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1. Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation

Author

Bakun, Pawel, primary, Kucinska, Malgorzata, additional, Kobyłka, Paulina, additional, Kuźmińska, Joanna, additional, Koczorowski, Tomasz, additional, Mlynarczyk, Dariusz T., additional, Popenda, Lukasz, additional, Górska, Katarzyna, additional, Kasperkowiak, Małgorzata, additional, Murias, Marek, additional, Jelińska, Anna, additional, and Goslinski, Tomasz, additional

Published
2024
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6. Clinical course and seroprevalence of COVID-19 in children with rheumatic diseases—cross-sectional study from a reference centre in Spain

Author

Claudia Millan-Longo, Rosa Alcobendas, Cristina Calvo, Sara Murias, Laura Valladares, Iker Falces-Romero, Monica Morales-Higuera, Agustin Remesal, Clara Udaondo, Celia Permuy, and Celia Muñoz

Subjects
Male, Coronavirus disease 2019 (COVID-19), Cross-sectional study, business.industry, SARS-CoV-2, Clinical course, COVID-19, General Medicine, Cross-Sectional Studies, Rheumatology, Seroepidemiologic Studies, Spain, Environmental health, Rheumatic Diseases, Seroprevalence, Medicine, Humans, Female, business, Child
Abstract

Background Patients with rheumatic diseases have been considered at risk of COVID-19. A significant percentage of infections in children are asymptomatic or mild and can go unnoticed. This study aims to describe the seroprevalence of SARS-CoV-2 in a cohort of children with rheumatic diseases and assess possible risk factors. Methods: A cross-sectional study was performed in a pediatric rheumatology unit from a reference hospital in Madrid, from September 2020 to February 2021. Serology of SARS-CoV-2 was performed at the same time as their routine laboratory tests, and a specific questionnaire was completed by parents. Demographics, treatment and disease activity from laboratory-confirmed COVID-19 patients were compared to the data of patients without laboratory-confirmed COVID-19.Findings A total of 105 children were included. SARS-CoV-2 infection was demonstrated in 27 patients (25.7%): 6 PCR and 21 positive IgG serology. The mean age was 11.8 years , and the majority of the patients were females (72.4%). Most of the children were diagnosed with juvenile idiopathic arthritis (JIA) (70.3%; 19/27), followed by PFAPA (11.1%; 3/27). Immunosuppresive treatment was given in 88% of cases (24/27). Overall, 44.4% (12/27) of infected patients were asymptomatic. Three patients required hospital admission because of COVID-19, however none of them required oxygen supplementation. A total of 66.7% (18/27) of patients did not require any treatment or medical assistance. The seroprevalence in our cohort was 20% in contrast to the 7.7% population seroprevalence observed during the same study period in Spanish children. SARS-CoV-2 confirmed children with positive IgG or PCR were less frequently in remission (52% vs 72%; p 0.014). Moderate disease activity and treatment with oral corticosteroids were associated with higher risk for COVID-19 (OR 5.05; CI 95%: 1.56 - 16.3 and OR 4.2; CI 95%: 1.26 - 13.9 respectively). Conclusions In a cohort of pediatric patients with rheumatic disease and immunosuppressive therapy, moderate disease activity and oral corticosteroids were associated with COVID-19 positive patients. Seroprevalence was significantly higher compared to the same age healthy population. The clinical manifestations were mild and there were no severe infections among the patients.

Published
2022
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7. Identification of Non-Invasive Exercise Thresholds: Methods, Strategies, and an Online App

Author

Felipe Mattioni Maturana, Daniel A. Keir, John M. Kowalchuk, Juan M. Murias, and Danilo Iannetta

Subjects
medicine.medical_specialty, Anaerobic Threshold, Sports medicine, Computer science, Physical Therapy, Sports Therapy and Rehabilitation, 030204 cardiovascular system & hematology, Incremental exercise, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Physical medicine and rehabilitation, Resource (project management), medicine, Humans, Orthopedics and Sports Medicine, Lactic Acid, Exercise physiology, Exercise, Pulmonary Gas Exchange, Lactate threshold, 030229 sport sciences, Mobile Applications, Comprehension, Identification (information), Exercise Test, Exercise intensity
Abstract

During incremental exercise, two thresholds may be identified from standard gas exchange and ventilatory measurements. The first signifies the onset of blood lactate accumulation (the lactate threshold, LT) and the second the onset of metabolic acidosis (the respiratory compensation point, RCP). The ability to explain why these thresholds occur and how they are identified, non-invasively, from pulmonary gas exchange and ventilatory variables is fundamental to the field of exercise physiology and requisite to the understanding of core concepts including exercise intensity, assessment, prescription, and performance. This review is intended as a unique and comprehensive theoretical and practical resource for instructors, clinicians, researchers, lab technicians, and students at both undergraduate and graduate levels to facilitate the teaching, comprehension, and proper non-invasive identification of exercise thresholds. Specific objectives are to: (1) explain the underlying physiology that produces the LT and RCP; (2) introduce the classic non-invasive measurements by which these thresholds are identified by connecting variable profiles to underlying physiological behaviour; (3) discuss common issues that can obscure threshold detection and strategies to identify and mitigate these challenges; and (4) introduce an online resource to facilitate learning and standard practices. Specific examples of exercise gas exchange and ventilatory data are provided throughout to illustrate these concepts and a novel online application tool designed specifically to identify the estimated LT (θLT) and RCP is introduced. This application is a unique platform for learners to practice skills on real exercise data and for anyone to analyze incremental exercise data for the purpose of identifying θLT and RCP.

Published
2021
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8. The MUSCAT Readout Electronics Backend: Design and Pre-deployment Performance

Author

S. Rowe, M. Tapia, P. S. Barry, K. S. Karkare, A. Papageorgiou, P. A. R. Ade, T. L. R. Brien, E. Castillo-Domínguez, D. Ferrusca, V. Gómez-Rivera, P. Hargrave, J. L. Hernández-Rebollar, A. Hornsby, J. M. Jáuregui-García, P. Mauskopf, D. Murias, E. Pascale, A. Pérez, M. W. L. Smith, C. Tucker, M. Velázquez, S. Ventura, D. H. Hughes, and S. Doyle

Subjects
General Materials Science, Condensed Matter Physics, Atomic and Molecular Physics, and Optics
Abstract

MUSCAT is a new large-format 1.1 mm continuum camera for local and extra-galactic astronomy currently being installed at the 50 m Large Millimetre Telescope Alfonso Serrano, LMT. The focal plane is populated with 1458 feedhorn coupled Aluminium LEKIDs, cooled to 130 mk, and read out with 6 frequency division multiplexed RF readout chains, each with a 500 MHz bandwidth. The nominal mux ratio is $$\sim$$ ∼ 250 resonators per chain with an average spacing of 2 MHz between resonators. In each RF chain, the multiplexed waveform generation/decomposition is performed with the BLAST-TNG firmware on a ROACH2 FPGA board with a MUSIC DAC/ADC. The quadrature modulated IF signals are mixed to and from the LEKID readout band on a custom card that houses IQ mixers, a programmable synthesizer, and additional programmable input and output gain control and filtering. Within the cryostat, the RF signals are attenuated prior to reaching the focal plane array and then amplified at 4K. A novel software system controls all the programmable hardware and handles instructions from the LMT instrument control system to record and store observation data, as well as performing automated resonator retuning and providing results of quick look analysis to the telescope operators. In this paper, we present the detailed design and in-lab performance of the cryogenic and room temperature electronics, and the software control system.

Published
2022
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9. The MUSCAT Readout Electronics Backend: Design and Pre-deployment Performance

Author

Rowe, S., primary, Tapia, M., additional, Barry, P. S., additional, Karkare, K. S., additional, Papageorgiou, A., additional, Ade, P. A. R., additional, Brien, T. L. R., additional, Castillo-Domínguez, E., additional, Ferrusca, D., additional, Gómez-Rivera, V., additional, Hargrave, P., additional, Hernández-Rebollar, J. L., additional, Hornsby, A., additional, Jáuregui-García, J. M., additional, Mauskopf, P., additional, Murias, D., additional, Pascale, E., additional, Pérez, A., additional, Smith, M. W. L., additional, Tucker, C., additional, Velázquez, M., additional, Ventura, S., additional, Hughes, D. H., additional, and Doyle, S., additional

Published
2022
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10. Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherapy

Author

J Burgos-Burgos, D Macias-Verde, Pedro C. Lara, E Vicente, V Vega, V Gómez, J Travieso, M Travieso-Aja, J Ospina, C Santana, and C Murias

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, Chemotherapy, Adjuvant chemotherapy, business.industry, medicine.medical_treatment, Cosmesis, General Medicine, medicine.disease, Surgery, Late toxicity, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Oncology, Whole Breast Irradiation, 030220 oncology & carcinogenesis, Toxicity, medicine, In patient, business
Abstract

Hypofractionated whole breast irradiation (hWBI) and intraoperative radiotherapy (IORT) could be associated in breast cancer patients showing high-risk factors of local recurrence after breast conserving therapy (BSC). The aim of this trial was to evaluate, for the first time, the toxicity and cosmesis of hWBI after photon-IORT in high-risk patients treated by adjuvant chemotherapy. Thirty-one high-risk localized breast cancer patients treated by BCS, IORT (20 Gy), and adjuvant chemotherapy were included from February 2019 to August 2020 in this prospective trial, of hWBI (40.5 Gy/2.67 Gy/15 fractions). Acute and late toxicity (CTCAEv5.0) and cosmesis (Harvard scale), were assessed after treatment. All patients completed their treatment and were evaluable after treatment. No patients showed severe (G3) acute/late toxicity. Excellent/good cosmesis at least 6 months after completing the treatment, was present in 93.6% of the patients. hWBI in high-risk localized breast cancer patients treated by chemotherapy seems to have similar toxicity and cosmetic results than conventionally fractionated WBI in combination to photon-IORT after BCS.

