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6. Overlay databank unlocks data-driven analyses of biomolecules for all

Author

Kiirikki, Anne M., primary, Antila, Hanne S., additional, Bort, Lara S., additional, Buslaev, Pavel, additional, Favela-Rosales, Fernando, additional, Ferreira, Tiago Mendes, additional, Fuchs, Patrick F. J., additional, Garcia-Fandino, Rebeca, additional, Gushchin, Ivan, additional, Kav, Batuhan, additional, Kučerka, Norbert, additional, Kula, Patrik, additional, Kurki, Milla, additional, Kuzmin, Alexander, additional, Lalitha, Anusha, additional, Lolicato, Fabio, additional, Madsen, Jesper J., additional, Miettinen, Markus S., additional, Mingham, Cedric, additional, Monticelli, Luca, additional, Nencini, Ricky, additional, Nesterenko, Alexey M., additional, Piggot, Thomas J., additional, Piñeiro, Ángel, additional, Reuter, Nathalie, additional, Samantray, Suman, additional, Suárez-Lestón, Fabián, additional, Talandashti, Reza, additional, and Ollila, O. H. Samuli, additional

Published
2024
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7. Soluble B7-H3 in Colorectal Cancer

Author

Kovaleva, O. V., primary, Gratchev, A. N., additional, Sokolov, N. Yu., additional, Maslennikov, V. V., additional, Kuzmin, Yu.B., additional, Gershtein, E. S., additional, Alferov, A. A., additional, Mamedli, Z. Z., additional, Stilidi, I. S., additional, and Kushlinskii, N. E., additional

Published
2023
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8. STCF conceptual design report (Volume 1): Physics & detector

