROM AUTHOR]

Increasing sorghum production per unit area in the farmer's field by developing high yielding tannin-free and grain mold tolerant varieties in Senegal is the goal of the present study. Line × tester mating design was used to cross eleven tannin-free non-photoperiodic male fertile sorghum varieties with two male-sterile A-lines to produce 22 F1 hybrids. These hybrids along with the thirteen parents and one grain mold resistant hybrid check were evaluated under natural grain mold infestation in two contrasted sites using a 6 × 6 lattice design with three replications. Results on combining ability suggested that additive gene actions were important in the control of grain mold resistance while non-additive gene actions were preponderant in the inheritance of grain yield. The parental lines F2-20, Macia, Faourou, and Dorado were the best general combiner for grain mold resistance. Of these, Dorado was identified as the best combiner for yield and yield components. Additionally, the hybrid CE310-31A × Sureño was identified as the best hybrids combination for yield, yield components and grain mold resistance. Furthermore, the hybrid crosses CE310-31A × F2-20, CE310-31A × Sureño and AVG-1 × Dorado showed the best mid-parent heterosis for grain yield and resistance to grain mold. Moreover, based on their combining ability and heterosis, seven hybrids were identified for their resistance to grain mold and high yielding. These hybrids could be tested in multi-location trials for a subsequent release. [ABSTRACT FROM AUTHOR]

Moringa oleifera Lam. is a commercial crop in Niger consumed as a leafy vegetable on daily basis in urban areas. Its production is, however, hampered by a defoliator pest, Noorda blitealis Walker for which farmers lack a practical management approach. For this, a structured questionnaire was used to interview individual Moringa farmers (n = 120) in two producing areas (Maradi and Tillaberi) to assess farmers' knowledge of N. blitealis, their perceptions, and management practices in Niger. Among the biotic constraints they faced, 70% of farmers ranked N. blitealis Walker as the most critical pest of Moringa. In the two regions, all the interviewed farmers could describe N. blitealis damage symptoms; however, only 21–25% of farmers were able to describe some of the development stages of N. blitealis. According to farmers, the perceived yield losses ranged from 4 to 99% across the regions, with the highest losses being recorded in the September–November production period. Farmers' knowledge of N. blitealis and their management practices were not significantly associated with their socioeconomic profiles. Farmers in both regions relied primarily on synthetic insecticides (60–80%) to control N. blitealis damage, although most farmers misused them (unsuitable molecules, excessive applications, or no attention to preharvest interval). Interestingly, some farmers relied only on sole neem sprays (3–5%) or alternate sprays of synthetic insecticides with neem sprays (15% of farmers in Maradi). Some farmers (10–17%) prune the trees to prevent N. blitealis infestation, while other farmers (3–7%) release chickens into their fields to feed on the N. blitealis caterpillars. These results indicate a crucial need to train farmers in terms of basic knowledge regarding the pest's biology and develop an integrated pest control approach that will minimize synthetic insecticides. [ABSTRACT FROM AUTHOR]

We consider a formulation of supervised learning that endows models with robustness to distributional shifts from training to testing. The formulation hinges upon the superquantile risk measure, also known as the conditional value-at-risk, which has shown promise in recent applications of machine learning and signal processing. We show that, thanks to a direct smoothing of the superquantile function, a superquantile-based learning objective is amenable to gradient-based optimization, using batch optimization algorithms such as gradient descent or quasi-Newton algorithms, or using stochastic optimization algorithms such as stochastic gradient algorithms. A companion software SPQR implements in Python the algorithms described and allows practitioners to experiment with superquantile-based supervised learning. [ABSTRACT FROM AUTHOR]

