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The 2020 COVID-19 pandemic resulted in worldwide school closures, moving children's education to the home setting, with parents taking over the responsibility of supporting their child's learning while managing other aspects of living with the pandemic. The impact of emergency remote learning has increased significance for children with disabilities who, abruptly, no longer had access to the specialized instruction and expertise of educators and service providers in the school setting. Employing an ecological systems framework, this study sought to examine the impact of emergency remote learning on the families of school-aged children with a range of disabilities in Singapore. Semi-structured interviews were conducted with 42 parents of children with disabilities from primary and special schools. Findings revealed parents took on multiple roles while balancing several responsibilities in supporting their child's emergency remote learning, with the additional or intensified demands heightening challenges. Several factors were found to either facilitate or challenge parents' ability to engage in supporting their child's emergency remote learning such as flexibility in meeting schoolwork deadlines, having regular check-ins with the child and family, technological familiarity, and, at a macro-level, having supportive employers. Implications for practice and policy include the need to equip students with technology and self-management skills, providing more coordinated supports for students and their families across government and educational bodies to reduce learning loss while alleviating pressure on parents. Highlights: Parents of children with disabilities across primary schools and special schools in Singapore participated in semi-structured interviews regarding their experience of emergency remote learning. Key parental challenges during the pandemic lay in new or abruptly intensified work and family responsibilities. Coordinated supports at the various levels of the ecological systems framework are needed to support families through large-scale school closures. [ABSTRACT FROM AUTHOR]

Social and non-social deficits in autism spectrum disorders (ASD) persist into adulthood and may share common regions of aberrant neural activations. The current meta-analysis investigated activation differences between ASD and neurotypical controls irrespective of task type. Activation likelihood estimation meta-analyses were performed to examine consistent hypo-activated and/or hyper-activated regions for all tasks combined, and for social and non-social tasks separately; meta-analytic connectivity modelling and behavioral/paradigm analyses were performed to examine co-activated regions and associated behaviors. One hundred studies (mean age range = 18–41 years) were included. For all tasks combined, the ASD group showed significant (p <.05) hypo-activation in one cluster around the left amygdala (peak − 26, -2, -20, volume = 1336 mm3, maximum ALE = 0.0327), and this cluster co-activated with two other clusters around the right cerebellum (peak 42, -56, -22, volume = 2560mm3, maximum ALE = 0.049) Lobule VI/Crus I and the left fusiform gyrus (BA47) (peak − 42, -46, -18, volume = 1616 mm3, maximum ALE = 0.046) and left cerebellum (peak − 42, -58, -20, volume = 1616mm3, maximum ALE = 0.033) Lobule VI/Crus I. While the left amygdala was associated with negative emotion (fear) (z = 3.047), the left fusiform gyrus/cerebellum Lobule VI/Crus I cluster was associated with language semantics (z = 3.724) and action observation (z = 3.077). These findings highlight the left amygdala as a region consistently hypo-activated in ASD and suggest the potential involvement of fusiform gyrus and cerebellum in social cognition in ASD. Future research should further elucidate if and how amygdala-fusiform/cerebellar connectivity relates to social and non-social cognition in adults with ASD. [ABSTRACT FROM AUTHOR]

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The extent to which early social communication behaviors predict later communication and intellectual outcomes was investigated via retrospective video analysis. Joint attention, imitation, and complex object play behaviors were coded from edited home videos featuring scenes of 29 children with ASD at 9-12 and/or 15-18 months. A quantitative interval recording of behavior and a qualitative rating of the developmental level were applied. Social communication behaviors increased between 9-12 and 15-18 months. Their mean level during infancy, but not the rate of change, predicted both Vineland Communication scores and intellectual functioning at 3-7 years. The two methods of measurement yielded similar results. Thus, early social communicative behaviors may play pivotal roles in the development of subsequent communication and intellectual functioning. [ABSTRACT FROM AUTHOR]

Benign prostatic hyperplasia (BPH) is one of the most common conditions associated with the aging male. Surgical management of lower urinary tract symptoms attributed to BPH has progressed over time as urologic surgeons search for more innovative and less invasive forms of treatment. Transurethral resection of the prostate (TURP) has long been the 'gold standard' to which all other forms of treatment are compared. There are several different methods of surgical treatment of BPH, including whole gland enucleation/intact removal, vaporization, and induction of necrosis with delayed reabsorption as well as hybrid techniques. As with any form of surgical intervention, long-term results define success. Long-term follow-up consists of examining overall efficacy with attention to associated adverse events. TURP has the luxury of the longest follow-up, while less invasive forms of treatment starting to acquire long-term data. There are several surgical options for BPH; newer methods do show promise, while the 'gold standard' continues to demonstrate excellent surgical results. [ABSTRACT FROM AUTHOR]

It has long been appreciated that a healthy lifestyle plays a critical role in cardiovascular health. It is now apparent that the same is true in the development of benign prostatic hyperplasia (BPH). Prospective cohort data originating from recently published randomized trials on the medical treatment of BPH and prevention of prostate cancer have been invaluable. A growing body of evidence suggests that exercise and the intake of specific macronutrients and micronutrients through regular diet play a beneficial role. Most strikingly, the magnitude of these effects is similar to medical therapies using α-blockers and 5-α-reductase inhibitors. The use of supplements for prostate disease is a multibillion dollar business in the United States, and supplements are more commonly prescribed than medical therapy in many countries. In contrast to consumption of micronutrients through regular diet, supplemental intake of micronutrients and phytotherapies currently lack evidence to support their efficacy. [ABSTRACT FROM AUTHOR]