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Background: Dysfunctional immune regulation plays a crucial role in the pathogenesis of airway allergies. Macrophages are one of the components of the immune regulation cells. The aim of this study is to elucidate the role of lysine demethylase 5 A (KDM5A) in maintaining macrophages' immune regulatory ability. Methods: DNA was extracted from Lactobacillus rhamnosus GG to be designated as LgDNA. LgDNA was administered to the mice through nasal instillations. M2 macrophages (M2 cells) were isolated from the airway tissues using flow cytometry. Results: We found that airway M2 cells of mice with airway Th2 polarization had reduced amounts of IL-10 and KDM5A. Mice with Kdm5a deficiency in M2 cells showed the airway Th2 polarization. The expression of Kdm5a in airway M2 cells was enhanced by nasal instillations containing LgDNA. KDM5A mediated the effects of LgDNA on inducing the Il10 expression in airway M2 cells. Administration of LgDNA mitigated experimental airway allergy. Conclusions: M2 macrophages in the airway tissues of mice with airway allergy show low levels of KDM5A. By upregulating KDM5A expression, LgDNA can increase Il10 expression and reconcile airway Th2 polarization. [ABSTRACT FROM AUTHOR]

High myopia (HM) is the primary cause of blindness, with the microstructural organization and composition of collagenous fibers in the cornea and sclera playing a crucial role in the biomechanical behavior of these tissues. In a previously reported myopic linkage region, MYP5 (17q21–22), a potential candidate gene, LRRC46 (c.C235T, p.Q79X), was identified in a large Han Chinese pedigree. LRRC46 is expressed in various eye tissues in humans and mice, including the retina, cornea, and sclera. In subsequent cell experiments, the mutation (c.C235T) decreased the expression of LRRC46 protein in human corneal epithelial cells (HCE-T). Further investigation revealed that Lrrc46−/− mice (KO) exhibited a classical myopia phenotype. The thickness of the cornea and sclera in KO mice became thinner and more pronounced with age, the activity of limbal stem cells decreased, and microstructural changes were observed in the fibroblasts of the sclera and cornea. We performed RNA-seq on scleral and corneal tissues of KO and normal control wild-type (WT) mice, which indicated a significant downregulation of the collagen synthesis-related pathway (extracellular matrix, ECM) in KO mice. Subsequent in vitro studies further indicated that LRRC46, a member of the important LRR protein family, primarily affected the formation of collagens. This study suggested that LRRC46 is a novel candidate gene for HM, influencing collagen protein VIII (Col8a1) formation in the eye and gradually altering the biomechanical structure of the cornea and sclera, thereby promoting the occurrence and development of HM. [ABSTRACT FROM AUTHOR]

We aimed to develop and validate multimodal ICU patient prognosis models that combine clinical parameters data and chest X-ray (CXR) images. A total of 3798 subjects with clinical parameters and CXR images were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and an external hospital (the test set). The primary outcome was 30-day mortality after ICU admission. Automated machine learning (AutoML) and convolutional neural networks (CNNs) were used to construct single-modal models based on clinical parameters and CXR separately. An early fusion approach was used to integrate both modalities (clinical parameters and CXR) into a multimodal model named PrismICU. Compared to the single-modal models, i.e., the clinical parameter model (AUC = 0.80, F1-score = 0.43) and the CXR model (AUC = 0.76, F1-score = 0.45) and the scoring system APACHE II (AUC = 0.83, F1-score = 0.77), PrismICU (AUC = 0.95, F1 score = 0.95) showed improved performance in predicting the 30-day mortality in the validation set. In the test set, PrismICU (AUC = 0.82, F1-score = 0.61) was also better than the clinical parameters model (AUC = 0.72, F1-score = 0.50), CXR model (AUC = 0.71, F1-score = 0.36), and APACHE II (AUC = 0.62, F1-score = 0.50). PrismICU, which integrated clinical parameters data and CXR images, performed better than single-modal models and the existing scoring system. It supports the potential of multimodal models based on structured data and imaging in clinical management. [ABSTRACT FROM AUTHOR]

Understanding the structures and reaction mechanisms of interfacial active sites in the Fisher-Tropsch synthesis reaction is highly desirable but challenging. Herein, we show that the ZrO2-Ru interface could be engineered by loading the ZrO2 promoter onto silica-supported Ru nanoparticles (ZrRu/SiO2), achieving 7.6 times higher intrinsic activity and ~45% reduction in the apparent activation energy compared with the unpromoted Ru/SiO2 catalyst. Various characterizations and theoretical calculations reveal that the highly dispersed ZrO2 promoter strongly binds the Ru nanoparticles to form the Zr-O-Ru interfacial structure, which strengthens the hydrogen spillover effect and serves as a reservoir for active H species by forming Zr-OH* species. In particular, the formation of the Zr-O-Ru interface and presence of the hydroxyl species alter the H-assisted CO dissociation route from the formyl (HCO*) pathway to the hydroxy-methylidyne (COH*) pathway, significantly lowering the energy barrier of rate-limiting CO dissociation step and greatly increasing the reactivity. This investigation deepens our understanding of the metal-promoter interaction, and provides an effective strategy to design efficient industrial Fisher-Tropsch synthesis catalysts. Understanding the structures of interfacial active sites is crucial in heterogeneous catalysis. Here the authors demonstrate that a ZrO2-Ru interface site significantly enhances reactivity in the Fischer-Tropsch to olefins process by altering the H-assisted CO dissociation route due to the presence of hydroxy species associated with Zr-OH*. [ABSTRACT FROM AUTHOR]

