1. Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma.
- Author
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Shimagaki, Tomonari, Yoshio, Sachiyo, Kawai, Hironari, Sakamoto, Yuzuru, Doi, Hiroyoshi, Matsuda, Michitaka, Mori, Taizo, Osawa, Yosuke, Fukai, Moto, Yoshida, Takeshi, Ma, Yunfei, Akita, Tomoyuki, Tanaka, Junko, Taketomi, Akinobu, Hanayama, Rikinari, Yoshizumi, Tomoharu, Mori, Masaki, and Kanto, Tatsuya
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SERUM , *LIVER cancer , *BIOLOGICAL tags , *PROTHROMBIN , *CIRRHOSIS of the liver - Abstract
Current serum hepatocellular carcinoma (HCC) biomarkers are insufficient for early diagnosis. We aimed to clarify whether serum MFG-E8 can serve as a diagnostic or prognostic biomarker of HCC. Serum MFG-E8 levels of 282 HCC patients, who underwent primary hepatectomy, were examined by ELISA. We also quantified serum MFG-E8 levels in patients with chronic hepatitis (CH), liver cirrhosis (LC), as well as in healthy volunteers (HVs). Serum MFG-E8 levels were significantly lower in HCC patients than in HVs regardless of the etiology of liver disease (3.6 ± 0.1 vs 5.8 ± 0.2 ng/mL, p < 0.0001), and recovered after treatment of HCC. Serum MFG-E8 levels in CH and LC patients were comparable to those in HVs. Serum MFG-E8 could detect HCCs, even α-fetoprotein (AFP)-negative or des-γ-carboxy prothrombin (DCP)-negative HCCs, in CH and LC patients. Our new HCC prediction model using MFG-E8 and DCP (Logit(p) = 2.619 − 0.809 × serum MFG-E8 + 0.0226 × serum DCP) distinguished HCC patients from CH and LC patients with an area under the curve of 0.923, a sensitivity of 81.1%, and a specificity of 89.8%. Futhermore, low preoperative serum MFG-E8 was an independent predictor of poor overall survival. Thus, serum MFG-E8 could serve as a feasible diagnostic and prognostic biomarker for HCC. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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