Author

Achasov, M., primary, Ai, X. C., additional, An, L. P., additional, Aliberti, R., additional, An, Q., additional, Bai, X. Z., additional, Bai, Y., additional, Bakina, O., additional, Barnyakov, A., additional, Blinov, V., additional, Bobrovnikov, V., additional, Bodrov, D., additional, Bogomyagkov, A., additional, Bondar, A., additional, Boyko, I., additional, Bu, Z. H., additional, Cai, F. M., additional, Cai, H., additional, Cao, J. J., additional, Cao, Q. H., additional, Cao, X., additional, Cao, Z., additional, Chang, Q., additional, Chao, K. T., additional, Chen, D. Y., additional, Chen, H., additional, Chen, H. X., additional, Chen, J. F., additional, Chen, K., additional, Chen, L. L., additional, Chen, P., additional, Chen, S. L., additional, Chen, S. M., additional, Chen, S., additional, Chen, S. P., additional, Chen, W., additional, Chen, X., additional, Chen, X. F., additional, Chen, X. R., additional, Chen, Y., additional, Chen, Y. Q., additional, Cheng, H. Y., additional, Cheng, J., additional, Cheng, S., additional, Cheng, T. G., additional, Dai, J. P., additional, Dai, L. Y., additional, Dai, X. C., additional, Dedovich, D., additional, Denig, A., additional, Denisenko, I., additional, Dias, J. M., additional, Ding, D. Z., additional, Dong, L. Y., additional, Dong, W. H., additional, Druzhinin, V., additional, Du, D. S., additional, Du, Y. J., additional, Du, Z. G., additional, Duan, L. M., additional, Epifanov, D., additional, Fan, Y. L., additional, Fang, S. S., additional, Fang, Z. J., additional, Fedotovich, G., additional, Feng, C. Q., additional, Feng, X., additional, Feng, Y. T., additional, Fu, J. L., additional, Gao, J., additional, Gao, Y. N., additional, Ge, P. S., additional, Geng, C. Q., additional, Geng, L. S., additional, Gilman, A., additional, Gong, L., additional, Gong, T., additional, Gou, B., additional, Gradl, W., additional, Gu, J. L., additional, Guevara, A., additional, Gui, L. C., additional, Guo, A. Q., additional, Guo, F. K., additional, Guo, J. C., additional, Guo, J., additional, Guo, Y. P., additional, Guo, Z. H., additional, Guskov, A., additional, Han, K. L., additional, Han, L., additional, Han, M., additional, Hao, X. Q., additional, He, J. B., additional, He, S. Q., additional, He, X. G., additional, He, Y. L., additional, He, Z. B., additional, Heng, Z. X., additional, Hou, B. L., additional, Hou, T. J., additional, Hou, Y. R., additional, Hu, C. Y., additional, Hu, H. M., additional, Hu, K., additional, Hu, R. J., additional, Hu, W. H., additional, Hu, X. H., additional, Hu, Y. C., additional, Hua, J., additional, Huang, G. S., additional, Huang, J. S., additional, Huang, M., additional, Huang, Q. Y., additional, Huang, W. Q., additional, Huang, X. T., additional, Huang, X. J., additional, Huang, Y. B., additional, Huang, Y. S., additional, Hüsken, N., additional, Ivanov, V., additional, Ji, Q. P., additional, Jia, J. J., additional, Jia, S., additional, Jia, Z. K., additional, Jiang, H. B., additional, Jiang, J., additional, Jiang, S. Z., additional, Jiao, J. B., additional, Jiao, Z., additional, Jing, H. J., additional, Kang, X. L., additional, Kang, X. S., additional, Ke, B. C., additional, Kenzie, M., additional, Khoukaz, A., additional, Koop, I., additional, Kravchenko, E., additional, Kuzmin, A., additional, Lei, Y., additional, Levichev, E., additional, Li, C. H., additional, Li, C., additional, Li, D. Y., additional, Li, F., additional, Li, G., additional, Li, H. B., additional, Li, H., additional, Li, H. N., additional, Li, H. J., additional, Li, H. L., additional, Li, J. M., additional, Li, J., additional, Li, L., additional, Li, L. Y., additional, Li, N., additional, Li, P. R., additional, Li, R. H., additional, Li, S., additional, Li, T., additional, Li, W. J., additional, Li, X., additional, Li, X. H., additional, Li, X. Q., additional, Li, Y., additional, Li, Y. Y., additional, Li, Z. J., additional, Liang, H., additional, Liang, J. H., additional, Liang, Y. T., additional, Liao, G. R., additional, Liao, L. Z., additional, Liao, Y., additional, Lin, C. X., additional, Lin, D. X., additional, Lin, X. S., additional, Liu, B. J., additional, Liu, C. W., additional, Liu, D., additional, Liu, F., additional, Liu, G. M., additional, Liu, H. B., additional, Liu, J., additional, Liu, J. J., additional, Liu, J. B., additional, Liu, K., additional, Liu, K. Y., additional, Liu, L., additional, Liu, Q., additional, Liu, S. B., additional, Liu, T., additional, Liu, X., additional, Liu, Y. W., additional, Liu, Y., additional, Liu, Y. L., additional, Liu, Z. Q., additional, Liu, Z. Y., additional, Liu, Z. W., additional, Logashenko, I., additional, Long, Y., additional, Lu, C. G., additional, Lu, J. X., additional, Lu, N., additional, Lü, Q. F., additional, Lu, Y., additional, Lu, Z., additional, Lukin, P., additional, Luo, F. J., additional, Luo, T., additional, Luo, X. F., additional, Lyu, H. J., additional, Lyu, X. R., additional, Ma, J. P., additional, Ma, P., additional, Ma, Y., additional, Ma, Y. M., additional, Maas, F., additional, Malde, S., additional, Matvienko, D., additional, Meng, Z. X., additional, Mitchell, R., additional, Nefediev, A., additional, Nefedov, Y., additional, Olsen, S. L., additional, Ouyang, Q., additional, Pakhlov, P., additional, Pakhlova, G., additional, Pan, X., additional, Pan, Y., additional, Passemar, E., additional, Pei, Y. P., additional, Peng, H. P., additional, Peng, L., additional, Peng, X. Y., additional, Peng, X. J., additional, Peters, K., additional, Pivovarov, S., additional, Pyata, E., additional, Qi, B. B., additional, Qi, Y. Q., additional, Qian, W. B., additional, Qian, Y., additional, Qiao, C. F., additional, Qin, J. J., additional, Qin, L. Q., additional, Qin, X. S., additional, Qiu, T. L., additional, Rademacker, J., additional, Redmer, C. F., additional, Sang, H. Y., additional, Saur, M., additional, Shan, W., additional, Shan, X. Y., additional, Shang, L. L., additional, Shao, M., additional, Shekhtman, L., additional, Shen, C. P., additional, Shen, J. M., additional, Shen, Z. T., additional, Shi, H. C., additional, Shi, X. D., additional, Shwartz, B., additional, Sokolov, A., additional, Song, J. J., additional, Song, W. M., additional, Song, Y., additional, Song, Y. X., additional, Sukharev, A., additional, Sun, J. F., additional, Sun, L., additional, Sun, X. M., additional, Sun, Y. J., additional, Sun, Z. P., additional, Tang, J., additional, Tang, S. S., additional, Tang, Z. B., additional, Tian, C. H., additional, Tian, J. S., additional, Tian, Y., additional, Tikhonov, Y., additional, Todyshev, K., additional, Uglov, T., additional, Vorobyev, V., additional, Wan, B. D., additional, Wang, B. L., additional, Wang, B., additional, Wang, D. Y., additional, Wang, G. Y., additional, Wang, G. L., additional, Wang, H. L., additional, Wang, J., additional, Wang, J. H., additional, Wang, J. C., additional, Wang, M. L., additional, Wang, R., additional, Wang, S. B., additional, Wang, W., additional, Wang, W. P., additional, Wang, X. C., additional, Wang, X. D., additional, Wang, X. L., additional, Wang, X. P., additional, Wang, X. F., additional, Wang, Y. D., additional, Wang, Y. P., additional, Wang, Y. Q., additional, Wang, Y. L., additional, Wang, Y. G., additional, Wang, Z. Y., additional, Wang, Z. L., additional, Wang, Z. G., additional, Wei, D. H., additional, Wei, X. L., additional, Wei, X. M., additional, Wen, Q. G., additional, Wen, X. J., additional, Wilkinson, G., additional, Wu, B., additional, Wu, J. J., additional, Wu, L., additional, Wu, P., additional, Wu, T. W., additional, Wu, Y. S., additional, Xia, L., additional, Xiang, T., additional, Xiao, C. W., additional, Xiao, D., additional, Xiao, M., additional, Xie, K. P., additional, Xie, Y. H., additional, Xing, Y., additional, Xing, Z. Z., additional, Xiong, X. N., additional, Xu, F. R., additional, Xu, J., additional, Xu, L. L., additional, Xu, Q. N., additional, Xu, X. C., additional, Xu, X. P., additional, Xu, Y. C., additional, Xu, Y. P., additional, Xu, Y., additional, Xu, Z. Z., additional, Xuan, D. W., additional, Xue, F. F., additional, Yan, L., additional, Yan, M. J., additional, Yan, W. B., additional, Yan, W. C., additional, Yan, X. S., additional, Yang, B. F., additional, Yang, C., additional, Yang, H. J., additional, Yang, H. R., additional, Yang, H. T., additional, Yang, J. F., additional, Yang, S. L., additional, Yang, Y. D., additional, Yang, Y. H., additional, Yang, Y. S., additional, Yang, Y. L., additional, Yang, Z. W., additional, Yang, Z. Y., additional, Yao, D. L., additional, Yin, H., additional, Yin, X. H., additional, Yokozaki, N., additional, You, S. Y., additional, You, Z. Y., additional, Yu, C. X., additional, Yu, F. S., additional, Yu, G. L., additional, Yu, H. L., additional, Yu, J. S., additional, Yu, J. Q., additional, Yuan, L., additional, Yuan, X. B., additional, Yuan, Z. Y., additional, Yue, Y. F., additional, Zeng, M., additional, Zeng, S., additional, Zhang, A. L., additional, Zhang, B. W., additional, Zhang, G. Y., additional, Zhang, G. Q., additional, Zhang, H. J., additional, Zhang, H. B., additional, Zhang, J. Y., additional, Zhang, J. L., additional, Zhang, J., additional, Zhang, L., additional, Zhang, L. M., additional, Zhang, Q. A., additional, Zhang, R., additional, Zhang, S. L., additional, Zhang, T., additional, Zhang, X., additional, Zhang, Y., additional, Zhang, Y. J., additional, Zhang, Y. X., additional, Zhang, Y. T., additional, Zhang, Y. F., additional, Zhang, Y. C., additional, Zhang, Y. M., additional, Zhang, Y. L., additional, Zhang, Z. H., additional, Zhang, Z. Y., additional, Zhao, H. Y., additional, Zhao, J., additional, Zhao, L., additional, Zhao, M. G., additional, Zhao, Q., additional, Zhao, R. G., additional, Zhao, R. P., additional, Zhao, Y. X., additional, Zhao, Z. G., additional, Zhao, Z. X., additional, Zhemchugov, A., additional, Zheng, B., additional, Zheng, L., additional, Zheng, Q. B., additional, Zheng, R., additional, Zheng, Y. H., additional, Zhong, X. H., additional, Zhou, H. J., additional, Zhou, H. Q., additional, Zhou, H., additional, Zhou, S. H., additional, Zhou, X., additional, Zhou, X. K., additional, Zhou, X. P., additional, Zhou, X. R., additional, Zhou, Y. L., additional, Zhou, Y., additional, Zhou, Y. X., additional, Zhou, Z. Y., additional, Zhu, J. Y., additional, Zhu, K., additional, Zhu, R. D., additional, Zhu, R. L., additional, Zhu, S. H., additional, Zhu, Y. C., additional, Zhu, Z. A., additional, Zhukova, V., additional, Zhulanov, V., additional, Zou, B. S., additional, and Zuo, Y. B., additional