Sustainability—maintaining catches within the historical range of socially and ecologically acceptable values—is key to fisheries success. Climate change may rapidly threaten sustainability, and recognizing these instances is important for effective climate adaptation. Here, we present one approach for evaluating changing sustainability under a changing climate. We use Bayesian regression models to compare fish population processes under historical climate norms and emerging anthropogenic extremes. To define anthropogenic extremes we use the Fraction of Attributable Risk (FAR), which estimates the proportion of risk for extreme ocean temperatures that can be attributed to human influence. We illustrate our approach with estimates of recruitment (production of young fish, a key determinant of sustainability) for two exploited fishes (Pacific cod Gadus macrocephalus and walleye pollock G. chalcogrammus) in a rapidly warming ecosystem, the Gulf of Alaska. We show that recruitment distributions for both species have shifted towards zero during anthropogenic climate extremes. Predictions based on the projected incidence of anthropogenic temperature extremes indicate that expected recruitment, and therefore fisheries sustainability, is markedly lower in the current climate than during recent decades. Using FAR to analyze changing population processes may help fisheries managers and stakeholders to recognize situations when historical sustainability expectations should be reevaluated. [ABSTRACT FROM AUTHOR]

Aim: The objective of this study was to correlate the preoperative radiological findings and intraoperative surgical findings during removal of impacted mandibular 3rd molar with respect to the inferior alveolar canal. Materials and Method: The prospective study design included 100 patients between the age group of 20 years and 50 years who visited the Department of Oral and Maxillofacial Surgery at Vydehi Institute of Dental Sciences and Research Centre, Whitefield, Bengaluru. A preoperative panoramic radiograph was taken and the parameters were assessed and a normal surgical protocol was followed to extract the impacted mandibular 3rd molar with intra-operative assessment as well. Results: Out of the 100 patients with definitive radiological signs showing close relation of the third molar to the mandibular canal who underwent surgical removal, only 12 patients presented with definitive clinical findings of the association. Conclusion: A true close relationship between the third molars and mandibular canal increases the risk of inferior alveolar nerve injury, and accurate evaluation of the relationship is essential to avoid the risk of surgery. The accuracy of the plain radiographs to diagnose an intimate relationship between the neurovascular bundle and the third molar root has its limitations, since only 12 of the 100 patients with positive radiological signs showed clinical evidence of involvement. Surgeons should be aware of the limitations of the radiographic markers of panoramic radiography and should consider more detailed imaging in more specific cases in which one or more radiographic marker is present. [ABSTRACT FROM AUTHOR]

R. Tyrell Rockafellar and his collaborators introduced, in a series of works, new regression modeling methods based on the notion of superquantile (or conditional value-at-risk). These methods have been influential in economics, finance, management science, and operations research in general. Recently, they have been subject of a renewed interest in machine learning, to address issues of distributional robustness and fair allocation. In this paper, we review some of these new applications of the superquantile, with references to recent developments. These applications involve nonsmooth superquantile-based objective functions that admit explicit subgradient calculations. To make these superquantile-based functions amenable to the gradient-based algorithms popular in machine learning, we show how to smooth them by infimal convolution and detail numerical procedures to compute the gradients of the smooth approximations. We put the approach into perspective by comparing it to other smoothing techniques and by illustrating it on toy examples. [ABSTRACT FROM AUTHOR]

The evolution of resistance to the Bacillus thuringiensis (Bt) toxins by insect pests is a major threat to Bt technology. However, the rate of resistance can be slowed with appropriate integrated insect resistance management (IRM) strategies. Surveys were conducted to identify alternate host species for Maruca vitrata (commonly called the legume pod borer or Maruca) that could serve as refuges for Pod-Borer Resistant (PBR) cowpea in three West African countries (Ghana, Nigeria, and Burkina Faso). Survey sites included 25 in northern Ghana, 44 in northern Nigeria, and 52 in north-central and southwestern Burkina Faso. Alternate hosts of Maruca identified from plant species belonging to the Fabaceae family that showed signs of Maruca damage on cowpea tissues were collected and dissected. Larvae that were found during these dissections were reared to adult moths in the laboratory then identified to species. The alternate host plants including species of Crotolaria, Sesbania, Tephrosia, and Vigna were the most frequently encountered among sites and locations. Flowering and podding of these plants overlapped with flowering and podding of the nearby (~200 m) cowpea crop. Abundance of these wild hosts and overlapping flowering patterns with the cowpea crop in most locations have the potential to sustain ample numbers of Bt susceptible Maruca that will mate with possible resistant Maruca and deter resistance development. Further quantitative studies, however, are required from each location to determine if actual Maruca production from alternate hosts is sufficient for a PBR IRM strategy. If verified, this approach would be compatible with the high dose/refuge IRM strategy that includes alternate hosts and non-Bt crops as refuges. [ABSTRACT FROM AUTHOR]

