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In this paper, we give a geometric construction of the three strong non-lifted (3 mod 5) -arcs in PG (3 , 5) of respective sizes 128, 143, and 168, and construct an infinite family of non-lifted, strong (t mod q) -arcs in PG (r , q) with t = (q + 1) / 2 for all r ≥ 3 and all odd prime powers q. [ABSTRACT FROM AUTHOR]

Tumor dissemination to the central nervous system (CNS) is almost a rule in the treatment journey of advanced HER2+ breast cancer (BC). Recent results demonstrated high intracranial efficacy with Trastuzumab Deruxtecan (T-DXd). However, a real-world evidence is lacking in literature. We conducted a multicenter, observational, retrospective real-world analysis on 39 cases collected at 12 Italian Oncological Units. Patients with brain metastases (BMs) from HER2 + BC treated with T-DXd in various treatment lines were enrolled. Primary endpoint was the intracranial overall response rate (iORR). Secondary endpoints were intra- and global progression free survival (iPFS - gPFS); other secondary objectives were the intracranial disease control rate (iDCR), duration of response (iDoR), clinical benefit rate at 6 and 12 months (iCBr), overall survival, and safety. iORR was 59%, iPFS was 15.6 months, gPFS was 11.8 months. iDCR was 94.9%, iDoR was 11.9 months, and iCBr at 6 and 12 months were 69.2% and 59%, respectively. OS was not reached, with an overall rate of 77.9% of patients alive at 12 months. This study confirmed the high intracranial efficacy and manageable safety profile of T-DXd in this first-ever real world analysis. [ABSTRACT FROM AUTHOR]

Isolated rapid-eye-movement sleep behavior disorder (iRBD) is a strong predictor of Parkinson’s disease and Dementia with Lewy bodies. Previous studies indicate that cortical atrophy in iRBD patients may be linked to cognitive impairment, but the pattern of atrophy is inconsistently reported. This study aimed to elucidate cortical atrophy patterns in a cognitively unimpaired iRBD cohort, focusing on regions associated with cognitive functions, particularly the cuneus/precuneus, and evaluated the predictive value for future phenoconversion. We conducted voxel-based morphometry and region of interest (ROI) analysis of structural MRI scans of 36 healthy controls and 19 iRBD patients, nine of whom also received a 3-year follow-up MRI scan. The iRBD patients were followed clinically for 8 years, and time-to-event analyses, using Cox regression, were performed based on baseline ROI volumes. The iRBD patients had lower gray-matter volume in the cuneus/precuneus region as well as in subcortical structures (caudate nuclei and putamen) compared to controls. Eight iRBD patients developed either Parkinson’s disease (N = 4) or Dementia with Lewy bodies (N = 4) during the follow-up period. Time-to-event analyses showed that lower right cuneus volume was associated with a higher risk of phenoconversion to alpha-synuclein-linked Parkinsonism in the iRBD patients (Hazard ratio = 13.0, CI: 1.53–110), and correlated with shorter time to conversion. In addition, lower volumes of the bilateral precuneus trended to indicate a higher risk of phenoconversion. These findings suggest a potential predictive value of cuneus and precuneus volumes in identifying iRBD patients at risk of disease progression, even before the onset of cognitive impairment. [ABSTRACT FROM AUTHOR]

REM sleep behaviour disorder (RBD) is a parasomnia characterised by dream-enacting behaviour with loss of muscle atonia during REM sleep and is a prodromal feature of α-synucleinopathies like Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Although cortical-to-subcortical connectivity is well-studied in RBD, cerebellar and subcortical nuclei reciprocal connectivity is less established. Nonetheless, it could be relevant since RBD pathology involves brainstem structures with an ascending gradient. In this study, we utilised resting-state functional MRI to investigate 13 people with isolated RBD (iRBD), 17 with Parkinson's disease and 16 healthy controls. We investigated the connectivity between the basal ganglia, thalamus and regions of the cerebellum. The cerebellum was segmented using a functional atlas, defined by a resting-state network-based parcellation, rather than an anatomical one. Controlling for age, we found a significant group difference (F4,82 = 5.47, pFDR = 0.017) in cerebellar-thalamic connectivity, with iRBD significantly lower compared to both control and Parkinson's disease. Specifically, cerebellar areas involved in this connectivity reduction were related to the default mode, language and fronto-parietal resting-state networks. Our findings show functional connectivity abnormalities in subcortical structures that are specific to iRBD and may be relevant from a pathophysiological standpoint. Further studies are needed to investigate how connectivity changes progress over time and whether specific changes predict disease course or phenoconversion. [ABSTRACT FROM AUTHOR]

Background: Cognitive dysfunction is increasingly recognized in multiple system atrophy (MSA). Locus coeruleus (LC) integrity is associated with cognitive performance both in healthy controls (HC) and neurodegenerative conditions such as Parkinson’s disease (PD). Furthermore, cortical glucose hypometabolism is associated with impaired cognitive performance in MSA. However, knowledge about LC sub-regional degeneration and its association with cognitive dysfunction and cortical glucose metabolism is lacking. Objective: To investigate LC sub-regional involvement and its association with cognitive impairment and brain metabolism in MSA. Methods: Eleven MSA, eighteen PD, and eighteen HC participants were included in the study. Neuromelanin-sensitive MRI was used to determine rostral, middle and caudal LC neuromelanin signals. Brain glucose metabolism was investigated with [18F]Fluorodeoxyglucose PET (FDG-PET). The Montreal Cognitive Assessment (MoCA) was used as a measure of global cognition. Results: Middle LC neuromelanin signal was significantly reduced in MSA [t(43) = 3.70, corrected-p = 0.004] and PD [t(43) = 2.63, corrected-p = 0.041] compared to HC, while caudal LC was only reduced in MSA [t(43) = 2.82, corrected-p = 0.030]. In MSA, decreased rostral LC neuromelanin was associated with lower MoCA scores (ρ = 0.760, p = 0.006) which, in turn, were associated with lower frontal cortex glucose metabolism. An association between rostral LC neuromelanin signal and frontal cortex glucose metabolism was found in exploratory analyses. Conclusion: Loss of LC neuromelanin signal was found in MSA, the middle and caudal parts being targeted. Rostral LC neuromelanin signal loss was associated with both frontal cortex hypometabolism and lower MoCA scores. This pathophysiological link should be further investigated as the noradrenergic system transmission is amenable to pharmacological manipulation. [ABSTRACT FROM AUTHOR]