Published
2023
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12. CCR and CAR Algebras are Connected Via a Path of Cuntz–Toeplitz Algebras

Author

Kuzmin, Alexey

Subjects
Mathematics - Quantum Algebra, FOS: Mathematics, Mathematics - Operator Algebras, Quantum Algebra (math.QA), Statistical and Nonlinear Physics, Operator Algebras (math.OA), Mathematical Physics
Abstract

For $$q \in {\mathbb {R}}$$ q ∈ R , $$|q| < 1$$ | q | < 1 we consider the universal enveloping $$C^*$$ C ∗ -algebra of a $$*$$ ∗ -algebra of q-canonical commutation relations (q-CCR), which is generated by $$a_1, \ldots , a_n$$ a 1 , … , a n subject to the relations $$\begin{aligned} a_i^* a_j = \delta _{ij} 1 + q a_j a_i^* . \end{aligned}$$ a i ∗ a j = δ ij 1 + q a j a i ∗ . It has a distinguished representation $$\pi _F$$ π F called the Fock representation, which is believed to be faithful. In this article we denote the image of the universal enveloping $$C^*$$ C ∗ -algebra of q-CCR in the Fock representation by $$\beth _{n,q}$$ ℶ n , q . The question whether $$C^*$$ C ∗ -isomorphism $$\beth _{n,q} \simeq \beth _{n,0}$$ ℶ n , q ≃ ℶ n , 0 holds has been considered in the literature and proved for $$|q| < 0.44$$ | q | < 0.44 . In this article we show that $$\beth _{n,q} \simeq \beth _{n,0}$$ ℶ n , q ≃ ℶ n , 0 for $$|q| < 1$$ | q | < 1 .

Published
2022
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23. Mechanisms of inward transmembrane proton translocation

Author

Kovalev, Kirill, primary, Tsybrov, Fedor, additional, Alekseev, Alexey, additional, Shevchenko, Vitaly, additional, Soloviov, Dmytro, additional, Siletsky, Sergey, additional, Bourenkov, Gleb, additional, Agthe, Michael, additional, Nikolova, Marina, additional, von Stetten, David, additional, Astashkin, Roman, additional, Bukhdruker, Sergey, additional, Chizhov, Igor, additional, Royant, Antoine, additional, Kuzmin, Alexander, additional, Gushchin, Ivan, additional, Rosselli, Riccardo, additional, Rodriguez-Valera, Francisco, additional, Ilyinskiy, Nikolay, additional, Rogachev, Andrey, additional, Borshchevskiy, Valentin, additional, Schneider, Thomas R., additional, Bamberg, Ernst, additional, and Gordeliy, Valentin, additional

Published
2023
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27. Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism

Author

Charles E. Rupprecht, Philip P. Mshelbwala, R. Guy Reeves, and Ivan V. Kuzmin

Abstract

Rabies is an ancient disease. Two centuries since Pasteur, fundamental progress occurred in virology, vaccinology, and diagnostics—and an understanding of pathobiology and epizootiology of rabies in testament to One Health—before common terminological coinage. Prevention, control, selective elimination, and even the unthinkable—occasional treatment—of this zoonosis dawned by the twenty-first century. However, in contrast to smallpox and rinderpest, eradication is a wishful misnomer applied to rabies, particularly post-COVID-19 pandemic. Reasons are minion. Polyhostality encompasses bats and mesocarnivores, but other mammals represent a diverse spectrum of potential hosts. While rabies virus is the classical member of the genus, other species of lyssaviruses also cause the disease. Some reservoirs remain cryptic. Although global, this viral encephalitis is untreatable and often ignored. As with other neglected diseases, laboratory-based surveillance falls short of the notifiable ideal, especially in lower- and middle-income countries. Calculation of actual burden defaults to a flux within broad health economic models. Competing priorities, lack of defined, long-term international donors, and shrinking local champions challenge human prophylaxis and mass dog vaccination toward targets of 2030 for even canine rabies impacts. For prevention, all licensed vaccines are delivered to the individual, whether parenteral or oral–essentially ‘one and done’. Exploiting mammalian social behaviors, future ‘spreadable vaccines’ might increase the proportion of immunized hosts per unit effort. However, the release of replication-competent, genetically modified organisms selectively engineered to spread intentionally throughout a population raises significant biological, ethical, and regulatory issues in need of broader, transdisciplinary discourse. How this rather curious idea will evolve toward actual unconventional prevention, control, or elimination in the near term remains debatable. In the interim, more precise terminology and realistic expectations serve as the norm for diverse, collective constituents to maintain progress in the field.

Published
2023
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31. Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants

Author

Jonas Koeppel, Juliane Weller, Elin Madli Peets, Ananth Pallaseni, Ivan Kuzmin, Uku Raudvere, Hedi Peterson, Fabio Giuseppe Liberante, and Leopold Parts

Subjects
Biomedical Engineering, Molecular Medicine, Bioengineering, Applied Microbiology and Biotechnology, Biotechnology
Abstract

Most short sequences can be precisely written into a selected genomic target using prime editing; however, it remains unclear what factors govern insertion. We design a library of 3,604 sequences of various lengths and measure the frequency of their insertion into four genomic sites in three human cell lines, using different prime editor systems in varying DNA repair contexts. We find that length, nucleotide composition and secondary structure of the insertion sequence all affect insertion rates. We also discover that the 3′ flap nucleases TREX1 and TREX2 suppress the insertion of longer sequences. Combining the sequence and repair features into a machine learning model, we can predict relative frequency of insertions into a site withR = 0.70. Finally, we demonstrate how our accurate prediction and user-friendly software help choose codon variants of common fusion tags that insert at high efficiency, and provide a catalog of empirically determined insertion rates for over a hundred useful sequences.

