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As the world's most populous developing country and the world's largest carbon emitter, China has already completed its 2020 Intended National Determined Contribution set out in the Paris Agreement. It achieved this result by adopting a dual-goal strategy of economic growth and reducing carbon emission, that is, low-carbon economic growth. Based on both parametric and nonparametric methods, quantitative and qualitative conclusions about China's low-carbon economic growth are presented. It is found that since the beginning of this century, China has maintained an annual growth efficiency of 1% in low-carbon total factor productivity (TFP) and low-carbon technological progress rate. The Eastern region has leading advantages in low-carbon TFP, low-carbon technology advancement, low-carbon efficiency, and low-carbon technology revolution. It has the potential to be the first to reach its CO2 turning point. The inefficiency ratio of labor and CO2 is higher at the national level and in the Eastern region, with the two accounting for about seven tenths and eight to nine tenths, respectively. The difference is that at the national level, the input–output inefficiency is similar, and the inefficiency in the Eastern region is more from the input side, about eight tenths. At the present stage, China is still lenient in the implementation of low-carbon environmental regulations. In the future, the adjustment of low-carbon policy should pay attention to regional heterogeneity, focus on reducing labor and CO2 inefficiency, and be more stringent in policy implementation. [ABSTRACT FROM AUTHOR]

Few reports have investigated the predictive value of urinary cadmium (UCd) and telomere length on renal function impairment. Therefore, we constructed nomogram models, using a cross-sectional survey to analyze the potential function of UCd and telomere length in renal function impairment risk. We randomly selected two community populations in Shanxi, China, and general information of the subjects was collected through face-to-face questionnaire surveys. Venous blood of subjects was collected to detect absolute telomere length (ATL) by real-time quantitative chain reaction (RT-PCR). Collecting urinary samples detected UCd and urinary N-acetyl-β-d-glucosaminidase (UNAG). Estimated glomerular filtration rate (eGFR) was obtained based on serum creatinine (SCr). Nomogram models on risk prediction analysis of renal function impairment was constructed. After adjusting for other confounding factors, UCd (β = 0.853, 95% confidence interval (CI): 0.739 ~ 0.986) and ATL (β = 1.803, 95%CI: 1.017 ~ 1.154) were independent risk influencing factors for increased UNAG levels, and the risk factors for eGFR reduction were UCd (β = 1.011, 95%CI: 1.187 ~ 1.471), age (β = 1.630, 95%CI: 1.303 ~ 2.038), and sex (β = 0.181, 95%CI: 0.105 ~ 0.310). Using UCd, ATL, sex, and age to construct the nomogram, and the C-statistics 0.584 (95%CI: 0.536 ~ 0.632) and 0.816 (95%CI: 0.781 ~ 0.851) were obtained by internal verification of the calibration curve, C-statistics revealed nomogram model validation was good and using decision curve analysis (DCA) confirmed a good predictive value of the nomogram models. In a nomogram model, ATL, UCd, sex, and age were detected as independent risk factors for renal function impairment, with UCd being the strongest predictor. [ABSTRACT FROM AUTHOR]

The stationary probability density function (PDF) solution of a variable-mass system is calculated under Gaussian white noises and Poisson white noises, respectively. For small mass disturbance, the corresponding Fokker–Planck–Kolmogorov equation and Kolmogorov–Feller equation of the system are derived. The solution procedure based on the exponential–polynomial closure (EPC) method is formulated to obtain and study the probabilistic solutions of the strongly nonlinear variable-mass system subjected to Gaussian white noises and Poisson white noises. Both odd and even nonlinear variable-mass systems are considered. Compared with Monte Carlo simulation results, good agreement is achieved with the EPC method in the case of sixth-order polynomial. For large mass disturbance, the PDFs and logarithmic PDFs of displacement and velocity are numerically calculated via the fourth-order Runge–Kutta algorithm. [ABSTRACT FROM AUTHOR]

