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2. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Perrone, Gennaro, primary, Giuffrida, Mario, additional, Abu-Zidan, Fikri, additional, Kruger, Vitor F., additional, Livrini, Marco, additional, Petracca, Gabriele Luciano, additional, Rossi, Giorgio, additional, Tarasconi, Antonio, additional, Tian, Brian W. C. A., additional, Bonati, Elena, additional, Mentz, Ricardo, additional, Mazzini, Federico N., additional, Campana, Juan P., additional, Gasser, Elisabeth, additional, Kafka-Ritsch, Reinhold, additional, Felsenreich, Daniel M., additional, Dawoud, Christopher, additional, Riss, Stefan, additional, Gomes, Carlos Augusto, additional, Gomes, Felipe Couto, additional, Gonzaga, Ricardo Alessandro Teixeira, additional, Canton, Cassio Alfred Brattig, additional, Pereira, Bruno Monteiro, additional, Fraga, Gustavo P., additional, Zem, Leticia Gonçalves, additional, Cordeiro-Fonseca, Vinicius, additional, de Mesquita Tauil, Renato, additional, Atanasov, Boyko, additional, Belev, Nikolay, additional, Kovachev, Nikola, additional, Meléndez, L. Juan José, additional, Dimova, Ana, additional, Dimov, Stefan, additional, Zelić, Zdravko, additional, Augustin, Goran, additional, Bogdanić, Branko, additional, Morić, Trpimir, additional, Chouillard, Elie, additional, Bajul, Melinda, additional, De Simone, Belinda, additional, Panis, Yves, additional, Esposito, Francesco, additional, Notarnicola, Margherita, additional, Lauka, Lelde, additional, Fabbri, Anna, additional, Hentati, Hassen, additional, Fnaiech, Iskander, additional, Aurélien, Venara, additional, Bougard, Marie, additional, Roulet, Maxime, additional, Demetrashvili, Zaza, additional, Pipia, Irakli, additional, Merabishvili, Giorgi, additional, Bouliaris, Konstantinos, additional, Koukoulis, Georgios, additional, Doudakmanis, Christos, additional, Xenaki, Sofia, additional, Chrysos, Emmanuel, additional, Kokkinakis, Stamatios, additional, Vassiliu, Panteleimon, additional, Michalopoulos, Nikolaos, additional, Margaris, Ioannis, additional, Kechagias, Aristotelis, additional, Avgerinos, Konstantinos, additional, Katunin, Jevgeni, additional, Lostoridis, Eftychios, additional, Nagorni, Eleni-Aikaterini, additional, Pujante, Antonio, additional, Mulita, Francesk, additional, Maroulis, Ioannis, additional, Vailas, Michail, additional, Marinis, Athanasios, additional, Siannis, Ioannis, additional, Bourbouteli, Eirini, additional, Manatakis, Dimitrios K., additional, Tasis, Nikolaos, additional, Acheimastos, Vasileios, additional, Maria, Sotiropoulou, additional, Stylianos, Kapiris, additional, Kuzeridis, Harilaos, additional, Korkolis, Dimitrios, additional, Fradelos, Evangelos, additional, Kavalieratos, George, additional, Petropoulou, Thalia, additional, Polydorou, Andreas, additional, Papacostantinou, Ioannis, additional, Triantafyllou, Tania, additional, Kimpizi, Despina, additional, Theodorou, Dimitrios, additional, Toutouzas, Konstantinos, additional, Chamzin, Alexandros, additional, Frountzas, Maximos, additional, Schizas, Dimitrios, additional, Karavokyros, Ioannis, additional, Syllaios, Athanasios, additional, Charalabopoulos, Alexandros, additional, Boura, Maria, additional, Baili, Efstratia, additional, Ioannidis, Orestis, additional, Loutzidou, Lydia, additional, Anestiadou, Elissavet, additional, Tsouknidas, Ioannis, additional, Petrakis, Georgios, additional, Polenta, Eleni, additional, Bains, Lovenish, additional, Gupta, Rahul, additional, Singh, Sudhir K., additional, Khanduri, Archana, additional, Bala, Miklosh, additional, Kedar, Asaf, additional, Pisano, Marcello, additional, Podda, Mauro, additional, Pisanu, Adolfo, additional, Martines, Gennaro, additional, Trigiante, Giuseppe, additional, Lantone, Giuliano, additional, Agrusa, Antonino, additional, Di Buono, Giuseppe, additional, Buscemi, Salvatore, additional, Veroux, Massimiliano, additional, Gioco, Rossella, additional, Veroux, Gastone, additional, Oragano, Luigi, additional, Zonta, Sandro, additional, Lovisetto, Federico, additional, Feo, Carlo V., additional, Pesce, Antonio, additional, Fabbri, Nicolò, additional, Lantone, Giulio, additional, Marino, Fabio, additional, Perrone, Fabrizio, additional, Vincenti, Leonardo, additional, Papagni, Vincenzo, additional, Picciariello, Arcangelo, additional, Rossi, Stefano, additional, Picardi, Biagio, additional, Del Monte, Simone Rossi, additional, Visconti, Diego, additional, Osella, Giulia, additional, Petruzzelli, Luca, additional, Pignata, Giusto, additional, Andreuccetti, Jacopo, additional, D’Alessio, Rossella, additional, Buonfantino, Massimo, additional, Guaitoli, Eleonora, additional, Spinelli, Stefano, additional, Sampietro, Gianluca Matteo, additional, Corbellini, Carlo, additional, Lorusso, Leonardo, additional, Frontali, Alice, additional, Pezzoli, Isabella, additional, Bonomi, Alessandro, additional, Chierici, Andrea, additional, Cotsoglou, Christian, additional, Manca, Giuseppe, additional, Delvecchio, Antonella, additional, Musa, Nicola, additional, Casati, Massimiliano, additional, Letizia, Laface, additional, Abate, Emmanuele, additional, Ercolani, Giorgio, additional, D’Acapito, Fabrizio, additional, Solaini, Leonardo, additional, Guercioni, Gianluca, additional, Cicconi, Simone, additional, Sasia, Diego, additional, