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Limited data are available for ceftazidime–avibactam (CZA) dosing in patients receiving renal replacement therapy, especially the data on the dosing in patients receiving intermittent hemodialysis (IHD). In this report, we firstly described a case in which CZA was administered as 2.5 g after each time of IHD, and a dose of 1.25 g was added on the 48th-hour for the 72-h interdialytic interval. Plasma concentrations of CZA measured at different time indicated that > 50% of administered ceftazidime and avibactam were removed during the 4-h hemodialysis. In addition, we described another case on continuous venovenous hemodialysis (CVVHD), in which CZA was administered as 2.5 g q12h in 2-h infusions. The dose regimen for these two cases could achieve trough concentration of ceftazidime higher than fourfold of the MIC and trough concentration of avibactam higher than the threshold of 1 μg/mL during the treatment, and exert efficient antimicrobial effect. [ABSTRACT FROM AUTHOR]

Sanghuangporus sanghuang is a well-known pharmacodynamic and economically important edible fungus associated with mulberry (Morus spp.). A distinctly new exopolysaccharide (EPS), designated SHP-2 was obtained from S. sanghuang P0988 broth, and its structure and anti-aging prosperity were characterized. SHP-2 was found to be composed of a back-bone of →4)-β-Manp-(1→4)-α-Araf-(1→3,4)-α-Glcp(1→3,4)-α-Glcp-(1→3,4)-α-Glcp-(1→3,4)-α-Glcp-(1→3,4)-α-Glcp-(1→6)-α-Galp-(1→4)-β-Manp-(1→ and five branches, including four α-D-Glcp-(1→ and one α-D-Manp-(1→SHP-2 was shown to increase antioxidant enzyme activities including catalase (CAT) and superoxide dismutase (SOD) activities, as well as trolox equivalent antioxidant (TEAC) capacity in serum of mice pre-treated with D-Gal, while reducing lipofuscin levels. SHP-2 exerted a favorable influence on immune organ coefficients and ameliorated the histopathological hepatic lesions and apoptosis in hepatocytes of D-galactose-aged mice almost in a dose-dependent manner. Using the same analytical methods, on comparison with previously studied EPS compounds (i.e. SHP-1), SHP-2 was found to have more complex structure, larger molecule weight, and different anti-aging properties. The results presented here suggest that not only does EPS bioactivity vary with respect to molecular structures and molecule weight, but that multiple structures with different activity can be expressed by a single fungal strain. These results may help understanding the anti-aging prosperity of these polysaccharides for use in health foods or dietary supplements. [ABSTRACT FROM AUTHOR]

This article investigates the robustness of switched multiple equilibrium points systems (SMEPSs) with unstable subsystems. Each subsystem has a unique equilibrium point that is different from all equilibrium points of the other subsystems. Unlike the most commonly used Lyapunov function method, the analytical solutions and numerical solutions are calculated to analyze the boundedness of the solutions for perturbation discrete-time and continuons-time SMEPSs, respectively. The given perturbation systems have good robustness if the ratio of total dwell time of unstable subsystems and the total dwell time of stable subsystems is less than or equal to a constant. A numerical example is employed to validate the correctness of the theoretical results. [ABSTRACT FROM AUTHOR]

This paper studies the regional stability for positive switched linear systems with multi-equilibrium points (PSLS-MEP). First, a sufficient condition is presented for the regional stability of PSLS-MEP via a common linear Lyapunov function. Second, by establishing multiple Lyapunov functions, a dwell time based condition is proposed for the regional stability analysis. Third, a suprasphere which contains all equilibrium points is constructed as a stability region of the considered PSLS-MEP, which is less conservative than existing results. Finally, the study of an illustrative example shows that the obtained results are effective in the regional stability analysis of PSLS-MEP. [ABSTRACT FROM AUTHOR]

This paper investigates the region stability analysis for switched nonlinear systems whose subsystems have different equilibria, which are referred to multi-equilibrium switched nonlinear systems, and proposes a number of new results on the region stability analysis. Through investigating the dynamical behavior of the multi-equilibrium switched system, two methods are established, based on which several new results are then obtained for the region stability. It is shown that the main results obtained in this paper not only guarantee the region stability of the multi-equilibrium switched nonlinear system under arbitrary switching, but also provide several new approaches to determine the corresponding regions of convergence. Moreover, an improved average dwell time (ADT) method is proposed for the stability of switched nonlinear systems whose subsystems do not share a common Lyapunov function. Finally, an illustrative example with numerical simulation is studied by using the obtained results. The study of example shows that our results work very well in analyzing the region stability of some multi-equilibrium switched nonlinear systems. [ABSTRACT FROM AUTHOR]

Correction to: Efficacy and Pharmacodynamic Target Attainment for Ceftazidime-Avibactam Off-Label Dose Regimens in Patients with Continuous or Intermittent Venovenous Hemodialysis: Two Case Reports The original article can be found online at https://doi.org/10.1007/s40121-022-00621-z. Correction to: Infect Dis Ther https://doi.org/10.1007/s40121-022-00621-z In the original publication of the article, there should be three corresponding authors; Chun-Hong Zhang, Xu-Ben Yu and Cong-Rong Tang This has been corrected in this paper. [Extracted from the article]

This paper investigates the H filtering problem for a class of linear continuous-time systems with both time delay and saturation. Such systems have time delay in their state equations and saturation in their output equations, and their process and measurement noises have unknown statistical characteristics and bounded energies. Based on the Lyapunov-Krasovskii stability theorem and the linear matrix inequalities (LMIs) technique, a generalized dynamic filter architecture is proposed, and a filter design method is developed. The linear H filter designed by the method can guarantee the H performance. The parameters of the designed filter can be obtained by solving a kind of LMI. An illustrative example shows that the design method proposed in this paper is very effective. [ABSTRACT FROM AUTHOR]