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This letter to the editor discusses the case of a 58-year-old man with Acute Wernicke Encephalopathy who underwent PET/CT imaging. The imaging revealed increased uptake in the midbrain, medial thalamus, and periaqueductal gray matter, which contrasts with previously reported decreased uptake associated with Wernicke encephalopathy. Treatment with vitamin B1 injection resulted in clinical improvement, and follow-up imaging showed decreased FDG uptake in the cerebral lesion areas. The study suggests that PET/CT can reflect glucose metabolism changes in vital organs affected by thiamine deficiency in Acute Wernicke's encephalopathy. [Extracted from the article]

Myocardial ischemia/reperfusion (MI/R) injury is a pathological process that seriously affects the health of patients with coronary artery disease. Long non-coding RNAs (lncRNAs) represents a new class of regulators of diverse biological processes and disease conditions, the study aims to discover the pivotal lncRNA in MI/R injury. The microarray screening identifies a down-regulated heart-enriched lncRNA-CIRPIL (Cardiac ischemia reperfusion associated p53 interacting lncRNA, lncCIRPIL) from the hearts of I/R mice. LncCIRPIL inhibits apoptosis of cultured cardiomyocytes exposed to anoxia/reoxygenation (A/R). Cardiac-specific transgenic overexpression of lncCIRPIL alleviates I/R injury in mice, while knockout of lncCIRPIL exacerbates cardiac I/R injury. LncCIRPIL locates in the cytoplasm and physically interacts with p53, which leads to the cytoplasmic sequestration and the acceleration of ubiquitin-mediated degradation of p53 triggered by E3 ligases CHIP, COP1 and MDM2. p53 overexpression abrogates the protective effects of lncCIRPIL. Notably, the human fragment of conserved lncCIRPIL mimics the protective effects of the full-length lncCIRPIL on cultured human AC16 cells. Collectively, lncCIRPIL exerts its cardioprotective action via sequestering p53 in the cytoplasm and facilitating its ubiquitin-mediated degradation. The study highlights a unique mechanism in p53 signal pathway and broadens our understanding of the molecular mechanisms of MI/R injury. Overexpression of long non-coding RNA, lncCIRPIL protects the heart from ischemia/reperfusion (I/R) injury. LncCIRPIL binds and sequesters p53 in the cytoplasm to exert the cardioprotective action. [ABSTRACT FROM AUTHOR]

This study was to investigate the synthesis and biological evaluation of [99mTc]Tc-labeled Buthus martensii Karsch Chlorotoxin ([99mTc]Tc-BmK CT) as a radiopharmaceutical for glioma single photon computed emission tomography (SPECT) imaging. The results showed that BmK CT peptide modified with a hexahistidine tag displayed good cytocompatibility in vitro, and could be efficiently radiolabeled with 99mTc via [99mTc]Tc-tricarbonyl chemistry. The [99mTc]Tc-BmK CT showed satisfactory radiochemical purity and stability in vitro, and could be developed as a probe for targeted SPECT imaging of glioma cells in vitro and in a tumor-bearing mouse model. Our data indicated that the synthesized [99mTc]Tc-BmK CT might be developed as a promising imaging agent for glioma diagnostic application. [ABSTRACT FROM AUTHOR]