Key message: Supplying Ca2+ and MT can be a key approach to elucidating the diverse physiological and biochemical mechanisms of plant growth, development, and resistance under environmental stresses. Although many studies have demonstrated the positive effects of exogenous melatonin (MT) under diverse stresses, most are related to crops and few have focused on woody trees. Moreover, the best outcomes related to the positive influence of MT on plants under chilling stress were obtained by applying MT alone. Thus, this work aimed to boost the strength of MT in the woody plant Dalbergia odorifera under cold stress through combination with the signaling molecule Ca2+, which has a major role in plant defense against abiotic stresses. Results showed that in D. odorifera seedlings, exogenous MT and Ca2+ application improved growth traits and relieved injuries, whereas chilling stress caused injuries and reduced growth. Exogenous MT and Ca2+increased photosynthetic activity and compatible solute (proline, glucose, fructose, and sucrose) accumulation. Starch degradation induced by chilling stress was significantly reduced in seedlings under treatment with MT combined with Ca2+. Furthermore, in D. odorifera seedlings, relative conductivity, lipid peroxidation, and reactive oxygen species were elevated under cold stress, whereas these indexes were strongly decreased by exogenous MT and Ca2+. Exogenous MT and Ca2+ enhanced the antioxidant activities against chilling stress. In addition, in D. odorifera seedlings under cold stress, exogenous MT and Ca2+ strongly elevated the levels of the phytohormones gibberellin (GA3) and auxin (IAA) but decreased those of abscisic acid (ABA) was decreased. The IAA and GA3 contents were increased respectively by 17.34% and 22.47% in seedlings treated with MT-Ca2+ compared to MT treatment. Meanwhile, the ABA content was decreased by 44.80% in MT-Ca2+-treated seedlings compared to MT treatment. In conclusion, exogenous MT and Ca2+ improved chilling stress tolerance in D. odorifera seedlings by regulating phytohormones, osmolytes, and antioxidant activities. [ABSTRACT FROM AUTHOR]

Para-toluic acid, a major pollutant in industrial wastewater, is hazardous to human health. It has been demonstrated that Gram-negative bacteria are among the most effective degraders of para-toluic acid. In this study, the ability of Comamonas testosteroni strain 3a2, isolated from a petrochemical industry wastewater, to degrade para-toluic acid was investigated. The effect of different carbon (glucose and ethylene glycol) and nitrogen sources (urea, yeast extract, peptone, NaNO3, NH4NO3) on the biodegradation of para-toluic acid by the isolate 3a2 was evaluated. Furthermore, ring hydroxylating dioxygenase genes were amplified by PCR and their expression was evaluated during the biodegradation of para-toluic acid. The results indicated that strain 3a2 was able to degrade up to 1000 mg/L of para-toluic acid after 14 h. The highest degradation yield was recorded in the presence of yeast extract as nitrogen source. However, the formation of terephthalic acid and phthalic acid was noted during para-toluic acid degradation by the isolate 3a2. Toluate 1,2-dioxygenase, terephthalate 1,2 dioxygenase, and phthalate 4,5 dioxygenase genes were detected in the genomic DNA of 3a2. The induction of ring hydroxylating dioxygenase genes was proportional to the concentration of each hydrocarbon. This study showed that the isolate 3a2 can produce terephthalate and phthalate during the para-toluic acid biodegradation, which were also degraded after 24 h. [ABSTRACT FROM AUTHOR]