An affine spread is a set of subspaces of AG (n , q) of the same dimension that partitions the points of AG (n , q) . Equivalently, an affine spread is a set of projective subspaces of PG (n , q) of the same dimension which partitions the points of PG (n , q) \ H ∞ ; here H ∞ denotes the hyperplane at infinity of the projective closure of AG (n , q) . Let Q be a non-degenerate quadric of H ∞ and let Π be a generator of Q , where Π is a t-dimensional projective subspace. An affine spread P consisting of (t + 1) -dimensional projective subspaces of PG (n , q) is called hyperbolic, parabolic or elliptic (according as Q is hyperbolic, parabolic or elliptic) if the following hold: Each member of P meets H ∞ in a distinct generator of Q disjoint from Π ; Elements of P have at most one point in common; If S , T ∈ P , | S ∩ T | = 1 , then ⟨ S , T ⟩ ∩ Q is a hyperbolic quadric of Q . In this note it is shown that a hyperbolic, parabolic or elliptic affine spread of PG (n , q) is equivalent to a spread of Q + (n + 1 , q) , Q (n + 1 , q) or Q - (n + 1 , q) , respectively. [ABSTRACT FROM AUTHOR]

Background: Limited data exist for global prevalence of claudin 18 isoform 2 (CLDN18.2) positivity and association of CLDN18.2 status with clinical and tumor characteristics in patients with locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma. We report prevalence of CLDN18.2 positivity (phase 3; SPOTLIGHT, NCT03504397; GLOW, NCT03653507) and concordance of CLDN18.2 status between a subset of pair-matched tumor samples (phase 2, ILUSTRO, NCT03505320; phase 1, NCT03528629) from clinical studies of zolbetuximab. Methods: Tumor samples from patients with LA unresectable or mG/GEJ adenocarcinoma were tested for CLDN18.2 status by immunohistochemistry. Human epidermal growth factor receptor 2 (HER2) expression was tested per central or local assessment. Results: Across SPOTLIGHT and GLOW, the prevalence of CLDN18.2 positivity (≥ 75% of tumor cells demonstrating moderate-to-strong membranous CLDN18 staining) was 38.4%. Prevalence was similar in gastric versus GEJ adenocarcinoma samples and regardless of collection method (biopsy versus resection) or collection site (primary versus metastatic). CLDN18.2 positivity was most prevalent in patients with diffuse-type tumors. In ILUSTRO and the phase 1 study, concordance of CLDN18.2 positivity was 61.1% between archival (i.e., any time before treatment) and baseline (i.e., ≤ 3 months before first treatment) samples, and concordance of any CLDN18 staining (≥ 1% of tumor cells demonstrating moderate-to-strong membranous CLDN18 staining) was 88.9%. Conclusions: CLDN18.2 was a highly prevalent biomarker in patients with HER2-negative, LA unresectable or mG/GEJ adenocarcinoma. CLDN18.2 positivity remained relatively stable over time in many patients. Biomarker testing for CLDN18.2 should be considered in standard clinical practice in these patients. [ABSTRACT FROM AUTHOR]

To assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI). Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12 h after transmission of positivity and Gram stain results from the first positive BC. This percentage was significantly higher in the multiplex PCR (mPCR) group (90/105 = 85.7% %, CI95% [77.5 ; 91.8] vs. 68/107 = 63.6%, CI95% [53.7 ; 72.6]; p < 10− 3) at interim analysis, resulting in the early termination of the study after the inclusion of 309 patients. For patients not optimized at baseline, the median time to obtain an optimized therapy was much shorter in the mPCR group than in the control group (6.9 h, IQR [2.9; 17.8] vs. 26.4 h, IQR [3.4; 47.5]; p = 0.001). Early optimization of antibiotic therapy resulted in a non-statistically significant decrease in mortality from 12.4 to 8.8% (p = 0.306), with a trend towards a shorter median length of stay (18 vs. 20 days; p = 0.064) and a non-significant reduction in the average cost per patient of €3,065 (p = 0.15). mPCR identified all the bacteria present in 88% of the samples. Despite its higher laboratory cost, the use of multiplex PCR for BSI diagnosis leads to early-optimised therapy, seems cost-effective and could reduce mortality and length of stay. Their impact could probably be improved if implemented 24/7. [ABSTRACT FROM AUTHOR]

The noradrenergic nucleus Locus Coeruleus (LC) is precociously involved in Alzheimer's Disease (AD) pathology, and its degeneration progresses during the course of the disease. Using Magnetic Resonance Imaging (MRI), researchers showed also in vivo in patients the disruption of LC, which can be observed both in Mild Cognitively Impaired individuals and AD demented patients. In this study, we report the results of a follow-up neuroradiological assessment, in which we evaluated the LC degeneration overtime in a group of cognitively impaired patients, submitted to MRI both at baseline and at the end of a 2.5-year follow-up. We found that a progressive LC disruption can be observed also in vivo, involving the entire nucleus and associated with clinical diagnosis. Our findings parallel neuropathological ones, which showed a continuous increase of neuronal death and volumetric atrophy within the LC with the progression of Braak's stages for neurofibrillary pathology. This supports the reliability of MRI as a tool for exploring the integrity of the central noradrenergic system in neurodegenerative disorders. [ABSTRACT FROM AUTHOR]

