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Abstract  As the domain of communication systems grows, heterogeneity among computers and subnetworks employed for a task also increases. Channel bandwidth available for a message on a communication network varies with time and link. This variation can have a significant effect on performance of an individual message and also that of the network as a whole. Therefore, it is important to understand effects of bandwidth heterogeneity on the network performance in order to optimally utilize a heterogeneous communication network. The ability to use such a network optimally is highly desirable in many applications such as network-based data-intensive high performance computing. The main goal of this paper is to analyze effects of temporal and spatial heterogeneity on performance of individual messages in detail via an extensive simulation, in terms of throughput, end-to-end delay, etc. Also, the problems of path selection and multi-path data transfer are considered to illustrate how the analysis results may be used in the future effort of optimizing the network performance by taking channel bandwidth heterogeneity into account. [ABSTRACT FROM AUTHOR]

Abstract   One of the distinct characteristics of computing platforms shared by multiple users such as a cluster and a computational grid is heterogeneity on each computer and/or among computers. Temporal heterogeneity refers to variation, along the time dimension, of computing power available for a task on a computer, and spatial heterogeneity represents the variation among computers. In minimizing the average parallel execution time of a target task on a spatially heterogeneous computing system, it is not optimal to distribute the target task linearly proportional to the average computing powers available on computers. In this paper, effects of the temporal and spatial heterogeneity on performance of a target task have been analyzed in terms of the mean and standard deviation of parallel execution time. Based on the analysis results, an approach to load balancing for minimizing the average parallel execution time of a target task is described. The proposed approach whose validity has been verified through simulation considers temporal and spatial heterogeneities in addition to the average computing power on each computer. [ABSTRACT FROM AUTHOR]

AMP-activated protein kinase (AMPK, also known as SNF1A) has been primarily studied as a metabolic regulator that is activated in response to energy deprivation. Although there is relatively ample information on the biochemical characteristics of AMPK, not enough data exist on the in vivo function of the kinase. Here, using the Drosophila model system, we generated the first animal model with no AMPK activity and discovered physiological functions of the kinase. Surprisingly, AMPK-null mutants were lethal with severe abnormalities in cell polarity and mitosis, similar to those of lkb1-null mutants. Constitutive activation of AMPK restored many of the phenotypes of lkb1-null mutants, suggesting that AMPK mediates the polarity- and mitosis-controlling functions of the LKB1 serine/threonine kinase. Interestingly, the regulatory site of non-muscle myosin regulatory light chain (MRLC; also known as MLC2) was directly phosphorylated by AMPK. Moreover, the phosphomimetic mutant of MRLC rescued the AMPK-null defects in cell polarity and mitosis, suggesting MRLC is a critical downstream target of AMPK. Furthermore, the activation of AMPK by energy deprivation was sufficient to cause dramatic changes in cell shape, inducing complete polarization and brush border formation in the human LS174T cell line, through the phosphorylation of MRLC. Taken together, our results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures. [ABSTRACT FROM AUTHOR]

With the growing emphasis on the development of scientific inquiry skills, there is a strong need for more research on students' ability to collect and interpret evidence. This paper calls attention to the notion of evidentiary competence that refers to the concepts and reasoning skills involved in the collection, organization, and interpretation of data. We proposed a set of concepts and skills involved in evidentiary competence and examined sixth of them—the priority, relevancy, objectivity, replicability of evidence, and the interpretation of examples and tables—using a written instrument contextualized in atmospheric science. Analyses of 40 sixth grade students' answers and explanations revealed that their understanding of scientific evidence and the data collection process was quite weak in several respects. For example, many students neither appreciated the role of empirical evidence in scientific inquiry, nor distinguished relevant evidence from irrelevant evidence, nor understood the importance of reliable and objective observations, nor interpreted examples and tables appropriately. Results suggest that more explicit instructions are needed in order to strengthen students' ability to collect and interpret data, especially in the current data rich information age. [ABSTRACT FROM AUTHOR]

C3H/HeJ mice were sensitized with ovalbumin (OVA) and choleratoxin (CT) for 5 weeks, and then Bifidobacterium bifidum BGN4 was administered continuously for 7 weeks, starting 2 weeks before (pre-treatment group) and 2 weeks after (post-treatment group) the initial sensitization. After sensitization, the OVA-induced (sham group) mice showed growth inhibition and had scab-covered tails which was associated with serum levels of 9887±175 ng OVA-specific IgE/ml and 758±525 ng IgG1/ml. The sera of the pre-treatment group had 4805±245 ng OVA-specific IgE/ml and 193±87 ng IgG1/ml, as well as less severe tail symptoms. The sera of the post-treatment group had 5723±207 ng OVA-specific IgE/ml but the IgG1 and IgG2a levels were the same as those of the sham group. In spleen cultures, both pre-treatment and post-treatment increased the levels of IFN-γ but decreased the levels of IL-6 and IL-18. Taken together, the in vivo and in vitro results show that treatment with Bifidobacterium before OVA sensitization suppresses or modulates the allergic response more effectively than treatment with Bifidobacterium following OVA sensitization. [ABSTRACT FROM AUTHOR]