1. Tumor characteristics and prognosis in familial breast cancer
- Author
-
Matilde Pensabene, Rossella Lauria, Mario Giuliano, Anna Crispo, Ivana Cerillo, Valeria Forestieri, C. De Angelis, Grazia Arpino, Maurizio Montella, S. De Placido, Raffaella Ruocco, Caterina Condello, Arpino, Grazia, Pensabene, Matilde, Condello, C., Ruocco, Raffaella, Cerillo, Ivana, Lauria, Rossella, Forestieri, Valeria, Giuliano, Mario, DE ANGELIS, Carmine, Montella, M., Crispo, Anna, and DE PLACIDO, Sabino
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,endocrine system diseases ,medicine.medical_treatment ,Genes, BRCA1 ,Estrogen receptor ,0302 clinical medicine ,Surgical oncology ,Young adult ,Family history ,Neoplasm Metastasis ,skin and connective tissue diseases ,Middle Aged ,Prognosis ,female genital diseases and pregnancy complications ,Tumor Burden ,Neoplasm Metastasi ,Receptors, Estrogen ,030220 oncology & carcinogenesis ,Female ,Survival Analysi ,Receptors, Progesterone ,Breast Neoplasm ,Human ,Research Article ,Adult ,medicine.medical_specialty ,animal structures ,Prognosi ,Breast Neoplasms ,03 medical and health sciences ,Young Adult ,Breast cancer ,Genetic ,Internal medicine ,medicine ,Biomarkers, Tumor ,Genetics ,Humans ,Survival analysis ,Radical mastectomy ,Aged ,Neoplasm Staging ,business.industry ,Cancer ,medicine.disease ,Survival Analysis ,030104 developmental biology ,Mutation ,Neoplasm Grading ,business - Abstract
BACKGROUND: Approximately 5-10% of breast cancers are hereditary and their biology and prognosis appear to differ from those of sporadic breast cancers. In this study we compared the biological features and clinical characteristics of non metastatic breast cancer in patients with BRCA mutations versus patients with a family history suggesting hereditary breast cancer but without BRCA mutations (BRCA wild type) versus patients with sporadic disease, and correlated these findings with clinical outcome. METHODS: We retrieved the clinical and biological data of 33 BRCA-positive, 66 BRCA-wild type and 1826 sporadic breast cancer patients contained in a single institution clinical database between 1980 and 2012. Specifically, we recorded age, tumor size, nodal status, treatment type, pattern of relapse, second primary incidence, outcome (disease-free survival and overall survival), and biological features (estrogen receptor [ER], progesterone receptor [PgR], tumor grade, proliferation and c-erbB2 status). Median follow-up was 70 months. RESULTS: BRCA-positive patients were significantly younger than sporadic breast cancer patients, and less likely to be ER-, PgR- or c-erbB2-positive than women with BRCA-wild type or sporadic breast cancer. Tumor size and grade, nodal status and proliferation did not differ among the three groups. Rates of radical mastectomy were 58, 42 and 37%, and those of conservative surgery were 42, 58 and 63% in women with BRCA-positive, BRCA-wild type and sporadic breast cancer (p = 0.03), respectively. The incidence of contralateral breast cancer was 12, 14 and 0% (p
- Full Text
- View/download PDF