Published
2021
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11. Association between $$\dot{\text{V}}$$O2 kinetics and $$\dot{\text{V}}$$O2max in groups differing in fitness status

Author

Juan M. Murias, Erin Calaine Inglis, and Danilo Iannetta

Subjects
Physics, Physiology, Public Health, Environmental and Occupational Health, 030229 sport sciences, General Medicine, Human physiology, Significant negative correlation, Positive correlation, Oxygen uptake, Combinatorics, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Orthopedics and Sports Medicine, 030217 neurology & neurosurgery
Abstract

This study evaluated (i) the relationship between oxygen uptake ( $$\dot{\text{V}}$$ O2) kinetics and maximal $$\dot{\text{V}}$$ O2 ( $$\dot{\text{V}}$$ O2max) within groups differing in fitness status, and (ii) the adjustment of $$\dot{\text{V}}$$ O2 kinetics compared to that of central [cardiac output (Q), heart rate (HR)] and peripheral (deoxyhemoglobin over $$\dot{\text{V}}$$ O2 ratio ([HHb]/ $$\dot{\text{V}}$$ O2)] O2 delivery, during step-transitions to moderate-intensity exercise. Thirty-six young healthy male participants (18 untrained; 18 trained) performed a ramp-incremental test to exhaustion and 3 step-transitions to moderate-intensity exercise. Q and HR kinetics were measured in 18 participants (9 untrained; 9 trained). No significant correlation between τ $$\dot{\text{V}}$$ O2 and $$\dot{\text{V}}$$ O2max was found in trained participants (r = 0.29; p > 0.05) whereas a significant negative correlation was found in untrained (r = − 0.58; p 0.05). τQ demonstrated a significant strong positive correlation with τHR in trained (r = 0.76; p 0.05). A significant overshoot in the [HHb]/ $$\dot{\text{V}}$$ O2 ratio was found in the untrained groups (p 0.05) The results indicated that when comparing participants of different fitness status (i) there is a point at which greater VO2max values are not accompanied by faster $$\dot{\text{V}}$$ O2 kinetics; (ii) central delivery of O2 does not seem to limit the kinetics of $$\dot{\text{V}}$$ O2; and (iii) O2 delivery within the active tissues might contribute to the slower $$\dot{\text{V}}$$ O2 kinetics response in untrained participants.

Published
2021
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12. Instrument-based screening for amblyopia risk factors in a primary care setting in children aged 18 to 30 months

Author

Diego van Esso, Mònica Vilà-de Muga, Rut Murias, Anna Callés, Silvia Alarcón, Romina Gomez, Charlotte Wolley Dod, Dolors Llop, Paula Baez, Montserrat Carreras, Emma Vilaró, and Dàlia Ribas

Subjects
Pediatrics, medicine.medical_specialty, genetic structures, Early detection, Primary care, Astigmatism, Amblyopia, Sensitivity and Specificity, 03 medical and health sciences, Vision Screening, 0302 clinical medicine, Risk Factors, 030225 pediatrics, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Stage (cooking), Prospective cohort study, Primary Health Care, business.industry, medicine.disease, Predictive value, Visual defects, Child, Preschool, Pediatrics, Perinatology and Child Health, business
Abstract

Amblyopia is the leading cause of vision impairment in children, and its early detection can avoid irreversible consequences for a child's visual ability. In this prospective study, to detect amblyopia risk factors, we examined patients aged 18 to 30 months in primary care settings. Patients were referred to an ophthalmologist for confirmation. The main aims were to detect amblyogenic risk factors and to assess the usefulness of a photoscreener in such settings. Out of 453 patients, 42 (9.3%) presented visual alterations according to the photoscreener, with astigmatism being the most common. The instrument had good sensitivity (89%) and specificity (91%), with a positive predictive value of 76% and a negative predictive value of 96%. Overall, 38% of the patients required follow-up, and 47% needed glasses. The automated screening device allowed these children to be diagnosed at an early stage.Conclusions: The use of a photoscreener to screen 2-year-old children in primary care settings was helpful and accurate. What is Known: • Early detection of amblyopic risk factors is important to avoid vision defects. However, it is very difficult to measure visual acuity using visual charts in children younger than 4 years old. What is New: • Instrument-based screening in children aged 18 to 30 months allows excellent detection of early amblyopia risk factors in primary care settings.

Published
2021
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13. Attention Allocation During Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study

Author

Tawny Tsang, Adam J. Naples, Erin C. Barney, Minhang Xie, Raphael Bernier, Geraldine Dawson, James Dziura, Susan Faja, Shafali Spurling Jeste, James C. McPartland, Charles A. Nelson, Michael Murias, Helen Seow, Catherine Sugar, Sara J. Webb, Frederick Shic, and Scott P. Johnson

Subjects
Developmental and Educational Psychology
Abstract

Visual exploration paradigms involving object arrays have been used to examine salience of social stimuli such as faces in ASD. Recent work suggests performance on these paradigms may associate with clinical features of ASD. We evaluate metrics from a visual exploration paradigm in 4-to-11-year-old children with ASD (n = 23; 18 males) and typical development (TD; n = 23; 13 males). Presented with arrays containing faces and nonsocial stimuli, children with ASD looked less at (p = 0.002) and showed fewer fixations to (p = 0.022) faces than TD children, and spent less time looking at each object on average (p = 0.004). Attention to the screen and faces correlated positively with social and cognitive skills in the ASD group (ps .05). This work furthers our understanding of objective measures of visual exploration in ASD and its potential for quantifying features of ASD.

Published
2022
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14. Atypical Tactile Perception in Early Childhood Autism

Author

Svenja Espenhahn, Kate J. Godfrey, Sakshi Kaur, Carly McMorris, Kara Murias, Mark Tommerdahl, Signe Bray, and Ashley D. Harris

Subjects
Developmental and Educational Psychology
Abstract

We assessed different aspects of tactile perception in young children (3–6 years) with autism. Autistic and neurotypical children completed vibrotactile tasks assessing reaction time, amplitude discrimination (sequential and simultaneous) and temporal discrimination (temporal order judgment and duration discrimination). Autistic children had elevated and more variable reaction times, suggesting slower perceptual-motor processing speed and/or greater distractibility. Children with autism also showed higher amplitude discrimination and temporal order judgement thresholds compared to neurotypical children. Tactile perceptual metrics did not associate with social or tactile sensitivities measured by parent-reports. Altered tactile behavioral responses appear in early childhood, can be quantified but appear dissociated from sensitivity. This implies these measures are complementary, but not necessarily related, phenomena of atypical tactile perception in autism.

Published
2022
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15. Attention Allocation During Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study

Author

Tsang, Tawny, primary, Naples, Adam J., additional, Barney, Erin C., additional, Xie, Minhang, additional, Bernier, Raphael, additional, Dawson, Geraldine, additional, Dziura, James, additional, Faja, Susan, additional, Jeste, Shafali Spurling, additional, McPartland, James C., additional, Nelson, Charles A., additional, Murias, Michael, additional, Seow, Helen, additional, Sugar, Catherine, additional, Webb, Sara J., additional, Shic, Frederick, additional, and Johnson, Scott P., additional

Published
2022
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16. Clinical course and seroprevalence of COVID-19 in children with rheumatic diseases—cross-sectional study from a reference centre in Spain

Author

Udaondo, Clara, primary, Millán-Longo, Claudia, additional, Permuy, Celia, additional, Valladares, Laura, additional, Falces-Romero, Iker, additional, Muñoz-Gómez, Celia, additional, Morales-Higuera, Mónica, additional, Alcobendas, Rosa, additional, Remesal, Agustín, additional, Murias, Sara, additional, and Calvo, Cristina, additional

Published
2022
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18. First-line Double Stentriever Thrombectomy for M1/TICA Occlusions

Author

Vega, Pedro, primary, Murias, Eduardo, additional, Jimenez, Jose Maria, additional, Chaviano, Juan, additional, Rodriguez, Jose, additional, Calleja, Sergio, additional, Delgado, Montserrat, additional, Benavente, Lorena, additional, Castañon, Maria, additional, Puig, Josep, additional, Cigarran, Helena, additional, Arias, Faustino, additional, and Chapot, Rene, additional

