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The use of a vertical well pattern results in productivity deficiency and poor development effect when developing buried hill reservoirs with complex properties. In this work, experiments are conducted to determine the best pattern for complex structure wells in buried hill reservoirs. Discretization is employed in an experimental method that uses unit cubic rocks with a size of 5 cm × 5 cm × 5 cm. The rocks are bonded in a spotty or reticular design to form a macroscopic model. Based on water flooding similarity criteria of fractured reservoir, an experimental model similar to a quarter of a five-spot unit in an actual reservoir is designed and manufactured. By selectively plugging wells in the model, various well patterns are established. Simulation results indicate that the vertical–vertical well pattern exhibits the fastest water breakthrough, fastest increase in water cut, and lowest recovery under the same pressure difference and well spacing. The horizontal–horizontal well pattern has the slowest water cut increase and the highest final oil recovery. For fishbone wells, this pattern facilitates an ideal development effect when the percolation direction is perpendicular to the plane determined by the mother bore and branch. When liquid rate, water cut, and recovery are considered, the horizontal–horizontal well pattern is recommended when conditions allow.