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Introduction: Sleep disorder is a common and unpleasant symptom in patients with chronic kidney disease (CKD), bringing a heavy burden on the patients and families. As a non-pharmacological therapy, exercise interventions are widely recommended for CKD patients. However, whether exercise can improve overall sleep quality in such a population remains ambiguous. The systematic review and meta-analysis aimed to evaluate the effect of exercise interventions on sleep quality in CKD patients. Methods: PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to April 22, 2022. A randomized controlled trial (RCT) added an exercise intervention to conventional treatment/usual care to assess the effect on sleep quality in CKD patients. Two authors independently selected literature, extracted data, assessed the risk of bias using the Cochrane risk of bias tool 2, and assessed the certainty of the evidence using the Grading of Recommendations, Assessment, Development, and Evaluation. The outcome was analyzed using a random-effect model using the Hartung-Knapp-Sidik-Jonkman method as a standardized mean difference (SMD). Additional statistical analysis includes the Egger regression test, subgroup analysis, sensitivity analysis, and meta-regression. Results: Nineteen articles (20 RCTs) enrolling 989 patients with CKD were included. The pooled SMD suggested favorably associated exercise interventions (SMD − 0.16; 95% CI − 0.62 to 0.31; very low evidence) with substantial heterogeneity (I2 = 87%). Subgroup analyses demonstrated that SMD for sleep quality favored moderate intensity and aerobic exercise, no matter the time, but not statistically significant. Meta-regression showed that the effect size of exercise interventions on sleep quality was not associated with the total sample size, the proportion of males, duration of intervention, mean age, and exercise volume but was associated with baseline sleep scores. In addition, there may be an exercise threshold for the effect of exercise on sleep in CKD patients (i.e., 80 min/week). Conclusion: This systematic review and meta-analysis suggest that exercise interventions may be associated with improved sleep quality in patients with CKD. However, high heterogeneity and a small effect size limit this result. More studies and standardized reporting of exercise intervention characteristics should be conducted in the future to strengthen the most convincing evidence in this field. [ABSTRACT FROM AUTHOR]

A class of binary sequences with period 2p is constructed using generalized cyclotomic classes, and their linear complexity, minimal polynomial over F q as well as 2-adic complexity are determined using Gauss period and group ring theory. The results show that the linear complexity of these sequences attains the maximum when p ≡ ± 1 (mod 8) and is equal to p+1 when p ≡ ± 3 (mod 8) over extension field. Moreover, the 2-adic complexity of these sequences is maximum. According to Berlekamp–Massey(B–M) algorithm and the rational approximation algorithm (RAA), these sequences have quite good cryptographic properties in the aspect of linear complexity and 2-adic complexity. [ABSTRACT FROM AUTHOR]

Linear codes with a few weights have nice applications in communication, secret sharing schemes, authentication codes, association schemes, block designs and so on. Projective binary linear codes are one of the most important subclasses of linear codes for practical applications. The objective of this paper is to construct projective binary linear codes with some special Boolean functions. Four families of binary linear codes with three or four weights are derived and the parameters of their duals are also determined. It turns out that the duals of these codes are optimal or almost optimal with respect to the sphere-packing bound. As applications, the codes presented in this paper can be used to construct association schemes and secret sharing schemes with interesting access structures. [ABSTRACT FROM AUTHOR]

The mutational spectrum and prognostic factors of NRAS-mutated (NRASmut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovered 152 NRASmut AML (13%). Of the 152 NRASmut AML, 89% had at least one companion mutated gene. DNA methylation-related genes confer up to 62% incidence. TET2 had the highest mutation frequency (51%), followed by ASXL1 (17%), NPM1 (14%), CEBPA (13%), DNMT3A (13%), FLT3-ITD (11%), KIT (11%), IDH2 (9%), RUNX1 (8%), U2AF1 (7%) and SF3B1(5%). Multivariate analysis suggested that age ≥ 60 years and mutations in U2AF1 were independent factors related to failure to achieve complete remission after induction therapy. Age ≥ 60 years, non-M3 types and U2AF1 mutations were independent prognostic factors for poor overall survival. Age ≥ 60 years, non-M3 types and higher risk group were independent prognostic factors for poor event-free survival (EFS) while allogenic hematopoietic stem cell transplantation was an independent prognostic factor for good EFS. Our study provided new insights into the mutational spectrum and prognostic factors of NRASmut AML. [ABSTRACT FROM AUTHOR]