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Background: The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives are to (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birth defects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of various chemicals, including tobacco. Methods: The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarize recent results, and suggest future directions. In particular, this report provides the latest details from questionnaire surveys, face-to-face examinations, and a collection of biological specimens from children and measurements of their chemical exposures. Results: The latest findings indicate different risk factors of parental characteristics on birth outcomes and the mediating effect between socioeconomic status and children that are small for the gestational age. Maternal serum folate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birth size and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones. We also found significant associations between the chemical levels and neuro development, asthma, and allergies. Conclusions: Chemical exposure to children can occur both before and after birth. Longer follow-up for children is crucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast, considering shifts in the exposure levels due to regulation is also essential, which may also change the association to health outcomes. This study found that individual susceptibility to adverse health effects depends on the genotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examining molecular biology perspectives. International collaborations can add a new dimension to the current knowledge and provide novel discoveries in the future. [ABSTRACT FROM AUTHOR]

The main aim was to assess Nepali adults' knowledge, health beliefs, and health promoting behaviors regarding cardiovascular diseases (CVDs). A descriptive, cross sectional study was conducted in five wards of Lalitpur Sub-Metropolitan City. A random sample of 300 Nepali individuals aged 20-65 years completed the heart disease knowledge questionnaire and health beliefs related to cardiovascular diseases. The health belief model related to CVDs was used. Sociodemographic and personal information was collected. Of the adults 45.3% were aged 20-40 years, and 50.7% were male. The male participants smoked and consumed alcohol more than the female participants (p < 0.05). The mean score on the heart disease knowledge questionnaire was 11.8 ± 4.6. Adults between 20 and 40 years age, non smokers, and daily exercisers had greater knowledge on CVDs. The mean score on the four subscales of the health beliefs related to cardiovascular disease scale were as follows: perceived susceptibility (11.5 ± 2.5), perceived severity (12.1 ± 3.5), perceived benefits (20.1 ± 2.9) and perceived barriers (19.4 ± 3.3). Adults performing health promoting activities had better knowledge and greater perceived susceptibility. A simple regression showed knowledge and education were predictors of health promoting activities. Adults who were performing more than two activities for health promotion had better knowledge of CVDs and perceived more susceptibility. Identifying the health needs, understanding cultural beliefs and misconceptions, and adopting health-promoting actions might help to improve the health behavior of Nepali adults. [ABSTRACT FROM AUTHOR]