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The main goal of this study is to investigate the strength and compaction characteristics of soil stabilized by fly ash with multiwalled carbon nanotube (MWCNT) as an additive. The materials used in the study were characterized using microscopic techniques like scanning electron microscopy-energy dispersive spectroscopy (SEM–EDS), and X-ray diffraction (XRD). The soil in the current study was replaced up to 50% by fly ash in the presence of MWCNT and sodium hexametaphosphate (SHMP) in different concentrations. The findings demonstrate that the Atterberg limits and specific gravity decrease with the increase in fly ash, MWCNT, and, SHMP. The maximum (46%) and minimum (24.2%) values of the liquid limit were recorded at 0% and 50% fly ash content, respectively. The maximum (34%) and minimum (20.2%) values of the plastic limit were observed at 0% and 50% fly ash content respectively. The specific gravity of natural soil decreases from the maximum value of 2.68 to the minimum value of 2.53 at 0% and 50% fly ash content, respectively. The optimum moisture content also decreases with the increase in fly ash, MWCNT, SHMP, and vice versa for maximum dry density. 0.01% w/w MWCNT + 80% Soil + 20% Fly Ash + 2% SHMP is the optimal mix. It gives maximum unconfined compressive strength (UCS) value in all the durations of curing, i.e. 0.50, 0.725, and 0.984 MPa at 1, 7, and 28 days of curing, respectively. The UCS value of this combination is 147% more than the UCS value of normal soil cured for 28 days. An economic analysis is also conducted to understand the feasibility of the application of MWCNTs in soil-fly ash mix. [ABSTRACT FROM AUTHOR]

Growing concern over the combustion cost and environment has made road engineers and scientists to explore the possible use of locally available materials for the construction of roads. The present study evaluated the strength and durability characteristics of five sites having locally available silty soils using lime and cement–sand stabilization technique. The test results showed that the cement–sand stabilization technique using 6% cement and 5% local sand resulted in higher strength and durability as compared to lime stabilization. There is also a significant increase in the value of the soaked California bearing ratio (CBR). As unconfined compressive strength (UCS) attained the threshold strength as prescribed by IRC SP 72 2015 for the granular sub-base (GSB) layer, by the use of sand cement stabilization, this technique of stabilization for local silty soils could be used for GSB for low volume road (LVR) construction. As observed from microstructural results which were performed by analysing SEM images, sand cement stabilisation leads to CSH gel and agglomerate formation thereby increasing strength and durability properties. The cost analysis for the replaced stabilized GSB layer showed that using sand–cement stabilization, the estimated cost can be reduced by 56% of the total cost as compared to the conventional method. [ABSTRACT FROM AUTHOR]

Warm mix asphalt mixtures became attractive paving mixes by reducing the production temperature to around 25–40 °C as compared to that of conventional hot mix asphalt (HMA). This study aims to evaluate the warm mix asphalt (WMA) using wax-based additives by incorporating two types of industrial wastes. The potential application of low calcium fly ash (FA), i.e. class F type and marble dust (MD), has been evaluated by varying different percentage. The cylindrical samples were prepared and assessed for moisture susceptibility by being subjected to Marshall stability, retained Marshall stability (RMS), indirect tensile strength (ITS) and tensile strength ratio (TSR) tests. Furthermore, the samples were also evaluated for finding the refusal density, Cantabro loss and the rutting performance. A scanning electron microscope (SEM) was also used to evaluate the size and microstructure of the filler particles. The results revealed that the inclusion of fillers into mixes had significant improvement in the mechanical properties and lowered the rutting value with FA and MD addition. The warm mix additive and fillers used were also useful in reducing the binder content of the mixes. The mixing temperature was found to be in the range of 120–130 °C using the warm mix additive. The optimum usage of FA and MD can be up to 5% based on the evaluation. The statistical results reported that there was a significant difference between FA-based and MD-based WMA. [ABSTRACT FROM AUTHOR]

Low-volume roads are anticipated to have less traffic and provide access to socio-economic activities in rural areas. The present study deals with the stabilisation of soil with locally available waste materials, i.e. low calcium fly ash (FA) and brick dust (BD). These two wastes are available abundantly and lead to an increase in pollution levels. Initially, lime was added to make the silty clayey soils plastic-free. The initial consumption of lime was found to be 5%. Then, the soil was stabilised with cement fly ash and cement brick dust techniques for strength, durability and shrinkage evaluation. The cement was varied from 2 to 8% with FA and BD by fixing the ratio to 1:3 as per AASHTO guidelines. The unconfined compressive strength (UCS), indirect tensile strength test and California bearing ratio were conducted for strength evaluation. The wetting and drying cycles were evaluated for durability analysis. The linear shrinkage cracking was evaluated after the curing period of 28 days. It was observed that there was a magnificent increase in strength and durability values. The maximum UCS attained value was so high that it could act as a replacement for the granular sub-base layer in the pavement structure. The linear shrinkage evaluated at fixed relative humidity was significantly reduced. The statistical analysis reported that there was a significant difference between the two admixtures. The utilisation of these wastes not only enhances strength, but also deficits the cost of construction along with reducing the pollutants in the environment. [ABSTRACT FROM AUTHOR]