Enfortumab vedotin is an antibody–drug conjugate comprised of a human monoclonal antibody directed to Nectin-4 and monomethyl auristatin E (MMAE), a microtubule-disrupting agent. The objectives of this review are to summarize the clinical pharmacology of enfortumab vedotin monotherapy and demonstrate that the appropriate dose has been selected for clinical use. Pharmacokinetics (PK) of enfortumab vedotin (antibody–drug conjugate and total antibody) and free MMAE were evaluated in five clinical trials of patients with locally advanced or metastatic urothelial carcinoma (n = 748). Intravenous enfortumab vedotin 0.5–1.25 mg/kg on days 1, 8, and 15 of a 28-day cycle showed linear, dose-proportional PK. No significant differences in exposure or safety of enfortumab vedotin and free MMAE were observed in mild, moderate, or severe renal impairment versus normal renal function. Patients with mildly impaired versus normal hepatic function had a 37% increase in area under the concentration-time curve (0–28 days), a 31% increase in maximum concentration of free MMAE, and a similar adverse event profile. No clinically significant PK differences were observed based on race/ethnicity with weight-based dosing, and no clinically meaningful QT prolongation was observed. Concomitant use with dual P-glycoprotein and strong cytochrome P450 3A4 inhibitors may increase MMAE exposure and the risk of adverse events. Approximately 3% of patients developed antitherapeutic antibodies against enfortumab vedotin 1.25 mg/kg. These findings support enfortumab vedotin 1.25 mg/kg monotherapy on days 1, 8, and 15 of a 28-day cycle. No dose adjustments are required for patients with renal impairment or mild hepatic impairment, or by race/ethnicity. [ABSTRACT FROM AUTHOR]

Objectives: Little is known about efficacy and safety of ethanol lock therapy (ELT) to treat totally implantable venous access device (TIVAD) infections. The objective of this trial was to evaluate the effectiveness and safety profile of a local treatment with ELT without removal for TIVAD infection due to coagulase-negative staphylococci. Methods: We performed a prospective, multicenter, double-blind, randomized clinical trial comparing the efficacy of 40% ELT versus vancomycin lock therapy (VLT) in TIVAD infections due to coagulase-negative staphylococci, complicated or not by bloodstream infection. Results: Thirty-one patients were assigned to the ELT group and 30 to the VLT arm. Concomitant bacteremia was present in 41 patients (67.2%). Treatment success was 58.1 % (18 of 31) for the ELT arm and 46.7% (14 of 30) for the VLT arm (p = 0.37). The overall treatment success was 52.5% (32). The risk of treatment failure due to uncontrolled infections, superinfections, and mechanical complications did not differ significantly between participants receiving ELT (13 out of 31 [42%]) and those receiving VLT (16 out of 30 [53%]) with a hazard ratio of 0.70 (p = 0.343; 95% CI [0.34–1.46], Cox model). Catheter malfunctions were significantly more frequent in the ELT arm (11 patients versus 2 in the VLT group, p = 0.01). Conclusions: We found an overall high rate of treatment failure that did not differ between the ELT arm and the VLT arm. TIVAD removal must be prioritized to prevent complications (uncontrolled infections, superinfections, and catheter malfunctions) except in exceptional situations. [ABSTRACT FROM AUTHOR]

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms (NMS). Among NMS, constipation and pain are both highly prevalent and debilitating affecting up to 80% of PD patients and impairing their quality of life. Here, we investigated the relationship between constipation and pain in PD patients. This is a retrospective study assessing the relationship between pain and constipation in a PD patient population from a clinical database of patients attending the outpatient clinic of the movement disorders division, Neurology Unit of Policlinico Tor Vergata, in Rome. Subjects were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS) part III, Hoehn and Yahr (H&Y) stage, King's Parkinson's Disease Pain Scale (KPPS), Brief Pain Inventory (BPI), Non-Motor Symptoms Scale (NMSS) and Beck Depression Inventory (BDI). Patients were further divided in two groups (Group 1, 32 patients with constipation and Group 2, 35 PD patients without constipation) ANOVA and ANCOVA analysis were used to compare the two groups. PD patients with constipation had significantly higher pain severity and pain interference, as measured by the BPI scale and higher total KPPS score, fluctuation-related pain, nocturnal pain, and radicular pain when compared to PD patients without constipation. This study highlights for the first time a possible interplay between constipation and pain in PD that deserves further investigations. [ABSTRACT FROM AUTHOR]

A previous paper of the author introduced a graphical method, allowing anyone interested to form one's own opinion on data published in the form of computer-maps to re-compute the map data by means of a simple and efficient use of commonly available computer-graphic products. This was shown to allow a data re-analysis of sound metrological quality—there applied to a NASA video concerning the ice coverage on the Earth's surface. In the present paper, the same procedure shows an efficient way to (re-)compute the annual value of the so-called Global Mean Surface Temperature (GMST)—a parameter normally provided by dedicated International Organizations, such as the ONU-supported IPCC—from whole-Earth maps of different types, often obtaining different results. A cartographic reason for this is given and discussed, explaining the differences found, some of which might have remained implicit in the published information. [ABSTRACT FROM AUTHOR]

Mycoparasitism is a key feature of Trichoderma (Hypocreales, Ascomycota) biocontrol agents. Recent studies of intracellular signal transduction pathways of the potent mycoparasite Trichoderma atroviride revealed the involvement of Tmk1, a mitogen-activated protein kinase (MAPK), in triggering the mycoparasitic response. We previously showed that mutants missing Tmk1 exhibit reduced mycoparasitic activity against several plant pathogenic fungi. In this study, we identified the most robustly regulated targets that were governed by Tmk1 during mycoparasitism using transcriptome and proteome profiling. Tmk1 mainly exerts a stimulating function for T. atroviride during its mycoparasitic interaction with the fungal plant pathogen Rhizoctonia solani, as reflected by 89% of strongly differently responding genes in the ∆tmk1 mutant compared to the wild type. Specifically, 54% of these genes showed strong downregulation in the response with a deletion of the tmk1 gene, whereas in the wild type the same genes were strongly upregulated during the interaction with the fungal host. These included the gene encoding the mycoparasitism-related proteinase Prb1; genes involved in signal transduction pathways such as a candidate coding for a conserved 14-3-3 protein, and a gene coding for Tmk2, the T. atroviride cell-wall integrity MAP kinase; genes encoding a specific siderophore synthetase, and multiple FAD-dependent oxidoreductases and aminotransferases. Due to the phosphorylating activity of Tmk1, different (phospho-)proteomics approaches were applied and identified proteins associated with cellular metabolism, energy production, protein synthesis and fate, and cell organization. Members of FAD- and NAD/NADP-binding-domain proteins, vesicular trafficking of molecules between cellular organelles, fungal translational, as well as protein folding apparatus were among others found to be phosphorylated by Tmk1 during mycoparasitism. Outstanding downregulation in the response of the ∆tmk1 mutant to the fungal host compared to the wild type at both the transcriptome and the proteome levels was observed for nitrilase, indicating that its defense and detoxification functions might be greatly dependent on Tmk1 during T. atroviride mycoparasitism. An intersection network analysis between the identified transcripts and proteins revealed a strong involvement of Tmk1 in molecular functions with GTPase and oxidoreductase activity. These data suggest that during T. atroviride mycoparasitism this MAPK mainly governs processes regulating cell responses to extracellular signals and those involved in reactive oxygen stress. [ABSTRACT FROM AUTHOR]