Published
2023
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34. Local structure and magnetic properties of a nanocrystalline Mn-rich Cantor alloy thin film down to the atomic scale

Author

Smekhova, Alevtina, primary, Kuzmin, Alexei, additional, Siemensmeyer, Konrad, additional, Luo, Chen, additional, Taylor, James, additional, Thakur, Sangeeta, additional, Radu, Florin, additional, Weschke, Eugen, additional, Buzanich, Ana Guilherme, additional, Xiao, Bin, additional, Savan, Alan, additional, Yusenko, Kirill V., additional, and Ludwig, Alfred, additional

Published
2023
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38. Extraction and separation of Cd(II) and Ni(II) with salts of Cyanex 301 and amines

Author

M. N. Leskiv, V. I. Kuzmin, N. V. Gudkova, and D. V. Kuzmin

Subjects
inorganic chemicals, Cadmium, Stripping (chemistry), General Chemical Engineering, Extraction (chemistry), chemistry.chemical_element, Sulfuric acid, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Biochemistry, Industrial and Manufacturing Engineering, 0104 chemical sciences, chemistry.chemical_compound, Nickel, Ammonia, chemistry, Materials Chemistry, Ammonium, Sulfate, 0210 nano-technology, Nuclear chemistry
Abstract

The extraction of cadmium from sulfuric acid solutions and its separation from nickel with salts of bis(2,4,4-trimethylpentyl)dithiophosphinic acid (Cyanex 301) and amines was studied. The data obtained show that extractants based on Cyanex 301 and Quaternary ammonium bases are most suitable for this since it is possible to extract cadmium in the form of sulfates and bisulfates as well as stripping metal from the organic phase. For deep extraction of cadmium from sulfate solutions in this system, 1–2 stages of extraction are sufficient. At this stage, the separation coefficient of cadmium and nickel βCd/Ni reaches values > 106, and the distribution coefficient of cadmium reaches almost 104. Cadmium stripping is achieved by treating the organic phase with an ammonia solution containing ammonia more than 4 mol/L. The process can be used in the processing of cadmium–nickel batteries.

Published
2020
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39. A new Time-of-flight detector for the R$$^3$$B setup

Author

Heil, M., Kelić-Heil, A., Bott, L., Almusidi, T., Alvarez-Pol, H., Atar, L., Atkins, L., Aumann, T., Benlliure, J., Boretzky, K., Brückner, B., Cabanelas, P., Caesar, C., Casarejos, E., Cederkall, J., Chulkov, L., Corsi, A., Dueñas, J., Erbacher, P., Rodriguez, S. Escribano, Falduto, A., Feijoo, M., Frotscher, A., Frühauf, J., Gašparić, I., Borge, M. J. G., Gerbig, J., Gernhäuser, R., Gilbert, M., Glorius, J., Gnoffo, B., Göbel, K., Caamaño, D. Gonzalez, Grein, A., Hartig, A.-L., Heggen, H., Heine, M., Heinz, A., Holl, M., Homm, I., Horvat, A., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kamenyero, A., Khodaparast, A., Kiselev, O., Klenze, P., Knösel, M., Koch, K., Körper, D., Kröll, T., Kurtulgil, D., Kurz, N., Löher, B., Langer, C., Lehr, C., Litvinov, Y., Liu, H., Morales, S. Murillo, Nácher, E., Nilsson, T., Park, J., Paschalis, S., Pellegri, L., Perea, A., Petri, M., Pohl, T., Ponnath, L., Popočovski, R., Reifarth, R., Rhee, H.-B., Sanchez, J. L. Rodriguez, Rossi, D., Sürder, C., Sánchez-Benítez, A. M., Savran, D., Scheit, H., Simon, H., Slavkovská, Z., Storck-Dutine, S., Sun, Y., Törnqvist, H. T., Tanaka, J., Tengblad, O., Thomas, B., Varga, L., Volknandt, M., Wagner, V., Wamers, F., Zanetti, L., Aliotta, Marialuisa, Alkhazov, Georgy, Almusidi, Tahani, Alvarez-Pol, Hector, André, Paul, Assié, Marlène, Atar, Leyla, Atkins, Liam, Audouin, Laurent, Aumann, Thomas, Authelet, Gilles, Ayyad, Yassid, Bajzek, Martin, Barriere, Antoine, Beceiro-Novo, Saul, Belogurov, Sergey, Bemmerer, Daniel, Benlliure, Jose, Bertulani, Carlos, Bezbakh, Andrey, Blanchon, Guillaume, Boos, Carl Georg, Boretzky, Konstanze, Borge, Maria J., Borzov, Ivan, Bott, Lukas, Brückner, Benjamin, Cabanelas Eiras, Pablo, Caesar, Christoph, Calinescu, Stefana, Casarejos, Enrique, Catford, Wilton, Cederkall, Joakim, Chatillon, Audrey, Cherciu, Madalin Ilie, Chishti, M Majid Rauf, Chulkov, Leonid, Cirstian, Andreea, Corsi, Anna, Cortina-Gil, Dolores, Cravo, Edgar, Crespo, Raquel, Danilov, Andrey, de Angelis, Giacomo, De Filippo, Enrico, Diaz-Torres, Alexis, Dickel, Timo, Dobrovolsky, Alexander, Doornenbal, Pieter, Duer, Meytal, Egelhof, Peter, Elekes, Zoltan, Enders, Joachim, Erbacher, Philipp, Escribano Rodriguez, Sonia, Fahlander, Claes, Falduto, Ashton, Feijoo, Martina, Fernandez Ruiz, Daniel, Fomichev, Andrey, Fulop, Zsolt, Galaviz Redondo, Daniel, Galiana, Elisabet, García, Gabriel, García Távora, Vicente, Gasparic, Igor, Ge, Zhuang, Geissel, Hans, Geraci, Elena, Gerl, Jürgen, Gernhäuser, Roman, Gillibert, Alain, Glorius, Jan, Gnoffo, Brunilde, Göbel, Kathrin, Golovkov, Mikhail, Golovtsov, Victor, Golubev, Pavel, González Caamaño, David, Gorshkov, Alexander, Graña González, Antia, Gridnev, Anatoly, Gruzinskii, Nikolai, Guimaraes, Valdir, Harakeh, Muhsin N., Hartig, Anna-Lena, Heftrich, Tanja, Heggen, Henning, Heil, Michael, Heinz, Andreas, Hen, Or, Henrich, Corinna, Henriques, Ana, Hensel, Thomas, Holl, Matthias, Homm, Ilja, Horvat, Andrea, Horváth, Ákos, Hucka, Jan-Paul, Inglessi, Alexander, Jedele, Andrea, Jelavic Malenica, Desa, Jenegger, Tobias, Ji, Liancheng, Johansson, Håkan, Jonson, Björn, Jurado, Beatriz, Kahlbow, Julian, Kalantar-Nayestanaki, Nasser, Kamenyero, Armel, Kazantseva, Erika, Kelic-Heil, Aleksandra, Khanzadeev, Alexey, Kiselev, Oleg, Klenze, Philipp, Knyazev, Alexander, Koch, Karsten, Kogimtzis, Moschos, Kokubun, Kei, Korolev, Guerman, Körper, Daniel, Korsheninnikov, Alexey, Korten, Wolfram, Kozlenko, Nikolai, Krasilovskaja, Sabina, Kresan, Dmytro, Krivshich, Anatoly, Kröll, Thorsten, Krupko, Sergey, Kudaibergenova, Eleonora, Kunne Sohler, Dorottya, Kurtulgil, Deniz, Kurz, Nikolaus, Kuzmin, Evgeny, Kuznetsov, Viacheslav, Labiche, Marc, Lagni, Andrea, Langer, Christoph, Lányi, Zsombor, Lazarus, Ian, Le Fèvre, Arnaud, Leifels, Yvonne, Lepine-Szily, Alinka, Lewitowicz, Marek, Lihtar, Ivana, Linh, Bui, Litvinov, Yuri, Liu, Hongna, Löher, Bastian, Lommel, Bettina, Lorenz, Enis, Lukasik, Jerzy, Macchiavelli, Augusto, Maev, Evgeny, Maillertet, Charles, Maisuzenko, Dmitrii, Maj, Adam, Martorana, Nunzia Simona, Mauss, Benoît, Mayri, Christophe, Milhomens da Fonseca, Leandro, Morfouace, Pierre, Mozumdar, Nikhil, Mücher, Dennis, Murillo Morales, Silvia, Nacher, Enrique, Nikolskii, Evgenii, Nilsson, Thomas, Nociforo, Chiara, Nolden, Fritz, Nyman, Göran, Obertelli, Alexandre, Pagano, Emanuele Vincenzo, Panin, Valerii, Park, Joochun, Paschalis, Stefanos, Pei, Junchen, Perea, Angel, Petri, Marina, Piasetzky, Eli, Pietri, Stephane, Pirrone, Sara, Politi, Giuseppe, Pollacco, Emauel, Ponnath, Lukas, Potlog, Petru-Mihai, Prajapat, Rinku, Pritula, Roman, Qi, Hang, Rappold, Christophe, Reifarth, Rene, Revel, Aldric, Rhee, Han-Bum, Risitano, Fabio, Rodriguez Sanchez, Jose Luis, Rose, Luke, Rossi, Dominic, Rudigier, Matthias, Russotto, Paolo, Sánchez-Benítez, Ángel-Miguel, Sanjari, Shahab, Santamaria, Clementine, Sarantsev, Victor, Savran, Deniz, Scheidenberger, Christoph, Scheit, Heiko, Schmidt, Konrad, Simon, Haik, Simon, Johannes, Slavkovská, Zuzana, Slepnev, Roman, Sorlin, Olivier, Sousa, Tomás, Spiridon, Alexandra, Stan, Emil, Stanoiu, Mihai, Stefanescu, Alexandra, Stefanescu, Ionut, Storck-Dutine, Sonja, Stott, Aaron, Sun, Baohua, Sun, Yelei, Sürder, Christian, Taieb, Julien, Tanaka, Junki, Tanihata, Isao, Taniuchi, Ryo, Tengblad, Olof, Terekhin, Pavel, Teubig, Pamela, Törnqvist, Hans, Trache, Livius, Trautmann, Wolfgang, Trimarchi, Marina, Typel, Stefan, Uesaka, Tomohiro, Unsworth, Carl, Uvarov, Lev, Vandebrouck, Marine, Varga, Laszlo, Velardita, Simone, Velho, Paulo, Vencelj, Matjaz, Volknandt, Meiko, Volkov, Sergei, von Tresckow, Martin, Wagner, Andreas, Wamers, Felix, Wang, Yanzhao, Whitehead, Matthew, Wienholtz, Frank, Wimmer, Kathrin, Winkler, Martin, Xarepe, Manuel, Ye, Yanlin, Zacarias, Sabrina, Zamora Cardona, Juan Carlos, Zhang, Wei, Zhdanov, Andrei, Zhukov, Mikhail, Zilges, Andreas, Zuber, Kai, Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), R3B, Federal Ministry of Education and Research (Germany), Helmholtz International Center for FAIR, Ministerio de Ciencia e Innovación (España), Xunta de Galicia, Agencia Estatal de Investigación (España), Swedish Research Council, Science and Technology Facilities Council (UK), Royal Society (UK), Projekt DEAL, Energy and Sustainability Research Institute Groni, and Nuclear Energy

