1. Highly selective separation of medical isotope 99mTc from irradiated 100Mo target using PEG-based resins.
- Author
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Fan, Fangli, Cheng, Nianwei, Jin, Zhuofan, Chen, Desheng, Tian, Wei, Huang, Qinggang, Cao, Shiwei, Tan, Cunmin, Wang, Jieru, Wu, Xiaolei, Bai, Jing, and Qin, Zhi
- Subjects
ISOTOPE separation ,RADIOACTIVE tracers ,RADIOISOTOPES ,COMMUNITIES ,NUCLIDES ,COLUMN chromatography - Abstract
The aim of present study was to determine the efficiency of commercially available PEG-based resins for separation of
99m Tc from irradiated100 Mo target. Stable and radioactive tracer studies demonstrated that these PEG-based resins have extreme selectivity toward ReO4 − (99m TcO4 − ) over MoO4 2− ions. Moreover, PEG-based resins still have 95% adsorption efficiency even after 600 kGy γ-irradiation, suggesting the excellent irradiation stability. The adsorption rate of ReO4 − and99m TcO4 − rapidly increased to 90% in 10 s. Subsequently, three-column chromatographic processing based on these superior resins for isolating99m Tc was developed and examined. The separation investigation of99m Tc medical radioisotope produced by100 Mo(p, 2n)99m Tc reaction was successfully performed. The recovery yield and the radionuclidic purity of99m Tc was about 90% and 99.9%, respectively. Moreover, the separation of99m Tc from a low specific activity99 Mo was also investigated. We are excited about the potential of this procedure with these accessible commercial availability PEG-based resins to address99m Tc separation problems and increase access to medical nuclide99m Tc for the general community. [ABSTRACT FROM AUTHOR]- Published
- 2023
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