At the former IMGC-CNR (now INRiM), the Italian national metrological Institute, a series of pure hydrocarbons were measured in past years to determine with high accuracy for the temperature of their triple point and of their solid-to-solid transition(s) when present. While results on methane, ethane, and propane were published; the 1982 measurements on n-butane were never so far. It seems useful to add these results now to the still scarce existing data for possible inclusion in reference data archives. The paper summarises the experimental setup and results, compared with previous determinations. For the triple point, a temperature Ttp,90 = 134.869(2) K was found showing a higher accuracy. For the s.s.t.-I, the temperature was T90,upper-end = 108.2(3) K, where the low accuracy is due to the peculiar s.s.t. properties. [ABSTRACT FROM AUTHOR]

The International Vocabulary of Metrology (VIM) is presently at its third Edition (2012) (VIM3). VIM3 was a major achievement done with an important contribution of Paul De Bièvre. Numerous comments can be found in the literature concerning the evaluation of VIM3 that will be taken here as a reference for the future developments. The present paper is based mainly on the concept that such a vocabulary is assumed to be of great help for the practitioners of metrology, i.e., in general of people that must correctly apply the idiom of metrology according to the current meaning of its terms. The core of VIM3, i.e., its few basic terms, which are those currently used in metrology (defined according to paper's Glossary), is identified, and their current meaning recalled together with the rationale for their choice. The above illustration is compared with recently proposed changes of several of them, and with some terms newly proposed. [ABSTRACT FROM AUTHOR]

The correction notice addresses an error in the Abstract section of the original article, providing the accurate abstract that evaluates the clinical impact and cost-consequence analysis of multiplex PCR panels for rapid bloodstream infection diagnosis. The study conducted at a French University hospital showed that the use of multiplex PCR led to early-optimized therapy, potentially reducing mortality and length of stay. Despite higher laboratory costs, the implementation of multiplex PCR for BSI diagnosis could be cost-effective and beneficial if available 24/7. [Extracted from the article]

Several classes of near-MDS sets of PG (3 , q) are described. They are obtained either by considering the intersection of an elliptic quadric ovoid and a Suzuki-Tits ovoid of a symplectic polar space W (3 , q) or starting from the q + 1 points of a twisted cubic of PG (3 , q) . As a by-product two classes of complete caps of PG (4 , q) of size 2 q 2 - q ± 2 q + 2 are exhibited. [ABSTRACT FROM AUTHOR]

The article discusses the relation between skills (or competences), creditability, and aptness. The positive suggestion is that we might make progress understanding the relation between creditability and aptness by inquiring more generally about how different kinds of competences and their exercise might underwrite allocation of credit. Whether or not a competence is acquired and whether or not a competence is actively exercised might matter for the credit that the agent deserves for the exercise of that competence. A fine-grained taxonomy of competences opens up the possibility of instinctual knowledge (knowledge by mere instincts) as well as the possibility of habitual knowledge (knowledge by mere habits), alongside knowledge by skills (or alongside knowledge by yet other sorts of competences). If instinctual knowledge were possible, it is suggested that it might not be of the sort that deserves credit at all. By piggybacking from the literature in evolutionary psychology, I suggest that, as inborn social learners, merely instinctual—and so not fully creditable—knowledge might be a reality for us. [ABSTRACT FROM AUTHOR]

Purpose of Review: During recent years, there has been a growing interest in GABAergic alterations in parkinsonian disorders. This paper aims to review the latest literature published, focusing on in vivo neuroimaging, and to suggest potential future avenues of research in the field. Recent Findings: A growing number of neuroimaging studies have focused on the association with different symptoms of Parkinson's disease, thereby suggesting a GABAergic role in motor symptoms, gait disturbances, frontal cognition, somatic symptom disorder, and hallucinations. However, there are a number of conflicting results, and further investigations in larger, clinically well-defined cohorts are needed to elucidate possible correlations. In progressive supranuclear palsy, recent evidence suggests a decrease of GABA in the frontal lobe. Summary: In this narrative review, we discuss the possible GABAergic role in the symptoms of PD and atypical parkinsonisms and outline possible research strategies for future neuroimaging of GABAergic changes in parkinsonian disorders. [ABSTRACT FROM AUTHOR]

This idea that what is distinctive of intentional performances (or at least of those intentional performances that amount to skilled actions is one’s practical knowledge in it—i.e., knowledge of what one is doing while doing it—famously traces back to Anscombe ([1963] 2000). While many philosophers have theorized about Anscombe’s notion of practical knowledge (e.g., Setiya, 2008; Thompson et al., 2011; Schwenkler, 2019; O’Brien, 2007), there is a wide disagreement about how to understand it. This paper investigates how best to understand practical knowledge for it to play the desired explanatory role in a reductive theory of intentional action, of intention-in-action, and of control-in-action. I argue that practical knowledge ought to be construed as a dynamic knowledge state and that structured practical senses are needed to model it. [ABSTRACT FROM AUTHOR]

Purpose of Review: Sleep disorders are among the most common non-motor symptoms in Parkinson's disease (PD). Recent longitudinal studies of sleep in PD have utilized validated sleep questionnaires and video-polysomnography performed over multiple time points. This review summarizes existing longitudinal studies focusing on the prevalence, associations, and changes of sleep disorders in PD over time, as well as the methodologies used in these studies. Recent Findings: Fifty-three longitudinal studies of sleep in PD were identified: excessive daytime sleepiness, insomnia, obstructive sleep apnea, rapid eye movement sleep behavior disorder (RBD), restless legs syndrome, and shift work disorder were studied in addition to other studies that had focused on either multiple sleep disorders or broadly on sleep disorders as a whole. The prevalence of sleep disorders increases over time and are associated particularly with non-motor features of disease. RBD is now considered an established prodromal feature of PD, but other sleep disorders do not clearly increase risk of subsequent PD. Further work is necessary to determine if treatment of sleep disorders in PD alters disease symptom and their progression or reduces PD risk. Summary: Longitudinal studies of sleep in PD have demonstrated a high prevalence of sleep disorders that are associated with non-motor features of PD which can increase over time. More work is necessary to determine if treatment of sleep disorders can alter the course of PD. [ABSTRACT FROM AUTHOR]

