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This paper addressed the rockburst hazards caused by tectonic stress in the "three hard" coal mine in Datong Coalfield. We analyzed tectonic stress characteristics in the mining area and the mechanism of tectonic stress inducing rockbursts. We built the stress analysis model for rockburst-inducing tectonic stress. The roadway of the coal seam 12# in Xinzhouyao Coal Mine of Datong Coalfield was explicitly analyzed as an example. It was found that roof bedding separation was very likely to happen under the action of local tectonic stress in the roadway of the "three hard" coal seam, causing rockbursts that pushed out the coal wall. Numerical simulation was performed to analyze the occurrence of rockbursts induced by tectonic stress. We validated that stress concentration was more likely to happen in the coal-rock masses under the action of the tectonic stress, causing rockbursts. Besides, a large horizontal stress gradient would be formed near the roadway coal wall when the principal stress was perpendicular to the roadway axis. Rockbursts were highly probable in the coal-rock masses under this situation. [ABSTRACT FROM AUTHOR]

Introduction: FCN-159 is a novel, oral, potent, selective MEK1/2 inhibitor in clinical development for the treatment of NRAS-mutant advanced melanoma and neurofibromatosis type 1. We investigated the effect of food on the pharmacokinetics (PK), safety, and tolerability of FCN-159. Methods: In this single-center, open-label, phase 1 study with a three-period, three-sequence, crossover design, healthy Chinese male subjects (n = 24) were randomized (1:1:1) to receive a single, oral 8 mg dose of FCN-159 in the fasted state (overnight, > 10 h), and with a low-fat and a high-fat meal, separated by a 10-day washout. PK parameters including time to maximum plasma concentration (Cmax) and area under the concentration–time curve (AUC) were compared using geometric least-squares mean ratios (GLSMR), with the fasted state as the reference. A 90% CI for the GLSMR within 80–125% indicated no significant food effect. Results: A low-fat meal (n = 23) did not affect the PK profile of FCN-159: G LSMR for AUC from time 0 to t (AUC0–t), 106.9% (90% CI 99.9–114.4%); AUC from time 0 to infinity (AUC0–∞), 106.8% (90% CI 100.0–114.0%); Cmax, 96.4% (90% CI 83.9–110.8%). A high-fat meal (n = 24) did not affect exposure to FCN-159 (GLSMR for AUC0–t, 99.4%; 90% CI 99.0–106.3%; AUC0–∞, 99.5 5%; 90% CI 93.2–106.1%), but modestly reduced Cmax by 15% (GLSMR 84.9%; 90% CI 74.0–97.3%). Both the low-fat and high-fat meals slightly prolonged the median time to Cmax by 0.5 h (90% CI 0.5–1.0 h). FCN-159 was generally well tolerated, with a lower incidence of treatment-emergent adverse events following administration in the fasted state than with a low-fat or high-fat meal (20.8%, 39.1%, and 37.5%, respectively). Conclusion: Food did not affect the PK profile of FCN-159 to a clinically meaningful extent compared with administration in the fasted state. [ABSTRACT FROM AUTHOR]

Identification of protein quantitative trait loci (pQTL) helps understand the underlying mechanisms of diseases and discover promising targets for pharmacological intervention. For most important class of drug targets, genetic evidence needs to be generalizable to diverse populations. Given that the majority of the previous studies were conducted in European ancestry populations, little is known about the protein-associated genetic variants in East Asians. Based on data-independent acquisition mass spectrometry technique, we conduct genome-wide association analyses for 304 unique proteins in 2,958 Han Chinese participants. We identify 195 genetic variant-protein associations. Colocalization and Mendelian randomization analyses highlight 60 gene-protein-phenotype associations, 45 of which (75%) have not been prioritized in Europeans previously. Further cross-ancestry analyses uncover key proteins that contributed to the differences in the obesity-induced diabetes and coronary artery disease susceptibility. These findings provide novel druggable proteins as well as a unique resource for the trans-ancestry evaluation of protein-targeted drug discovery. Integrating genetic information with circulating proteomics can help understand mechanisms of disease. Here, the authors conduct genome-wide association analyses of the serum proteome in 2,958 Han Chinese individuals, uncovering proteins which may contribute to ancestry differences in cardiometabolic disease susceptibility. [ABSTRACT FROM AUTHOR]

