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Objectives: This study aims to develop and validate a virtual biopsy model to predict microsatellite instability (MSI) status in preoperative gastric cancer (GC) patients based on clinical information and the radiomics of deep learning algorithms. Methods: A total of 223 GC patients with MSI status detected by postoperative immunohistochemical staining (IHC) were retrospectively recruited and randomly assigned to the training (n = 167) and testing (n = 56) sets in a 3:1 ratio. In the training set, 982 high-throughput radiomic features were extracted from preoperative abdominal dynamic contrast-enhanced CT (CECT) and screened. According to the deep learning multilayer perceptron (MLP), 15 optimal features were optimized to establish the radiomic feature score (Rad-score), and LASSO regression was used to screen out clinically independent predictors. Based on logistic regression, the Rad-score and clinically independent predictors were integrated to build the clinical radiomics model and visualized as a nomogram and independently verified in the testing set. The performance and clinical applicability of hybrid model in identifying MSI status were evaluated by the area under the receiver operating characteristic (AUC) curve, calibration curve, and decision curve (DCA). Results: The AUCs of the clinical image model in training set and testing set were 0.883 [95% CI: 0.822–0.945] and 0.802 [95% CI: 0.666–0.937], respectively. This hybrid model showed good consistency in the calibration curve and clinical applicability in the DCA curve, respectively. Conclusions: Using preoperative imaging and clinical information, we developed a deep-learning-based radiomics model for the non-invasive evaluation of MSI in GC patients. This model maybe can potentially support clinical treatment decision making for GC patients. Key points: MSI is an important biomarker for immunotherapy in gastric cancer. Quantitative radiomics features were closely related to MSI in gastric cancer. Combining clinical and radiomics features with deep learning could evaluate MSI noninvasively. [ABSTRACT FROM AUTHOR]

The thermal expansion is one of the important reasons for the stress increase in polymer bonded explosive (PBX) and the damage of the long-term storage structure of explosives. Herein, the thermal expansion characteristics and crystal damage behavior under thermal stimulation of three crystal forms (β, α and γ) of 4,4′,5,5′-tetranitro-1H,1′H- [2,2′-biimidazole]-1,1′-diamine (DATNBI) were analyzed. The results show that DATNBI has obvious anisotropic thermal expansion, in which β- and α-DATNBI are first-order thermal expansion, and γ-DATNBI is second-order thermal expansion. The thermal expansion of DATNBI is reversible, but the crystal damage caused by thermal expansion is irreversible. Combined with Rietveld Refinement of powder X-ray diffraction (XRD) patterns, the volumetric expansion coefficients are 17.98 × 10−5 °C−1 (β-DATNBI), 23.28 × 10−5 °C−1 (α-DATNBI) and 14.39 × 10−5 °C−1 (γ-DATNBI), respectively. The relationship between crystal packing and thermal expansion characteristics of DATNBI at different temperatures was studied. It is demonstrated that the thermal expansion can probe certain intermolecular interactions resulting in anisotropic expansion behavior. Usually, the thermal expansion of most crystals (β-DATNBI) is positive, but slip or dislocation may cause a smaller negative expansion of a certain axis of the crystal cell (α-DATNBI). However, the unique cross-cross grid crystal packing (γ-DATNBI) will make a certain axis of the cell appear obvious negative expansion, which may lead to the overall decrease in the volumetric expansion coefficient of the crystal. [ABSTRACT FROM AUTHOR]

Carbonyl iron powder–polymer coating is one of the effective microwave absorption systems, which can be widely used as medium temperature structural materials in the aerospace industry. However, the significant mismatch of the coefficient of thermal expansion (CTE) between coatings and the titanium alloy substrates will cause serious cracking and peeling problems in practical applications. Thus, we designed to introduce Y2Mo3O12 (YMO) with negative CET into the carbonyl iron powder–boron-modified phenolic (BP) resin coating to reduce the CET of coating. The result showed that the CTE of the coatings is significantly decreased by the addition of Y2Mo3O12. The YMO/CIP/BP coating of 8 wt% YMO - 67 wt% CIP - 25 wt% BP shows a CTE of 21.1 × 10–6 ℃−1, which is 68% smaller than that of CIP/BP coating. The minimum RL (maximum of microwave absorption) of 8 wt% YMO - 67 wt% CIP - 25 wt% BP is – 12.3 dB at the thickness of 1.4 mm, which makes it an excellent candidate for the microwave absorptions applied on the titanium alloy surfaces. [ABSTRACT FROM AUTHOR]