Published
2022
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19. The Autism Biomarkers Consortium for Clinical Trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials

Author

Shic, Frederick, primary, Naples, Adam J., additional, Barney, Erin C., additional, Chang, Shou An, additional, Li, Beibin, additional, McAllister, Takumi, additional, Kim, Minah, additional, Dommer, Kelsey J., additional, Hasselmo, Simone, additional, Atyabi, Adham, additional, Wang, Quan, additional, Helleman, Gerhard, additional, Levin, April R., additional, Seow, Helen, additional, Bernier, Raphael, additional, Charwaska, Katarzyna, additional, Dawson, Geraldine, additional, Dziura, James, additional, Faja, Susan, additional, Jeste, Shafali Spurling, additional, Johnson, Scott P., additional, Murias, Michael, additional, Nelson, Charles A., additional, Sabatos-DeVito, Maura, additional, Senturk, Damla, additional, Sugar, Catherine A., additional, Webb, Sara J., additional, and McPartland, James C., additional

Published
2022
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22. Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives

Author

I. Okulicz-Kozaryn, Michał Szulc, Błażej Rubiś, Mariusz Kaczmarek, Marek Murias, Przemysław Ł. Mikołajczak, Ewa Kamińska, Joanna Kurek, Agnieszka Kurant, and Krzysztof Myszkowski

Subjects
Male, 0301 basic medicine, Molecular biology, medicine.drug_class, Science, Analgesic, Pharmacology, Article, Anti-inflammatory, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, Colchicine, Cytotoxic T cell, Doxorubicin, Rats, Wistar, Cytotoxicity, Cancer, Analgesics, Multidisciplinary, Sulfur Compounds, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Cell cycle, Antineoplastic Agents, Phytogenic, Chemical biology, Rats, 030104 developmental biology, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Medicine, Drug Screening Assays, Antitumor, medicine.drug
Abstract

10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods and their biological activities as: cytotoxic, anti-inflammatory and analgesic activities have been tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was reported and tested compounds showed to be more active than commonly used doxorubicin. Some of tested C-10 alkylthiolated colchicines have been found to exhibit cytotoxicity at levels comparable to that of the natural product—colchicine. 10-Methylthiocolchicine has IC50 = 8 nM and 10-ethylthiocolchicine has IC50 = 47 nM in comparison to colchicine IC50 = 37 nM. Moreover for 10-alkylthioderivatives apoptosis test, cyclin B1 and cell cycle tests were performed. 10-n-Butylthiocolchicine was tested for anti-inflammatory and analgesic activities it showed to produce analgesic rather than anti-inflammatory effect.

Published
2021
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23. Development of spatial orientation skills: an fMRI study

Author

Sana Tariq, Edward Slone, Giuseppe Iaria, and Kara Murias

Subjects
Male, medicine.medical_specialty, Cognitive Neuroscience, Precuneus, Prefrontal Cortex, Hippocampus, Posterior parietal cortex, Audiology, Insular cortex, 050105 experimental psychology, 03 medical and health sciences, Behavioral Neuroscience, Cellular and Molecular Neuroscience, Child Development, 0302 clinical medicine, Supramarginal gyrus, Parietal Lobe, Neural Pathways, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Child, Orientation, Spatial, medicine.diagnostic_test, Resting state fMRI, 05 social sciences, Brain, Magnetic Resonance Imaging, Psychiatry and Mental health, medicine.anatomical_structure, Neurology, Female, Neurology (clinical), Functional magnetic resonance imaging, Psychology, 030217 neurology & neurosurgery, Parahippocampal gyrus
Abstract

The ability to orient and navigate in spatial surroundings is a cognitive process that undergoes a prolonged maturation with progression of skills, strategies and proficiency over much of childhood. In the present study, we used functional Magnetic Resonance Imaging (fMRI) to investigate the neurological mechanisms underlying the ability to orient in a virtual interior environment in children aged 10 to 12 years of age, a developmental stage in which children start using effective spatial orientation strategies in large-scale surroundings. We found that, in comparison to young adults, children were not as proficient at the spatial orientation task, and revealed increased neural activity in areas of the brain associated with visuospatial processing and navigation (left cuneus and mid occipital area, left inferior parietal region and precuneus, right inferior parietal cortex, right precentral gyrus, cerebellar vermis and bilateral medial cerebellar lobes). When functional connectivity analyses of resting state fMRI data were performed, using seed areas that were associated with performance, increased connectivity was seen in the adults from the right hippocampal/parahippocampal gyrus to the contralateral caudate, the insular cortex, and the posterior supramarginal gyrus; children had increased connectivity from the right paracentral lobule to the right superior frontal gyrus as compared to adults. These findings support the hypothesis that, as children are maturing in their navigation abilities, they are refining and increasing the proficiency of visuospatial skills with a complimentary increase in connectivity of longer-range distributed networks allowing for flexible use of efficient and effective spatial orientation strategies.

Published
2019
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24. Differences in vascular function between trained and untrained limbs assessed by near-infrared spectroscopy

Author

Juan M. Murias, Mitchell A. George, Rogério Nogueira Soares, and David N. Proctor

Subjects
Adult, Male, medicine.medical_specialty, Sports medicine, Physiology, 030204 cardiovascular system & hematology, Vascular occlusion, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endurance training, Physiology (medical), Internal medicine, Occlusion, Humans, Medicine, Orthopedics and Sports Medicine, Exercise, Oxygen saturation (medicine), Leg, Spectroscopy, Near-Infrared, business.industry, Microcirculation, Large effect size, Public Health, Environmental and Occupational Health, Area under the curve, General Medicine, body regions, Case-Control Studies, Arm, Cardiology, medicine.symptom, business, Vascular function, 030217 neurology & neurosurgery
Abstract

The aim of this study was to examine whether differences in vascular responsiveness associated with training status would be more prominent in the trained limb (leg) than in the untrained limb (arm) microvasculature. Thirteen untrained (26 ± 5 year) and twelve trained (29 ± 4 year) healthy men were submitted to a vascular occlusion test (VOT) (2 min baseline, 5 min occlusion, and 8 min re-oxygenation). The oxygen saturation signal (StO2) was assessed using near-infrared spectroscopy (NIRS) throughout the VOT. Vascular responsiveness within the microvasculature was evaluated by the re-oxygenation Slope 2 (Slope 2 StO2) and the area under the curve (StO2AUC) of (StO2) signal during re-oxygenation in the leg and arm. There was a significant interaction between training status and limb for the slope 2 StO2 (P

Published
2018
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28. Evaluating the Accuracy of Using Fixed Ranges of METs to Categorize Exertional Intensity in a Heterogeneous Group of Healthy Individuals: Implications for Cardiorespiratory Fitness and Health Outcomes

Author

Iannetta, Danilo, primary, Keir, Daniel A., additional, Fontana, Federico Y., additional, Inglis, Erin Calaine, additional, Mattu, Anmol T., additional, Paterson, Donald H., additional, Pogliaghi, Silvia, additional, and Murias, Juan M., additional

Published
2021
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30. Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum

Author

Espenhahn, Svenja, primary, Godfrey, Kate J., additional, Kaur, Sakshi, additional, Ross, Maia, additional, Nath, Niloy, additional, Dmitrieva, Olesya, additional, McMorris, Carly, additional, Cortese, Filomeno, additional, Wright, Charlene, additional, Murias, Kara, additional, Dewey, Deborah, additional, Protzner, Andrea B., additional, McCrimmon, Adam, additional, Bray, Signe, additional, and Harris, Ashley D., additional

Published
2021
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35. Gastric Inflammatory Prognostic Index (GIPI) in Patients with Metastatic Gastro-Esophageal Junction/Gastric Cancer Treated with PD-1/PD-L1 Immune Checkpoint Inhibitors

Author

Formica, Vincenzo, primary, Morelli, Cristina, additional, Patrikidou, Anna, additional, Murias, Carmen, additional, Butt, Sabeeh, additional, Nardecchia, Antonella, additional, Lucchetti, Jessica, additional, Renzi, Nicola, additional, Shiu, Kai-Keen, additional, Roselli, Mario, additional, and Arkenau, Hendrik-Tobias, additional

Published
2020
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37. Neural Correlates of Sensory Hyporesponsiveness in Toddlers at High Risk for Autism Spectrum Disorder

Author

Carissa J. Cascio, Lisa V. Ibañez, Mark T. Wallace, Tiffany G. Woynaroski, Michael Andrew Murias, Cara R. Damiano, David M. Simon, and Wendy L. Stone

Subjects
Male, medicine.medical_specialty, Autism Spectrum Disorder, media_common.quotation_subject, Population, Sensation, Sensory system, Electroencephalography, Audiology, behavioral disciplines and activities, Article, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Perception, mental disorders, Developmental and Educational Psychology, medicine, Humans, 0501 psychology and cognitive sciences, education, media_common, Neural correlates of consciousness, education.field_of_study, medicine.diagnostic_test, Siblings, 05 social sciences, medicine.disease, Brain Waves, Autism spectrum disorder, Child, Preschool, Autism, Female, Psychology, 030217 neurology & neurosurgery, 050104 developmental & child psychology
Abstract

Altered patterns of sensory responsiveness are a frequently reported feature of Autism Spectrum Disorder (ASD). Younger siblings of individuals with ASD are at a greatly elevated risk of a future diagnosis of ASD, but little is known about the neural basis of sensory responsiveness patterns in this population. Younger siblings (n = 20) of children diagnosed with ASD participated in resting electroencephalography (EEG) at an age of 18 months. Data on toddlers’ sensory responsiveness were obtained using the Sensory Experiences Questionnaire. Correlations were present between hyporesponsiveness and patterns of oscillatory power, functional connectivity, and signal complexity. Our findings suggest that neural signal features hold promise for facilitating early identification and targeted remediation in young children at risk for ASD.