Purpose: Long intergenic non-coding RNA LINC01088 is a newly discovered long non-coding RNA (lncRNA). Its biological function in colorectal cancer (CRC) remains unknown. Methods: Here, 36 paired CRC and para-cancerous tissues were collected. In vitro, fluorescence in situ hybridization (FISH) assay, qPCR, western blotting analysis and cellular functional experiments, RNA immunoprecipitation (RIP) assay and dual-luciferase reporter system analysis were performed. In vivo, xenograft tumor mouse models were generated. Besides, patient-derived intestinal organoid (PDO) was generated ex vivo. Results: We found that LINC01088 was significantly upregulated in colorectal cancer tissues and CRC cell lines compared to adjacent normal tissues and colonic epithelial cells. High LINC01088 levels were correlated with adverse outcomes in patients with CRC. LINC01088 was mainly located in the cytoplasm. LINC01088 knockdown suppressed the proliferation, migration, invasion, and immune escape of colorectal cancer cells. Mechanistically, LINC01088 bound directly to miR-548b-5p and miR-548c-5p that were significantly upregulated Ras GTPase-activating protein-binding proteins 1 (G3BP1) and programmed death ligand 1 (PD-L1) expression, altering CRC cell phenotypes. In mouse xenograft models, LINC01088 knockdown restrained CRC tumor growth and lung metastasis. Furthermore, G3BP1 overexpression reversed LINC01088-knockdown-mediated inhibitory effects on tumor growth. Notably, LINC01088 knockdown downregulated PD-L1 expression, while G3BP1 overexpression restored PD-L1 expression in xenograft tumors. Besides, LINC01088 knockdown repressed CRC organoid growth ex vivo. Conclusion: Overall, these findings suggested that LINC01088 directly targeted miR-548b-5p and miR-548c-5p, promoting G3BP1 and PD-L1 expression, which facilitated colorectal cancer progression and immune escape. [ABSTRACT FROM AUTHOR]

E Difference analysis of grain number in different panicle parts, the panicle is divided into 3 parts namely top (top, from 1-1 to 4-2 panicle positons), middle (mid, from 5-1 to 8-2 panicle positons) and bottom (bot, from 9-1 to 12-2 panicle positons) respectively. B Eating quality of different panicle locations under H treatment, the panicle is divided into 3 parts namely top (top, from 1-1 to 4-2 panicle positons), middle (mid, from 5-1 to 8-2 panicle positons) and bottom (bot, from 9-1 to 12-2 panicle positons) respectively. [Extracted from the article]

Ep type is an important morphological improvement (following dwarf breeding and ideal plant type) that has contributed to breeding super-high yielding, and shows a pleiotropic effect in increasing grain yield and also nitrogen-use efficiency (NUE) in rice. Nevertheless, it remains unclear whether Ep has adverse effects on eating quality and how it affects nitrogen uptake and assimilation. In this study, we developed a pair of near-isogenic lines (NILs) for panicle type (NIL-Ep, NIL-non Ep) in the Liaogeng 5 (LG5) and Akihikari (AKI) backgrounds. Rice plants of the NIL-Ep had higher grain numbers per panicle in the middle to bottom spike positions than plants of the NIL-non Ep. The increased grain number is not only is the key factor leading to increased yield but also is the reason for reduced the eating quality. The content of prolamin and glutelin was significantly higher in NIL-Ep, which resulted in higher hardness and worse viscosity of rice after cooking. In addition, the activity of several essential enzymes catalyzing nitrogen metabolism was higher in the NIL-Ep line grains than in the NIL-non Ep, especially from the mid to late grain filling stage. Based on these results, we conclude that Ep positively regulates grain protein accumulation, primarily through enhancing the activity of enzymes involved in nitrogen assimilation and redistribution during the mid to late grain-filling stage, resulting in excessive accumulation of grain protein and decreased eating quality. [ABSTRACT FROM AUTHOR]

