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The morphological and physiological characteristics of Bacillus thuringiensis strains were analyzed and conditions for obtaining culture fluid with maximum yield of secreted RNases were determined. Zymographic analysis showed that culture fluid of B. thuringiensis strains along with low-molecular-weight (15-20 kDa) RNases contained enzymes with a molecular weight ~55 kDa and their content depended on the duration and conditions of culturing. Preparations based on B. thuringiensis culture fluid were effective against human influenza virus A/Aichi/2/68 (H3N2). In experiments on mice infected with 10 LD50 influenza virus strain A/Aichi/2/68 (H3N2), we selected effective variants of preparations based on culture fluid of B. thuringiensi strains for preventive administration that provided reliable protection of infected animals (protection coefficient 50%), close to that of the reference drug Tamiflu.

The results of studies of a newly isolated Serratia species K-57 strain are presented. The strain is characterized by antiviral activity towards human influenza A/Aichi/2/68/H3N2, vaccinia, mouse smallpox, and herpes simplex-2 viruses. The detected characteristics of the strain, including the data on activities on nucleolytic enzymes, recommend it for the development of therapeutic and preventive antiviral drugs.

We present the experimental results of measurements of the masses of a separately observed erythrocyte and a latex particle placed in a variable electric field. We show that the experimentally measured and theoretically computed masses of reference latex particles are in good agreement.

The experimental method is described and the measurement results of the value of polarizability of erythrocytes and latex particles in a non-uniform alternating electric field are presented. The results show that the values of experimentally measured and theoretically calculated polarizablity values of latex particles are in good agreement.

Theoretical analysis of the relative error of measurement of polarizability of cells using the dielectrophoresis method is described. Information about the magnitude of error ensures objective evaluation of the disease dynamics and the effectiveness of treatment.