The request for an efficient traceability system able to identify hazelnut cultivars along the entire processing chain is becoming a critical point for avoiding fraudulent practices and safeguarding the interests of growers, food processors and consumers. In this study, DNA was extracted from different hazelnut matrices, including plant material (leaf, kernel and kernel episperm), and processed foods (paste, grain, flour and different types of snacks containing hazelnuts). The efficiency of Simple Sequence Repeat (SSR) markers was tested to identify the hazelnut cultivar 'Tonda Gentile' in all the supply chain. The analysis at 10 SSR loci was able to verify the presence/absence of the alleles of a declared cultivar contained in these matrices. The SSR analysis of DNA from raw episperm offers the possibility of identifying the mother cultivar and is suggested as an effective way to discover frauds since DNA analysis can be performed on individual kernels. For food matrices containing hazelnuts, the presence of the mother cultivar's DNA can be assessed based on the identification of its alleles in the sample, although the presence of multiple alleles from the pollenizers makes the interpretation of results more difficult. [ABSTRACT FROM AUTHOR]

Agricultural sensors are powerful tools to optimize crop productivity while conserving natural resources. Here we report a crop water-stress detector based on a plasmonically-enhanced micromechanical photoswitch capable of detecting water content in leaves that is lower than a predetermined threshold without consuming electrical power when the leaf is healthy. The detection mechanism exploits the energy in a specific narrow-spectral band of solar radiation reflected off leaves that is strongly correlated to the water content in plants. This biosensor relies on a spectrally selective infrared plasmonic absorber and a thermally sensitive micro-cantilever to harvest the reflected solar energy and further produce a digitized wakeup-bit only when the monitored leaf is water-stressed. In particular, we demonstrate that the detector activates a commercial water pump when a soybean plant is water-stressed. The 10-year battery lifetime of the proposed detector pave the way for the development of high-granularity, maintenance-free sensor networks for large-scale smart-farms. [ABSTRACT FROM AUTHOR]

We improve on the lower bound of the maximum number of planes of PG (8 , q) mutually intersecting in at most one point leading to the following lower bound: A q (9 , 4 ; 3) ≥ q 12 + 2 q 8 + 2 q 7 + q 6 + q 5 + q 4 + 1 . We also construct two new non–equivalent (6 , (q 3 - 1) (q 2 + q + 1) , 4 ; 3) q –constant dimension subspace orbit–codes. [ABSTRACT FROM AUTHOR]

Nickel matrix was electrodeposited on a conducting substrate from nickel Watts's bath having priorly dispersed graphene nanoplatelets (GNPs) to produce GNPs-Ni composite coatings. It was found, by atomic force microscopy, that addition of GNPs improved the hardness as well as the roughness of the coatings in proportion to the GNPs addition. While observing the torn surfaces under scanning electron microscope, pure nickel coatings showed a pure ductile behavior but as the volume of GNPs is increased, the torn surfaces showed nearly brittle behavior as for the 0.4 wt.% GNPs composites. The electrochemical and thermo-mechanical analysis showed 0.2 wt.% GNPs' addition as optimum concentration with highest corrosion resistance and strain recovery in comparison to other compositions. The corrosion rate of nickel matrix was best inhibited by 0.2 wt.% GNPs addition due to the uniform dispersion and dense structure overall. The thermomechanical analysis at 473 K temperature showed highest strain recovery rate for the 0.2 wt.% GNPs composites due to homogeneous dispersion. [ABSTRACT FROM AUTHOR]

The locus coeruleus is the main noradrenergic nucleus of the brain and is often affected in neurodegenerative diseases. Recently, magnetic resonance imaging with specific T1-weighted sequences for neuromelanin has been used to evaluate locus coeruleus integrity in patients with these conditions. In some of these studies, abnormalities in locus coeruleus signal have also been found in healthy controls and related to ageing. However, this would be at variance with recent post-mortem studies showing that the nucleus is not affected during normal ageing. The present study aimed at evaluating locus coeruleus features in a well-defined cohort of cognitively healthy subjects who remained cognitively intact on a one-year follow-up. An ad-hoc semiautomatic analysis of locus coeruleus magnetic resonance was applied. Sixty-two cognitively intact subjects aged 60–80 years, without significant comorbidities, underwent 3 T magnetic resonance with specific sequences for locus coeruleus. A semi-automatic tool was used to estimate the number of voxels belonging to locus coeruleus and its intensity was obtained for each subject. Each subject underwent extensive neuropsychological testing at baseline and 12 months after magnetic resonance scan. Based on neuropsychological testing 53 subjects were cognitively normal at baseline and follow up. No significant age-related differences in locus coeruleus parameters were found in this cohort. In line with recent post-mortem studies, our in vivo study confirms that locus coeruleus magnetic resonance features are not statistically significantly affected by age between 60 and 80 years, the age range usually evaluated in studies on neurodegenerative diseases. A significant alteration of locus coeruleus features in a cognitively intact elderly subject might be an early sign of pathology. [ABSTRACT FROM AUTHOR]

Cultivated beets (Beta vulgaris ssp. vulgaris), including sugar beet, rank among the most important crops. The wild ancestor of beet crops is the sea beet Beta vulgaris ssp. maritima. Species and subspecies of wild beets are readily crossable with cultivated beets and are thus available for crop improvement. To study genomic relationships in the genus Beta, we sequence and analyse 606 beet genomes, encompassing sugar beet, sea beet, B. v. adanensis, B. macrocarpa, and B. patula. We observe two genetically distinct groups of sea beets, one from the Atlantic coast and the other from the Mediterranean area. Genomic comparisons based on k-mers identify sea beets from Greece as the closest wild relatives of sugar beet, suggesting that domestication of the ancestors of sugar beet may be traced to this area. Our work provides comprehensive insight into the phylogeny of wild and cultivated beets and establishes a framework for classification of further accessions of unknown (sub-)species assignment. While a large amount of genomic resources is available, the phylogeny of wild and cultivated beets remains unclear. Here, the authors use the k-mer-based Mash method to analyze resequenced genomes of 606 accessions of the genus Beta and reveal Greece as the domestication site of sugar beet. [ABSTRACT FROM AUTHOR]