Assembling cellulose nanocrystals (CNCs) can induce solid-state photoluminescence based on Stokes scattering. Such photoluminescent materials are free of photo-quenching and show great potential in optical applications, whereas poor flexibility of assembled CNC arrays limits their applications. Here, a binary co-assembly of 1D nanoparticles and long-chain polymers was explored to produce the uniaxial CNC arrays into transparent poly(vinyl alcohol) (PVA) membranes, which enhanced the mechanical properties, especially ductility. Besides, the CNC assembly was controlled by adjusting the mass ratio between CNCs and PVA. The result indicated that co-assembling with PVA could improve the uniaxial orientation of CNC arrays, which played a crucial role in enhancing the emission quantum efficiency (EQE). Stretching the PVA/CNC membrane could further induce an enhancement in EQE together with a blue shift in excitation wavelength. The mechanism study on stimulation-response suggested that the EQE enhancement and blue shift came from the change in uniaxial orientation degree and periodicity of the CNC assembly, respectively. Since the stimulation-responsive enhancement in EQE (from ca. 40 to 60%) can even be observed by naked eyes, we believe such cellulose-based materials can be widely used in optical sensors. [ABSTRACT FROM AUTHOR]

Nowadays, graph-structured data are increasingly used to model complex systems. Meanwhile, detecting anomalies from graph has become a vital research problem of pressing societal concerns. Anomaly detection is an unsupervised learning task of identifying rare data that differ from the majority. As one of the dominant anomaly detection algorithms, one-class support vector machine has been widely used to detect outliers. However, those traditional anomaly detection methods lost their effectiveness in graph data. Since traditional anomaly detection methods are stable, robust and easy to use, it is vitally important to generalize them to graph data. In this work, we propose one-class graph neural network (OCGNN), a one-class classification framework for graph anomaly detection. OCGNN is designed to combine the powerful representation ability of graph neural networks along with the classical one-class objective. Compared with other baselines, OCGNN achieves significant improvements in extensive experiments. [ABSTRACT FROM AUTHOR]

Electrochemical nitrogen fixation has received great attention in recent years due to its reliable and stable electrolytic efficiency. In this work, boron-doped carbon nitride with π-electron delocalization and vacancies was prepared by an in situ decomposition-thermal polymerization method. A series of characterizations were utilized to analyze the structure, morphology, and property. The results demonstrated that the secondary sintering and boron doping enhanced π-electron delocalization and induced the nitrogen vacancies of g-C3N4. The 0.24% boron-doped g-C3N4 electrocatalyst achieved the best ammonia yield (5.4 μg·h−1·mgcat−1) and the highest Faraday efficiency (14.1%) at −0.7 V vs reversible hydrogen electrode in 0.1 M Na2SO4. Furthermore, a feasible mechanism was proposed for the electrochemical nitrogen reduction process. [ABSTRACT FROM AUTHOR]

This paper presents a new variable-frequency phase-shift control method to improve the conversion efficiency for a high-power wide-range converter based on a phase-shifted full-bridge (PSFB) converter. The proposed converter can adjust the switching-frequency according to the load power to make the input impedance be inductive. The main switches of the converter can achieve zero voltage switching (ZVS) over a wide load range (500 W–50 kW) without any auxiliary circuit. The maximum switching-frequency of high-power insulated gate bipolar transistor (IGBT) is determined by analyzing the influence of collector current on IGBT switching time. The necessary condition for the proposed converter to realize ZVS is given according to the steady-state model of the full-bridge converter. This paper analyzed the influence of voltage, current and temperature on the switching time of high-power IGBT in detail, and obtained the relationship between the load current and the dead time of high-power IGBT. The optimal switching-frequency under different loads was determined by establishing a switching-frequency loss model of the proposed converter. A 50 kW prototype of the proposed converter was developed and the experimental and simulation results verify the effectiveness and efficiency of the proposed method. [ABSTRACT FROM AUTHOR]

SiO2 nanoparticles (SiO2 NPs) modified 0.02B2O3–0.98SiO2 ceramics were prepared by solid state sintering. The microstructure and microwave dielectric properties were investigated. All the modified samples exhibited low-cristobalite phase with small amount of quartz. The quartz phase inhibited the cracking caused by crystallization process of low-cristobalite. The densification of 0.02B2O3–0.98SiO2 ceramics improved with SiO2 NPs addition. The introduction of 1.5 wt% SiO2 NPs brings excellent microwave dielectric properties with εr = 4.4, Q × f = 42000 GHz, τf = − 5 ppm/°C for the samples sintered at 1250 °C, which can be a low-temperature sintering system as microwave substrate materials. [ABSTRACT FROM AUTHOR]