The main purpose of this article is to demonstrate that bursting oscillations can be exploited to enhance the harvested electrical power. A vibration-based bistable Duffing energy harvester, a tristable energy harvester and an asymmetric bistable energy harvester are examined, and bursting oscillations are observed in the energy-harvesting systems with periodic excitation when an order gap exists between the exciting frequency and the natural frequency. The bifurcation mechanism of the bursting oscillations is presented via the bifurcation diagram and the transformed phase portrait of fast subsystem, which reveals that fold bifurcations occur at the transition between the quiescent states and the repetitive spiking states. Then, we investigate the influence of resistive load on the output power, and the optimal resistance is employed to determine the maximum of the power. Furthermore, compared with the method of traditional resonance energy harvesting, results clearly illustrate an improved output power. [ABSTRACT FROM AUTHOR]

In this paper, the probability density function (PDF) and the mean up-crossing rate of nonlinear ship rolling in random beam seas are investigated. The excitation of stationary random sea waves is approximated as a second-order linear filtered white noise. The Fokker–Planck–Kolmogorov (FPK) equation governing the probability density function of ship rolling is a four-dimensional linear partial differential equation with varying coefficients, and obtaining its exact solution is much more sophisticated. The exponential-polynomial closure (EPC) method is applied to solve the corresponding FPK equation of the system. In numerical examples, linear-plus-cubic damping model and linear-plus-quadratic damping model with three different sea states are further examined. Comparison with the equivalent linearisation (EQL) method and Monte Carlo simulated results show that the proposed procedure is effective to obtain a satisfactory probability density function solution, especially in the tail region. [ABSTRACT FROM AUTHOR]

Even though a vaccine that targets tumor-associated carbohydrate antigens on epithelial carcinoma cells presents an attractive therapeutic approach, relatively poor immunogenicity limits its development. In this study, we investigated the immunological activity of a fluoro-substituted Sialyl-Tn (F-STn) analogue coupled to the non-toxic cross-reactive material of diphtheria toxin197 (CRM197). Our results indicate that F-STn-CRM197 promotes a greater immunogenicity than non-fluorinated STn-CRM197. In the presence or absence of adjuvant, F-STn-CRM197 remarkably enhances both cellular and humoral immunity against STn by increasing antigen-specific lymphocyte proliferation and inducing a mixed Th1/Th2 response leading to production of IFN-γ and IL-4 cytokines, as well as STn-specific antibodies. Furthermore, antisera produced from F-STn-CRM197 immunization significantly recognizes STn-positive tumor cells and increases cancer cell lysis induced by antibody-dependent cell-mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) pathways. Our data suggest that this F-STn vaccine may be useful for cancer immunotherapy and possibly for prophylactic prevention of cancer. [ABSTRACT FROM AUTHOR]

Background: The typical manifestations of Penicillium marneffei (nowadays Talaromyces marneffei) infection in children without human immunodeficiency virus (HIV) remain unclear. The current work presents the case of a child without an underlying disease who was infected with P. marneffei comorbid with eosinophilia.Case presentation: A 2-year-old male was infected with P. marneffei. A physical examination revealed a high-grade fever, ulcerated lesions in the oral mucosa, anemia, pruritic erythematous papules on the sac and thigh and watery diarrhea. A chest enhanced computed tomography scan showed multiple small, nodular, high-density shadows in the lungs, multiple lymphadenectasis in the hilum of the lungs and mediastinum, and liquid in the right pleural cavity. The patient's plasma was negative for HIV. Routine blood tests initially indicated that the patient had leucopenia; however, later tests indicated that he had leukocytosis. This peak was caused by a significant increase in eosinophils. The total IgE and specific allergen levels were normal. The stool was negative for parasite eggs. Aspergillus antigen (galactomannan, GM) levels were significantly increased and were present in the serum for a relatively long period.Conclusions: Eosinophilia can occur during P. marneffei infection, and this finding might provide additional information on the activity of this intracellular parasite. In addition, GM detection might be useful for monitoring the effect of antifungal treatments; however, this theory requires more data for verification. [ABSTRACT FROM AUTHOR]