Hydroformylation is an industrial process for the production of aldehydes from alkenes1,2. Regioselective hydroformylation of propene to high-value n-butanal is particularly important, owing to a wide range of bulk applications of n-butanal in the manufacture of various necessities in human daily life3. Supported rhodium (Rh) hydroformylation catalysts, which often excel in catalyst recyclability, ease of separation and adaptability for continuous-flow processes, have been greatly exploited4. Nonetheless, they usually consist of rotationally flexible and sterically unconstrained Rh hydride dicarbonyl centres, only affording limited regioselectivity to n-butanal5–8. Here we show that proper encapsulation of Rh species comprising Rh(I)-gem-dicarbonyl centres within a MEL zeolite framework allows the breaking of the above model. The optimized catalyst exhibits more than 99% regioselectivity to n-butanal and more than 99% selectivity to aldehydes at a product formation turnover frequency (TOF) of 6,500 h−1, surpassing the performance of all heterogeneous and most homogeneous catalysts developed so far. Our comprehensive studies show that the zeolite framework can act as a scaffold to steer the reaction pathway of the intermediates confined in the space between the zeolite framework and Rh centres towards the exclusive formation of n-butanal.Rhodium catalysts confined in zeolite pores exhibit high regioselectivity in the hydroformylation process of propene to high-value n-butanal, surpassing the performance of all heterogeneous and most homogeneous catalysts developed so far. [ABSTRACT FROM AUTHOR]

The recommended bearing capacity of medium weathering mudstone foundation is less than the capacity of the rock structure to withstand loads in Southwest China. A comprehensive failure characterization of medium weathering mudstone in Chengdu has been performed including bearing plate test (BPT), binocular vision measurement (BVM) test, uniaxial compressive strength test, trial trench test of shallow rock surface and 3D imaging in this paper. Failure behavior of rock has been modeled with 3D imaging algorithm that utilizes Zhang's calibration method in BVM system combination with trial trench test of shallow rock surface. The bearing capacity of medium weathering mudstone foundation were extracted from uniaxial experiments and BPT-BVM test by fitting relevant material properties to the data. The results revealed that: Bearing capacity of medium weathering mudstone of layered isotropic in Chengdu is undervalued. Specifically, the characteristic load carrying value is in the range 1500–2500 kP, that is 50% higher than in the local standard system. Failure process is different from Hoek–Brown Failure Criterion, presenting a wave peak transfer phenomenon of the increment displacement into the distance. Thus, it can be reduced to that of punching failures for thin bedded structures of Moudstone foundations. Compressive strength of soft rock proves to be main factor limiting the bearing capacity, a clear correlation between the uniaxial compressive strength reduction coefficient and the bearing capacity has been used to establish, leading to the proposal of a load bearing capacity prediction model. [ABSTRACT FROM AUTHOR]

Aim: Nonpharmaceutical interventions (NPIs) are important strategies to utilize in reducing the negative systemic impact pandemic disasters have on human health. However, early on in the pandemic, the lack of prior knowledge and the rapidly changing nature of pandemics make it challenging to construct effective epidemiological models that can be used for anti-contagion decision-making. Subject and methods: Based on the parallel control and management theory (PCM) and epidemiological models, we developed a Parallel Evolution and Control Framework for Epidemics (PECFE), which can optimize epidemiological models according to the dynamic information during the evolution of pandemics. Results: The cross-application between PCM and epidemiological models enabled us to successfully construct an anti-contagion decision-making model for the early stages of COVID-19 in Wuhan, China. Using the model, we estimated the effects of gathering bans, intra-city traffic blockades, emergency hospitals, and disinfection, forecasted pandemic trends under different NPIs strategies, and analyzed specific strategies to prevent pandemic rebounds. Conclusion: The successful simulation and forecasting of the pandemic showed that the PECFE could be effective in constructing decision models during pandemic outbreaks, which is crucial for emergency management where every second counts. [ABSTRACT FROM AUTHOR]

The direct conversion of low alkane such as ethane into high-value-added chemicals has remained a great challenge since the development of natural gas utilization. Herein, we achieve an efficient one-step conversion of ethane to C2 oxygenates on a Rh1/AC-SNI catalyst under a mild condition, which delivers a turnover frequency as high as 158.5 h−1. 18O isotope-GC–MS shows that the formation of ethanol and acetaldehyde follows two distinct pathways, where oxygen and water directly participate in the formation of ethanol and acetaldehyde, respectively. In situ formed intermediate species of oxygen radicals, hydroxyl radicals, vinyl groups, and ethyl groups are captured by laser desorption ionization/time of flight mass spectrometer. Density functional theory calculation shows that the activation barrier of the rate-determining step for acetaldehyde formation is much lower than that of ethanol, leading to the higher selectivity of acetaldehyde in all the products. The direct conversion of low alkane-like ethane into high-value chemicals has posed a significant challenge. Herein, the authors successfully accomplish a one-step conversion of ethane to C2 oxygenates using a Rh single-atom catalyst under mild conditions. [ABSTRACT FROM AUTHOR]

The strength and hardness of rock are much higher at freezing temperatures than at room temperature. This results in high excavation costs and low excavation efficiency in frozen rock layers. This study proposes a novel way to thaw porous and water-bearing rock by microwave irradiation. It is applicable to a wide range of strata and is not dependent on whether the rock contains wave-absorbing minerals. Quartz sandstone specimens free from absorbing minerals and of different saturation levels were used in an investigation of thawing and softening behaviors under microwave irradiation. The rock pore structures were observed before and after irradiation. The results show that (1) frozen quartz sandstone irradiated by microwaves undergoes three stages: (i) rapid melting of pore ice, (ii) intense vaporization of meltwater, and (iii) drying. (2) Microwave irradiation significantly reduces the strength of frozen quartz sandstone. (3) The mechanisms are vaporization expansion, which causes the propagation of intergranular cracks, and thermal expansion, which induces trans-granular cracking. (4) Softening of 40–100%-saturated frozen quartz sandstone is caused by both vapor and thermal expansion, while 0–40%-saturated sandstone is mainly affected by thermal expansion. This study provides theoretical and experimental support for microwave-assisted breakage of frozen porous and water-bearing rock. Highlights: Microwave irradiation is a promising auxiliary method in excavation of frozen rock. Microwave irradiation heating melts frozen sandstone completely within only 40 s. Unfrozen water in frozen sandstone is the fundamental cause of the rapid melting. Softening effect on frozen sandstone is enhanced by increasing saturation degree. [ABSTRACT FROM AUTHOR]

Blackwater occurs every winter in reservoirs with Eucalyptus plantations. The complexation reaction between ferric iron (Fe3+) and Eucalyptus leachate tannic acid from logging residues (especially leaves) is the vital cause of water blackness. However, the effect of Eucalyptus leaf leaching on the dynamic of iron in sediments and its contribution to reservoir blackwater remain unclear. In this study, two experiments were conducted to simulate the early decomposition processes of exotic Eucalyptus and native Pinus massoniana leaves in water (LW) and water-sediment (LWS) systems. In LW, high concentrations of tannic acid (>45.25 mg/L) rapidly leached from the Eucalyptus leaves to the water column, exceeding those of Pinus massoniana leaves (<1.80 mg/L). The chrominance increased from 5~10 to 80~140, and the water body finally appeared brown instead of black after the leaching of Eucalyptus leaves. The chrominance positively correlated with tannic acid concentrations (R=0.970, p<0.01), indicating that tannic acid was vital for the water column's brown color. Different in LWS, blackwater initially emerged near the sediment-water interface (SWI) and extended upward to the entire water column as Eucalyptus leaves leached. Dissolved oxygen (DO) and transmission values in the overlying water declined simultaneously (R>0.77, p<0.05) and were finally below 2.29 mg/L and 10%, respectively. During the leaching of Eucalyptus leaves, the DGT-labile Fe2+ in sediments migrated from deep to surface layers, and the diffusive fluxes of Fe2+ at the SWI increased from 12.42~19.93 to 18.98~26.28 mg/(m2·day), suggesting that sediment released abundant Fe3+ into the aerobic overlying water. Fe3+ was exposed to high concentrations of tannic acid at the SWI and immediately generated the black Fe-tannic acid complex. The results indicated that the supplement of dissolved Fe3+ from sediments is a critical factor for the periodic blackwater in the reservoirs with Eucalyptus plantations. Reducing the cultivation of Eucalyptus in the reservoir catchment is one of the effective ways to alleviate the reservoir blackwater. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Central South University is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Acquired thrombotic thrombocytopenic purpura (aTTP) is a fatal hematologic disease. Despite the currently high standards of care, some patients who develop refractory or recurrent disease still have a poor prognosis. Although N-acetylcysteine (NAC) is recommended for the treatment of aTTP, its use in aTTP treatment is still controversial. We aimed to evaluate the association of NAC with mortality in patients with aTTP. This was a retrospective cohort study of patients with aTTP with in-hospital mortality as the primary outcome and time to platelet recovery and neurological recovery as secondary outcomes. We used multifactorial COX regression analysis to check for an association of NAC with mortality. Moreover, we performed a sensitivity analysis check the stability of our results. Finally, 89 patients with aTTP were enrolled. After adjusting for potential confounders, we found NAC to be associated with 75% lower in-hospital mortality (HR = 0.25, 95% CI = 0.1–0.64). The results of sensitivity analyses performed remained stable as the risk of in-hospital mortality in patients reduced in patients with comorbid neurological symptoms (HR = 0.23, 95% CI = 0.06–0.89). However, NAC use did not affect the time to platelet recovery (HR = 1.19, 95% CI = 0.57–2.5) or neurological recovery (HR = 0.32, 95% CI = 0.08–1.25) in patients with aTTP. NAC treatment reduces in-hospital mortality in patients with aTTP but does not shorten the time to platelet recovery or neurological recovery. [ABSTRACT FROM AUTHOR]

Mach cones are expected to form in the expanding quark-gluon plasma (QGP) when energetic quarks and gluons traverse the hot medium at a velocity faster than the speed of sound in high-energy heavy-ion collisions. The shape of the Mach cone and the associated diffusion wake are sensitive to the initial jet production location and the propagation direction of the parton shower relative to the radial flow because of the distortion caused by the collective expansion of the QGP and the large density gradient. The shape of jet-induced Mach cones and their distortions in heavy-ion collisions provide a unique and direct probe of the dynamical evolution and the equation of state of QGP. However, it is difficult to identify the Mach cone and the diffusion wake in current experimental measurements of final hadron distributions because they are averaged over all possible initial jet production locations and parton-shower propagation directions. To overcome this difficulty, we develop a deep learning assisted jet tomography which uses the full information of the final hadrons from jets to localize the initial jet production positions. This method can help to constrain the initial regions of jet production in heavy-ion collisions and enable a differential study of Mach-cones with different path lengths and orientations relative to the radial flow of the QGP in heavy-ion collisions. [ABSTRACT FROM AUTHOR]

The temporal variations of water quality in rivers reflect the changes in the pollutant load of a basin to a certain extent. The temporal variations of pollution source structures reflect the changes in the contribution rates of different pollution sources. The temporal variations of water quality and pollution source structures were combined in this study to investigate and analyze the water pollution control effects on different pollution sources over 15 years in the upper Tuojiang River Basin (UTRB). The seasonal trend decomposition using loess (STL), principal component analysis (PCA), factor analysis (FA), absolute principal component score (APCS), and multiple linear regression (MLR) were employed in the analysis. According to the results, except for TN, the concentrations of BOD, AN, and TP showed a downward trend. The precipitation had a strong influence on the pollution seasonal patterns. BOD and AN were primarily influenced by urban and rural living sources, while the primary sources for TN and TP were agricultural NPS and phosphate chemical industry sources, respectively. The systematic and comprehensive pollution control strategies in the third stage (2016–2020) have become more effective. In particular, the reduction of TP was successfully achieved by strengthening the pollution abatement on phosphate chemical industry sources. In contrast, the reduction in agricultural NPS emissions was not significant during the study period. [ABSTRACT FROM AUTHOR]

One of the primary tasks for effective disaster relief after a catastrophic earthquake is robust communication. In this paper, we propose a simple logistic method based on two-parameter sets of geology and building structure for the failure prediction of the base stations in post-earthquake. Using the post-earthquake base station data in Sichuan, China, the prediction results are 96.7% and 90% for the two-parameter sets and all parameter sets, respectively, and 93.3% for the neural network method sets. The results show that the two-parameter method outweighs the whole parameter set logistic method and the neural network prediction and can effectively improve the accuracy of the prediction. The weight parameters of two-parameter set by the actual field data significantly show that the failure of base stations after earthquake is mainly due to the geological differences where the base stations are located. It can be envisioned that if the geological distribution between the earthquake source and the base station is parameterized, the multi-parameter sets logistic method can not only effectively solve the failure prediction after earthquakes and the evaluation of communication base stations under complex conditions, but also provide site selection evaluation for the construction of civil buildings and power grid towers in earthquake-prone areas. [ABSTRACT FROM AUTHOR]