Subjects
Nuclear and High Energy Physics, ddc:530, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

19 pags., 16 figs., 8 tabs., We present the design, prototype developments and test results of the new time-of-flight detector (ToFD) which is part of the R3B experimental setup at GSI and FAIR, Darmstadt, Germany. The ToFD detector is able to detect heavy-ion residues of all charges at relativistic energies with a relative energy precision σΔE/ ΔE of up to 1% and a time precision of up to 14 ps (sigma). Together with an elaborate particle-tracking system, the full identification of relativistic ions from hydrogen up to uranium in mass and nuclear charge is possible., This work received support from BMBF (05P19RFFN1, 05P15RDFN1, 05P19RDFN1) and HIC for FAIR. J.P. has been supported by the Institute for Basic Science (IBS-R031-D1). E.C. has been supported by the Ministry of Science and Innovation in Spain (PGC2018-099746-B-C22). J.L.R.S. thanks the support from the Regional Government of Galicia under the program of postdoctoral fellowships ED481B-2017-002 and ED481D-2021-018. O.T. has been supported by AEI/FEDER, UE project No. PID2019-104390GB-I00. G.B., A.H., H.T.J., B.J. and T.N. have been supported by the Swedish Research Council under contract 2017-03839. This work was supported by the Royal Society and UK STFC awards ST/L005727/1, ST/P003885/1.