Arguments have always played a central role within logic and philosophy. But little attention has been paid to arguments as a distinctive kind of discourse, with its own semantics and pragmatics. The goal of this essay is to study the mechanisms by means of which we make arguments in discourse, starting from the semantics of argument connectives such as 'therefore'. While some proposals have been made in the literature, they fail to account for the distinctive anaphoric behavior of 'therefore', as well as for uses of argument connectives in complex arguments, suppositional arguments, arguments with non-declarative conclusions, as well as arguments with parenthetical remarks. We argue that a comprehensive account of arguments requires imposing a distinctive tree-like structure on contexts. We show how to extend our account to accommodate modal subordination and different flavors of argument connectives. [ABSTRACT FROM AUTHOR]

Microbiological diagnosis of bloodstream infection (BSI) is made several hours after blood culture sampling. This delay could be critical in ambulatory clinics, emergency departments, and hospital day care units, as the patient may be discharged prior to blood culture positivity. Our aim was to evaluate the clinical outcome (including the number of readmissions) of patients diagnosed with BSI after discharge. We prospectively included all adult patients with positive blood culture for BSI that was confirmed after discharge from our center (Grenoble-Alpes University Hospital) in 2016. Patients were contacted about their blood culture results, and their clinical status was controlled via an external consultation or their family physician, with hospital readmission if necessary. Clinical outcome, accuracy of initial diagnosis, microbiological epidemiology, and antibiotic prescription were assessed. In 2016, 1433 episodes of positive blood culture were detected in our hospital, with 50 (3.5%) occurring after patient discharge. Clinically relevant bacteria were determined in 32/50 cases (64%), while other positive blood culture results were considered to be contaminants. Clinical reevaluation was performed in 45 patients (90%). The diagnosis was changed during the clinical reassessment of 24/49 patients (49%). Antibiotics were prescribed prior to discharge for 24/50 patients (48%), modified during follow-up for 15/45 (33%), and initiated for 13/45 (29%) at the reevaluation. Overall, 24/45 (53%) patients were readmitted to hospital units after reevaluation. The clinical follow-up of patients with positive blood culture after discharge led to diagnostic changes and hospital readmission in around half of patients. [ABSTRACT FROM AUTHOR]

Locus Coeruleus (LC) is the main noradrenergic nucleus of the brain, which is involved in many physiological functions including cognition; its impairment may be crucial in the neurobiology of a variety of brain diseases. Locus Coeruleus-Magnetic Resonance Imaging (LC-MRI) allows to identify in vivo LC in humans. Thus, a variety of research teams have been using LC-MRI to estimate LC integrity in normal aging and in patients affected by neurodegenerative disorders, where LC integrity my work as a biomarker. A number of variations between LC-MRI studies exist, concerning post-acquisition analysis and whether this had been performed within MRI native space or in ad hoc-built MRI template space. Moreover, the reproducibility and reliability of this tool is still to be explored. Therefore, in the present study, we analyzed a group of neurologically healthy, cognitively intact elderly subjects, using both a native space- and a template space-based LC-MRI analysis. We found a good inter-method agreement, particularly considering the LC Contrast Ratio. The template space-based approach provided a higher spatial resolution, lower operator-dependency, and allowed the analysis of LC topography. Our ad hoc-developed LC template showed LC morphological data that were in line with templates published very recently. Remarkably, present data significantly overlapped with a recently published LC "metaMask", that had been obtained by averaging the results of a variety of previous LC-MRI studies. Thus, such a template space-based approach may pave the way to a standardized LC-MRI analysis and to be used in future clinic–anatomical correlations. [ABSTRACT FROM AUTHOR]

This essay develops and defends a diagnosis of Carroll's (Mind 4(14):278–280, 1895) regress of the premises according to which the moral of the regress is that arguments are constitutively presuppositional. It is argued that this diagnosis allows to vindicate the key insights of the rule-following account of the regress, while overcoming the main difficulties that the rule-following account faces. [ABSTRACT FROM AUTHOR]

Can we think of a task in a distinctively practical way? Can there be practical concepts? In recent years, epistemologists, philosophers of mind, as well as philosophers of psychology have appealed to practical concepts in characterizing the content of know-how or in explaining certain features of skilled action. However, reasons for positing practical concepts are rarely discussed in a systematic fashion. This paper advances a novel argument for the psychological reality of practical concepts that relies on evidence for a distinctively productive kind of reasoning. [ABSTRACT FROM AUTHOR]

Key message: We propose to use the natural variation between individuals of a population for genome assembly scaffolding. In today's genome projects, multiple accessions get sequenced, leading to variant catalogs. Using such information to improve genome assemblies is attractive both cost-wise as well as scientifically, because the value of an assembly increases with its contiguity. We conclude that haplotype information is a valuable resource to group and order contigs toward the generation of pseudomolecules. Quinoa (Chenopodium quinoa) has been under cultivation in Latin America for more than 7500 years. Recently, quinoa has gained increasing attention due to its stress resistance and its nutritional value. We generated a novel quinoa genome assembly for the Bolivian accession CHEN125 using PacBio long-read sequencing data (assembly size 1.32 Gbp, initial N50 size 608 kbp). Next, we re-sequenced 50 quinoa accessions from Peru and Bolivia. This set of accessions differed at 4.4 million single-nucleotide variant (SNV) positions compared to CHEN125 (1.4 million SNV positions on average per accession). We show how to exploit variation in accessions that are distantly related to establish a genome-wide ordered set of contigs for guided scaffolding of a reference assembly. The method is based on detecting shared haplotypes and their expected continuity throughout the genome (i.e., the effect of linkage disequilibrium), as an extension of what is expected in mapping populations where only a few haplotypes are present. We test the approach using Arabidopsis thaliana data from different populations. After applying the method on our CHEN125 quinoa assembly we validated the results with mate-pairs, genetic markers, and another quinoa assembly originating from a Chilean cultivar. We show consistency between these information sources and the haplotype-based relations as determined by us and obtain an improved assembly with an N50 size of 1079 kbp and ordered contig groups of up to 39.7 Mbp. We conclude that haplotype information in distantly related individuals of the same species is a valuable resource to group and order contigs according to their adjacency in the genome toward the generation of pseudomolecules. [ABSTRACT FROM AUTHOR]

