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Optoelectronic neural interfaces can leverage the photovoltaic effect to convert light into electrical current, inducing charge redistribution and enabling nerve stimulation. This method offers a non-genetic and remote approach for neuromodulation. Developing biodegradable and efficient optoelectronic neural interfaces is important for achieving transdermal stimulation while minimizing infection risks associated with device retrieval, thereby maximizing therapeutic outcomes. We propose a biodegradable, flexible, and miniaturized silicon-based neural interface capable of transdermal optoelectronic stimulation for neural modulation and nerve regeneration. Enhancing the device interface with thin-film molybdenum significantly improves the efficacy of neural stimulation. Our study demonstrates successful activation of the sciatic nerve in rodents and the facial nerve in rabbits. Moreover, transdermal optoelectronic stimulation accelerates the functional recovery of injured facial nerves. Optoelectronic neural interfaces allow for non-genetic and remote modulation of neural activity. Here, the authors propose a biodegradable, flexible and miniaturized neural interface based on molybdenum-modified silicon diodes that allows transdermal neuromodulation and promotes nerve regeneration. [ABSTRACT FROM AUTHOR]

Purpose: To explore the position change of fetal conus medullaris by ultrasound, and to propose gestational age-specific references for the lower limits of fetal conus medullaris level. Methods: We prospectively collected the imaging and clinical data of fetuses whose mothers accepted routine prenatal ultrasonic follow-ups in the Department of Medical Ultrasonics, Chinese PLA General Hospital, between November 2020 and April 2021. By assigning to the conus medullaris levels, calculating statistical data, and performing linear regression analysis, we determined the correlation between the conus medullaris level and gestational week, as well as between the 95th percentile of the conus medullaris level, i.e., the lower limit of the conus medullaris level, and gestational week. Results: We included 1202 different fetuses at 17–40 gestational weeks in the study. Both the conus medullaris level and the 95th percentile of the conus medullaris level were linearly correlated with gestational week. We calculated the adjusted values of the lower limits of fetal conus medullaris levels, that is, the theoretical references of the lower limits, according to the linear regression equation, and composed a comparison table. Conclusion: The fetal conus medullaris position continues changing cranially with gestational weeks during the whole pregnancy. The conus medullaris of a term fetus should not lie below the L2 vertebra level at birth. We proposed reference criteria of fetal low-lying conus medullaris for each gestational week from 17 to 40 weeks of gestational age, which potentially help prompt diagnosis and improve prognosis of fetal tethered cord syndrome. [ABSTRACT FROM AUTHOR]

Single-stage surgery was performed to resect the intramedullary AVM and lipoma, detether the spinal cord, excise the lipidated filum terminale, and rebuild the dural sac. Spinal arteriovenous malformations (SAVMs) represent 3-7% of spinal cord tumors, with congenital intramedullary arteriovenous malformations (AVMs) being the rarest [[6]]. Microsurgery promises a good prognosis: lipoma resection detethered the spinal cord; removal of the intramedullary AVM released the venous hypertension and congestion. [Extracted from the article]