1. A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity
- Author
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Masaya Takemura, Yoshiaki Yuba, Kazufumi Takamatsu, Takashi Nakayama, Manabu Ishitoko, Masataka Matsumoto, Ryo Itotani, Shinko Suzuki, Daiki Inoue, Minoru Sakuramoto, Motonari Fukui, and Osamu Yoshie
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Cancer Research ,Lung Neoplasms ,Case Report ,G-CSF ,Neutrophilia ,Fluorodeoxyglucose F18 ,medicine ,Carcinoma ,Genetics ,Humans ,Interleukin 8 ,FDG-PET ,Lung cancer ,Interleukin 6 ,IL-6 ,Lung ,IL-8 ,biology ,business.industry ,Interleukin ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Oncology ,Positron-Emission Tomography ,biology.protein ,Cytokines ,Stem cell ,Tomography, X-Ray Computed ,business ,CD8 - Abstract
Background Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung cancers. Case presentation We encountered a patient with a pleomorphic carcinoma of the lung. This tumor produced interleukin (IL)-8, granulocyte colony-stimulating factor and IL-6, which in turn recruited inflammatory cells, such as CD8 positive lymphocytes, around the tumor, resulting in a rapidly growing tumor shadow. Conclusion 18 F-fluoro-deoxy-glucose positron emission tomography, in addition to a conventional radiological approach such as computed tomography, may detect immunological responses around a tumor.
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