Assessing the scale effects of land use on water quality is of great significance for effectively controlling nonpoint source (NPS) pollution in river basins. In this study, redundancy analysis (RDA) and stepwise multiple linear regression (SMLR) analysis were applied to assess the effects of land use on water quality across multiscales in the Tuojiang River Basin. All monitoring sections were classified into three groups according to the characteristics of land use and cluster analysis of water quality. Results showed that the improvement in water quality of rivers in the Tuojiang River Basin lies in the emphasis and protection of the small-scale scope. Concomitantly, the linkages between individual water quality parameter and land use were highly dependent on spatial scales and regional basis. For the upstream group A, urban land is the main source of COD and TN pollution, while industrial and rural residential land contributed the most to TP pollution. Water body exhibits favorable effects on ammonia nitrogen due to its absorption and degradation, together with the growth of phytoplankton within it. For group B in the middle-lower reaches, controlling the input of organic fertilizers in paddy field will effectively alleviate COD pollution. Increasing the proportion of grassland near the riparian zone can have a positive effect on TN and TP pollution. It should continue to strengthen the strict supervision of NH3-N concentration in wastewater discharge from industrial enterprises. Our results can provide important information for land use planning and making multiple scale measures for water quality conservation. [ABSTRACT FROM AUTHOR]

Alkali metals have been widely used as promoters of metal catalysts in various applications, yet the atomic understanding of the promotional mechanism remains elusive. In this work, we for the first time report the significant promotional effect of potassium to the Co-N-C single-atom catalyst for the direct dehydrogenation of ethylbenzene. K cation was introduced by impregnation of Co-N-C with KCl followed by calcination at 600 °C, which resulted in the bonding of K to the Co-O moiety of the Co-N-C catalyst as revealed by X-ray absorption spectroscopy in combination with theoretical calculations. The formation of Co-O-K moiety led to the increase of electron density at the O atom due to electron transfer of K to O, and consequently facilitated the heterolytic cleavage of the C-H bond of ethylbenzene across the Co-O moiety. The promotional effect of K was found to be a volcano-function with the K/Co ratio and became the greatest at the K/Co ratio of 1.36, which resulted in the highest steady-state reaction rate of 9.7 mmolEB·gcat−1·h−1 reported thus far. Moreover, the catalyst exhibited excellent stability during 100 h time on stream. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Central South University is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Central South University is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Syngas conversion serves as a competitive strategy to produce olefins chemicals from nonpetroleum resources. However, the goal to achieve desirable olefins selectivity with limited undesired C1 by-products remains a grand challenge. Herein, we present a non-classical Fischer-Tropsch to olefins process featuring high carbon efficiency that realizes 80.1% olefins selectivity with ultralow total selectivity of CH4 and CO2 (<5%) at CO conversion of 45.8%. This is enabled by sodium-promoted metallic ruthenium (Ru) nanoparticles with negligible water-gas-shift reactivity. Change in the local electronic structure and the decreased reactivity of chemisorbed H species on Ru surfaces tailor the reaction pathway to favor olefins production. No obvious deactivation is observed within 550 hours and the pellet catalyst also exhibits excellent catalytic performance in a pilot-scale reactor, suggesting promising practical applications.Zhong et al report sodium-promoted metallic Ru nanoparticles for the direct production of olefins from syngas with ultrahigh carbon efficiency where the total selectivity of undesired CH4 and CO2 is suppressed to only 5% for over 500 hours on stream. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the effects of livin on the Th2 immune response in airway allergic diseases (AAD) and explore the interaction among livin, GATA3, IL-4 in peripheral blood CD4+ T cells of AAD patients. Methods: WT mice and livin KO mice were developed for model of AAD. Th2 cell levels in the lung tissues and spleen were assessed by flow cytometry. Also, it was assessed in the culture after exposing to livin inhibitor (Lp-15); the protein and mRNA levels of livin, GATA3 and IL-4 in peripheral blood CD4+ T cells isolated from patients with or without AAD were measured by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting, respectively. Finally, Co-immunoprecipitation (Co-IP) was employed to identify the interaction between livin and GATA3. Results: Compared with WT mouse, Th2 cell frequency in lung tissues and spleen was significantly decreased in livin KO mouse; after adding Lp-15, the differentiation from Naive CD4+T cells in spleen to Th2 cells was blocked; the protein and mRNA levels of livin, GATA3 and IL-4 in AAD group were higher than that in control group. The levels of livin were positively correlated with IL-4, and GATA3 was also positively correlated with IL-4 and livin. GATA3 was detected in the protein complex co-precipitated with livin antibody, and livin was also detected in the protein complex co-precipitated by GATA3 antibody. Conclusion: Livin increases the expression of IL-4 and facilitates naive CD4+ T cells to differentiate into Th2 cells, which triggers airway allergy. [ABSTRACT FROM AUTHOR]

Immune checkpoint molecules play critical roles in regulating the anti-tumor immune response, and tumor cells often exploit these pathways to inhibit and evade the immune system. The B7-family immune checkpoint B7x is widely expressed in a broad variety of cancer types, and is generally associated with advanced disease progression and poorer clinical outcomes, but the underlying mechanisms are unclear. Here, we show that transduction and stable expression of B7x in multiple syngeneic tumor models leads to the expansion of immunosuppressive regulatory T cells (Tregs). Mechanistically, B7x does not cause increased proliferation of Tregs in tumors, but instead promotes the conversion of conventional CD4+ T cells into Tregs. Further, we find that B7x induces global transcriptomic changes in Tregs, driving these cells to adopt an activated and suppressive phenotype. B7x increases the expression of the Treg-specific transcription factor Foxp3 in CD4+ T cells by modulating the Akt/Foxo pathway. B7x-mediated regulation of Tregs reduces the efficacy of anti-CTLA-4 treatment, a therapeutic that partially relies on Treg-depletion. However, combination treatment of anti-B7x and anti-CTLA-4 leads to synergistic therapeutic efficacy and overcomes the B7x-mediated resistance to anti-CTLA-4. Altogether, B7x mediates an immunosuppressive Treg-promoting pathway within tumors and is a promising candidate for combination immunotherapy. B7x is a B7-family ligand with suppressive effects on effector T cells. Here the authors show that tumor-expressed B7x promotes the conversion of conventional CD4+ T cells into regulatory T cells within the tumor microenvironment to promote immune evasion and resistance to anti-CTLA-4 therapy. [ABSTRACT FROM AUTHOR]

