1. Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine.
- Author
-
Fukami, Hirotaka, Morinaga, Jun, Nakagami, Hironori, Hayashi, Hiroki, Okadome, Yusuke, Matsunaga, Eiji, Kadomatsu, Tsuyoshi, Horiguchi, Haruki, Sato, Michio, Sugizaki, Taichi, Miyata, Keishi, Torigoe, Daisuke, Mukoyama, Masashi, Morishita, Ryuichi, and Oike, Yuichi
- Subjects
BOOSTER vaccines ,VACCINE safety ,VACCINE effectiveness ,VACCINES ,IMMUNOGLOBULINS ,MICE ,DYSLIPIDEMIA - Abstract
Previously, we reported that an ANGPTL3 vaccine is a hopeful therapeutic option against dyslipidemia. In our current study, we assess durability and booster effects of that vaccine over a period representing a mouse's lifespan. The vaccine remained effective for over one year, and booster vaccination maintained suppression of circulating triglyceride levels thereafter without major adverse effects on lungs, kidneys, or liver, suggesting vaccine efficacy and safety. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF