1. Identification of loci associated with schizophrenia by genome-wide association and follow-up.
- Author
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Michael C. O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L. Marchini, Chris C. A. Spencer, Bryan Howie, Hin-Tak Leung, Annette M. Hartmann, Hans-Jürgen Möller, Derek W. Morris, and YongYong Shi
- Subjects
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PSYCHOSES , *SCHIZOPHRENIA , *BIPOLAR disorder , *META-analysis , *GENETICS - Abstract
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10−5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10−4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10−8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10−7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10−9). [ABSTRACT FROM AUTHOR]
- Published
- 2008
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