1. Butyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques.
- Author
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Ortiz, Alexandra M., Simpson, Jennifer, Langner, Charlotte A., Baker, Phillip J., Aguilar, Cynthia, Brooks, Kelsie, Flynn, Jacob K., Vinton, Carol L., Rahmberg, Andrew R., Hickman, Heather D., and Brenchley, Jason M.
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BUTYRATES ,SODIUM butyrate ,MACAQUES ,SHORT-chain fatty acids ,SIMIAN immunodeficiency virus ,RHESUS monkeys ,DIETARY supplements - Abstract
Defective gastrointestinal barrier function and, in turn, microbial translocation have been identified as significant contributors to persistent inflammation in antiretroviral (ARV)-treated people living with HIV. Metabolic supplementation of short-chain fatty acids (SCFAs), generally produced by the commensal microbiome, may improve these outcomes. Butyrate is a SCFA that is essential for the development and maintenance of intestinal immunity and has a known role in supporting epithelial integrity. Herein we assessed whether supplementation with the dietary supplement sodium butyrate would improve immune reconstitution and reduce inflammation in ARV-treated, simian immunodeficiency virus (SIV)-infected rhesus macaques. We demonstrate that butyrate supplementation does not significantly improve immune reconstitution, with no differences observed in systemic CD4+ T-cell frequencies, T-cell functionality or immune activation, microbial translocation, or transcriptional regulation. Our findings demonstrate that oral administration of sodium butyrate is insufficient to reduce persistent inflammation and microbial translocation in ARV-treated, SIV-infected macaques, suggesting that this therapeutic may not reduce co-morbidities and co-mortalities in treated people living with HIV. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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