To address the issue of white noise at partial discharge (PD) ultra high frequency (UHF) signal in gas insulated substation (GIS), this paper develops an external sensor and proposes new empirical mode decomposition (EMD) denoising method based on autocorrelation coefficient and similar wavelet soft threshold. Four types of typical GIS defects at the PD UHF signal were obtained through experiment. The autocorrelation coefficient of intrinsic mode functions (IMF) components at the PD UHF signal was computed, the cut-off point between the noise signal dominant mode and the UHF signal dominant mode was found. The similar wavelet soft threshold denoising was performed on the signal which is dominated by the noise signal, all the UHF signals were finally reconstructed. The signal-to-noise ratio computed by the proposed denoising method was compared with the one computed by the wavelet denoising method, the results shows that the proposed denoising method in this paper is more effective than the wavelet denoising method. [ABSTRACT FROM AUTHOR]

Background: Rice ( Oryza sativa L .) is cultivated in a wide range of climatic conditions, and is one of mankind's major staple foods. The interaction of environmental factors with genotype effects major agronomic traits such as yield, quality, and resistance in rice. However, studies on the environmental factors affecting agronomic traits are often difficult to conduct because most environmental factors are dynamic and constantly changing. Results: A series of recombinant inbred lines (RILs) derived from an indica/japonica cross were planted into four typical rice cultivated areas arranging from latitude N22° to N42°. The environmental data from the heading to mature (45 days) stages were recorded for each RIL in the four areas. We determined that light, temperature, and humidity significantly affected the milling quality and cooking quality overall the four areas. Within each area, these environmental factors mainly affected the head rice ratio, grain length, alkali consumption, and amylose and protein content. Moreover, the effect of these environmental factors dynamically changed from heading to mature stage. Compared to light and humidity, temperature was more stable and predictable, and night temperature showed a stronger correlation efficiency to cooking quality than day temperature, and the daily temperature range had contrary effects compared to day and night temperature on grain quality. Conclusions: The present study evaluated the critical phase during the grain filling stage by calculating the dynamic changes of correlation efficiency between the quality traits and climate parameters. Our findings suggest that the sowing date could be adjusted to improve rice quality so as to adjust for environmental changes. [ABSTRACT FROM AUTHOR]

The sintering behavior, microstructure and microwave dielectric properties of (BaSm)((CoMg)Nb)O (0.01 ≤ x ≤ 0.04) ceramics has been investigated. A small amount of Sm-substitution facilitates the densification of Ba (CoMg)NbO ceramics. All ceramic samples are well-sintered and the relative densities are beyond 97%. Small homogeneous grains and low porosity have been observed by scanning electron microscopy photograghs. Single-phase solid solutions are achieved in all compositions and no secondary phase was detected by X-ray diffraction patterns. The appropriate amount of Sm-substitution on A-site leads to the improved degree of 1:2 B-site cation ordering, while the ordered degree decreases gradually as the Sm content increases, which is related to the A-site deficiency caused by the inequitable substitution. The degree of 1:2 ordering structure is responsible for the microwave dielectric properties of the Sm-substituted samples, especially Q × f values. A good combination of microwave dielectric properties have been obtained for (BaSm)((CoMg)Nb)O sintered at 1420 °C: ε = 32.9, Q × f = 50309 GHz and τ = 6 ppm/C. [ABSTRACT FROM AUTHOR]

Plasmonic Au nanoparticle (NP)–decorated g-C3N4 nanosheets were synthesized by a direct in situ decomposition-thermal polymerization method with dicyandiamide and gold chloride trihydrate (HAuCl4·3H2O) as the precursors. Au NPs were closely anchored on the surface of g-C3N4 with high dispersion, and Au/g-C3N4 composites showed strong surface plasmon resonance in the visible light region. The photocurrent density of Au/g-C3N4 composite with 1 wt% Au (0.32 μA/cm2) was 6.3 times higher than that of pure g-C3N4 (0.05 μA/cm2) under simulated sunlight irradiation. The 1 wt% Au/g-C3N4 composite exhibited improved activity in the photodegradation of organic dyes under natural sunlight and enhanced photocatalytic water reduction performance under simulated sunlight illumination due to the uniform distribution of Au NPs and heterostructure at the interface of Au/g-C3N4. This work provided a new platform for the preparation of metal/g-C3N4 to replace traditional photoreduction or chemical reduction method. [ABSTRACT FROM AUTHOR]