Published
2022
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40. Intramolecular photo-driven charge transfer in a series of pyridyl substituted phenyloxazoles. Structural relaxation in meta-substituted ethylpyridinium derivative of phenyloxazole

Author

Mikhail Ya. Melnikov, Vladimir A. Kuzmin, Victor A. Nadtochenko, Alexey A. Kostyukov, M. N. Khimich, Ivan V. Shelaev, Fedor E. Gostev, Valery V. Volchkov, Anton E. Egorov, and M. V. Rusalov

Subjects
Materials science, Time-dependent density functional theory, Fluorescence spectroscopy, symbols.namesake, chemistry.chemical_compound, chemistry, Excited state, Stokes shift, Ultrafast laser spectroscopy, symbols, Physical chemistry, Pyridinium, Physical and Theoretical Chemistry, Spectroscopy, Conformational isomerism
Abstract

A series of pyridyl (pyridinium) substituted benzoxazoles were studied by steady state absorption, fluorescence spectroscopy, time-resolved fluorescence spectroscopy, fs pulse absorption and polarization spectroscopy, and quantum–chemical calculations. The spectral and kinetic parameters of the fluorophores in MeCN and EtOAc were obtained experimentally and were calculated by means of DFT and TDDFT methods. A scheme including four transient excited states was proposed for the interpretation of differential absorption kinetics of the charged fluorophores. Expressions describing the actual kinetics graphs, the decay associated spectra, and the species-associated spectra were derived. The charge shift step was found to be dependent on average solvation times. A charge shift followed by the formation of the twisted conformer was found for the excited 1-ethyl-3-(5-phenyloxazol-2-yl)pyridinium 4-methyl-1-benzenesulfonate in MeCN and EtOAc. Conformational analysis confirms a large amplitude motion of the meta-substituted ethylpyridinium group as an additional structural relaxation path producing an abnormally large fluorescence Stokes shift.

Published
2021
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41. A compendium of uniformly processed human gene expression and splicing quantitative trait loci

Author

Kateryna Peikova, Peter Walter, Nurlan Kerimov, Helen Parkinson, Jonathan R. Manning, Tony Burdett, Irene Papatheodorou, Liis Kolberg, Daniel R. Zerbino, Stephen J. Trevanion, Manoj Pandian Sakthivel, Marija Samoviča, James D. Hayhurst, Simon Jupp, Kaur Alasoo, Andrew D. Yates, and Ivan Kuzmin

Subjects
CD4-Positive T-Lymphocytes, Multifactorial Inheritance, Cell type, Quantitative Trait Loci, Datasets as Topic, Genome-wide association study, Computational biology, Quantitative trait locus, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Quantitative Trait, Heritable, 0302 clinical medicine, Databases, Genetic, Gene expression, Genetics, Humans, Transcriptomics, Gene, Genetic association study, 030304 developmental biology, 0303 health sciences, Compendium, Gene Expression Regulation, RNA splicing, Expression quantitative trait loci, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Many gene expression quantitative trait locus (eQTL) studies have published their summary statistics, which can be used to gain insight into complex human traits by downstream analyses, such as fine mapping and co-localization. However, technical differences between these datasets are a barrier to their widespread use. Consequently, target genes for most genome-wide association study (GWAS) signals have still not been identified. In the present study, we present the eQTL Catalogue (https://www.ebi.ac.uk/eqtl), a resource of quality-controlled, uniformly re-computed gene expression and splicing QTLs from 21 studies. We find that, for matching cell types and tissues, the eQTL effect sizes are highly reproducible between studies. Although most QTLs were shared between most bulk tissues, we identified a greater diversity of cell-type-specific QTLs from purified cell types, a subset of which also manifested as new disease co-localizations. Our summary statistics are freely available to enable the systematic interpretation of human GWAS associations across many cell types and tissues., The eQTL Catalogue provides uniform processing of 21 eQTL studies, allowing the identification of highly reproducible eQTLs affecting whole gene and transcript expression levels.

Published
2021
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42. Helminth Assemblages of the Antarctic Black Rockcod, Notothenia coriiceps (Actinopterygii: Nototheniidae) in Coastal Waters near Galindez Island (Argentine Islands, West Antarctic): Temporal Changes in the Endoparasite Community

Author

Tetiana A. Kuzmina, Zdzisław Laskowski, Olga I. Lisitsyna, Krzysztof Zdzitowiecki, Oleksander O. Salganskij, and Yuriy Kuzmin

Subjects
biology, Quantitative parasitology, Actinopterygii, Zoology, Species evenness, Helminths, Nototheniidae, Parasitology, Marine ecosystem, Taxonomic rank, Species richness, biology.organism_classification
Abstract

Analysis and comparison of the helminth assemblages in Antarctic rockcod Notothenia coriiceps collected near the UAS “Akademik Vernadsky” (Argentine Islands, West Antarctica) in 2002 and 2014–2015 were performed to characterise the parasite community and investigate the temporal changes in helminth assemblages and infection parameters. All specimens of N. coriiceps (n = 194) were caught at depths of 10–30 m. Parasites (22,856 helminth specimens and 15,057 cysts) were collected manually and identified based on their morphology. Statistical analysis of the quantitative data was performed using the Quantitative Parasitology 3.0 (QP 3.0), Paleontological Statistics (PAST v. 3.1), and PRIMER 6 software. Twenty-seven species of four taxonomic groups were recorded: trematodes (8 species), cestodes (4), nematodes (5), and acanthocephalans (10). Helminth samples collected in 2002 and 2014–2015 showed a rather high similarity in species composition. The species richness was higher in the sample collected in 2014–2015, while the evenness and diversity in the two samples were similar. The dissimilarity between helminth infracommunities in the two samples appeared to be statistically significant. Larval cestodes Diphyllobotrium sp., the acanthocephalan Metacanthocephalus rennicki, and the trematode Neoleoburia antarctica were found to make the most significant impact on the dissimilarity. The analysis of the composition and structure of helminth community in N. coriiceps revealed the changes that have happened during the last decade. At least some of the changes are attributed to the changes in marine ecosystems in Western Antarctica.

Published
2021
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43. A new species of Serpentirhabdias Tkach, Kuzmin et Snyder, 2014 (Nematoda: Rhabdiasidae) parasitic in the herald snake, Crotaphopeltis hotamboeia (Laurenti) (Reptilia: Serpentes: Colubridae) in South Africa

Author

Roman Svitin, Yuriy Kuzmin, and Louis H. Du Preez

Subjects
food.ingredient, biology, Crotaphopeltis hotamboeia, Zoology, biology.organism_classification, Nematode, food, Genus, Excretory system, Animal ecology, Colubridae, Parasitology, Serpentirhabdias, Crotaphopeltis
Abstract

Serpentirhabdias mamlambo n. sp. is described from the lung of the herald snake, Crotaphopeltis hotamboeia (Laurenti) in KwaZulu-Natal Province, South Africa. The new species is characterised by the small lips, the absence of the buccal capsule, the large excretory glands (1.5–2.3 times longer than the oesophagus), and the numerous eggs in uteri. Serpentirhabdias mamlambo n. sp. differs from other Serpentirhabdias spp. in the presence of M-shaped cuticular folds on dorsal and ventral sides of apical surface, the eye-shaped internal labial papillae, and the distinct dilatation of the oesophagus at its mid-length. Morphological differentiation of S. mamlambo n. sp. from its congeners is supported by molecular evidence based on cox1 mitochondrial gene, and ITS and partial 28S region of nuclear rDNA. Serpentirhabdias mamlambo n. sp. is the first species of the genus Serpentirhabdias described from the Afrotropical Realm.