Published
2017
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38. Comment on: 'Relative Proximity of Critical Power and Metabolic/Ventilatory Thresholds: Systematic Review and Meta-Analysis'

Author

Felipe Mattioni Maturana, Danilo Iannetta, Juan M. Murias, and Daniel A. Keir

Subjects
medicine.medical_specialty, Physical medicine and rehabilitation, Sports medicine, business.industry, Meta-analysis, Critical power, MEDLINE, Medicine, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, business
Published
2020
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39. Relative Average Look Duration and its Association with Neurophysiological Activity in Young Children with Autism Spectrum Disorder

Author

Samantha Major, David E. Carlson, Geraldine Dawson, Guillermo Sapiro, Dmitry Isaev, Michael Murias, and Kimberly L. H. Carpenter

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Autism Spectrum Disorder, Brain activity and meditation, lcsh:Medicine, Audiology, Electroencephalography, Article, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, Humans, Attention, Child, Social Behavior, lcsh:Science, Association (psychology), Neurologic Examination, Multidisciplinary, Social communication, medicine.diagnostic_test, lcsh:R, Brain, Diagnostic markers, Autism spectrum disorders, Neurophysiology, medicine.disease, Preference, 030104 developmental biology, Duration (music), Autism spectrum disorder, Child, Preschool, Feasibility Studies, Female, lcsh:Q, Psychology, 030217 neurology & neurosurgery
Abstract

Autism Spectrum Disorder (ASD) is characterized by early attentional differences that often precede the hallmark symptoms of social communication impairments. Development of novel measures of attentional behaviors may lead to earlier identification of children at risk for ASD. In this work, we first introduce a behavioral measure, Relative Average Look Duration (RALD), indicating attentional preference to different stimuli, such as social versus nonsocial stimuli; and then study its association with neurophysiological activity. We show that (1) ASD and typically developing (TD) children differ in both (absolute) Average Look Duration (ALD) and RALD to stimuli during an EEG experiment, with the most pronounced differences in looking at social stimuli; and (2) associations between looking behaviors and neurophysiological activity, as measured by EEG, are different for children with ASD versus TD. Even when ASD children show attentional engagement to social content, our results suggest that their underlying brain activity is different than TD children. This study therefore introduces a new measure of social/nonsocial attentional preference in ASD and demonstrates the value of incorporating attentional variables measured simultaneously with EEG into the analysis pipeline.

Published
2020
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40. The relationship between oxygen uptake kinetics and neuromuscular fatigue in high-intensity cycling exercise

Author

Felipe Mattioni Maturana, Arthur Peyrard, John Temesi, Guillaume Y. Millet, Tatiane Piucco, and Juan M. Murias

Subjects
Adult, Male, medicine.medical_specialty, Physiology, Peak power output, High-Intensity Interval Training, 030204 cardiovascular system & hematology, Oxygen uptake kinetics, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Nuclear magnetic resonance, Isometric Contraction, Physiology (medical), medicine, Humans, Orthopedics and Sports Medicine, Muscle, Skeletal, Excitation Contraction Coupling, Muscle fatigue, Chemistry, High intensity, Public Health, Environmental and Occupational Health, 030229 sport sciences, General Medicine, Coupling (probability), Neuromuscular fatigue, Muscle Fatigue, Physical therapy, Female, Cycling, Anaerobic exercise
Abstract

In theory, a slow oxygen uptake ( $$\dot VO_2$$ ) kinetics leads to a greater accumulation of anaerobic by-products, which can, in turn, induce more neuromuscular fatigue. However, the existence of this relationship has never been tested. After two sessions to measure peak $$\dot VO_2$$ , peak power output (POpeak), and $$\dot VO_2$$ kinetics responses in the unfatigued state (τ $$\dot VO_2$$ MOD), 10 healthy young adults performed a 6-min cycling bout at 80% POpeak (INT6-min). $$\dot VO_2$$ kinetics responses were also measured during INT6-min. Neuromuscular fatigue was measured isometrically pre- and post-INT6-min (immediately post- and 15-s post-INT6-min) with an innovative cycle ergometer. Maximal voluntary contraction (MVC) force, high-frequency doublet amplitude, and the ratio of low- to high-frequency doublet amplitudes decreased by 34 ± 7, 43 ± 11, and 31 ± 13%, respectively (all P

Published
2017
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42. Proceedings of the 24th Paediatric Rheumatology European Society Congress: Part three

Author

Erato Atsali, Dimitra Kassara, Pelagia Katsimbri, Sorina Boiu, Dimitrios T. Boumpas, Vana Papaevangelou, Olena A. Oshlyanska, Ludmila I. Omelchenko, Tatiana A. Ljudvik, Katerina Bouchalova, Marcel Schüller, Jana Franova, Jarmila Skotakova, Marie Macku, Antoni Fellas, Fiona Hawke, Derek Santos, Andrea Coda, Anthi Kelempisioti, Paula Keskitalo, Virpi Glumoff, Petri Kulmala, Paula Vahasalo, Mohammed A. Mozaffar, Asraa K. Turkistani, Samaa O. Sangoof, Vladislav Sevostyanov, Elena Zholobova, Evangelia Bountouvi, konstantinos Theodoropoulos, Renata Moutsiou, Christina Tsalapaki, Talia Diaz, Sofia Osorio, Maria Teresa Braña, Yuridiana Ramirez, Luis Aparicio, Andres Rodriguez, Enrique Faugier, Rocio Maldonado, Maria Francesca Gicchino, Carmela Granato, Giulia Macchini, Daniela Capalbo, Alma Nunzia Olivieri, Nathan Hasson, Achille Marino, Sona Narula, Melissa Lerman, Maria Amelia Muñoz Calonge, Sara Maria Murias Loza, Rosa Maria Alcobendas, Agustin Remesal, Esmeralda Núñez-Cuadros, Rocio Galindo Zavala, Gisela Díaz-Cordovés Rego, Cristina Antúnez Fernández, Yaiza García Molina, Antonio L. Urda Cardona, Nihal Sahin, Habibe S. Durmus, Ayse S. Pinarbasi, Zubeyde Gunduz, Muammer H. Poyrazoglu, Zehra F. Karaman, Turhan Oktem, Mithat Oner, Ruhan Dusunsel, Gordana Susic, Tamara Krstajic, Dragana Vujovic, Nedeljko Radlovic, Zoran Lekovic, Dusica Novakovic, Gordana Milosevski Lomic, Karina Mördrup, Gunilla Hesselstrand, Iva Sorić, Lovro Lamot, Mandica Vidovic, Mirta Lamot, Miroslav Harjacek, Eva Adank, Elvira Cannizzaro Schneider, Eiman Abdalla, Irfan Ullah, L. Jeyaseelan, Reem Abdwani, Laila A. L. Shaqsi, Ibrahim A. l. Zakwani, Antonis Fanouriakis, Mahesh Janarthanan, Dhanarathnamoorthy Vetrichelvan, P. Ramachandran, Sangeetha Geminiganesan, Dinesh Kumar, Subba Rao, Eleni-Maria Papatesta, Despoina Maritsi, Irini Eleftheriou, Maria Tsolia, Olga Vougiouka, Mustafa Çakan, Nuray Aktay Ayaz, Şerife Gül Karadağ, Gonca Keskindemirci, Vladimir Keltsev, Lyudmila Grebenkina, Kwang Nam Kim, Jong Gyun Ahn, Young Dae Kim, Maria Cristina Maggio, Rolando Cimaz, Maria Concetta Failla, Piera Dones, Mirella Collura, Giovanni Corsello, Jung-Woo Rhim, Ki-Hwan Kim, Soo-Young Lee, Seung-Beom Han, Jin-Han Kang, Jae-Hee Chung, Soo-Jung Lee, Dae-Chul Jeong, Andrei Santimov, Regina Rupp, Igor Alekseev, Natalya Plutova, Ekaterina Moskvina, Marina Kruchina, Aleksandra Tarasenko, Natalya Sokolova, Ekaterina Saveleva, Ilia Bogdanov, Dmitrii Ivanov, Tatiana Kandrina, Olga Kopanevich, Anastasiia Grafskaia, Natalia Ignateva, Daria Pulukchu, Natalia Pavlova, Olga Kalashnikova, Tatiana Kornishina, Margarita Dubko, Vyacheslav Chasnyk, Mikhail Kostik, Shama Sowdagar, Janani Sankar, Venkateswari Ramesh, Iulia E. Szabo, Claudia Sirbe, Cristina Pamfil, Laura Damian, Simona Rednic, Maria Deac, Mihaela Sparchez, Ileana Filipescu, Mirela Parvu, Dumitrita Balint, and Ancuta Nicoara

