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The Salt Range/Potwar Plateau (SRPP) is part of the Himalayan foreland and an important petroleum province in north Pakistan. The hydrocarbons are commonly produced from stacked Cambrian to Eocene clastic and carbonate reservoirs which have an average thickness of 1 km. These strata are overlain by at least 5 km of Miocene and younger continental molasse sedimentation in the deepest part of the foreland basin. Surface and subsurface (seismic interpretations and borehole data) geology combined with the timing and the patterns of sedimentation has allowed to interpret the deformation as thin skinned, with a detachment in weak Eocambrian evaporates and the development of ramp-and-flat structures, since about 8 Ma. We have reviewed the structural interpretations with new borehole logs, field geology, and reserve estimates in this paper to precisely define oil-field structures with a view on future exploration. As a result of this work, 12 oil fields are classified as three detachment folds, four fault-propagation folds, four pop-ups, and one triangle zone structure. The latter two are identified as better prospects with the last one as the best with estimated reserves of 51 million barrels of oil (MMBO). Hence, the triangle zones along with other ramp-and-flat structures from the North Potwar Deformed Zone (NPDZ) are recognized to provide potential future prospects. Finally, a 40-km-long structural cross section from NPDZ is used to discuss complex deformation of the triangle zone and duplex structures as future potential prospects. About 55 km of shortening across the NPDZ during Plio-Pleistocene time is calculated, which has important bearing on the geometry of prospects, reserve calculations, and the future exploration. [ABSTRACT FROM AUTHOR]

Sensorineural hearing loss is genetically heterogeneous. Here, we report that mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). One mutation in CIB2 is a prevalent cause of deafness DFNB48 in Pakistan; other CIB2 mutations contribute to deafness elsewhere in the world. In mice, CIB2 is localized to the mechanosensory stereocilia of inner ear hair cells and to retinal photoreceptor and pigmented epithelium cells. Consistent with molecular modeling predictions of calcium binding, CIB2 significantly decreased the ATP-induced calcium responses in heterologous cells, whereas mutations in deafness DFNB48 altered CIB2 effects on calcium responses. Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function and proper development of hair cells and retinal photoreceptor cells. We also show that CIB2 is a new member of the vertebrate Usher interactome. [ABSTRACT FROM AUTHOR]