In this paper, the carbonyl iron powder/boron-modified phenolic resin (CIP/B-modified PR) composite coatings were designed and prepared by hot-pressing process. The density, microstructure, mechanical strength and microwave absorption properties of the coatings were investigated by Archimede’s method, scanning electron microscopy, universal mechanical testing machine and vector network analyzer, respectively. Results has demonstrated that the CIP/B-modified PR coatings with 75 wt% CIP give an ultra-strong adhesion strength above 12 MPa and a minimum reflection loss (RL) of −19.8 dB at 9.4 GHz with a thickness of 1.4 mm. In addition, the effective absorption band (RL < −10 dB) of 75 wt% CIP/B-modified PR coating measured at room temperature is fully covered in the X-band when the absorption thickness is only 1.2 mm. Moreover, the CIP/B-modified PR composite coatings can maintain a relatively stable microwave absorption capability in the X-band with a long-term life at high temperature (250 ℃ for 100 h). Therefore, CIP/B-modified PR coatings with an exceptional absorbing performance could be used in the field of high-temperature microwave absorption materials. [ABSTRACT FROM AUTHOR]

Displays play an extremely important role in modern information society, which creates a never-ending demand for the new and better products and technologies. The latest requirements for novel display technologies focus on high resolution and high color gamut. Among emerging technologies that include organic light-emitting diode (OLED), micro light-emitting diode (micro-LED), quantum dot light-emitting diode (QLED), laser display, holographic display and others, QLED is promising owing to its intrinsic high color gamut and the possibility to achieve high resolution with photolithography approach. However, previously demonstrated photolithography techniques suffer from reduced device performance and color impurities in subpixels from the process. In this study, we demonstrated a sacrificial layer assisted patterning (SLAP) approach, which can be applied in conjunction with photolithography to fabricate high-resolution, full-color quantum dot (QD) patterns. In this approach, the negative photoresist (PR) and sacrificial layer (SL) were utilized to determine the pixels for QD deposition, while at the same time the SL helps protect the QD layer and keep it intact (named PR-SL approach). To prove this method's viability for QLED display manufacture, a 500-ppi, full-color passive matrix (PM)-QLED prototype was fabricated via this process. Results show that there were no color impurities in the subpixels, and the PM-QLED has a high color gamut of 114% National Television Standards Committee (NTSC). To the best of our knowledge, this is the first full-color QLED prototype with such a high resolution. We anticipate that this innovative patterning technique will open a new horizon for future display technologies and may lead to a disruptive and innovative change in display industry. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the clinical value of real-time three-dimensional contrast-enhanced ultrasound (3D-CEUS) in the detection of sentinel lymph nodes (SLNs) and drainage lymphatics in breast cancer patients.Method: The prospective study was performed in women with pathology-confirmed T1/2 breast cancer between June 2016 and December 2017 who underwent sentinel lymph node biopsy and 3D-CEUS. The number, size, location, enhancement pattern of SLNs, and the lymphatic drainage patterns were reviewed. The routes, location of SLNs, and lymph channels (LCs) on the surface were marked. All patients underwent blue dye-guided sentinel lymph node biopsy (SLNB) finally.Results: According to the postoperative pathology findings and the blue dye staining of the lymphatic drainage routes, there are six patterns of lymphatic drainage routes and the coincidence rate of the 3D-CEUS was 97.4%; the sensitivity, specificity, positive predictive value, negative predictive value, the LN detection rate, and the correct diagnosis rate of the 3D-CEUS were 75%, 93.0%, 81.8%, 89.9%, 95.3%, and 87.7%, respectively.Conclusion: 3D-CEUS is a new feasible and useful approach to detect the SLNs and LCs. 3D-CEUS can accurately localize the LCs and SLNs and estimate the presence of metastatic lymph nodes.Key Points: • The three-dimensional contrast-enhanced ultrasound can detect the sentinel lymph nodes. • The three-dimensional contrast-enhanced ultrasound can show the stereo direction of sentinel lymph nodes and lymph drainage routes. • The three-dimensional contrast-enhanced ultrasound can accurately localize the LCs and SLNs and estimate the presence of metastatic lymph nodes. [ABSTRACT FROM AUTHOR]