Search

FOLFIRINOX, a combination of chemotherapy drugs (Fluorouracil, Oxaliplatin, Irinotecan -FOI), provides the best clinical benefit in pancreatic ductal adenocarcinoma (PDAC) patients. In this study we explore the role of miRNAs (MIR) as modulators of chemosensitivity to identify potential biomarkers of response. We find that 41 and 84 microRNA inhibitors enhance the sensitivity of Capan1 and MiaPaCa2 PDAC cells respectively. These include a MIR1307-inhibitor that we validate in further PDAC cell lines. Chemotherapy-induced apoptosis and DNA damage accumulation are higher in MIR1307 knock-out (MIR1307KO) versus control PDAC cells, while re-expression of MIR1307 in MIR1307KO cells rescues these effects. We identify binding of MIR1307 to CLIC5 mRNA through covalent ligation of endogenous Argonaute-bound RNAs cross-linking immunoprecipitation assay. We validate these findings in an in vivo model with MIR1307 disruption. In a pilot cohort of PDAC patients undergoing FOLFIRONX chemotherapy, circulating MIR1307 correlates with clinical outcome. Understanding which patients will respond to FOLFIRINOX therapy is important for clinical outcome. Here, the authors show that the MIR1307 is increased pancreatic cancer cell lines and inhibition of the microRNA sensitises cells to treatment.' stratifying patients to achieve the best clinical outcome. Here, the authors show that the MIR1307 is increased in a subgroup of human pancreatic cancers and inhibition of the microRNA in in vitro and in vivo models of pancreatic cancer sensitises cells to treatment. [ABSTRACT FROM AUTHOR]

Passive radiometry is a health-safe alternative to other imaging techniques conceived to be used on human beings for security screening or medical imaging applications. In this work we address a study on the feasibility of W-band passive radiometers in nano-scale CMOS technology for imaging applications. In particular, this study takes into account some of the most relevant aspects regarding the system-on-a-chip implementation, from system to circuit and technology limitations, with emphasis on the impact of the non-idealities of the detector on the overall system performances. Excluding the hardware differences between the investigated receiver architectures and their substantial implications, especially in case of array systems, the investigation shows how there is no a clear evidence to identify a priori the best performance receiver architecture, but it depends on the circuits, as well as operating frequency and technology. [ABSTRACT FROM AUTHOR]