The two most common polymorphs of MnO2, ramsdellite and pyrolusite, are often found in natural association. Our starting sample is from the Mistake mine (Arizona) containing macroscopic crystals of both ramsdellite (a = 4.5131(6), b = 9.2689(13), c = 2.8610(4) Å, V = 119.69(3) Å3; S.G. Pbmn) and pyrolusite (a = 4.4030(2), c = 2.87392(16) Å, V = 55.715(5) Å3; S.G. P42/mnm), along with a smaller amount of “groutellite”. A mixed powder was used to study the ramsdellite→pyrolusite transformation by in situ high-temperature X-ray powder diffraction. Our results reveal that this transformation is not a direct transition, but it occurs in two steps, as a function of temperature; ramsdellite transforms into an amorphous phase, which then recrystallizes into pyrolusite. Amorphization of ramsdellite and crystallization of pyrolusite kinetics were studied by the universal equation for solid–solid reactions. The two activation energies are comparable, but the pre-exponential factor of the ramsdellite amorphization is two orders of magnitude larger than pyrolusite crystallization’s. As a consequence, ramsdellite→pyrolusite transformation implies the formation of an amorphous transition, due to a mismatch between the conversion rates, that reaches its maximum at around 630 K and then decreases at higher T, when pyrolusite crystallization is strongly promoted. [ABSTRACT FROM AUTHOR]

The occurrence of phlogopite and amphibole in mantle ultramafic rocks is widely accepted as the modal effect of metasomatism in the upper mantle. However, their simultaneous formation during metasomatic events and the related sub-solidus equilibrium with the peridotite has not been extensively studied. In this work, we discuss the geochemical conditions at which the pargasite-phlogopite assemblage becomes stable, through the investigation of two mantle xenoliths from Mount Leura (Victoria State, Australia) that bear phlogopite and the phlogopite + amphibole (pargasite) pair disseminated in a harzburgite matrix. Combining a mineralogical study and thermodynamic modelling, we predict that the P–T locus of the equilibrium reaction pargasite + forsterite = Na-phlogopite + 2 diopside + spinel, over the range 1.3–3.0 GPa/540–1500 K, yields a negative Clapeyron slope of -0.003 GPa K–1 (on average). The intersection of the P–T locus of supposed equilibrium with the new mantle geotherm calculated in this work allowed us to state that the Mount Leura xenoliths achieved equilibrium at 2.3 GPa /1190 K, that represents a plausible depth of ~ 70 km. Metasomatic K-Na-OH rich fluids stabilize hydrous phases. This has been modelled by the following equilibrium equation: 2 (K,Na)-phlogopite + forsterite = 7/2 enstatite + spinel + fluid (components: Na2O,K2O,H2O). Using quantum-mechanics, semi-empirical potentials, lattice dynamics and observed thermo-elastic data, we concluded that K-Na-OH rich fluids are not effective metasomatic agents to convey alkali species across the upper mantle, as the fluids are highly reactive with the ultramafic system and favour the rapid formation of phlogopite and amphibole. In addition, oxygen fugacity estimates of the Mount Leura mantle xenoliths [Δ(FMQ) = –1.97 ± 0.35; –1.83 ± 0.36] indicate a more reducing mantle environment than what is expected from the occurrence of phlogopite and amphibole in spinel-bearing peridotites. This is accounted for by our model of full molecular dissociation of the fluid and incorporation of the O-H-K-Na species into (OH)-K-Na-bearing mineral phases (phlogopite and amphibole), that leads to a peridotite metasomatized ambient characterized by reduced oxygen fugacity. [ABSTRACT FROM AUTHOR]

We investigate dalbavancin efficiency and tolerance among elderly in Grenoble-Alpes 32 university hospital. Among the 65 patients who received dalbavancin, 51% (33) were considered as old. Patients presented mainly bones and joint infections (52%), surgical site infection 34 (31%), and infective endocarditis (IE) (8%). Clinical cure was confirmed for 79% of old 35 patients at 1, 3, and 6 months. Six adverse events (9%) were reported after 36 dalbavancin's administration, but each time in combination with other antibiotics. 37 Dalbavancin had a significant effectiveness and safety profile and represents a real 38 therapeutic option in the management of deep and complex infections of elderly patients. [ABSTRACT FROM AUTHOR]

A good surgeon knows how to perform a surgery; a good architect knows how to design a house. We value their know-how. We ordinarily look for it. What makes it so valuable? A natural response is that know-how is valuable because it explains success. A surgeon's know-how explains their success at performing a surgery. And an architect's know-how explains their success at designing houses that stand up. We value know-how because of its special explanatory link to success. But in virtue of what is know-how explanatorily linked to success? This essay provides a novel argument for the thesis that know-how's special link to success is to be explained at least in part in terms of its being, or involving, a doxastic attitude that is epistemically alike propositional knowledge. It is argued that the role played by know-how in explaining intentional success shows that the epistemic differences between know-how and knowledge, if any, are less than usually thought; and that "revisionary intellectualism", the view that know-how is true belief that might well fall short of knowledge, is not really a stable position. If its explanatory link to success is what makes know-how valuable, an upshot of my argument is that the value of know-how is due, to a considerable extent, to its being, or involving, a kind of propositional knowledge. [ABSTRACT FROM AUTHOR]

Our objective was to evaluate risk factors of nosocomial influenza (NI) in an university hospital during the 2015/2016 influenza season. All hospitalized patients with influenza-like illness associated with laboratory confirmation by polymerase chain reaction were included in a prospective observational study. We identified 44 cases (19%) of NI among the 233 cases of influenza: 38/178 (21%) in adults and 6/55 (11%) in children. Among adults, hospitalization in a double or multi-occupancy room was independently associated with NI (adjusted Odds Ratio, 3.42; 95% CI, 1.29–9.08; p = 0.013). The results of the study underline the importance of single room to prevent NI. [ABSTRACT FROM AUTHOR]

