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How a protein propagates the conformational changes throughout its structure remains largely unknown. In thermosensitive TRP channels, this allosteric communication is triggered by ligand interaction or in response to temperature changes. Because dynamic allostery suggests a dynamic role of disordered regions, in this work we set out to thoroughly evaluate these regions in six thermosensitive TRP channels. Thus, by contrasting the intrinsic flexibility of the transmembrane region as a function of the degree of disorder in those proteins, we discovered several residues that do not show a direct correlation in both parameters. This kind of structural discrepancy revealed residues that are either reported to be dynamic, functionally relevant or are involved in signal propagation and probably part of allosteric networks. These discrepant, potentially dynamic regions are not exclusive of TRP channels, as this same correlation was found in the Kv Shaker channel. [ABSTRACT FROM AUTHOR]

This document is a correction notice for an article titled "Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects" published in the European Biophysics Journal. The correction states that the wrong supplementary figures were initially published with the article, but they have now been replaced with the correct figures. The correction notice also includes a link to the electronic supplementary material. The document concludes with a note from the publisher, Springer Nature, stating their neutrality regarding jurisdictional claims and institutional affiliations. The authors of the article are Abigail García-Morales, Nancy O. Pulido, and Daniel Balleza. [Extracted from the article]

This document is a correction notice for an article titled "Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects" published in the European Biophysics Journal. The correction states that in the original version of the article, the names of the authors were interchanged. The correct author names are Abigail García-Morales, Nancy O. Pulido, and Daniel Balleza. The original article has been corrected. The publisher, Springer Nature, remains neutral regarding jurisdictional claims and institutional affiliations. [Extracted from the article]