This paper presents an experimental study to assess the behaviour of coal samples under tensile loadings to better understand the failure mechanisms and the interactions with the coal characteristics. A set of Brazilian splitting tests were carried out using disk specimens obtained from Tashan Coal Mine in China. The digital speckle correlation method and acoustic emission (AE) were used to capture the deformation localisation and AE characteristics of each specimen during the loading process. The precursor characteristics of AE and the failure mechanism are discussed. It was found that the entire loading process mainly consists of compaction, elastic and post-peak dropping stage without an obvious yielding stage. Two kinds of deformation localisation were observed: central symmetry and axis symmetry. The corresponding AE evolution patterns have different phases, including gradual rise, step rise, transient rise and steady rise. During the subcritical failure stage, AE counts demonstrate a "rapidly increasing + flatten" intermittent feature. The results provide a reference for a better understanding of the damage process of the brittle coal material and its application in ground control design. [ABSTRACT FROM AUTHOR]

Now indoor fingerprint maps are mostly generated and maintained by professional companies, where the generation efficiency and update frequency are relatively slow. To address such issues, the paper devises a crowdsourcing method, which uses the sensed data from personal smart devices to build a Wi-Fi fingerprint based map for indoor navigation. Our method uses the positions with high centrality as landmarks. Moreover, based on the improved Euclidean Distance method and Access Points (APs) rank, we devise a Coefficient Weighting algorithm to match the Wi-Fi fingerprints among the Wi-Fi Received Signal Strength (RSS) sequences, which also applied together with a scoring matrix to decrease the redundant data brought by trajectories overlapping. The experimental results show that: (1) our proposed method not only reducing the redundant data brought by crowdsourcing, but also updating the map in a near-real-time manner; (2) the mean positioning error of the generated map is < 2 m, which obviously outperforms the known methods such as LiFs, CALL, etc. [ABSTRACT FROM AUTHOR]

Environmental pressures have rapidly increased in various regions worldwide due to globalization. Thus, sustainable consumption and production are crucial for sustainable resource development. The material footprint (MF) of 180 countries was calculated from 1995 to 2015, and spatial autocorrelation analysis was conducted to investigate the spatiotemporal trend of the global MF. The results show that the global MF presented an upward trend from 1995 to 2015, increasing by 83%, and we find that the global per capita MF exhibits clustering, with an increasing trend during the study period. The findings indicate that resource consumption is similar in neighboring areas, especially in countries with a high MF surrounded by countries with a high MF (high-high clustering) and countries with low-low clustering. In addition, the number of countries with high clustering increased during the study period. We should take advantage of clustering, improve resource utilization, increase the technical carrying capacity, and develop energy-saving technologies. In African regions with low-low clustering, the economy of the surrounding areas should be stimulated to strengthen economic and technological clustering. In addition, advanced technology should be incorporated to improve the efficiency of using natural resources. This study can provide a reference for the spatial distribution of sustainable resource development. [ABSTRACT FROM AUTHOR]

The strain after rolling plays an important role in the prediction of the microstructure and properties and plate deformation permeability. So, it is necessary to establish a more accurate theoretical strain model for the rolling process. This paper studies the modeling method of the equivalent strain based on the upper bound principle and the stream function method. The rolling deformation region is divided into three zones (inlet rigid zone, plastic zone, and outlet rigid zone) according to the kinematics. The boundary conditions of adjacent deformation zones are modified according to the characteristics of each deformation zone. A near-real kinematics admissible velocity field is established by the stream function method on this basis. The geometric boundary conditions of the deformation region are obtained. The deformation power, friction power, and velocity discontinuous power are calculated according to the redefined geometric boundary conditions. On this basis, the generalized shear strain rate intensity is calculated according to the minimum energy principle. Finally, the equivalent strain model after rolling is obtained by integrating the generalized shear strain rate in time. The plate rolling experiments of AA1060 and the numerical simulations are carried out with different rolling reductions to verify the analytic model precision of the equivalent strain. The results show that the minimum and the maximum relative equivalent strain deviation between the analytic model and the experiment is 0.52% and 9.96%, respectively. The numerical calculation and experimental results show that the model can accurately calculate the strain along the plate thickness. This model can provide an important reference for the rolling process setup and the microstructure and properties prediction. [ABSTRACT FROM AUTHOR]

In the process of underground coal mining, the energy released by fracture of roof beam is the main source of rock burst energy. This part of energy is affected by its size and material properties. This study redefined the geometric parameter (GEO) and material parameter (MAT) that characterize the properties of rock beams. Three point bending tests were designed and carried out on account of the two parameters. The parameter representing the energy release capacity of rock beams was proposed, and the effects of GEO and MAT on the parameter were quantitatively analyzed by numerical simulation. Finally, a new method for predicting the energy released by rock beam fracture was proposed. The results show that with the increase of MAT and GEO, the total energy stored in the rock beam and the energy released during fracture both showed an upward trend. MAT is the main parameter that affects the load–deflection curve and AE parameter distribution characteristics, while the influence of GEO on the test curve was only reflected in the numerical change. The energy release ratio ranges from 0.5 to 0.7, which exhibits a quadratic function relationship with the MAT of the rock beam. The proposed new method for predicting the energy released by rock beam fracture was successfully used in the 10,301 working face of Jining No. 2 Coal Mine. The prediction results of the basic roof and the direct roof beam were consistent with the field microseismic test results, and the errors were only 10.88% and 11.50%, respectively. [ABSTRACT FROM AUTHOR]