In this research work, nanocomposite coatings of nickel reinforced with graphene oxide (GOs) were produced by electrodeposition on steel substrate discs from the modified Watts bath. The resultant coatings were evaluated in terms of their surface morphology by atomic force microscopy and thermomechanical and electrochemical corrosion characteristics. The electrodeposited coatings showed variation in the electrochemical and thermomechanical behavior as the function of GO content where they show the optimum characteristics for 0.1 wt.% GO. The relatively lower concentrations of GO produced composites with greater surface homogeneity and lower roughness, whereas when the GO content is increased, the coatings show increased surface roughness. Electrochemical corrosion resistance of nickel is increased by incorporation of GO up to 0.1 wt.% due to decreased grain boundary area in the coatings and the uniform dispersion of the nanophase ensured by prior probe sonication and magnetic stirring during the co-deposition. The nickel composite coatings with 0.1 wt.% GO also showed improved thermomechanical behavior with higher recovery at 473 K. [ABSTRACT FROM AUTHOR]

Background: Sleep disorders can occur in early Parkinson's disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. Objective: To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia, and probable REM sleep behavior disorder (pRBD) in early PD. Methods: Data were obtained from the Parkinson's Progression Markers Initiative (PPMI). EDS, insomnia, and pRBD were defined using the Epworth Sleepiness Scale, MDS-UPDRS Part I sub-item 1.7, and RBD screening questionnaire. Results: 218 PD subjects and 102 controls completed 5 years of follow-up. At baseline, 69 (31.7%) PD subjects reported one type of sleep disturbance, 25 (11.5%) reported two types of sleep disturbances, and three (1.4%) reported all three types of sleep disturbances. At 5 years, the number of PD subjects reporting one, two, and three types of sleep disturbances was 85 (39.0%), 51 (23.4%), and 16 (7.3%), respectively. Only 41(18.8%) patients were taking sleep medications. The largest increase in frequency was seen in insomnia (44.5%), followed by EDS (32.1%) and pRBD (31.2%). Insomnia was the most common sleep problem at any time over the 5-year follow-up. The frequency of sleep disturbances in HCs remained stable. Conclusions: There is a progressive increase in the frequency of sleep disturbances in PD, with the number of subjects reporting multiple sleep disturbances increasing over time. Relatively a few patients reported multiple sleep disturbances, suggesting that they can have different pathogenesis. A large number of patients were not treated for their sleep disturbances. [ABSTRACT FROM AUTHOR]

In Earth science, original data elaboration is often very complex and the results are generally provided in the form of (computer-made) maps, a qualitative representation. The aim of this paper is to illustrate a graphic method of analysis that allows the reverse: tracing back, on scientific bases, quantitative data from computer-mapped information, by using widely-available graphic tools, including an estimate of the precision of the numerical outcomes. That may be needed, e.g., for independent evaluation of published data or, for comparison with new elaborations. A NASA video was used as an example, reconstructing the maps of the Earth surface yearly from 1998 to 2017. Static frames were extracted from it and used to obtain numerical data on the evolution of the min/max snow/ice-covered land/sea surfaces, separately for the two hemispheres. The use of the proposed method allows concerned scientists to obtain the quantitative values of the relevant data, including an uncertainty estimate, e.g., in order to compare them with those found in the literature and on websites. The paper focuses on the map-analysis method, and on the metrological evaluation of the uncertainty of the retrieved data. Finally, some quantitative results are commented and found consistent with literature data on the same subject matter. [ABSTRACT FROM AUTHOR]

The major difficulty to study bone preservation is to define which diagenetic parameters need to be taken into account when any information on environmental conditions is missing. Through this research, we contribute towards understanding the complex interplay of factors that affects human bones during diagenetic process. The work focuses on how organic and mineral components influence each other and how they influence the resulting micro-structural assessment of human bone. The mineral and organic properties of 24 adult human long bones from archaeological to contemporary burials in Milan (Italy) were characterized through different analytical techniques, in relation to the preservation of their microstructure and porosity. The 3D microstructure of the bone tissue was carried out through the use of phase contrast synchrotron radiation computed micro-tomography (SR-μCT). The results show that when diagenesis proceeds, (i) the bone tissue is progressively attacked by microbes; (ii) the diagenetic porosity increases at the expense of vascular ones; (iii) the volumes, diameters, and interconnections of vascular canals are markedly reduced; (iii) the amount of organic and carbonate fraction decreases whereas bone crystallinity and mean crystal length increase; (iv) the Ca/P mole ratio in CHA crystals increases; (v) the anisotropy along c-axis in CHA crystals is lost, resulting in an increase of their domain size. Since the conservation of organic and mineral fractions is variable in relation to bone microstructure within the same period and site, the research points out the needs to perform a multi-analytical approach to characterize the bone diagenesis at different scales of observation. [ABSTRACT FROM AUTHOR]

Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of putaminal 18F-DOPA uptake. Three of them had significantly raised nigral 11C-PK11195 binding bilaterally. These findings indicate that nigrostriatal dysfunction and neuroinflammation occur in LRRK2-NMCs. Studies in larger cohorts with appropriate follow-up are needed to elucidate the significance of neuroinflammation in the premotor phase of LRRK2-PD. [ABSTRACT FROM AUTHOR]

The lack of robust and low-cost sorbent materials still represents a formidable technological barrier for long-term storage of (renewable) thermal energy and more generally for Adsorptive Heat Transformations—AHT. In this work, we introduce a novel approach for synthesizing cement-based composite sorbent materials. In fact, considering the number of available hygrosopic salts that can be accommodated into a cementitious matrix—whose morphological properties can be also fine-tuned—the new proposed in situ synthesis paves the way to the generation of an entire new class of possible sorbents for AHT. Here, solely focusing on magnesium sulfate in a class G cement matrix, we show preliminary morphological, mechanical and calorimetric characterization of sub-optimal material samples. Our analysis enables us to theoretically estimate one of the most important figures of merit for the considered applications, namely the energy density which was found to range within 0.088–0.2 GJ/m3 (for the best tested sample) under reasonable operating conditions for space heating applications and temperate climate. The above estimates are found to be lower than other composite materials in the literature. Nonetheless, although no special material optimization has been implemented, our samples already compare favourably with most of the known materials in terms of specific cost of stored energy. Finally, an interesting aspect is found in the ageing tests under water sorption-desorption cycling, where a negligible variation in the adsorption capability is demonstrated after over one-hundred cycles. [ABSTRACT FROM AUTHOR]