Subjects
Rheumatology, business.industry, Pediatrics, Perinatology and Child Health, Immunology and Allergy, Library science, Athens greece, Medicine, Meeting Abstracts, business, Paediatric rheumatology
Published
2017
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43. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one

Author

Virpi Glumoff, Dumitrita Balint, Mustafa Çakan, Gonca Keskindemirci, Laila A. L. Shaqsi, Rocio Maldonado, Natalia Ignateva, Young Dae Kim, Ludmila I. Omelchenko, Laura Damian, Eleni-Maria Papatesta, Gunilla Hesselstrand, Dragana Vujovic, Ekaterina Saveleva, Claudia Sirbe, Melissa A. Lerman, Mahesh Janarthanan, Sara Maria Murias Loza, Andrei Santimov, Karina Mördrup, Rocio Galindo Zavala, Tatiana Kandrina, Agustin Remesal, Regina Rupp, Enrique Faugier, Rosa Alcobendas, Marina K. Kruchina, Igor Alekseev, Seung Beom Han, Mandica Vidović, Eiman Abdalla, Mihaela Sparchez, Antoni Fellas, Ayşe Seda Pınarbaşı, Marie Macku, Maria Amelia Muñoz Calonge, Katerina Bouchalova, Daniela Capalbo, Gisela Díaz-Cordovés Rego, Antonis Fanouriakis, L. Jeyaseelan, Jae-Hee Chung, Olga Vougiouka, Mikhail Kostik, Mohammed A. Mozaffar, Olga Kalashnikova, Lovro Lamot, Dae-Chul Jeong, Achille Marino, Christina Tsalapaki, Mirela Parvu, P. Ramachandran, Konstantinos C. Theodoropoulos, Tamara Krstajic, Maria Teresa Braña, Vladimir Keltsev, Iulia E. Szabo, Subba Rao, E. Zholobova, Natalya Plutova, Nathan Hasson, Janani Sankar, Zübeyde Gündüz, Mirella Collura, Dmitrii Ivanov, Nedeljko Radlovic, Cristina Antúnez Fernández, Rolando Cimaz, Zehra Filiz Karaman, Maria Cristina Maggio, Soo-Jung Lee, Maria Concetta Failla, Nuray Aktay Ayaz, Esmeralda Núñez-Cuadros, Tatiana A. Ljudvik, Simona Rednic, Cristina Pamfil, Andrea Coda, Venkateswari Ramesh, Tatiana Kornishina, Erato Atsali, Ilia Bogdanov, Zoran Lekovic, Miroslav Harjacek, Anthi Kelempisioti, Mirta Lamot, Iva Sorić, Natalia Pavlova, Ancuta Nicoara, Pelagia Katsimbri, Jin Han Kang, Habibe Selver Durmuş, Dinesh Kumar, Eva Adank, Soo Young Lee, Gordana Susic, Lyudmila Grebenkina, Talia Diaz, Ruhan Düşünsel, Andres Rodriguez, Sangeetha Geminiganesan, Irfan Ullah, Luis Aparicio, Maria Tsolia, Evangelia Bountouvi, Renata Moutsiou, Muammer Hakan Poyrazoğlu, Maria Francesca Gicchino, Marcel Schüller, Dimitra Kassara, Olga Kopanevich, Natalya Sokolova, Şerife Gül Karadağ, Fiona Hawke, Jong Gyun Ahn, Sofia Osorio, Yuridiana Ramirez, Reem Abdwani, Jung-Woo Rhim, Shama Sowdagar, Vladislav Sevostyanov, Derek Santos, Maria Deac, Turhan Oktem, Ibrahim Al Zakwani, Vana Papaevangelou, Alma Nunzia Olivieri, Dimitrios T. Boumpas, Paula Vähäsalo, Nihal Şahin, Irini Eleftheriou, Ileana Filipescu, Kwang Nam Kim, Sona Narula, Antonio L. Urda Cardona, Carmela Granato, Jarmila Skotakova, Sorina Boiu, Anastasiia Grafskaia, Elvira Cannizzaro Schneider, Margarita Dubko, Gordana Milosevski Lomic, Samaa O. Sangoof, Paula Keskitalo, Ekaterina Moskvina, Yaiza García Molina, Mithat Oner, Ki Hwan Kim, Asraa K. Turkistani, Dhanarathnamoorthy Vetrichelvan, Piera Dones, Jana Franova, Giulia Macchini, Vyacheslav Chasnyk, Giovanni Corsello, Daria Pulukchu, Olena A. Oshlyanska, Despoina Maritsi, Dusica Novakovic, Aleksandra Tarasenko, and Petri Kulmala

Subjects
030203 arthritis & rheumatology, medicine.medical_specialty, Pediatrics, business.industry, Rheumatology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Family medicine, Pediatrics, Perinatology and Child Health, Immunology and Allergy, Medicine, 030212 general & internal medicine, business, Paediatric rheumatology
Published
2017
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44. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two