Metal particles can be deposited on nylon 12 (PA12) surface with excellent metal/substrate interface and distribution by electroless plating (EP), but the use of noble metal as EP catalyst would enhance the cost of raw materials and restrict its application. In this work, we developed a polymer brush (PB)-induced EP method to prepare Cu particle/PA12 composite powder (CPP) as an enhancing component for improving the strength of the selective laser sintering (SLS) part. The results showed hydrolyzed 3-amino-propyltriethoxysilane attached on the modified PA12 surface, which presented in PB form. The PB effectively reduced the stability of [Cu-EDTA] complex and REDOX barrier, subsequently, PB acted as catalytic site to reduce Cu ion into Cu metal by EP. The deposit consisted of Cu particles (spherical, about 1 μm) and a small quantity of Cu2O particles (cubic, about 0.3 μm), the ratio of Mplated particle/M(plated particle+PA12) is 15%. The PA12 particles were spheroidized firstly, then formed sintered neck during neighboring particles and sintered body in turn under laser action. Based on the excellent Cu/PA12 interface and dispersion, the tensile strength of the SLS part sintered with 10 W laser energy increased by an average of around 26.2% to 53 MPa. [ABSTRACT FROM AUTHOR]

A new high-resolution velocity model of the southern Kyushu-Palau Ridge (KPR) was derived from an active-source wide-angle seismic reflection/refraction profile. The result shows that the KPR crust can be divided into the upper crust with the P-wave velocity less than 6.1 m/s, and lower crust with P-wave velocity between 6.1 km/s and 7.2 km/s. The crustal thickness of the KPR reaches 12.0 km in the center, which gradually decreases to 5.0–6.0 km at sides. The velocity structure of the KPR is similar to the structures of the adjacent West Philippine Basin and Parece Vela Basin (PVB), indicating a typical oceanic crust. Isostatic analysis shows that some regional compensation occurs during the loading of the KPR, which implies that the KPR was built mainly by magmatism during the splitting of the Izu-Bonin-Mariana arc and the following back-arc seafloor spreading of the PVB during 30–28 Ma BP. The absence of the thick middle crust (6.0–6.5 km/s) and high velocity lower-crustal layers (7.2–7.6 km/s) suggest that arc magmatism plays a less important role in the KPR formation. [ABSTRACT FROM AUTHOR]

The nonlinear flow of liquids through nanoscale channels play an important role in the separation and purification properties of porous membranes, the manufacture of biofilm ionic channels and microfluidic chips, the production of micro electro-mechanical systems. Silicon oil flow experiments were conducted through anodic alumina films with pore sizes of 26, 67, 89, and 124 nm, in which flow mechanism and characteristics of the oil through the nanoscale channels were analyzed. Four nanoflow features are revealed: (1) The experimental flow rate is less than the theoretical flow rate through nanochannels, as solid-liquid interaction increasing flow resistance. (2) At small shear rate, the boundary layer is one, indicating existence of a threshold pressure of oil flow through nanochannels. (3) The boundary layer decreases with the increasing of shear rate, and it rapidly decreases as shear rate increases when the value of shear rate is small. (4) The drag coefficient decreases nonlinearly with increasing shear rate, decreasing more slowly when value of shear rate is big, and trending towards 1 in the case of large shear rate. It is shown that the non-linearity of flow is induced by great solid-liquid interaction in nano and microscale, and increasing the driving force can raise the efficiency at the nanometer scale. [ABSTRACT FROM AUTHOR]

During the construction of the freezing wall of the coal mine shaft, the long-term stability of the freezing wall is a key issue to control engineering safety. The creep deformation of frozen rock is one of the factors that cause the destruction of the frozen wall. Taking the Cretaceous saturated frozen sandstone as the research object, the creep mechanics test of frozen rock under different confining pressure conditions is carried out, and the strain–time curve clusters under different loading stress states are obtained. Based on the Riemann–Liouville-type integral function and borrowing from classic modeling ideas, a 5-element nonlinear creep damage constitutive equation considering low-temperature-damage-stress coupling is established, and the model verification is carried out. The results show: when the rock is in the elastic stage, the creep parameter E 1 theory under each loading level should be exactly the same. But it shows a trend of increasing first and then decreasing, so the creep of frozen sandstone is a kind of nonlinear creep. The viscoelastic modulus E 2 is a measure of the amount of deformation in the creep attenuation stage, indicating that it gradually decreases as the load factor increases. After the strain gradually increased to a certain fixed value, E 1 remained basically constant. As the loading stress increases, the interior of the rock will undergo stages of compression, slippage, and recombination, and the friction between particles will increase, showing that the viscosity coefficients η1 and η2 gradually increase. The influence of the parameters ζ and γ on the creep effect is analyzed through the results of the creep mechanics test. There is creep damage in the accelerated creep stage. As the load increases, the damage gradually expands. The same laws are shown under different confining pressure conditions. The research results can provide a theoretical model and the experimental basis for evaluating the instability and failure of the frozen wall induced by creep. [ABSTRACT FROM AUTHOR]

A quality of life questionnaire specific to sarcopenia (SarQoL®) was successfully developed. There is a huge demand for translation and validation in Chinese. The aim of this study was to translate the SarQoL® into Chinese and investigate its psychometric properties. The translation and cross-cultural adaptation process recommended by the developers of the initial questionnaire was followed. A total of 159 participants were investigated. The translation process consists of five steps: (1) two bilinguals independently translate initial English to Chinese; (2) synthesize the two translations into one; (3) backward translations; (4) expert committee review and (5) test of the pre-final version. The validation consists of three parts: (1) validity (discriminative power, construct validity); (2) reliability (internal consistency, test–retest reliability) and (3) floor and ceiling effects. There was no difficulty in translation process. Regarding the validity, good discriminant validity {quality of life for sarcopenic subjects [35.56 (29.73–42.70)] vs. non-sarcopenic ones [73.22 (60.09–82.90)], p < 0.001} and consistent construct validity [high correlations (spearman's r) of SarQoL® with generic Short Form-36 version 2 questionnaire (0.250 to 0.824) and EuroQoL-5-Dimension questionnaire (− 0.114 to − 0.823)] were found in SarQoL®. Regarding reliability, high internal consistency (Cronbach's alpha coefficient was 0.867) and excellent test–retest reliability (intraclass coefficient correlation was 0.997, 95% CI 0.994–0.998) were found. No ceiling/floor effect was reflected. A valid SarQoL® questionnaire is now available for Chinese population. It can provide a better understanding of the sarcopenia disease burden and serve as a therapeutic outcome indicator in research. [ABSTRACT FROM AUTHOR]

