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Massive open online courses (MOOCs) have become a popular platform owing to their open nature. However, the shortage of emotional interaction in MOOCs can cause a high attrition rate among learners. Appropriate emotional expression can enhance knowledge delivery and students' learning performance. To tackle this issue, exploring the correlation between teachers' emotions and students' learning behaviors is of great value for instructors to understand how their emotions can impact students' learning performance and improve their teaching skills. However, manually watching and studying MOOCs videos are often tedious and time-consuming. There is a lack of efficient methods to help users conduct correlation exploration, which is challenging due to the large-scale, multi-dimensional, and time-series nature of students' learning behaviors and their complex correlation to teachers' multimodal emotions. In this paper, we propose an interactive visual system called TSSeer to facilitate correlation analysis in MOOCs videos. Specifically, the level view and correlation view allow users to obtain a quick overview of the correlation at different video levels. The detail view shows detailed temporal changes and enables a deeper understanding of the correlation with time-series visualization. Through comprehensive evaluations, including two usage scenarios and five expert interviews, the effectiveness and usefulness of TSSeer are demonstrated. [ABSTRACT FROM AUTHOR]

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Balancer chromosomes, primarily discovered and used in Drosophila melanogaster, are valuable tools to maintain lethal mutations in a particular genomic segment. Full-length balancer chromosomes would be particularly useful because of the capacity to maintain whole genomic traits. However, murine full-length balancer chromosomes generated via a single Cre/loxP recombination are still not demonstrated. In this study, we developed a novel mouse strain with full-length inverted chromosome 17 (Ch17Inv balancer) via a single Cre/loxP recombination event in mES cells. The Ch17Inv balancer mice are viable and phenotypically normal. When bred with other strains, the haplotype of chromosome 17 can be stably maintained as determined by the high throughput SNPs assay. Interestingly, we found that the recombination events were efficiently reduced within the inverted region but not eliminated. The method established in this study can be applied to generate other full-length balancer chromosomes. Moreover, the Ch17Inv balancer strain would be a valuable resource to maintain the entire chromosome 17 from different donor strains. [ABSTRACT FROM AUTHOR]

Mouse models are essential for dissecting disease mechanisms and defining potential drug targets. There are more than 18,500 mouse strains available for research communities in National Resource Center for Mutant Mice (NRCMM) of China, affiliated with Model Animal Research Center of Nanjing University and Gempharmatech Company. In 2019, Gempharmatech launched the Knockout All Project (KOAP) aiming to generate null mutants and gene floxed strains for all protein-coding genes in mouse genome within 5 years. So far, KOAP has generated 8,004 floxed strains and 9,769 KO (knockout) strains (updated to Oct, 2021). NRCMM also created hundreds of Cre transgenic lines, mutant knock-in models, immuno-deficient models, and humanized mouse models. As a member of the international mouse phenotyping consortium (IMPC), NRCMM provides comprehensive phenotyping services for mouse models. In summary, NRCMM will continue to support biomedical community with new mouse models as well as related services. [ABSTRACT FROM AUTHOR]