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Background: The EORTC QLQ-STO22 (QLQ-STO22) is a firmly established and validated measure of health-related quality of life (HRQoL) for people with gastric cancer (GC), developed over two decades ago. Since then there have been dramatic changes in treatment options for GC. Also, East Asian patients were not involved in the development of QLQ-STO22, where GC is most prevalent and the QLQ-STO22 is widely used. A review with appropriate updating of the measure was planned. This study aims to capture HRQoL issues associated with new treatments and the perspectives of patients and health care professionals (HCPs) from different cultural backgrounds, including East Asia. Methods: A systematic literature review and open-ended interviews were preformed to identify potential new HRQoL issues relating to GC. This was followed by structured interviews where HCPs and patients reviewed the QLQ-STO22 alongside new issues regarding relevance, importance, and acceptability. Results: The review of 267 publications and interviews with 104 patients and 18 HCPs (48 and 9 from East Asia, respectively) generated a list of 58 new issues. Three of these relating to eating small amounts, flatulence, and neuropathy were recommended for inclusion in an updated version of the QLQ-STO22 and covered by five additional questions. Conclusions: This study supports the content validity of the QLQ-STO22, suggesting its continued relevance to patients with GC, including those from East Asia. The updated version with additional questions and linguistic changes will enhance its specificity, but further testing is required. [ABSTRACT FROM AUTHOR]

The formation of phase clusters in a hierarchical ensemble of coupled Van der Pol oscillators has been studied. It has been shown that a hierarchically organized ensemble at the dynamic mode demonstrates the formation of phase clusters at each hierarchy level and this is accompanied by the clustering of frequencies corresponding to the spectrum of normal modes. It has been shown that clustering is not destroyed in the case of nonidentity of the eigenfrequencies of the oscillators and the random distribution of their initial phases. In the clustering state, the elements of the ensemble that are at the same hierarchy level have the same phase values. [ABSTRACT FROM AUTHOR]

Purpose: Cutaneous toxicities from novel anticancer treatments are an emerging problem in dermato-oncology. However, the prevalence of those toxicities and necessity of skin consultations are currently unknown. The purpose of our study was to perform an epidemiologic analysis of cutaneous toxicities that were referred to our cutaneous toxicity clinic in Athens, Greece.Methods: All patients examined at the oncodermatology department over a 42-month period were included. Gender, age, type of cancer, type of antineoplastic treatment, and type of toxicity were recorded and analyzed.Results: Four hundred fifty-nine patients (182 males, 277 females) with mean age (SD) 60.6 years (13.05) were included in the analysis. Six hundred seventy-two cutaneous toxicities were recorded. Chemotherapy-induced toxicities were the most commonly recorded incidents, with taxanes being the most commonly involved agent. Immune-related adverse events (IRAEs) have steadily increased over the past 3 years. Treatment modifications due to skin toxicities were more common in patients treated with targeted agents and immune checkpoint inhibitors than in those treated with chemotherapy. The toxicities that led to the most treatment modifications were acneiform eruptions and perionychias. The most common IRAEs recorded were psoriasis in 11 patients, followed by pruritus, macular rash, and lichenoid-type eruptions. In addition, 4 interesting cases of IRAEs are discussed.Conclusion: Antineoplastic treatments can lead to a wide range of cutaneous toxicities. Our study underlines the need for a multidisciplinary approach in oncologic patients. The dermatologists' role is crucial in effectively managing those reactions and preventing antineoplastic drug dose adjustments or discontinuation of treatment. [ABSTRACT FROM AUTHOR]

We propose a superconducting metamaterial design consisting of meta-atoms which are each composed of a direct current superconducting quantum interference device and a superconducting rod. This design provides negative refraction index behavior for a wide range of structure parameters. [ABSTRACT FROM AUTHOR]