Published
2021
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45. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H., primary, Adkins, Scott, additional, Alkhovsky, Sergey V., additional, Avšič-Županc, Tatjana, additional, Ayllón, María A., additional, Bahl, Justin, additional, Balkema-Buschmann, Anne, additional, Ballinger, Matthew J., additional, Bandte, Martina, additional, Beer, Martin, additional, Bejerman, Nicolas, additional, Bergeron, Éric, additional, Biedenkopf, Nadine, additional, Bigarré, Laurent, additional, Blair, Carol D., additional, Blasdell, Kim R., additional, Bradfute, Steven B., additional, Briese, Thomas, additional, Brown, Paul A., additional, Bruggmann, Rémy, additional, Buchholz, Ursula J., additional, Buchmeier, Michael J., additional, Bukreyev, Alexander, additional, Burt, Felicity, additional, Büttner, Carmen, additional, Calisher, Charles H., additional, Candresse, Thierry, additional, Carson, Jeremy, additional, Casas, Inmaculada, additional, Chandran, Kartik, additional, Charrel, Rémi N., additional, Chiaki, Yuya, additional, Crane, Anya, additional, Crane, Mark, additional, Dacheux, Laurent, additional, Bó, Elena Dal, additional, de la Torre, Juan Carlos, additional, de Lamballerie, Xavier, additional, de Souza, William M., additional, de Swart, Rik L., additional, Dheilly, Nolwenn M., additional, Di Paola, Nicholas, additional, Di Serio, Francesco, additional, Dietzgen, Ralf G., additional, Digiaro, Michele, additional, Drexler, J. Felix, additional, Duprex, W. Paul, additional, Dürrwald, Ralf, additional, Easton, Andrew J., additional, Elbeaino, Toufic, additional, Ergünay, Koray, additional, Feng, Guozhong, additional, Feuvrier, Claudette, additional, Firth, Andrew E., additional, Fooks, Anthony R., additional, Formenty, Pierre B. H., additional, Freitas-Astúa, Juliana, additional, Gago-Zachert, Selma, additional, García, María Laura, additional, García-Sastre, Adolfo, additional, Garrison, Aura R., additional, Godwin, Scott E., additional, Gonzalez, Jean-Paul J., additional, de Bellocq, Joëlle Goüy, additional, Griffiths, Anthony, additional, Groschup, Martin H., additional, Günther, Stephan, additional, Hammond, John, additional, Hepojoki, Jussi, additional, Hierweger, Melanie M., additional, Hongō, Seiji, additional, Horie, Masayuki, additional, Horikawa, Hidenori, additional, Hughes, Holly R., additional, Hume, Adam J., additional, Hyndman, Timothy H., additional, Jiāng, Dàohóng, additional, Jonson, Gilda B., additional, Junglen, Sandra, additional, Kadono, Fujio, additional, Karlin, David G., additional, Klempa, Boris, additional, Klingström, Jonas, additional, Koch, Michel C., additional, Kondō, Hideki, additional, Koonin, Eugene V., additional, Krásová, Jarmila, additional, Krupovic, Mart, additional, Kubota, Kenji, additional, Kuzmin, Ivan V., additional, Laenen, Lies, additional, Lambert, Amy J., additional, Lǐ, Jiànróng, additional, Li, Jun-Min, additional, Lieffrig, François, additional, Lukashevich, Igor S., additional, Luo, Dongsheng, additional, Maes, Piet, additional, Marklewitz, Marco, additional, Marshall, Sergio H., additional, Marzano, Shin-Yi L., additional, McCauley, John W., additional, Mirazimi, Ali, additional, Mohr, Peter G., additional, Moody, Nick J. G., additional, Morita, Yasuaki, additional, Morrison, Richard N., additional, Mühlberger, Elke, additional, Naidu, Rayapati, additional, Natsuaki, Tomohide, additional, Navarro, José A., additional, Neriya, Yutaro, additional, Netesov, Sergey V., additional, Neumann, Gabriele, additional, Nowotny, Norbert, additional, Ochoa-Corona, Francisco M., additional, Palacios, Gustavo, additional, Pallandre, Laurane, additional, Pallás, Vicente, additional, Papa, Anna, additional, Paraskevopoulou, Sofia, additional, Parrish, Colin R., additional, Pauvolid-Corrêa, Alex, additional, Pawęska, Janusz T., additional, Pérez, Daniel R., additional, Pfaff, Florian, additional, Plemper, Richard K., additional, Postler, Thomas S., additional, Pozet, Françoise, additional, Radoshitzky, Sheli R., additional, Ramos-González, Pedro L., additional, Rehanek, Marius, additional, Resende, Renato O., additional, Reyes, Carina A., additional, Romanowski, Víctor, additional, Rubbenstroth, Dennis, additional, Rubino, Luisa, additional, Rumbou, Artemis, additional, Runstadler, Jonathan A., additional, Rupp, Melanie, additional, Sabanadzovic, Sead, additional, Sasaya, Takahide, additional, Schmidt-Posthaus, Heike, additional, Schwemmle, Martin, additional, Seuberlich, Torsten, additional, Sharpe, Stephen R., additional, Shi, Mang, additional, Sironi, Manuela, additional, Smither, Sophie, additional, Song, Jin-Won, additional, Spann, Kirsten M., additional, Spengler, Jessica R., additional, Stenglein, Mark D., additional, Takada, Ayato, additional, Tesh, Robert B., additional, Těšíková, Jana, additional, Thornburg, Natalie J., additional, Tischler, Nicole D., additional, Tomitaka, Yasuhiro, additional, Tomonaga, Keizō, additional, Tordo, Noël, additional, Tsunekawa, Kenta, additional, Turina, Massimo, additional, Tzanetakis, Ioannis E., additional, Vaira, Anna Maria, additional, van den Hoogen, Bernadette, additional, Vanmechelen, Bert, additional, Vasilakis, Nikos, additional, Verbeek, Martin, additional, von Bargen, Susanne, additional, Wada, Jiro, additional, Wahl, Victoria, additional, Walker, Peter J., additional, Whitfield, Anna E., additional, Williams, John V., additional, Wolf, Yuri I., additional, Yamasaki, Junki, additional, Yanagisawa, Hironobu, additional, Ye, Gongyin, additional, Zhang, Yong-Zhen, additional, and Økland, Arnfinn Lodden, additional

