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Objectives: Little was known regarding the current age of onset patterns of stroke. This study aimed to examine the prevalence of stroke and explore the age of onset patterns of stroke in Jiangsu Province, China. Materials and methods: Participants were recruited from April 2012 to April 2013 in Jiangsu Province, China. Survival analysis models were used to evaluate the hazards of stroke by a single year of age. Kaplan–Meier analysis and the log-rank test were used to explore the disparities of the age of onset patterns of stroke. Results: This population-based study was conducted among 39,887 participants aged ≥ 18 years in Jiangsu Province, China. Of the 740 (1.9%) events of stroke, 13.2% suffered from hemorrhagic stroke (HS) and 86.8% suffered from ischemic stroke (IS). The prevalence of HS and IS were 0.3% and 1.7%, respectively. The estimated mean age of onset of stroke was 71.98 (95% CI: 71.97–71.99) years by the survival model. Up to age of 45 years, the estimated hazards of stroke onset were at a relatively low level. From the age of 45 years, the increases in hazards accelerated and peaked at age 75 years. Urban, smoking, and drinking males had a higher risk of stroke than their counterparts (P < 0.05). However, no such difference was found among females. Conclusions: The findings emphasize the importance of implementing stroke prevention interventions in Jiangsu Province, China, especially for urban, smoking, and drinking males. It is of great significance to strengthen comprehensive management of health-related behaviors, including smoking cessation and moderate consumption of alcohol to have sustained beneficial effects on stroke risk. Chenlu He and Qian Chen contributed equally to this work. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to examine the prevalence of stroke and associated factors of stroke in patients with type 2 diabetes(T2DM) in China. Methods: Participants were 18,013 T2DM patients recruited with stratified random cluster sampling method from December 2013 to January 2014 in China. Propensity score matching was used to eliminate confounding effects between groups and logistic regression analysis was used to examine factors associated with stroke among T2DM patients. Results: Overall, the prevalence of stroke in the subjects with T2DM was 9.5%. After nearest neighbor matching, smoking (OR = 1.60, 95%CI: 1.26–2.03), hypertension (OR = 2.96, 95%CI: 2.55–3.43), dyslipidemia (OR = 2.00, 95%CI: 1.71–2.33), family history of stroke (OR = 2.02, 95%CI: 1.61–2.54), obesity (OR = 1.21, 95%CI: 1.01–1.45) and sleep duration < 6 h/day (OR = 1.44, 95%CI: 1.20–1.73) or > 8 h/day (OR = 1.22, 95%CI: 1.05–1.42) were positively associated with stroke, whereas drinking 1–3 days/week (OR = 0.64, 95%CI: 0.45–0.90) or daily (OR = 0.45, 95%CI: 0.33–0.60), effective exercise (OR = 0.65, 95%CI: 0.57–0.73) and underweight (OR = 0.30, 95%CI: 0.13–0.71) were negatively related to stroke. Besides, the risk of stroke increased substantially with accumulation of above seven modified risk factors. The odds ratio values of stroke in patients having ≥ 5 of the above seven risk factors was 14.39 (95% CI: 8.87–23.26). Conclusions: The prevalence of stroke was high among T2DM in China. It is of great significance to strengthen comprehensive management of health-related behaviors including smoking cessation, moderate alcohol consumption, effective exercise, 6–8 h of sleep duration, keeping normal weight and the prevention of hypertension and dyslipidemia to have sustained beneficial effects on improvements of stroke risk factors. [ABSTRACT FROM AUTHOR]