Determining the optimal parameters of the friction stir welding (FSW) process, which are suitable for a given joint configuration, remains a great challenge and is often achieved through extremely time-consuming and costly experimental investigations. The present paper aims to propose a strategy for the identification of the optimal parameters for a butt-welded joint of 3-mm thick quasi-pure copper plates. This strategy is based on FEM (finite element method) simulations and the optimal temperature that is supposedly known. A robust and efficient finite element model that is based on the Coupled Eulerian-Lagrangian (CEL) approach has been adopted and a temperature-dependent friction coefficient has been used. Besides, the mass scaling technique has been used to significantly reduce the simulation time. The thermo-mechanical behavior of the butt-welded joint was modeled using a Johnson-Cook plasticity model that was identified through lab tests at different temperatures. The results of the parametric study help to define the numerical surface response, and based on this latter one can find the optimal parameters, advancing (va) and rotational (vr) speeds, of the FSW process. This numerical surface response has been validated with good agreement between the numerical prediction of the model and the experimental results. Furthermore, experimental investigations involving x-ray radiography, digital image correlation method, and fracture surface analysis have helped a better understanding of the effects of FSW parameters on the welded joint quality. [ABSTRACT FROM AUTHOR]

The stigma of addiction in Muslim communities is a significant barrier to accessing mental health services. The objective of this study was to evaluate the impact of a newly developed spiritually-adapted addictions psychoeducational program with adult Muslims in the mosque setting. Ninety-three individuals were recruited from nine different mosques within Toronto, Canada. Ninety-minute seminars were presented. This study used a convergent mixed method design. There was a significant increase in the participants' self-reported knowledge (t = 3.6; p < 0.001), a more positive attitude on two scales (t = 3.7; p < 0.001 and t = 2.9; p = 0.005) and an increase in willingness to seek help from a medical doctor and mental health professional (t = 4.4; p < 0.001 and t = 2.2; p = 0.03, respectively) post-seminar as compared to baseline. Qualitative data confirmed these changes. Evidence-informed spiritually-adapted outreach program in the mosque setting can help reduce addiction related stigma in Muslim communities. [ABSTRACT FROM AUTHOR]

Main conclusion: Plant traits of interest for sorghum breeders to develop dual-purpose varieties are stem diameter, flag leaf size, crop cycle, and number of grains per panicle. To develop dual-purpose varieties, breeders need to improve traits linked both to grain and biomass production. To identify these traits, we studied the phenotypic plasticity of eighteen traits and the performance of ten contrasting sorghum genotypes, used in West Africa. Trials were carried out in a randomized complete blocks design with four replicates from 2013 to 2016 in Bambey, Sinthiou Malem and Nioro du Rip in Senegal. The results revealed three plant types. The first type, “biomass production”, contained genotypes IS15401 and SK5912, and was linked to cycle duration, leaf area, and plant height. The second type, “grain production”, grouped the caudatum race sorghum 621B, F2-20 and Soumba, and was associated with the number of grains per panicle and the width of the flag leaf. The third group, “dual-purpose”, corresponding to the genotypes Fadda, Nieleni and Pablo, combined some favourable traits for grain and biomass: stem diameter, internode length, number of green leaves and number of grains per panicle. The study showed that high and stable grain yields were associated with stability in flag leaf size, phenology and number of grains per panicle, and a high and stable biomass yield was associated with stability in stem diameter. Those stable plant traits might be of interest for sorghum breeders selecting to develop dual-purpose varieties. [ABSTRACT FROM AUTHOR]

Progressive Hedging is a popular decomposition algorithm for solving multi-stage stochastic optimization problems. A computational bottleneck of this algorithm is that all scenario subproblems have to be solved at each iteration. In this paper, we introduce randomized versions of the Progressive Hedging algorithm able to produce new iterates as soon as a single scenario subproblem is solved. Building on the relation between Progressive Hedging and monotone operators, we leverage recent results on randomized fixed point methods to derive and analyze the proposed methods. Finally, we release the corresponding code as an easy-to-use Julia toolbox and report computational experiments showing the practical interest of randomized algorithms, notably in a parallel context. Throughout the paper, we pay a special attention to presentation, stressing main ideas, avoiding extra-technicalities, in order to make the randomized methods accessible to a broad audience in the Operations Research community. [ABSTRACT FROM AUTHOR]