Previous study showed that the magnesium-protoporphyrin IX chelatase H subunit (CHLH/ABAR) positively regulates abscisic acid (ABA) signaling. Here, we investigated the functions of a CHLH/ABAR interaction protein, the chloroplast co-chaperonin 20 (CPN20) in ABA signaling in Arabidopsis thaliana. We showed that down-expression of the CPN20 gene increases, but overexpression of the CPN20 gene reduces, ABA sensitivity in the major ABA responses including ABA-induced seed germination inhibition, postgermination growth arrest, promotion of stomatal closure and inhibition of stomatal opening. Genetic evidence supports that CPN20 functions downstream or at the same node of CHLH/ABAR, but upstream of the WRKY40 transcription factor. The other CPN20 interaction partners CPN10 and CPN60 are not involved in ABA signaling. Our findings show that CPN20 functions negatively in the ABAR-WRKY40 coupled ABA signaling independently of its co-chaperonin role, and provide a new insight into the role of co-chaperones in the regulation of plant responses to environmental cues. [ABSTRACT FROM AUTHOR]

To accurately quantify gene expression using quantitative PCR amplification, it is vital that one or more ideal internal control genes are used to normalize the samples to be compared. Ideally, the expression level of those internal control genes should vary as little as possible between tissues, developmental stages and environmental conditions. In this study, 32 candidate genes for internal control were obtained from the analysis of nine independent experiments which included 333 Affymetrix GeneChip Wheat Genome arrays. Expression levels of the selected genes were then evaluated by quantitative real-time PCR with cDNA samples from different tissues, stages of development and environmental conditions. Finally, fifteen novel internal control genes were selected and their respective expression profiles were compared using NormFinder, geNorm, Pearson correlation coefficients and the twofold-change method. The novel internal control genes from this study were compared with thirteen traditional ones for their expression stability. It was observed that seven of the novel internal control genes were better than the traditional ones in expression stability under all the tested cDNA samples. Among the traditional internal control genes, the elongation factor 1-alpha exhibited strong expression stability, whereas the 18S rRNA, Alpha-tubulin, Actin and GAPDH genes had very poor expression stability in the range of wheat samples tested. Therefore, the use of the novel internal control genes for normalization should improve the accuracy and validity of gene expression analysis. [ABSTRACT FROM AUTHOR]

The gene encoding the BmαTX14 (α-neurotoxin TX14) protein, derived from the cDNA library of the Chinese scorpion Buthus martensii Karsch, was expressed in Pichia pastoris. The recombinant protein was purified by metal chelate affinity chromatography and gel filtration chromatography. Using patch-clamp technique, electrophysiological activity of rBmαTX14 was identified. In the neurons isolated from mice trigeminal root ganglion, the Na+ current amplitude was reduced by 80% under whole cell patch-clamp recording. There were no apparent modifications to the gating mechanism in the presence of rBmαTX14. Although BmαTX14 shared a high amino acid sequence similarity with other typical α-toxins, it has different effects on neurons. Further electrophysiological analysis suggested that rBmαTX14 selectively blocked Na+ channels and is a member of a new group of scorpion toxins. [ABSTRACT FROM AUTHOR]

The 239+240Pu content of the marine sediments and seawater of the costal sea of Korea was measured. In marine sediments the 239+240Pu concentrations were in the range of 0.11-1.91 Bq/kg dry weight and in the coastal sea of Korea the ratio of 239+240Pu/137Cs was 0.27. The correlations between 239+240Pu and 137Cs concentrations and the content of organic matter (C, O, H, N, S) as well as the grain size of marine sediment were investigated by regression analysis. The distribution coefficient of 239+240Pu was 1.22. 105. The 239+240Pu concentration in seawater increased with seawater depth. However, the 137Cs concentration in seawater did not change considerably with depth. [ABSTRACT FROM AUTHOR]