1. Advanced lung cancer inflammation index and its prognostic value in HPV-negative head and neck squamous cell carcinoma: a multicentre study
- Author
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Marco Benazzo, Roberto Di Carlo, Andrea Ciorba, Anna Menegaldo, Daniele Marchioni, Paolo Bossi, Chiara Bianchini, Piergiorgio Gaudioso, Giancarlo Tirelli, Gabriele Molteni, Jerry Polesel, Vittorio Giacomarra, Stefano Pelucchi, Daniele Borsetto, Piero Nicolai, Margherita Tofanelli, Mantegh Sethi, Cristoforo Fabbris, Fiordaliso Cragnolini, Simone Mauramati, Jonathan Fussey, Paolo Boscolo-Rizzo, Boscolo-Rizzo, Paolo [0000-0002-4635-7959], Apollo - University of Cambridge Repository, Gaudioso, P., Borsetto, D., Tirelli, G., Tofanelli, M., Cragnolini, F., Menegaldo, A., Fabbris, C., Molteni, G., Marchioni, D., Nicolai, P., Bossi, P., Ciorba, A., Pelucchi, S., Bianchini, C., Mauramati, S., Benazzo, M., Giacomarra, V., Di Carlo, R., Sethi, M., Polesel, J., Fussey, J., and BOSCOLO RIZZO, Paolo
- Subjects
Oncology ,Male ,Inflammatory indexes ,medicine.medical_specialty ,Lung Neoplasms ,Survival ,medicine.medical_treatment ,Advanced lung cancer inflammation index ,Head and neck cancer ,Nutrition ,Inflammatory indexe ,Inflammation ,Head and neck cancer, Nutrition, Advanced lung cancer inflammation index, Inflammatory indexes, Survival ,NO ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,HPV Negative ,medicine ,Humans ,Lung cancer ,030304 developmental biology ,Aged ,Retrospective Studies ,0303 health sciences ,business.industry ,Squamous Cell Carcinoma of Head and Neck ,Retrospective cohort study ,Pneumonia ,Middle Aged ,medicine.disease ,Prognosis ,Head and neck squamous-cell carcinoma ,Progression-Free Survival ,Female ,030220 oncology & carcinogenesis ,Cohort ,Original Article ,medicine.symptom ,business ,Adjuvant - Abstract
Funder: Università degli Studi di Trieste, PURPOSE: The aim of this study is to evaluate the prognostic value of pre-treatment advanced lung cancer inflammation index (ALI) in patients with HPV-negative HNSCC undergoing up-front surgical treatment. METHODS: The present multi-centre, retrospective study was performed in a consecutive cohort of patients who underwent upfront surgery with or without adjuvant (chemo)-radiotherapy for head and neck squamous cell carcinoma (HNSCC). Patients were stratified by ALI, and survival outcomes were compared between groups. In addition, the prognostic value of ALI was compared with two other indices, the prognostic nutritional index (PNI) and systemic inflammatory index (SIM). RESULTS: Two hundred twenty-three patients met the inclusion criteria (151 male and 72 female). Overall and progression-free survival were significantly predicted by ALI < 20.4 (HR 3.23, CI 1.51-6.90 for PFS and HR 3.41, CI 1.47-7.91 for OS). Similarly, PNI < 40.5 (HR = 2.43, 95% CI: 1.31-4.51 for PFS and HR = 2.40, 95% CI: 1.19-4.82 for OS) and SIM > 2.5 (HR = 2.51, 95% CI: 1.23-5.10 for PFS and HR = 2.60, 95% CI: 1.19-5.67 for OS) were found to be significant predictors. Among the three indices, ALI < 20.4 identified the patients with the worst 5-year outcomes. Moreover, patients with a combination of low PNI and low ALI resulted to be a better predictor of progression (HR = 5.26, 95% CI: 2.01-13.73) and death (HR = 5.68, 95% CI: 1.92-16.79) than low ALI and low PNI considered alone. CONCLUSIONS: Our results support the use of pre-treatment ALI, an easily measurable inflammatory/nutritional index, in daily clinical practice to improve prognostic stratification in surgically treated HPV-negative HNSCC.
- Published
- 2021