In the middle of the second decade of the 21st century, Complexity Science has reached a turning point. Its rapid advancement over the last 30 years has led to remarkable new concepts, methods and techniques, whose applications to complex systems of the physical, biological and social sciences has produced a great number of exciting results. The approach has so far depended almost exclusively on the solution of a wide variety of mathematical models by sophisticated numerical techniques and extensive simulations that have inspired a new generation of researchers interested in complex systems. Still, the impact of Complexity beyond the natural sciences, its applications to Medicine, Technology, Economics, Society and Policy are only now beginning to be explored. Furthermore, its basic principles and methods have so far remained within the realm of high level research institutions, out of reach of society's urgent need for practical applications. To address these issues, evaluate the current situation and bring Complexity Science closer to university students, a series of Ph.D. Schools on Mathematical Modeling of Complex Systems was launched, starting in July 2011 at the University of Patras, Greece (see ). These Schools lasted two weeks each and included, beyond introductory lectures, a conference component of 2-3 days where students were exposed to recent results mainly presented by young researchers. The Ph.D. Schools continued successfully, the 2nd one taking place at Pescara, Italy (2012), (see ), the 3d one at Heraklion, Crete, Greece (2013) (see ) and the 4th one in Athens, Greece (2014) (see ) (2014). This Special Theme volume contains the proceedings of the 5th Ph.D. School-Conference of this series held at the University of Patras, Greece, 20 30 July, 2015 (see ) and includes many of the introductory lectures and research talks presented at this event. The primary concern of all those that participated in these events was to emphasize the role of mathematics, modeling and numerical simulation, which are indispensable for understanding what we call complex behavior of physical, biological, technological and socio - economical systems. In the discussions that took place, a great number of participants expressed the need to formulate a unifying theory of complex systems based on the main conclusions that have been reached so far in the science of Complexity. As Guest Editors of this volume, we also feel that it is important to reach some fundamental conclusions concerning common phenomena, theories and methodologies that arise in Complexity. We should all work to explore common rules and approaches, particularly in view of the remarkable challenges that face us all regarding complex social problems that threaten present day society and civilization as we know them. [ABSTRACT FROM AUTHOR]

Superconducting metamaterials comprising rf Superconducting QUantum Interference Devices (SQUIDs) have been recently realized and investigated with respect to their tuneability, permeability, and dynamic multistability properties. These properties are a consequence of intrinsic nonlinearities due to the sensitivity of the superconducting state to external stimuli. SQUIDs, made of a superconducting ring interrupted by a Josephson junction, possess yet another source of nonlinearity, which makes them widely tuneable with an applied dc dlux. A model SQUID metamaterial, based on electric equivalent circuits, is used in the weak coupling approximation to demonstrate the dc flux tuneability, dynamic multistability, and nonlinear transmission in SQUID metamaterials comprising non-hysteretic SQUIDs. The model equations reproduce the experimentally observed tuneability patterns and predict tuneability with the power of an applied ac magnetic field. Moreover, the results indicate the opening of nonlinear frequency bands for energy transmission through SQUID metamaterials, for sufficiently strong ac fields. [ABSTRACT FROM AUTHOR]

$${\mathcal {PT}}$$ -symmetric dimers with a time-periodic gain/loss function in a balanced configuration where the amount of gain equals that of loss are investigated analytically and numerically. Two prototypical dimers in the linear regime are investigated: a system of coupled classical oscillators, and a Schrödinger dimer representing the coupling of field amplitudes, each system representing a wide class of physical models. Through a thorough analysis of their stability behavior, we find that turning on the coupling parameter in the classical dimer system leads initially to decreased stability but then to re-entrant transitions from the exact to the broken $${\mathcal {PT}}$$ -phase and vice versa, as it is increased beyond a critical value. On the other hand, the Schrödinger dimer behaves more like a single oscillator with time-periodic gain/loss. In addition, we are able to identify the conditions under which the behavior of the two dimer systems coincides and/or reduces to that of a single oscillator. [ABSTRACT FROM AUTHOR]