Author

David Kern, Masato Yashiro, Gerd Horneff, Ana P. Sakamoto, Berent J. Prakken, Paula Vähäsalo, Juergen Brunner, Ezgi H. Baris, Helen McCarthy, Janet E. McDonagh, A. Grom, Adriana Albu, Lenka Linkova, I. Nikishina, Daniel Álvarez de la Sierra, Bruno Papia, Peggy Lee, Luisa Giannone, Tobias Schwarz, Mekibib Altaye, Margarita Onoufriou, Tatiana Sleptsova, N. Ruperto, O Thana, A. Baheti, Ilonka Orbán, Kai Lehmberg, F. Zulian, Helga Sanner, Karin Palmblad, Kousuke Shabana, Sebastiaan Vastert, Marta Rusmini, Olga Vougiouka, Dirk Holzinger, D. Shaikhani, Shouichi Ohga, Ismail Dursun Dursun, Claire T Deakin, Ingrid Herta Rotstein Grein, Maria Trachana, Ariane Klein, Eugenia Enriquez, Angelo Ravelli, Paul A. Brogan, L.S. Nazarova, Laila Al Shaqshi, Paulina Vele, Liana Guerra, Antonia Pascarella, Jelena Vojinovic, Juliana Molina, Kjell Tullus, S. Rodionovskaya, Chris Scott, A. N. Olivieri, Cliff Taggart, Clare Heard, Ricardo Pujol Borrell, Jens Klotsche, Grendel Burrell, Oriany L. Pereira, Silvia Giliani, Sandra Pereira, Jennifer Horonjeff, Beth A. Mueller, Lyudmyla M. Byelyaeva, Sergio Tufik, Carlo Agostoni, Valentina Muratore, Rostislav M. Filonovich, Fiona Hawke, Virginia Messia, Bo Magnusson, Kerry West, Sara Murias, Mustafa Doğan, Hafize Emine Sönmez, Annet van Royen-Kerkhof, K. Minden, Raquel Campanilho-Marques, Reem Abdawani, Maria Ceci, Maria Ekelund, Seza Ozen, Ratna Puri, Girolamo Luppino, Shannon Carr, Rita A. Amorim, K Kobrová, Rachael D. Wright, Chantal Job-Deslandre, Daniel J. Lovell, Jorge Kalil, Yi-jin Gao, Kubra Ozturk, Fulvio Parentin, Ursula Fearon, Frank Weller-Heinemann, Elizabeth Ang, Charles A Mebus, Andrea Superti-Furga, Alina Ferster, Rikard Wicksell, Mohammadreza Modaressi, F La Torre, Ela Tarakci, Wendy Thomson, Giorgia Malighetti, Antonio Eleuteri, Helena K. Khrustaleva, Alan Easton, Alexander Mushkin, Sara Marsal Barril, Erkan Demirkaya, Florence Kanakoudi-Tsakalidou, Diana Ekdawy, Lana Tambić Bukovac, Suvi Peltoniemi, Nur Arslan, Hermine I. Brunner, Tim Rapley, Donatella Vairo, Kirill Savostyanov, Fumiko Okazaki, Rachel Corkhill, Tufan Kutlu, MG Alpigiani, Fabio Fernandes Morato Castro, Juliana Farhat, Butsabong Lerkvaleekul, Scolozzi Paolo, Akihiko Saitoh, Jason Dare, Gustavo Rocha, Tatiana V. Viktorova, Riva Brik, Jason Palman, Fabrizia Corona, Susan Nielsen, Johannes Roth, Ma. Theresa M. Collante, Leonardo Oliveira Mendonça, D. Alexeev, Randy Q. Cron, Sriharsha Grevich, Andrea L. Jorgensen, Lúcia Maria de Arruda Campos, Kiran Nistala, Fernando Martins, R. Cimaz, Angela C. Mosquera, Ruy Carrasco, Reyhan Dedeoglu, Giovanni Filocamo, J. Dare, Paula Keskitalo, Ana J. D. F. C. Lichtenfels, Florence Uettwiller, Umberto Conte, Gecilmara Salviato Pileggi, Michal Uher, Mercedes Chan, Sarka Fingerhutova, Anne M. Stevens, Peter Bale, Mikel Alberdi-Saugstrup, Olga L Kopchak, Thomas A. Griffin, Constantin Ailioaie, Clifton Bingham, Ekaterina Alexeeva, Loshinidevi D Bathi, Jane Hurst, AnnaCarin Horne, Laura Muntean, Nermin Uncu, Mara Carraro, C Vargas, Lorenzo Quartulli, Ayşenur Paç Kısaarslan, Angela Mauro, F. Corona, Donato Rigante, Helen J. Lachmann, Ana Cordeiro, Ivan Foeldvari, Faysal Gok, Tatiana Gonzalez, S. S. M. Kamphuis, Hasret Ayyildiz-Civan, Claudia Pastorino, Gleice C. S. Russo, J. B. Kuemmerle-Deschner, Serena Pastore, Nigel Klein, M. Jorini, Tatjana Freye, Maria Tsolia, Philippe Jacqmin, Suzanne M M Verstappen, Syuji Takei, Khalid Hussain, Renzo Marcolongo, Yuichi Yamasaki, Sharmila Jandial, K. Leon, Maria Pia Sormani, T. A. Simon, Mohammed Muzaffer, Catalina Mosquera, Clovis Aa Silva, Zelal Ekinci, Zübeyde Gündüz, Bernd Denecke, Felicitas Bellutti Enders, Despina Eleftheriou, Ishbel MacGregor, Andrew Cant, Luisa Bonafé, Valda Staņēviča, Helen E. Foster, Alberto Tommasini, Nora Bartholomä, Nural Kiper, A. Kardolus, Eloisa Bonfa, Alessandro Consolaro, Lillemor Berntson, Umberto Garagiola, Richard K. Vehe, Vanessa Bugni Miotto e Silva, Chihaya Imai, Kathleen G. Lomax, Brian Best, Barbara Bonafini, M. Toth, D. Rigante, Eiman Abdalla, Leona Prochazkova, Lucy Wedderburn, Lovro Lamot, S. Verazza, Raffaella Carlomagno, Gillian I. Rice, Norm Ilowite, K. de Leeuw, Havva Evrengül, Jerold Jeyaratnam, Andrew Zeft, Andrea Taddio, R. Podda, Samuel Cassidy, Grant S. Schulert, Silvia Rosina, Marija Jelušić, Olivier Gilliaux, Rubén Burgos-Vargas, Mao Mizuta, Akihiro Yachie, Angel Phuti, Antonio Zea Mendoza, Emily Boulter, Zane Dāvidsone, Sofia Torreggiani, Marco Cattalini, Natali W. Gormezano, Fatma Dedeoglu, Hercília Guimarães, A. Insalaco, Andrea Coda, Viktor A. Malievsky, Thomas Zumbrunn, Agostino Nocerino, Ronald Pederson, Katarzyna Kobusinska, Anasuya Hazra, Ananadreia S. Lopes, Elena Campione, Toshiyuki Kitoh, Elena Tsitsami, Henny G. Hotten, Radka Kaneva, R. J. E. M. Dolhain, Ndate Fall, Francesco Licciardi, Deepti Suri, G. D’Angelo, Valentina Seraya, Elżbieta Smolewska, Anastasia Dropol, Ezgi Deniz Batu, Andreas Woerner, Christine Arango, Nadia E. Aikawa, Zoilo Morel, Megan Yuasa, Sandra Ammann, Erbil Unsal, Tomohiro Kubota, Toshitaka Kizawa, Fabrizio De Benedetti, Catherine Laing, Liudmila Rakovska, Yonatan Butbul Aviel, J-Peter Haas, Marta Minute, Christine Alvey, Vasiliko Dermentzoglou, Vania Schinzel, Isree Leelayuwattanakul, Ekim Taskiran, Gabriele Simonini, N. Martin, Nathalie Canham, Nicky Brice, Beatrice Vergara, Ika Birkić, Cengizhan Acikel, Johannes-Peter Haas, Ruth Fritsch, Alisa Vitebskaya, Fatih Yazici, Iva Brito, Nataša Toplak, Veronica Moshe, Gordon J Hendry, Nadia Luca, Deniz Doğru-Ersöz, Marco Matucci-Cerinic, Claudia Toppino, Zoë Johnson, Beatrice Goilav, Siyaram Didel, K. Marzan, Tamar B. Rubinstein, Angela Barnicoat, Peter Nourse, Thita Pacharapakornpong, Adele Civino, Inmaculada Calvo Penades, H. I. Brunner, Massimo Imazio, V. Gerloni, Ayla Kacar, Heinrike Schmeling, Marija Perica, Silvestre García de la Puente, Tadej Avcin, Filipa Oliveira-Ramos, S. Arsenyeva, Phillip J Hashkes, Sabrina Schuller, Adriana Rodriguez Vidal, Kathy de Graaf, Giedre Januskeviciute, M. Kaleda, Lee Dossetter, Jelena Basic, Elena Kaschenko, Erik Sundberg, Gizem Pamuk, Marek Zak, I. Foeldvari, Rachael Quarmby, Marc D. Natter, Antonarakis Gregory, P. A. Brogan, João Eurico Fonseca, Andrea Jorgensen, Ana F. Mourão, Gaurav Gulati, Yelda Bilginer, Banu Acar Celikel, Utako Kaneko, Karen L. Durrant, Alice Grossi, Maurizio Aricò, Ibrahim Al Zakwani, Yildirim Karslioglu, Takuji Murata, Monika Stoll, Maria Teresa Terreri, Ariana Kariminejad, Teresa A. Simon, Laura B Lewandowski, Marina Garcia Prat, Walter G. Ferlin, Albena Telcharova, Giovanni Maria Severini, Judith Wienke, Panagiota Nalbanti, Hakan Poyrazoglu, Athimalaipet V. Ramanan, Manisha Lamba, Z. Guo, J. Bohnsack, Norberto Guelbert, John F. Bohnsack, Lucy R. Wedderburn, Elvira Cannizzaro Schneider, Raul Gutiérrez Suárez, Debra Grech, Yonit Reis, Chris Pruunsild, Amit Rawat, Nienke M. ter Haar, Hiroshi Tamai, Alexander Pushkov, A. De Fanti, Valentina Marzetti, Sheila Weitzman, I. E. M. Bultink, Dilek Keskin, Sania Valieva, Klaus Tenbrock, Ana Luisa Rodriguez-Lozano, Lianne Kearsley-Fleet, Luca Messina, Chiara Gorio, Amra Adrovic, Stephanie J. W. Shoop, Davide Cumetti, Sana Al Zuhbi, Helena Khrustaleva, E. Zirkzee, Elio Castagnola, Clarissa Pilkington, Jingyao Leong, Vitor A. Teixeira, Reinhard Würzner, Sonia Melo Gomes, Orla Killeen, Antony C. Fisher, Sevket Erbil Unsal, Edward M. Behrens, Kristiina Aalto, Rebecca Nicolai, Thomas C. Stock, Luiz Cláudio Danzmann, Y. K. O. Teng, Stephen D. Marks, Fotios Papachristou, Valda Stanevicha, Richard Saffrey, Elizabeth Ralph, Johannes Peter Haas, Mary Slatter, Maria Tsinti, Mehmet Alikasifoglu, Mónica Martínez Gallo, Rayfel Schneider, Rosa Maria Rodrigues Pereira, Maria F. D. A. Giacomin, Alfésio Luís Ferreira Braga, Giulia Camilla Varnier, James McElnay, Jessica Foster, Ingrida Rumba-Rozenfelde, Francesca Minoia, Laurence Goffin, Roger C. Allen, Zehra S. Arıcı, Mette Nørgaard, Alberto Martini, Hofer Michaël, Andreas Eikelberg, Junko Yasumura, Maria José Santos, Tom Wolfs, Ada B. Sinoplu, Natalia Balera Ferreira Pinto, Michael Lang, Umberto Corpora, Hidenobu Kaneyasu, Fiorenzo Gaita, Olga Lomakina, Dimitrina Mihaylova, Gian Luca Erre, Fugen Cullu-Cokugras, Mesut Topdemir, Sriram Krishnaswami, Irina Nikishina, Noortje Groot, S. Pastore, Joke Dehoorne, Paula Estanqueiro, Shafe Fahoum, Francisca Aguiar, Mabel Ladino, Nico M Wulffraat, Jana Franova, Helena Erlandsson-Harris, Denise Pires Marafon, Adrian Liston, Edward H. Schuchman, Jaime C. Branco, Maria Teresa R. Terreri, Radoslava Saraeva, Ulrika Järpemo Nykvist, Maria Cristina Maggio, Kazuko Yamazaki, Lídia Teixeira, Hanquinet Sylviane, Ricardo Yepez, Susan Maillard, Tommy Gerschman, G. Horneff, Anne-Louise Ponsonby, Meredith Riebschleger, Alessandra Alongi, José Melo-Gomes, Iris Haug, Maria De Iorio, Ekaterina Alekseeva, Jan-Inge Henter, Elisa Pisaneschi, H. Kupper, Martina Niewerth, Berta López Montesinos, Shunji Hasegawa, Zahra Hadipour, R. M. Kuester, Silvia