Durability of bituminous mixes is affected by presence or intrusion of moisture into it. The intrusion and amount of trapped moisture largely depend on the air voids present in the mixes. This study explores the combined influence of air voids and hydrated lime (HL, as anti-stripping agent) on moisture-induced damage of bituminous mixes prepared from two different aggregate sources. The aggregates used in the study are siliceous sandstone and basalt. Tensile Strength Ratio (TSR) test was used to determine the moisture susceptibility of bituminous mixes. A higher value of TSR depicts that the mixes are more moisture resistant. TSR was reaffirmed to be lowest at an air void range of about 5% to 13% which is termed as pessimum air void range. At this air void range, moisture gets trapped within the mix, resulting in moisture-induced damage. TSR results showed that bituminous mixes prepared with siliceous sandstone is more susceptible to moisture-induced damage as compared to mixes prepared with basalt. Boil water test reconfirmed the results. Use of HL in bituminous mixes improved its moisture-induced damage resistance only marginally. Thus, moisture-induced damage control at pessimum air void range using anti-stripping agent is not always sufficient. Observations show that air void plays a critical role in moisture-induced damage and control of air void during construction needs to be ensured. [ABSTRACT FROM AUTHOR]

Introduction: Universal coverage of vaccines alone cannot be relied upon to protect at-risk populations in lower- and middle-income countries against the impact of the coronavirus disease 2019 (COVID-19) pandemic and newer variants. Live vaccines, including Bacillus Calmette–Guérin (BCG), are being studied for their effectiveness in reducing the incidence and severity of COVID-19 infection. Methods: In this multi-centre quadruple-blind, parallel assignment randomised control trial, 495 high-risk group adults (aged 18–60 years) were randomised into BCG and placebo arms and followed up for 9 months from the date of vaccination. The primary outcome was the difference in the incidence of COVID-19 infection at the end of 9 months. Secondary outcomes included the difference in the incidence of severe COVID-19 infections, hospitalisation rates, intensive care unit stay, oxygen requirement and mortality at the end of 9 months. The primary analysis was done on an intention-to-treat basis, while safety analysis was done per protocol. Results: There was no significant difference in the incidence rates of cartridge-based nucleic acid amplification test (CB-NAAT) positive COVID-19 infection [odds ratio (OR) 1.08, 95% confidence interval (CI) 0.54–2.14] in the two groups, but the BCG arm showed a statistically significant decrease in clinically diagnosed (symptomatic) probable COVID-19 infections (OR 0.38, 95% CI 0.20–0.72). Compared with the BCG arm, significantly more patients developed severe COVID-19 pneumonia (CB-NAAT positive) and required hospitalisation and oxygen in the placebo arm (six versus none; p = 0.03). One patient belonging to the placebo arm required intensive care unit (ICU) stay and died. BCG had a protective efficacy of 62% (95% CI 28–80%) for likely symptomatic COVID-19 infection. Conclusions: BCG is protective in reducing the incidence of acute respiratory illness (probable symptomatic COVID-19 infection) and severity of the disease, including hospitalisation, in patients belonging to the high-risk group of COVID-19 infection, and the antibody response persists for quite a long time. A multi-centre study with a larger sample size will help to confirm the findings in this study. Clinical Trials Registry: Clinical Trials Registry India (CTRI/2020/07/026668). Plain Language Summary: The Bacillus Calmette–Guérin (BCG) vaccine has been studied previously in several settings, including reducing childhood mortalities due to viral infections and induction of trained immunity and reducing upper respiratory tract infections and pneumonia in older adults. This multi-centre trial has tried to evaluate the efficacy of BCG revaccination in reducing the incidence and severity of COVID-19 infections in adults between 18 and 60 years of age belonging to the high-risk group owing to the presence of comorbidities including diabetes, chronic kidney disease, chronic liver disease and chronic lung diseases. A single dose of BCG vaccine produced significantly high titres of BCG antibodies lasting for six months. While there was no significant reduction in the incidence of COVID-19 infection, there was an 8.4% reduction in the incidence of symptomatic COVID-19 disease at the end of 9 months of follow-up. In addition, there were significantly fewer severe COVID-19 infections requiring hospital stay and oxygen support. However, the overall numbers of severe COVID-19 infections were low. Thus, the study shows that BCG can protect against symptomatic and severe COVID-19 disease. However, it might not reduce the incidence of new infections. The study results are significant for low- and middle-income countries without adequate coverage of primary doses of COVID-19 vaccination, let alone the booster doses. Future studies should evaluate the BCG vaccine's efficacy as a booster compared with routine COVID-19 vaccine boosters. [ABSTRACT FROM AUTHOR]

Correction to: Efficacy of Bacillus Calmette-Guérin (BCG) Vaccination in Reducing the Incidence and Severity of COVID-19 in High-Risk Population (BRIC): a Phase III, Multi-centre, Quadruple-Blind Randomised Control Trial The original article can be found online at https://doi.org/10.1007/s40121-022-00703-y. The supplementary material file has been corrected and the original article has been updated. [Extracted from the article]