1. Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells.
- Author
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Tran, Thi, Lavillegrand, Jean-Remi, Lereverend, Cedric, Esposito, Bruno, Cartier, Lucille, Montabord, Melanie, Tran-Rajau, Jaouen, Diedisheim, Marc, Gruel, Nadège, Ouguerram, Khadija, Paolini, Lea, Lenoir, Olivia, Pinteaux, Emmanuel, Brabencova, Eva, Tanchot, Corinne, Urquia, Pauline, Lehmann-Che, Jacqueline, Le Naour, Richard, Merrouche, Yacine, and Stockmann, Christian
- Subjects
MYELOID cells ,HIGH cholesterol diet ,HIGH-fat diet ,MONOCYTES ,DYSLIPIDEMIA - Abstract
Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity and inflammation. However, the role of pro-atherogenic environment and its associated low-grade inflammation in tumor progression remains underexplored. Here we show that feeding C57BL/6J mice with a non-obesogenic high fat high cholesterol diet (HFHCD) for two weeks to induce mild dyslipidemia, increases the pool of circulating Ly6C
hi monocytes available for initial melanoma development, in an IL-1β-dependent manner. Descendants of circulating myeloid cells, which accumulate in the tumor microenvironment of mice under HFHCD, heighten pro-angiogenic and immunosuppressive activities locally. Limiting myeloid cell accumulation or targeting VEGF-A production by myeloid cells decrease HFHCD-induced tumor growth acceleration. Reverting the HFHCD to a chow diet at the time of tumor implantation protects against tumor growth. Together, these data shed light on cross-disease communication between cardiovascular pathologies and cancer. Obesity and inflammation have been associated to cancer progression. Here, the authors show that high fat and cholesterol diet, in a non-obese context, promotes tumourigenesis through increasing inflammatory monocytes and myeloid-derived pro-angiogenic factors. [ABSTRACT FROM AUTHOR]- Published
- 2022
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