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The aim of present study was to determine the efficiency of commercially available PEG-based resins for separation of 99mTc from irradiated 100Mo target. Stable and radioactive tracer studies demonstrated that these PEG-based resins have extreme selectivity toward ReO4− (99mTcO4−) over MoO42− ions. Moreover, PEG-based resins still have 95% adsorption efficiency even after 600 kGy γ-irradiation, suggesting the excellent irradiation stability. The adsorption rate of ReO4− and 99mTcO4− rapidly increased to 90% in 10 s. Subsequently, three-column chromatographic processing based on these superior resins for isolating 99mTc was developed and examined. The separation investigation of 99mTc medical radioisotope produced by 100Mo(p, 2n)99mTc reaction was successfully performed. The recovery yield and the radionuclidic purity of 99mTc was about 90% and 99.9%, respectively. Moreover, the separation of 99mTc from a low specific activity 99Mo was also investigated. We are excited about the potential of this procedure with these accessible commercial availability PEG-based resins to address 99mTc separation problems and increase access to medical nuclide 99mTc for the general community. [ABSTRACT FROM AUTHOR]

This work reports the synthesis, radiolabeling and preliminary biodistribution results in tumor-bearing mice of [Tc(CO)(PA-TZ-CHC)]. The novel colchicine (CHC) ligand was successfully synthesized via 'click' reaction. Radiolabeling was performed in high yield with [Tc(CO)] core to get [Tc(CO)(PA-TZ-CHC)], which was hydrophilic and cationic, and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that [Tc(CO)(PA-TZ-CHC)] accumulated in the tumor with good uptake while comparatively low retention. The clearance of the Tc-complex from normal organs was fast, resulting in increasing tumor/blood and tumor/muscle ratios. The promising results in preliminary biodistribution studies warrant further research to improve tumor targeting efficacy and pharmacokinetic profile of radiolabeled CHC derivative by structural modification. [ABSTRACT FROM AUTHOR]

This study reports the synthesis, radiolabeling and preliminary biodistribution results of [Tc(CO)(MN-TZ-BPA)] in tumor-bearing mice. The novel nitroimidazole derivative was successfully synthesized by conjugation of bis(pyridin-2-ylmethyl)amine (BPA) to 2-methyl-5-niroimidazole via 'click' reaction. The ligand could be labeled by [Tc(CO)] core in high yield to get [Tc(CO)(MN-TZ-BPA)], which was very hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that [Tc(CO)(MN-TZ-BPA)] accumulated in the tumor with certain initial uptake while poor retention. The rapid clearance from normal organs with favorable tumor/muscle ratios warrants further research to improve tumor targeting efficacy and pharmacokinetic profile of radiolabeled nitroimidazoles by structural modification. [ABSTRACT FROM AUTHOR]

This work reports the synthesis, radiolabeling and preliminary biodistribution results in tumor-bearing mice of [Tc(CO)(IDA-PEG-CB)]. The novel chlorambucil derivative was successfully synthesized by conjugation of iminodiacetic acid (IDA) to chlorambucil via a pegylated linker. The ligand could be labeled by [Tc(CO)] core in high yield to get [Tc(CO)(IDA-PEG-CB)], which was very hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that [Tc(CO)(IDA-PEG-CB)] accumulated in the tumor with favorable uptake and retention. The good accumulation in tumor tissue with high tumor/muscle ratios warrants further research to improve tumor targeting efficacy and pharmacokinetic profile of radiolabeled chlorambucil derivative by structural modification. [ABSTRACT FROM AUTHOR]