Maestroni, Pilar Guarnizo, Antonio Brucato, Tamaki Nakamura, Gustavo Antonio Moreira, Chaim Putterman, A. Hospach, Joost Frenkel, Svetlana O Salugina, A. Ravelli, Pavla Dolezalova, Gunnar L. Olsson, Eva González-Roca, Ellen Dalen Arnstad, Mohammad Alhemairi, Tina Hinnershitz, P. Quartier, Yildirim Karsioglu, Davinder Singh Grewal, Sergio Davì, Gökçen D. Tuğcu, Tomo Nozawa, Emily Robinson, M. C. Maggio, Maria Ballabio, Eleonora Bellucci, Alexei A. Grom, Rosa M. Pereira, Federica Vanoni, Shumpei Yokota, Justine A. Ellis, Helen Bristow, Mohammad-Hassan Moradinejad, Ricardo Russo, Harun Evrengül, Mario Abinun, Laura Carenini, Francesca Santarelli, C. Wallace, Maria Beatriz Fonseca, Timothy Beukelman, Saša Sršen, Véronique Hentgen, Sezgin Sahin, Silvia Zaffarano, Salvatore Albani, Valentin Brodszky, Clovis A. Silva, Graciela Espada, Jana Pachlopnik Schmid, Margaux Gerbaux, Stefano Stagi, Valentina Leone, Brian Leroux, Isabelle Koné-Paut, Gabriella Giancane, Soley Omarsdottir, Benedetta Schiappapietra, Alessandra Carobbio, Ricardo Menendez-Castro, Yoshifumi Kawano, Ozge Erdemli, Monia Lorini, Arjan Boltjes, Ellen Nordal, Carol A. Wallace, Mustafa Çakan, Reni Tzveova, Stefano Lanni, Salah Shokry, Kirsty McLellan, Qiong Wu, Nilay Arman, Adelina Tsakova, Michael W. Beresford, A. Consolaro, Francesca Bovis, Margarita Ganeva, Christoph Kessel, A. Martini, Taichi Kanetaka, Andre Schultz, Flora McErlane, Ronnie Wang, Mojca Zajc Avramovič, Thaschawee Arkachaisri, Boris Huegle, Funda Öztunç, Jane E Munro, Yanick J. Crow, Hiroyuki Wakiguchi, Rita Fonseca, Kim E. Nichols, Mia Glerup, Nils Venhoff, R. Filonovich, Erika Van Nieuwenhove, Nadia Rafiq, Elena Kamenets, Yasuo Nakagishi, Giampietro Farronato, Consuelo Modesto Caballero, Tulay Erkan, Jan Bonhoeffer, Jack Bukowski, Myrthes Toledo Barros, Gladys C. C. Esteves, Mirta Lamot, Rosa Alcobendas, Cláudia Moura, Florencia María Barbé-Tuana, Joo Guan Yeo, Mark Friswell, Yuko Sugita, Ari Shapiro, Nagla Abdelrahman, Phu-Quoc Lê, Kevin Murray, Susanne M Benseler, Anna Monica Bianco, J. Kalabic, Ana Catarina Duarte, Ivan Caiello, Joyce Davidson, Maria Isabel Gonzalez Fernandez, Larisa Zajtseva, Ebun Omoyinmi, Jaime de Inocencio, Dragana Lazarevic, Ritambhra Nada, Claudia Saad-Magalhães C, G. Conti, Andrew Gennery, Caroline Jones, Christophe Lelubre, Brian Rusted, Geneviève Lapeyre, Giulia Zani, Alina Boteanu, Maria T. Terreri, Nataliya Panko, Julia Albrecht, Federica Mongini, Lucio Giordano, Daniela Kaiser, Robert Nelson, Hans-Iko Huppertz, Gonca Keskindemirci, Karla Ištuk, Raffaele Strippoli, Dorota Rowczenio, Emma MacDermott, Roberta Caorsi, Emiliano Marasco, Sandra Sousa, Fatoş Yalçınkaya, Jaanika Ilisson, Yuki Kimura, Marco Turco, Nami Okamoto, Parveen Bhatti, Ekaterina M. Kuchinskaya, Stefano Volpi, Min Wang, Jeffrey M. Craig, M. Bijl, Giusi Prencipe, Fatemeh Tahghighi, W. van Dijk, Christiaan Scott, Masaki Shimizu, Alexey Maletin, Braydon Meyer, Joost F Swart, Sylvia Costa Lima Farhat, Anna Taparkou, R. Fritsch-Stork, Paolo Cressoni, Reiji Hirano, I. Chyzheuskaya, Stefania Simou, Kseniya Isayeva, Mariluz Gámir Gámir, Paivi Miettunen, Francesca Ricci, Ruta Šantere, George Lazaros, Madeleine Rooney, Stefan Stefanov, Huseyin Ozkan, Céline La, Boris Hügle, Vita Dolžan, P. Barone, R. Gallizzi, Aline L. de Oliveira, Silvia Federici, Lauren J. Lahey, Kimme L. Hyrich, Claudia Saad-Magalhães, Selçuk Yüksel, Valda Stanevica, Silvia De Pauli, Seid-Reza Raeeskarami, Calin Lazar, Sema Akman, Laurence Chatel, Kirsten Minden, Ismaiel A. Tekko, Philipp Henneke, E. Cortis, Elena Košková, Gil Amarilyo, Ana M. Marín Sánchez, Antonella Insalaco, Z. Birsin Ozcakar, Melissa Mariti Fraga, Lena Klevenvall, Luis Lira, Phoi-Ngoc Duong, Tatiana Bzarova, Neus Quilis, Wilco de Jager, Gary Sterba, Rina Denisova, Miroslav Harjacek, Eve M D Smith, N Ruperto, Gemma Lepri, Evgeniya Chistyakova, Rachel Kaufmann, Liliana Lourenço Jorge, Violeta Panaviene, Helena Canhão, Riccardo Belli, Grigoris Pardalos, Larisa I. Zajtseva, Nicolino Ruperto, Ezgi Batu, Paola Montesano, Alexander Solyom, Nicola Smith, Ales Janda, Sagar Bhattad, Liora Harel, Philip N. Hawkins, Gozde Yucel, François Willermain, Paolo Picco, Alessandro Rimini, Gordana Susic, Esi M. Morgan, Jessica Beckmann, Arina Lazareva, Agustin Remesal, Özge Altuğ Gücenmez, Troels Herlin, Andreas Groll, T. Yuraga, Ekaterina Zaharova, Adriana E. M. Sallum, Zeynep Birsin Özçakar, D. Milojevic, Can Kosukcu, Isabella Ceccherini, Sandrine Lacassagne, Tania M. Castro, R. Consolini, Klaus Müller, Dogan Simsek, Frank Rühle, Katia Kozu, Femke van Wijk, Yasin Sahin, Jonathan S. Hausmann, Gokalp Basbozkurt, M. Cattalini, Mª José Santos, Norman T. Ilowite, Adriana M. E. Sallum, Simona Rednic, Sirisucha Soponkanaporn, Giancarla Di Landro, Semanur Özdel, Timothy R. Radstake, Anastasia Wiener, Betül Sözeri, Estefania Quesada-Masachs, E. Zholobova, Joshua Newson, Ozgur Kasapcopur, Davide Montin, Terence Flood, Amir Mendelson, Manuela Pardeo, Flávia Heloísa dos Santos, Jamie Eaton, Vignesh Pandiarajan, Lyudmila Belyaeva, Edson Amaro Junior, Claudio Arnaldo Len, Tamás Constantin, Livia de Freitas Keppeke, Cristina Ferrari, Margarita Soloshenko, C. Rabinovich, David Popp, Jeremy Sokolove, Jaymi Taiani, Chiara Passarelli, de Min Cristina, José Costa, Stefanie Herresthal, Thomas Giner, Laure Caspers, Dilek Konukbay, Ulrich Salzer, Jorre S. Mertens, Marijan Frković, Yosef Uziel, Sabrina Chiesa, Luisa Bracci-Laudiero, Anders Fasth, Raul A. Chavez Valencia, Jordan T. Jones, Francesca Lancini, Alessandra Ferrari, Dana Nemcova, Mark Difrancesco, Ricardo Figueira, John Mitchell, Zohreh Nademi, E. Fedorov, Thomas Vogl, Carine Wouters, Mónica Eusébio, Hannah Leahey, Alessandra Pontillo, Marco Gattorno, Mandica Vidović, Lucas L. van den Hoogen, Mikhail Kostik, Giovanni Corsello, Gian Marco Moneta, Richard Mouy, Mariana Rodrigues, Veronica Medeghini, Gökçe Gür, Lucas Kich Grun, Stephan Ehl, Edi Paleka Bosak, Walter Ferlin, Hanna Lythgoe, Tsuyoshi Yamatou, Navdha R. Ramchurn, Carolina Furtado, Estefania Barral, Cecilia Lazea, Nikolay Tzaribachev, Vahid Ziaee, Fatemeh Hadipour, Alberto Sifuentes Giraldo, Kimberly Gilmour, Marite Rygg, Anna Valenti, María M Katsicas, Raju Khubchandani, Despoina Maritsi, Alessandra Tesser, R. M. Laxer, Clotilde Alizzi, Francisco Rivas-Larrauri, Aysen Tezcaner, Anne Dennos, Vasiliki Tzimouli, Vibeke Strand, Banu Acar, Fabio Candotti, Kseniia V. Danilko, Joachim Schultze, María Luz Gámir Gámir, Alessia Omenetti, Berit Flatø, Ruth Eraso, Bernard Lauwerys, Angela Pistorio, Andressa G. F. Alves, Gerd Ganser, Sara Signa, Ana Lopes, Emese Kiss, Charlene Foley, Sylvia Kamphuis, Maja Di Rocco, Kenan Barut, Ilaria Parissenti, Aida Koka, Nicholas Ng, Francis Corazza, Vinícius L. Braga, Laura E. Schanberg, Karin Beutel, Camila Hirotsu, Jonathan D Akikusa, Mihaela Sparchez, Karoline Ehlert, Jordi Anton, Adriana M. Sallum, Maria Cristina Castiglione, Surjit Singh, Julie Jones, Katya Temelkova, Tania S. Amin, Jasmin B Kuemmerle-Deschner, Samantha Bell, Sakda A.-O. Vallipakorn, Manuel Salgado, Filipa Ramos, Balahan Makay, Nadezhda Tsurikova, Gianmaria Viglizzo, Rosalba Ferraro, Sandra Hansmann, Nilgün Çakar, Ismail Dursun, Maria Stavrakidou, T. Bzarova, Sally Pino, Dhouib Amira, Salla Kangas, Antonella Meini, Dirk Foell, Dolunay Gürses, Dace Bērziņa, A. Speziale, Juan I. Arostegui Gorospe, Kelly L. Mieszkalski, Dawn M. Wahezi, S. Davì, Radoslav Srp, Daniel J. Kingsbury, Alexei A Grom, Falcini Fernanda, Peng Yin, Claire T. Deakin, Eva Hlavackova, Pavla Doležalová, Maria Mercedes Picarelli, Ezgi D. Batu, Alessandra Tricarico, Soamarat Vilaiyuk, Ivan Costa-Filho, A. Civino, Lukas Hackl, Pilar Gomez, Michael Hofer, M Manuela Costa, Zbigniew Zuber, Elena Ligostaeva, Carlos D. Rose, Jozef Hoza, Pranoot Tanpaiboon, Bonnie Vlahos, Sandra Garrote Corral, Martina Finetti, Giedre Grigelioniene, Susanne M. Benseler, X Wei, Pieter Van Dijkhuizen, Lee Nelson, Elettra Santori, David Martino, Anju Gupta, Nuray Aktay Ayaz, Noa Rabinowicz, Susan Shenoi, Rachel Chiaroni-Clarke, Claudia Bracaglia, Ruhan Düşünsel, M. Hofer, Rolando Cimaz, Juan I. Aróstegui, Ana Filipa Mourão, Ivonne Arroyo, Laura Damian, Marco F. C. D. Silva, D. J. Lovell, Marta Torcoletti, Clara Malagón, Luisa Klotz, Krisztina Sevcic, Douglas Veale, Belen Serrano Benavente, N. Groot, Polyxeni Pratsidou, Nicole Johnson, Karen Wynne, SR Rodionovskaya, Melania Saifridova, Kaara Tiewsoh, Ryan F. Donnelly, Fernanda Falcini, Valérie Badot, M. G. Alpigiani, L. Breda, Farida Abduragimova, Veronika Gjertsen Rypdal, Sophie Hambleton, E. Chalom, Anna Horne, Antonio Novelli, O. Kostareva, Panagiotis Tziavas, Yara Barrense-Dias, Cecilia Bava, Sarah Ringold, William H. Robinson, Sirirat Charuvanij, D. Kingsbury, Shuichi Ito, Luiz A. A. Pereira, Marcus Herbert Jones, S. I. Valieva, Flavio Sztajnbok, Florence Guilhot, Cristina de Min, Adriana Diaz-Maldonado, Simone A. Lotufo, Beril Talim, M. Heinrich, Paul Newland, and Laura Pagani