A one dimensional, parity-time ( $\mathcal{PT}$)-symmetric magnetic metamaterial comprising split-ring resonators having both gain and loss is investigated. In the linear regime, the transition from the exact to the broken $\mathcal{PT}$-phase is determined through the calculation of the eigenfrequency spectrum for two different configurations; the one with equidistant split-rings and the other with the split-rings forming a binary pattern ( $\mathcal{PT}$ dimer chain). The latter system features a two-band, gapped spectrum with its shape determined by the gain/loss coefficient as well as the interelement coupling. In the presence of nonlinearity, the $\mathcal{PT}$ dimer chain configuration with balanced gain and loss supports nonlinear localized modes in the form of a novel type of discrete breathers below the lower branch of the linear spectrum. These breathers that can be excited from a weak applied magnetic field by frequency chirping, can be subsequently driven solely by the gain for very long times. The effect of a small imbalance between gain and loss is also considered. Fundamental gain-driven breathers occupy both sites of a dimer, while their energy is almost equally partitioned between the two split-rings, the one with gain and the other with loss. We also introduce a model equation for the investigation of classical $\mathcal{PT}$ symmetry in zero dimensions, realized by a simple harmonic oscillator with matched time-dependent gain and loss that exhibits a transition from oscillatory to diverging motion. This behavior is similar to a transition from the exact to the broken $\mathcal{PT}$ phase in higher-dimensional $\mathcal{PT}$-symmetric systems. A stability condition relating the parameters of the problem is obtained in the case of a piece-wise constant gain/loss function that allows the construction of a phase diagram with alternating stable and unstable regions. [ABSTRACT FROM AUTHOR]

Kinesin and related motor proteins utilize ATP fuel to propel themselves along the external surface of microtubules in a processive and directional fashion. We show that the observed step-like motion is possible through time-varying charge distributions furnished by the ATP hydrolysis cycle while the static charge configuration on the microtubule provides the guide for motion. Thus, while the chemical hydrolysis energy induces appropriate local conformational changes, the motor translational energy is fundamentally electrostatic. Numerical simulations of the mechanical equations of motion show that processivity and directionality are direct consequences of the ATP-dependent electrostatic interaction between the different charge distributions of kinesin and the microtubule. [ABSTRACT FROM AUTHOR]

The conditions leading to flat dispersionless frequency bands in truly one-dimensional parity-time (PT) symmetric metamaterials comprised of split‐ring resonators (SRRs) arranged in a binary pattern are obtained analytically. In this paradigmatic system, in which the SRRs are coupled through both electric and magnetic dipole-dipole forces, flat-bands may arise from tailoring its natural parameters (such as, e.g., the coupling coefficients between SRRs) and not from geometrical effects. For sets of parameters which values are tailored to flatten the upper band of the spectrum, the solution of the corresponding quadratic eigenvalue problem reveals the existence of compact, two-site localized eigenmodes. Numerical simulations confirm the existence and the dynamic stability of such modes, which can be formed through the evolution of single-site initial excitations without disorder or nonlinearity. [ABSTRACT FROM AUTHOR]

The combinatorial frequency generation (CFG) in active periodic semiconductor-dielectric structures has been explored through illumination by a pair of pump waves with dissimilar frequencies and incidence angles. We study the influence of gain on linear refraction properties of the stack and on the efficiency of the mixing processes by the system with the resistive character of nonlinearity. We demonstrate that the introduction of gain dielectric material inside the stack not only compensates for losses caused by the collisions of the electrons in semiconductor media but also improves the efficiency of the CFG. We show that in systems with weak asymmetry of linear response we can get significant nonreciprocity of nonlinear interaction. [ABSTRACT FROM AUTHOR]

Semiconductor laser arrays have been investigated experimentally and theoretically from the viewpoint of temporal and spatial coherence for the past forty years. In this work, we are focusing on a rather novel complex collective behavior, namely chimera states, where synchronized clusters of emitters coexist with unsynchronized ones. For the first time, we find such states exist in large diode arrays based on quantum well gain media with nearest-neighbor interactions. The crucial parameters are the evanescent coupling strength and the relative optical frequency detuning between the emitters of the array. By employing a recently proposed figure of merit for classifying chimera states, we provide quantitative and qualitative evidence for the observed dynamics. The corresponding chimeras are identified as turbulent according to the irregular temporal behavior of the classification measure. [ABSTRACT FROM AUTHOR]