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Background:BCR-ABL1 mutation analysis is recommended for chronic myeloid leukaemia patients. However, mutations may become undetectable after changing therapy, and it is unknown whether they have been eradicated.Methods:We examined longitudinal data of patients with imatinib-resistant mutations, which became undetectable by Sanger sequencing to determine whether mutations could reappear, and the related circumstances.Results:Identical imatinib- and nilotinib-resistant mutations reappeared following further therapy changes in five patients, and was associated with subsequent nilotinib resistance in four.Conclusion:The data suggest that some BCR-ABL1 mutations may persist at undetectable levels for many years after changing therapy, and can be reselected and confer resistance to subsequent inhibitors. [ABSTRACT FROM AUTHOR]

In cooperative dynamic games, a stringent condition-that of subgame consistency-is required for a dynamically stable cooperative solution. In particular, under a subgame-consistent cooperative solution an extension of the solution policy to a subgame starting at a later time with a state brought about by prior optimal behavior will remain optimal. This paper extends subgame-consistent solutions to dynamic (discrete-time) cooperative games with random horizon. In the analysis, new forms of the Bellman equation and the Isaacs-Bellman equation in discrete-time are derived. Subgame-consistent cooperative solutions are obtained for this class of dynamic games. Analytically tractable payoff distribution mechanisms, which lead to the realization of these solutions, are developed. This is the first time that subgame-consistent solutions for cooperative dynamic games with random horizon are presented. [ABSTRACT FROM AUTHOR]

Summary: The study cohort comprised 196 females and 163 males. Lumbar spine bone mineral density (BMD) and magnetic resonance imaging (MRI) were acquired. Females had more severe disc degeneration than males. Lumbar spine lower BMD was associated with less severe disc degeneration. Lumbar disc spaces were more likely to be narrower when vertebral BMD was higher. Introduction: The purpose of this paper is to study the relationship between gender, BMD, and disc degeneration in the lumbar spine. Methods: The study cohort comprised 196 females and 163 males (age range 67-89 years) with no age difference between the two groups. Lumbar spine BMD was measured with dual X-ray densitometry, and MRI was acquired at 1.5 T. A subgroup of 48 males had additional lumbar vertebral quantitative computerized tomography densitometry. Lumbar disc degeneration was assessed using a MRI-based eight-level grading system. Results: Female subjects had more severe disc degeneration than male subjects. After removing age effect, a positive trend was observed between T-score and severity of lumbar disc degeneration. This was significant in female subjects while not significant in male subjects. Lumbar disc spaces were more likely to be narrowed when vertebral BMD was higher. These observations were more significant in the midlumbar region (L3/4 and L4/5) and less so at the thoracolumbar junction. Conclusion: Female subjects tended to have slightly more severe lumbar disc degeneration than male subjects. Lower lumbar spine BMD was associated with less severe disc degeneration. [ABSTRACT FROM AUTHOR]

In cooperative games over time with uncertainty, a stringent condition (subgame consistency) is required for a dynamically stable solution. In particular, a cooperative solution is subgame consistent if an extension of the solution policy to a situation with a later starting time and any feasible state brought about by prior optimal behavior would remain optimal. This paper derives an analytically tractable payoff distribution procedure leading to the realization of subgame consistent solutions in cooperative stochastic dynamic games. This is the first time that subgame consistent solutions in discrete-time dynamic games under uncertainty are provided. [ABSTRACT FROM AUTHOR]

This paper presents a cooperative differential game of transboundary industrial pollution. A noted feature of the game model is that the industrial sectors remain competitive among themselves while the governments cooperate in pollution abatement. It is the first time that time consistent solutions are derived in a cooperative differential game on pollution control with industries and governments being separate entities. A stochastic version of the model is presented and a subgame-consistent cooperative solution is provided. This is the first study of pollution management in a stochastic differential game framework. [ABSTRACT FROM AUTHOR]

This paper presents evaluation and comparison of the TCP performance in different mobile scenarios generated by Random Waypoint (RW) and Social Network (SN) mobility models. To our knowledge, TCP performance in SN mobility is discussed for the first time. The impact of AODV and DSDV routing protocols on the TCP goodput, delay and drop rate performance is also discussed. Extensive simulation results and analysis showed that TCP has better performance over AODV than over DSDV and has more stable performance in SN mobility than in RW mobility. We suggest using more mobility models, in particular, such as SN, in the evaluations of the transport layer or routing layer protocols because the mobility patterns have impacts on the protocol performance. [ABSTRACT FROM AUTHOR]