The central deformation extent of the thick plate can be improved and the approaching uniform deformation will be realized by the snake/gradient temperature rolling (SGTR). At present, the existing rolling force analytical models cannot be directly used for SGTR because of the great difference with the synchronous rolling. The rolling force model should be established so as to meet the production demand of the SGTR with different roll diameters. The thick plate is divided into three layers according to the numerical results of the short-term ultra-fast cooling for the thick plate. The deformation region is simplified into different zones and layers according to the temperature gradient and neutral point position. The traditional von Mises yield criterion was optimized by the introduced coefficients c1 and c2 according to the slip line field theory to correct the deviation caused by the uniform and shear stress assumption. The specific pressure equation is established by the slab method. The deformation region with different composition cases is analyzed, and the rolling force and torque analytical models are established according to the boundary conditions on this basis. The short-term ultra-fast cooling and rolling process were simulated by ANSYS software. The deformation resistance gradient produced by short-term ultra-fast cooling and roll diameter ratio are the main factors to affect the rolling force, while the roll offset has little effect on the rolling force because of its small proportion in the deformation region. The position of neutral points not only affects the rolling torque, but also changes its direction in certain conditions. The model precision was analyzed, and the rolling force calculated by the established analytic model is in good agreement with the numerical method, which serves as a theoretical basis for the rolling mill design and process parameter setting. [ABSTRACT FROM AUTHOR]

Circular RNA (circRNA) plays an important role in the regulation of multiple biological processes. However, circRNA profiling and the potential biological role of circRNA in influenza A virus (IAV)-induced lung injury have not been investigated. In the present study, circRNA expression profiles in lung tissues from mice with and without IAV-induced lung injury were analyzed using high-throughput sequencing, and differentially expressed circRNAs were verified by quantitative PCR. The gene homology of candidate circRNAs was investigated and the expression of plasma circRNAs from patients with IAV-induced acute respiratory distress syndrome (ARDS) was detected. The target microRNAs (miRNAs) of circRNAs were predicted. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. In total, 781 circRNAs were differentially expressed between ARDS mice and control (467 were up-regulated and 314 were down-regulated). Moreover, the candidate circRNAs (Slco3a1, Nfatc2, Wdr33, and Dmd) expression showed the same trend with the sequencing results. The isoforms of circRNA Slco3a1 and Wdr33 were highly conserved between humans and mice. Plasma circRNA Slco3a1 and Wdr33 presented differential expression in patients with IAV-induced ARDS compared to control. The circRNA-miRNA interaction network and GO and KEGG analyses indicated the potential biological role of circRNAs in the development of IAV-induced lung injury. Taken together, a large number of differentially expressed circRNAs were identified in our study. CircRNA Slco3a1 and Wdr33 had significantly different expression in specimens from mice and humans, and showed a potential biological role in IAV-induced lung injury by bioinformatics analysis. [ABSTRACT FROM AUTHOR]

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Precision optical systems, such as lithographic projection lens or cameras for satellites, typically composed of glass or ceramics optical components. In the manufacturing processes of glass and ceramics components, grinding is a key technique for curvature generation (CG) of optical surface. However, dimension errors and sub-surface damage (SSD) of components occur during the CG process. High material removal rates during the CG leads to deeper SSD on optical surface. The SSD must be removed by subsequent lapping and polishing processes to ensure high optical surface quality. However, these processes are complex, and a precise process to remove SSD from the aspheric surfaces with tens or hundreds of microns of departure from best fit sphere (BFS) is required. Thus, an efficient precision lens fabrication method can reduce the depth of SSD and help to control the dimension error during the CG process. We developed a five-axis grinding system with intelligent machining techniques to improve the quality of CG process. The intelligent grinding system based on the Tongtai five-axis machine (GT-630) was combined with two measurement modules of the Renishaw measurement probe. A customized computer-aided manufacturing software was developed and applied to this grinding system. Spherical and aspherical components with a maximum diameter of 600 mm can be fabricated using the grinding system. To improve the grinding efficiency, an ultrasonic-assisted module was combined with the BBT 40 tool arbor. The frequency range, amplitude, and power of the ultrasonic device were 15–40 kHz, 0.2–2 μm, and 1000 W, respectively. The intelligent grinding system included several vibration, temperature, and acoustic emission sensors and a microphone to monitor the dynamic status of machine during the grinding process and help to quality control. The wear of the diamond grinding wheel could be predicted immediately by analyzing the collected data in this system. A five-axis machine was applied to an intelligent grinding system for large glass lenses. The fabrication time of 200 mm diameter aspheric lenses reduced about 3 weeks by using this intelligent grinding system to integrate aspherization processes into curvature generation to become an aspheric curvature generation step. [ABSTRACT FROM AUTHOR]

An experimental apparatus including a dipleg and a trickle valve was established to simulate the operation of a suspended dipleg-trickle valve system of cyclone used in fluid catalytic cracking (FCC) unit. The flow regimes in the dipleg and the discharge modes in the trickle valve were studied by combining the observation of experimental phenomena with the analysis of transient pressure fluctuation. The results show that the flow regimes in the dipleg have two types—the dilute–dense phase coexisting falling flow and the dilute falling flow. Correspondingly, the trickle valve also has two discharge modes—the intermittent periodic dumping discharge and the continuous trickling discharge. The power spectrum density of pressure fluctuation displays that the gas–solids flow in the dipleg-trickle valve system is characterized by a low-frequency pulsation. The coherence coefficient explains the origin and propagation of pressure fluctuation in the system. Eventually, a map describing the flow regimes and discharge modes related to the operation parameters was proposed, which can provide a helpful guidance for the operation of cyclone dipleg-trickle valve system in FCC unit. [ABSTRACT FROM AUTHOR]

