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The document explores the impact of genetic profiles and treatment on outcomes and hematological toxicity in CEBPA-mutated AML patients. The study analyzes a cohort of 50 intensively treated patients, focusing on baseline characteristics and treatment details. Results show delayed hematopoietic recovery in CEBPA-mutated patients with additional mutations, suggesting the need to incorporate NGS data for therapeutic management. The study highlights the importance of limiting anthracycline dosage to reduce hematological toxicity and improve treatment adherence in this patient population. [Extracted from the article]

Water–rock interactions are one of the main factors that control water quality in rivers worldwide. Hydro-geochemical analyses from mountain rivers of the North of the Sierra de Velasco (Argentina), in combination with petrological studies of the granitic rocks, suggest that A-type plutons are one of the main fluorine suppliers in surface waters that drain these granitic terrains. In the rivers of the northern sector of the study area, the dissolved F− is above 1.72 mg L−1 and reach up to 3.65 mg L−1, while in the southern sector the values range between 0.27 and 1.05 mg L−1. Conversely, there are no significant differences in the major hydrochemistry of the studied rivers, since all the waters are diluted (TDS: 36–116 mg L−1), slightly alkaline (pH: 7.50–8.16), of bicarbonate-calcium type, and with no seasonal influence of precipitation. The elevated values of F− in waters spatially match the F-rich A-type strongly peraluminous granite of La Costa Pluton. Fluorine in this unit is five to ten times higher than in the S-type peraluminous granite from the southern sector, and is mainly hosted in micas and fluorapatite. The higher dissolved trace elements and REE in the northern sector, also match the different lithological sources. Therefore, the identification of A-type peraluminous granites in a catchment area could be used as a petrological indicator to predict a possible high fluoride content in river waters. Additionally, high fluoride values in surface waters could be a valuable proxy of the presence of A-type plutons in the nearby region. [ABSTRACT FROM AUTHOR]

In the present study, the hydrochemical dynamic and the water quality of La Purísima reservoir, Central Mexico, have been determined. The reservoir presents total dissolved solids (TDSs) between 146 and 328 mg L−1 and water quality neutral to slightly alkaline (pH 7.0 to 8.7) during the dry season, whereas it becomes clearly alkaline (pH 8.1–9.9) in the rainy-warm season. Through its main tributaries, La Purísima reservoir has been receiving water affected by anthropic activities, such as mining, urbanization, and agriculture. La Purísima reservoir indicates water quality suitable for irrigation and aquatic lives, but unsuitable for drinking purposes. A geochemical evolution from the riverine to the lacustrine zone is evidenced by the complexation of several free ions: the higher saturation indexes; the lower toxic metal concentrations; and the lower trophic status, which ameliorate the water quality in the lacustrine zone. Trace elements co-precipitate and are adsorbed onto bottom sediments. During summer, high evaporation rates and atmospheric precipitation are found to decline the water quality. Cluster analyses reflect the geo-setting and different pollution levels: urban impact from the north coast, and agricultural activities from the east coast. The sensitivity of the lake to geochemical behavior can be used to understand the complex dissolved geochemical dynamics in a lake and the potential effects from long-term anthropic impact variability. The information about water quality of La Purísima reservoir may be useful to preserve the ecosystem and its biodiversity. [ABSTRACT FROM AUTHOR]

A Late Pleistocene–Holocene loess–paleosol sequence in central Argentina was studied to obtain a weathering insight and to probe geochemical tools as paleoclimatic proxies. Three paleosols and a buried soil interlayered with loess mantles compose Corralito I sequence (32°00′7″ S, 64°11′08″ W, 469 m a.s.l). Several weathering indices (CIA, CIA-K, and LWI) and elemental ratios (∑Bases/Al2O3, Rb/Sr, CaO/TiO2, Na2O/TiO2) were calculated. An incipient weathering degree throughout the sequence was detected, denoting that the parent material (i.e., loess mantles) has not been substantially modified by pedogenesis. Although a statistically significant correlation between magnetic susceptibility and several weathering indices was identified, the weathering intensity was not strong enough to produce a decrease in the magnetic signal of the paleosols, which is, in part, inherited from the detrital fraction. Paleoprecipitation indices, calculated using geochemical data, suggest slightly wetter conditions during paleosol formation when compared to loess. Paleosols were formed during humid conditions (paleosols II and II during MIS 5e, and paleosol I during MIS 3) with sedimentation pause and soil development, whereas loess layers were deposited during more arid conditions. [ABSTRACT FROM AUTHOR]

Suquía River is a medium-sized hydrological system (basin area of ~7,700 km) that supplies fresh water to Córdoba city, a town of ~1,500,000 inhabitants in central Argentina. This paper examines the present-day hydrochemistry of Suquía River urban catchment analyzing its major and minor dissolved components, and the nutrients variability by means of QUAL-2K modeling software. The Suquía River has bicarbonate-type waters upstream the city and sulfate-type waters right downstream, whereas they exhibit a mixed-to-alkali-type cationic composition. The seasonal analysis of its major dissolved constituents clearly showed a dilution process during the wet season (i.e. austral summer). In the last 20 years, the Suquía River has modified its anionic composition, now showing higher relative concentrations of SO as a consequence of urban activities. However, trace elements dissolved concentrations do not evidence a strong pollution effect. Nutrients [nitrogen species, total phosphorous (TP)] and related parameters, such as biochemical oxygen demand (BOD), and dissolved oxygen (DO), evidence a clear influence of human activities. The QUAL-2K model was used to evaluate the spatial behavior of selected nutrients and associated variables, (i.e. TP, N-NH, N-NO, DO, BOD). Nutrient concentrations are affected by point sources of contaminants, particularly domestic waste and sewage, as well as by diffuse agricultural pollution. A calibrated QUAL-2K modeling exercise clearly shows the impact of the Córdoba city's municipal wastewater treatment plant on the Suquía River water quality. [ABSTRACT FROM AUTHOR]

The Paraná River is one of the largest drainage systems in the Americas. Its hydrology is characterized by an active teleconnection with the ENSO, and by a significant discharge increase trend, evident since the mid-1970s. An Eh-pH data set collected in the Paraná's middle stretch suggests that large flood events, such as the one triggered by the 1982-1983 ENSO, are discernible in the plot, probably due to the influx of water draining flood plain water bodies. The total (particulate + dissolved) concentration of a set of heavy metals (Cr, Mn, Ni, Cu, Zn, As, Cd, and Pb) was determined in a downriver survey of the middle stretch. With the exception of Cu, Cd, and Pb, the metals exhibit a significantly increasing concentration trend towards the river mouth. The slopes of the regression lines imply that Zn and Ni, on one hand, and Mn and Cr, on the other would have common controlling sources. Another set of analyses were performed during the 1982-1983 flooding event; besides an increased variability observable during the flood arrival, most elements, with the only exception of Pb, did not show a variability coherent with the discharge series. [ABSTRACT FROM AUTHOR]

The authors reflect on the first meeting of the I Reunión Argentina de Geoquímica de la Superficie (I RAGSU) regarding the geochemistry of earth's surface. They argue that the environmental crisis has initiated several scientific studies which unveil anthropogenic environmental dilemma. The authors mention that the meeting includes topics on environmental geochemistry, isotopic geochemistry, and soil geochemistry.