1. Association between interleukin 1β and interleukin 10 concentrations: a cross-sectional study in young adolescents in Taiwan
- Author
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Chyi Huey Bai, Tsai Cheng-Shiuan, Kuo-Ching Chao, Jung Su Chang, Shyh-Hsiang Lin, Eve Yiwen Chien, and Chun-Chao Chang
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Male ,musculoskeletal diseases ,medicine.medical_specialty ,Adolescent ,Cross-sectional study ,Interleukin-1beta ,Taiwan ,chemical and pharmacologic phenomena ,Type 2 diabetes ,Overweight ,Body Mass Index ,Overweight and obese adolescents ,Risk Factors ,immune system diseases ,Internal medicine ,Bayesian multivariate linear regression ,parasitic diseases ,medicine ,Humans ,Obesity ,Pediatrics, Perinatology, and Child Health ,Retrospective Studies ,business.industry ,Incidence ,Incidence (epidemiology) ,hemic and immune systems ,medicine.disease ,Interleukin-10 ,Interleukin 10 ,Cross-Sectional Studies ,Endocrinology ,Pediatrics, Perinatology and Child Health ,Female ,IL1β ,medicine.symptom ,business ,Body mass index ,Biomarkers ,Follow-Up Studies ,Research Article ,IL10 - Abstract
Background In adults, low circulating interleukin 10 (IL10) has been associated with obesity and type 2 diabetes. However, studies investigating IL10 in overweight and obese children have yielded conflicting results. The aim of this study was to investigate factors associated with serum IL10 concentration in young Chinese adolescents. Methods Young adolescents (n=325) ages 13.33±1.10 years were recruited into the cross-sectional study from 2010 to 2011. Parameters of obesity, individual components of MetS, iron status and serum IL10 were evaluated. Results Compared with their normal weight counterparts, overweight adolescents had lower serum IL10 but higher TNFα, nitric oxide (NO) and IL1β concentrations (all p Conclusions Our study confirmed that low IL10 concentration is associated with overweight and obesity in young adolescents. We also demonstrated for the first time that pro-inflammatory cytokine IL1β is independently associated with IL10. A decline in IL10 concentration in overweight and obese adolescents may further contribute to the IL1β-mediated inflammatory environment associated with obesity.
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