Automated bonnet polishing is achieved using computer numerical control (CNC) technology. However, owing to specific toolpaths, CNC bonnet polishing is generally accompanied by the mid-spatial frequency (MSF) of surface textures on polished surfaces that could produce surface ripples or waviness and degrade image quality. In this study, the MSF surface textures on fused silica are investigated by developing a CNC bonnet polishing technique using a cerium oxide-filled polyurethane pad (LP66)—a cellular polyurethane material designed to handle high flatness and surface finishing requirements for optical glass materials. To minimize the MSF, optimal combinations of various polishing parameters, including tool offset, head speed, track spacing, and surface feed rate, are studied. Experimental results demonstrate that the head speed and feed rate significantly affect the surface texture during bonnet polishing. Although the tool offset does not cause surface textures, the material removal rate is affected. A series of optimization experiments is conducted, consequently leading to the effective removal of irregular surface ripples and a reduction of MSF errors. By optimizing the polishing parameters, extremely accurate surface quality is achieved, along with a root mean square error of 1.6 nm. These results demonstrate the potential applications of LP66 in CNC bonnet polishing for highly accurate freeform optical components. [ABSTRACT FROM AUTHOR]

The low density, high specific strength, and good creep properties make TiAl alloys being promising high-temperature structural materials in aerospace and automotive industries. However, the insufficient oxidation resistance limits their extensive practical applications. It is the intention of this review to illustrate the mechanism and development of sol–gel-based coatings, a surface modification approach for oxidation protection of TiAl alloys, but not to present a general review on the oxidation protection of TiAl alloys. The oxidation behavior and mechanism of TiAl alloys were addressed briefly. The discussion focused mainly on the sol–gel coatings preparation method and generation mechanism. Finally, the development trend of sol–gel-based coatings for high-temperature oxidation of TiAl alloys was prospected. [ABSTRACT FROM AUTHOR]

In this pilot study, we explored a quantitative method to analyse characteristics of breast tumours using 3D volumetric data obtained from a three-dimensional (3D) photoacoustic/ultrasound (PA/US) functional imaging system. Imaging results from 24 Asian patients with maximum tumour diameters less than 2 cm, including 8 benign tumours, 16 T1 stage invasive breast cancers (IBCs), and 22 normal breasts, were analysed. We found that the volumetric mean oxygenation saturation (SO2) in tumour regions of T1 stage IBCs was 7.7% lower than that of benign tumours (P = 0.016) and 3.9% lower than that of healthy breasts (P = 0.010). The volumetric mean SO2 in tumour surrounding regions of T1 stage IBCs was 4.9% lower than that of benign tumours (P = 0.009). For differentiating T1 stage IBCs and benign tumours, with a cut-off SO2 value of 78.2% inside tumours, we obtained a sensitivity of 100%, a specificity of 62.5%, and an AUC of 0.81; with a cut-off SO2 value of 77.9% in regions surrounding tumours, we obtained a sensitivity of 100%, a specificity of 75% and an AUC of 0.84. Our preliminary results demonstrate that 3D PA/US functional imaging has the potential to provide valuable quantitative physiological information that may be useful for the detection and evaluation of breast tumours. [ABSTRACT FROM AUTHOR]

Oxidative stress is a major pathogenic mechanism in Parkinson's disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production and incorporation of free radicals to protect neurons from oxidative damage. GSH level is decreased in the brains of PD patients. Hence, clarifying the molecular mechanism of GSH deficiency may help deepen our knowledge of PD pathogenesis. Here we report that the astrocytic dopamine D2 receptor (DRD2) regulates GSH synthesis via PKM2-mediated Nrf2 transactivation. In addition we find that pyridoxine can dimerize PKM2 to promote GSH biosynthesis. Further experiments show that pyridoxine supplementation increases the resistance of nigral dopaminergic neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in wild-type mice as well as in astrocytic Drd2 conditional knockout mice. We conclude that dimerizing PKM2 may be a potential target for PD treatment. Dopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation. [ABSTRACT FROM AUTHOR]

This research increases the ability and value of a traditional vertical lathe and applies to manufacture a precise lens cell for the optical industry. The optical performance is limited by the residual centration error and position accuracy of conventional assembly methods. Recently, the development of a poker-chip assembly system with high-precision lens barrels has overcome these limitations and provided a solution for ultra-high-performance optical systems. To develop a high-precision lens cell by using poker-chip assembly, an alignment turning system (ATS), is developed based on a vertical lathe and equipped with tactile and optical measurement modules. Inside the ATS, the building-in the vibration/temperature monitoring sensors, which help to self-monitoring and network communication with the intelligent manufacturing techniques, to understand and master the reliability and efficiency of ATS. This system can manufacture precise lens cells, applied for optical metrology, high numerical aperture objective lenses, and lithography projection lenses. This paper describes the design and development of the ATS and its capabilities. The ATS is composed of measurement, alignment, and turning modules. After the ATS completes the measurement, alignment, and turning processes, the centration error of a lens cell, which is 200 mm in diameter, can be controlled to within 10 arcsec. Here, a lens cell with three subcells was assembled through the poker-chip method; each subcell was measured and then it underwent alignment and turning processes. The lens assembly test was performed five times by three technicians, and the average transmission centration error of the assembly lens was 12.45 arcsec. The results demonstrate that the ATS can achieve considerable assembly efficiency for high-precision optical systems. [ABSTRACT FROM AUTHOR]

During the past decade’s exploitation of coal seams in Muchengjian Mine in Jingxi Coalfield, there were nearly thirty rock burst events, which hindered the safe and efficient coal production. Two typical mining areas were selected for analysis where almost half of rock burst events occurred. The research was aimed at finding connections between the occurrence of rock bursts and geological characteristics. The temporal and spatial characteristics of rock bursts were described in detail, the geological characteristics were investigated carefully, and the possible reasons for rock bursts were analyzed. The details documented in these cases not only provide an essential reference value for understanding the development mechanism of rock bursts, but also provide a basis for selecting control measures and optimizing related technical parameters during tunneling or mining under complicated geological conditions. [ABSTRACT FROM AUTHOR]