1. Sensory deprivation in Staphylococcus aureus
- Author
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Miguel Martí, Cristina Solano, José R. Penadés, Igor Ruiz de los Mozos, Iñigo Lasa, Beatriz Rapún, Begoña García, Alejandro Toledo-Arana, Maite Villanueva, Jaione Valle, IdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutua, Ministerio de Economía y Competitividad (España), Penadés, José R. [0000-0002-6439-5262], Toledo-Arana, Alejandro [0000-0001-8148-6281], Penadés, José R., and Toledo-Arana, Alejandro more...
- Subjects
0301 basic medicine ,Staphylococcus aureus ,ENVZ ,Science ,030106 microbiology ,CROSS-TALK ,Regulator ,2-COMPONENT SYSTEM ,PHOSPHATASE-ACTIVITY ,General Physics and Astronomy ,Virulence ,Human pathogen ,Staphylococcal infections ,medicine.disease_cause ,Sensory deprivation ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Bacterial Proteins ,medicine ,CELL-CYCLE ,Humans ,TRANSCRIPTION ,lcsh:Science ,Genetics ,Science & Technology ,Multidisciplinary ,biology ,BIOFILM FORMATION ,fungi ,Biofilm ,IN-VITRO ,Gene Expression Regulation, Bacterial ,General Chemistry ,Staphylococcal Infections ,medicine.disease ,biology.organism_classification ,Multidisciplinary Sciences ,INTERFACE ,Two-component systems ,Science & Technology - Other Topics ,lcsh:Q ,SIGNAL-TRANSDUCTION PATHWAYS ,Adaptation ,Bacteria - Abstract
12 Páginas, 7 Figuras. Contiene información suplementaria en: http://dx.doi.org/10.1038/s41467-018-02949-y, Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions. Characterization of S. aureus derivatives containing individual TCSs reveals that each TCS appears to be autonomous and self-sufficient to sense and respond to specific environmental cues, although some level of cross-regulation between non-cognate sensor-response regulator pairs occurs in vivo. This organization, if confirmed in other bacterial species, may provide a general evolutionarily mechanism for flexible bacterial adaptation to life in new niches., This work was supported by the Spanish Ministry of Economy and Competitiveness grants BIO2011-30503-C02-02, BIO2014-53530-R, SAF2014-56716-REDT , and RTC-2015-3184-1. J.V. was supported by Ramon y Cajal (RYC-2009-03948) contract from the Spanish Ministry of Economy and Competitiveness. more...
- Published
- 2018