The paradigm of randomly furcating differential games incorporates stochastic elements via randomly branching payoffs in differential games. This paper considers dynamically stable cooperative solutions in randomly furcating differential games. Analytically tractable payoff distribution procedures contingent upon specific random events are derived. This new approach widens the application of cooperative differential game theory to problems where future environments are not known with certainty. [ABSTRACT FROM AUTHOR]

Subgame consistency is a fundamental element in the solution of cooperative stochastic differential games. In particular, it ensures that the extension of the solution policy to a later starting time and any possible state brought about by the prior optimal behavior of the players would remain optimal. Recently, mechanisms for the derivation of subgame consistent solutions in stochastic cooperative differential games with transferable payoffs have been found. In this paper, subgame consistent solutions are derived for a class of cooperative stochastic differential games with nontransferable payoffs. The previously intractable subgame consistent solution for games with nontransferable payoffs is rendered tractable. [ABSTRACT FROM AUTHOR]

Subgame consistency is a fundamental element in the solution of cooperative stochastic differential games. In particular, it ensures that: (i) the extension of the solution policy to a later starting time and to any possible state brought about by the prior optimal behavior of the players would remain optimal; (ii) all players do not have incentive to deviate from the initial plan. In this paper, we develop a mechanism for the derivation of the payoff distribution procedures of subgame consistent solutions in stochastic differential games with transferable payoffs. The payoff distribution procedure of the subgame consistent solution can be identified analytically under different optimality principles. Demonstration of the use of the technique for specific optimality principles is shown with an explicitly solvable game. For the first time, analytically tractable solutions of cooperative stochastic differential games with subgame consistency are derived. [ABSTRACT FROM AUTHOR]

In this paper, we consider infinite-horizon stochastic differential games with an autonomous structure and steady branching payoffs. While the introduction of additional stochastic elements via branching payoffs offers a fruitful alternative to modeling game situations under uncertainty, the solution to such a problem is not known. A theorem on the characterization of a Nash equilibrium solution for this kind of games is presented. An application in renewable resource extraction is provided to illustrate the solution mechanism. [ABSTRACT FROM AUTHOR]

In this paper, we consider a class of differential games in which the game ends when a subset of its state variables reaches a certain target at the terminal time. A special feature of the game is that its horizon is not fixed at the outset, but is determined endogenously by the actions of the players; conditions characterizing a feedback Nash equilibrium (FNE) solution of the game are derived for the first time. Extensions and illustrations of the derivation of FNE solutions of the game are provided. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented in which relapse of BCR-ABL1-like acute lymphoblastic leukaemia (ALL) mediated by the ABL1 kinase domain mutation T315I following initial response to dasatinib treatment is being discussed.

γ-Glutamylcysteine synthetase is present in barely detectable amounts in foetal kidney. Its activity starts to increase in postnatal life. In contrast, oxoproline is already found in significant quantities in the foetal tissue. Both enzymes show marked elevation in activities during the weaning period. [ABSTRACT FROM AUTHOR]

Reference data for weight, recumbent length and head circumference at 1-month intervals from 1 through 18 months have been developed from measurements of 351 healthy infants born at term in Montreal or Toronto. Each infant was measured serially from 1 to 18 months. A 3-parameter mathematical model was fitted to the serial data for each infant. The model fitted the serial data well for almost all the infants as evaluated by the residual mean square errors. Subsequently, values were estimated for each month of age from 1 through 18 months for each infant. These estimated values allowed the development of reference data that have been presented in tables and in graphs.

Guidelines for professionals counselling mothers of newborns and infants were established by the Canadian Pediatric Society's Nutrition Committee in 1979. To determine the role of health professionals in providing infant nutrition information, 404 mothers of infants were interviewed between July 1984 and February 1985 in Metropolitan Toronto. Their primary sources for information on infant nutrition were prenatal classes, hospitals (post-delivery), and public health nurses, family physicians and pediatricians, postnatally. Dietitian/nutritionists, family physicians, pediatricians and public health nurses were considered reliable sources. However, the information required and desired was not consistently provided in either a comprehensive or appropriate format, suggesting that health professionals have an opportunity to improve in meeting their responsibilities to provide information to mothers on the topic of infant nutrition.