Subjects
030203 arthritis & rheumatology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, Rheumatology, business.industry, 030220 oncology & carcinogenesis, Family medicine, Pediatrics, Perinatology and Child Health, medicine, Immunology and Allergy, business, Paediatric rheumatology
Published
2017
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45. Final results of a phase II study of paclitaxel, bevacizumab, and gemcitabine as first-line therapy for patients with HER2-negative metastatic breast cancer

Author

A Murias, JR Mel, M. C. de Villena, J. Bayo, P. Sanchez Rvira, Javier Salvador, J. M. Baena, J. Casal, Miguel Gil, I. Blancas, Eva Ciruelos, J. de la Haba, Carlos Jara, Ana Jaén, A Galan, and Luis Manso

Subjects
Adult, Oncology, Cancer Research, medicine.medical_specialty, Paclitaxel, Bevacizumab, Receptor, ErbB-2, medicine.medical_treatment, Phases of clinical research, Breast Neoplasms, Neutropenia, Antibodies, Monoclonal, Humanized, Deoxycytidine, Receptor, Angiotensin, Type 1, Translational Research, Biomedical, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Survival rate, Aged, Neoplasm Staging, Aged, 80 and over, Chemotherapy, business.industry, General Medicine, Middle Aged, Neoplastic Cells, Circulating, Prognosis, medicine.disease, Gemcitabine, Metastatic breast cancer, Survival Rate, Female, business, Febrile neutropenia, Follow-Up Studies, medicine.drug
Abstract

Efficacy and safety data for combining bevacizumab, gemcitabine, and paclitaxel for locally advanced/metastatic breast cancer are limited.AVALUZ trial evaluates the combination of bevacizumab 10 mg/kg, gemcitabine 2,000 mg/m(2) plus paclitaxel 150 mg/m(2), on days 1 and 15 of each 28-day course in previously untreated HER-2 negative patients.Median progression-free survival (PES): 12.3 months. The overall response and clinical benefit rate (CR + PR + SD) were 72 % (95 % CI 60.9-82.0 %) and 89 % (95 % CI 80.3-95.3 %), respectively. Median overall survival: 27.4 mo. Baseline circulating tumor cell (CTCs) ≥2 versus CTCs 2 was associated with lower PFS, p = 0.046. Overall response was significantly greater in patients with intense angiotensin type 1 receptor (AGTR1) expression (99 vs. 60 % [p = 0.021]). The most frequent grade 3/4 adverse events were: neutropenia (10 %); febrile neutropenia (1 %); sensory neuropathy (13 %); and asthenia (6 %). Grade 3 adverse events of interest with bevacizumab included bleeding (1 %) and hypertension (4 %). One patient developed cardiac ischemia (1 %).Adding bevacizumab to chemotherapy appeared feasible and well tolerated, producing toxicity comparable to other effective combined first-line regimens. Baseline circulating endothelial cells and AGTR1 expression are predictive of PFS and response.

Published
2014
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46. Faster $$\dot{V}{\text{O}}_{ 2}$$ V ˙ O 2 kinetics after eccentric contractions is explained by better matching of O2 delivery to O2 utilization

Author

Brendan P. Major, Joshua P. Nederveen, Donald H. Paterson, and Juan M. Murias

Subjects
Physics, Crystallography, Physiology, Eccentric exercise, Physiology (medical), Kinetics, Public Health, Environmental and Occupational Health, Moderate exercise, Orthopedics and Sports Medicine, Eccentric contractions, General Medicine, Human physiology, Muscle damage
Abstract

This study examined the impact of eccentric exercise-induced muscle damage on the rate of adjustment in muscle deoxygenation and pulmonary O2 uptake ( $$\dot{V}{\text{O}}_{{2{\text{p}}}}$$ ) kinetics during moderate exercise. Fourteen males (25 ± 3 year; mean ± SD) completed three step transitions to 90 % θL before (Pre), 24 h (Post24) and 48 h after (Post48) eccentric exercise (100 eccentric leg-press repetitions with a load corresponding to 110 % of the participant’s concentric 1RM). Participants were separated into two groups: phase II $$\dot{V}{\text{O}}_{{2{\text{p}}}}$$ time constant (τ $$\dot{V}{\text{O}}_{{2{\text{p}}}}$$ ) ≤ 25 s (fast group; n = 7) or τ $$\dot{V}{\text{O}}_{{2{\text{p}}}}$$ > 25 s (slow group; n = 7). $$\dot{V}{\text{O}}_{{2{\text{p}}}}$$ and [HHb] responses were modeled as a mono-exponential. In both groups, isometric peak torque (0°/s) at Post24 was decreased compared to Pre (p

Published
2014
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