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Although the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established1–6, little is known about how host genetics regulates the genetic diversity of gut microorganisms. Here we conducted a meta-analysis of associations between human genetic variation and gut microbial structural variation in 9,015 individuals from four Dutch cohorts. Strikingly, the presence rate of a structural variation segment in Faecalibacterium prausnitzii that harbours an N-acetylgalactosamine (GalNAc) utilization gene cluster is higher in individuals who secrete the type A oligosaccharide antigen terminating in GalNAc, a feature that is jointly determined by human ABO and FUT2 genotypes, and we could replicate this association in a Tanzanian cohort. In vitro experiments demonstrated that GalNAc can be used as the sole carbohydrate source for F. prausnitzii strains that carry the GalNAc-metabolizing pathway. Further in silico and in vitro studies demonstrated that other ABO-associated species can also utilize GalNAc, particularly Collinsella aerofaciens. The GalNAc utilization genes are also associated with the host’s cardiometabolic health, particularly in individuals with mucosal A-antigen. Together, the findings of our study demonstrate that genetic associations across the human genome and bacterial metagenome can provide functional insights into the reciprocal host–microbiome relationship.A meta-analysis of associations between human genetic variation and gut microbial structural variations shows that ABO genotype differentially affects the presence of Faecalibacterium prausnitzii strains containing GalNAc utilization pathway in the gut. [ABSTRACT FROM AUTHOR]

Recent developments have demonstrated that the brake pedal simulator (BPS) is becoming an indispensable apparatus for the break-by-wire systems in future electric vehicles. Its main function is to provide the driver with a comfortable pedal feel to improve braking safety and comfort. This paper presents the development and control of an adjustable BPS, using a disk-type magnetorheological (MR) damper as the passive braking reaction generator to simulate the traditional pedal feel. A detailed description of the mechanical design of the MR damper-based BSP (MRDBBPS) is presented in this paper. Several basic performance experiments on the MRDBBPS prototype are conducted. A return-to-zero (RTZ) algorithm is proposed to avoid hysteresis and improve the repeatability of the pedal force. In addition, an RTZ algorithm-based real-time current-tracking controller (RTZRC) is designed in consideration of the response lag of the coil circuit. Finally, an experimental system is established by integrating the MRDBBPS prototype into a self-developed automotive MR braking test bench (AMRBTB), and several control and braking experiments are performed. This research proposes a RTZRC control algorithm which can significantly increase the tracking accuracy of the brake pedal characteristic curve, particularly at a high pedal velocity. Additionally, the designed MRDBBPS prototype can achieve an effective and favorable control of the AMRBTB with a good repeatability. [ABSTRACT FROM AUTHOR]

Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively homogenous strain of H. pylori. In this work, we performed SNP (single nucleotide polymorphism)-based, gene-based and pathway-based genome-wide association analyses to investigate the genetic basis of host susceptibility to H. pylori infection in 480 Chinese individuals. We also profiled the composition and function of the gut microbiota between H. pylori infection cases and controls. We found several genes and pathways associated with H. pylori infection (P < 0.05), replicated one previously reported SNP rs10004195 in TLR1 gene region (P = 0.02). We also found that glycosaminoglycan biosynthesis related pathway was associated with both onset and progression of H. pylori infection. In the gut microbiome association study, we identified 2 species, 3 genera and several pathways had differential abundance between H. pylori infected cases and controls. This paper is the first GWAS for H. pylori infection in Chinese population, and we combined the genetic and microbial data to comprehensively discuss the basis of host susceptibility to H. pylori infection. [ABSTRACT FROM AUTHOR]

Herein, we conceptualized a transient mediator approach that has the capability of para-selective C-H functionalization of monosubstituted aromatics. This approach is enabled by in situ generation of a versatile sulfonium salt via highly electrophilic phenoxathiine or thianthrene dication intermediate which can be readily generated from its sulfoxide with trifluoromethanesulfonic anhydride. Preliminary mechanistic study implied that the remarkable para selectivity might be related to the incredible electrophilicity of thianthrene dication intermediate. The versatility of this approach was demonstrated via para-borylation of various monosubstituted simple aromatics combining the sulfonium salt formation with further photocatalyzed transformation. [ABSTRACT FROM AUTHOR]

Material properties of the components of magnetorheological (MR) fluids are critical to their control accuracy and service life. The aim of this study was to reveal the effects of temperature on the material properties of MR fluid components. In this paper, a detailed introduction to the components of MR fluids, including main performance indicators and commonly used materials, was presented at first. Then, theoretical analysis and experimental investigation were performed on the temperature-dependent material properties of MR fluid components. These material properties included the magnetization properties of the magnetic particle, as well as the shear viscosity and thermal expansion of the carrier fluid. Experimental results indicated that both the mass magnetization and coercivity of MR particles decreased as the temperature increased and the phenomenon was particularly obvious at high temperatures. Moreover, an increasing temperature could lead to a severe decrease of the shear viscosity and a relatively large thermal expansion of the carrier fluid. Research results from this study may serve to provide a theoretical and an experimental basis for the preparation of MR fluids with high thermal stability. [ABSTRACT FROM AUTHOR]