Published
2022
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46. Structural insights into light-driven anion pumping in cyanobacteria

Author

Astashkin, R., primary, Kovalev, K., additional, Bukhdruker, S., additional, Vaganova, S., additional, Kuzmin, A., additional, Alekseev, A., additional, Balandin, T., additional, Zabelskii, D., additional, Gushchin, I., additional, Royant, A., additional, Volkov, D., additional, Bourenkov, G., additional, Koonin, E., additional, Engelhard, M., additional, Bamberg, E., additional, and Gordeliy, V., additional

Published
2022
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48. Denisovans, Neanderthals, and Early Modern Humans: A Review of the Pleistocene Hominin Fossils from the Altai Mountains (Southern Siberia)

Author

Susan G. Keates, V. S. Slavinsky, Yaroslav V. Kuzmin, and Aleksander A. Tsybankov

Subjects
010506 paleontology, Archeology, geography, Artifact (archaeology), Taphonomy, geography.geographical_feature_category, Neanderthal, 060102 archaeology, Pleistocene, biology, General Arts and Humanities, 06 humanities and the arts, biology.organism_classification, 01 natural sciences, Archaeology, Cave, Middle Paleolithic, biology.animal, Upper Paleolithic, 0601 history and archaeology, Denisovan, 0105 earth and related environmental sciences
Abstract

This paper reviews significant issues related to the fossil hominins from the Altai Mountains of Siberia (Russia), namely Denisovans, Neanderthals, and early modern humans. Uncritical acceptance of the recovered information by some authors has resulted in unreliable chronologies of the Middle and Upper Paleolithic artifact assemblages and the animal and hominin fossils. We examine the chronostratigraphic contexts and archaeological associations of hominin and animal fossils and the lithics discovered at the Denisova, Okladnikov, Strashnaya, and Chagyrskaya cave sites. Taphonomic, site formation, and geomorphological studies show evidence of disturbance and redeposition caused by carnivore activity and sediment subsidence at these sites, which complicates the dating of the human remains. Our analysis indicates that the Middle Paleolithic is dated to ca. 50,000–130,000 years ago, and the Upper Paleolithic to ca. 12,000–48,000 years ago. The best age estimate for Denisovans is ca. 73,000–130,000 years ago. The ages of Neanderthals can be determined as more than 50,000–59,000 years ago, and of modern humans at roughly 12,000–48,000 years ago. Denisovan and Neanderthal fossils are associated with Middle Paleolithic complexes only.

Published
2021
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49. Advanced information technology for development of electric power market

Author

Viacheslav V. Voronin, Vardan Mkrttchian, Vitaly Kuzmin, Vsevolod Chernyshenko, and Valentin Ya Afanasyev

Subjects
0209 industrial biotechnology, business.industry, Computer science, Mechanical Engineering, Big data, Information technology, 02 engineering and technology, Data science, Industrial and Manufacturing Engineering, Field (computer science), Computer Science Applications, System dynamics, 020901 industrial engineering & automation, Control and Systems Engineering, Market data, Distributed data store, Electric power, User interface, business, Software
Abstract

Features of the electric power market functioning, in comparison with common properties of modern markets, are considered. It is shown that continuous reforms, which take place in many countries, are far from reaching effective solution. Sectoral peculiarities, connected with both technological complexity of the field and economic specificity of the market participants, form very special model of the market. The main way to increase effectivity of the market, to make it more competitive and, in the same time, socially responsible, is to use widely and deeply the modern information technologies, including technologies of artificial intelligence. A technological scheme (especially targeted on features of the electric power market) has been proposed in the article. First, the technologies merge methods of collection, storage, processing, and presentation of information. The collection of market data should be automated, particularly, by the so-called intellectual avatars, which operate in the market as virtual agents. A reliable distributed storage of data, based on blockchain technology, is chosen. The big data technologies of data structuring, storage, and processing are involved. Datamining methods include effective presentation of results in forms of graphs and diagrams. The second set of technologies includes core mathematical models and “digital twins.” They are aimed for data interpolation and extrapolation, in particular, for prediction of further system dynamics. The used neural networks have option of self-learning and self-development. At last, the third set is a set of user interfaces, which provides market actors by complete and adopted information and is organized in accordance with ideas of ergonomics.

Published
2021
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50. Helminths of the Antarctic dragonfish, Parachaenichthys charcoti (Perciformes, Notothenioidei, Bathydraconidae) Studied near Galindez Island (Argentine Islands, West Antarctica)

Author

Eleonora M. Korol, Oleksander O. Salganskij, Anna Faltýnková, Tetiana A. Kuzmina, Ihor V. Dykyy, Yuriy Kuzmin, and Olga I. Lisitsyna

Subjects
0303 health sciences, Bathydraconidae, biology, 030231 tropical medicine, Species diversity, Zoology, Notothenioidei, biology.organism_classification, Perciformes, 030308 mycology & parasitology, 03 medical and health sciences, Diversity index, 0302 clinical medicine, parasitic diseases, Helminths, Dominance (ecology), Parasitology, Acanthocephala
Abstract

The Antarctic dragonfish, Parachaenichthys charcoti is a notothenioid teleost fish endemic to the Southern Ocean surrounding Antarctica. It is a relatively rare fish species; therefore, published data on the parasite communities of P. charcoti are limited. The present study was performed on the Ukrainian Antarctic Station "Akademik Vernadsky", Argentine Islands, West Antarctica and the purpose was to examine the species diversity of the parasites of P. charcoti and to identify the parameters of helminth infection and helminth component community. Fifteen specimens of P. charcoti were caught at a depth of 10–30 m and examined using standard parasitological techniques. All helminths (6251 specimens) were collected manually, fixed in 70% ethanol and identified based on their morphology. All examined specimens of P. charcoti were found to be infected with helminths; each fish harboured 10–20 helminth species (mean 13.2; median 13) and 237–804 helminth specimens (mean 417; median 401). Twenty-seven helminth species were found, including nine species of trematodes, 4 of cestodes, 4 of nematodes and 10 of acanthocephalans. P. charcoti is the definitive host for 11 out of 27 helminth species recorded. In the helminth component community, the diversity indices were 2.03 (Shannon's index) and 0.79 (Simpson's index); Pielou evenness index was 0.61, and Berger–Parker dominance index was 0.38. Our results indicate a high species diversity and complex structure of the helminth community in Antarctic dragonfish P. charcoti in the Argentine Islands.

Published
2021
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