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1. Peptide modification by introduction of α-trifluoromethyl substituted amino acids.

Author

Sewald, N., Hollweck, W., Mütze, K., Schierlinger, C., Seymour, L., Gaa, K., Burger, K., Koksch, B., and Jakubke, H.

Abstract

Methodology for the synthesis and incorporation of α-trifluoromethyl substituted amino acids into N- and C-terminal position of peptides is described. The incorporation of α-trifluoromethyl substituted amino acids into strategical positions of peptides enhances proteolytic stability and lipophilicity. Furthermore, it improves transport rates in vivo and permeability through certain body barriers. [ABSTRACT FROM AUTHOR]

Published
1995
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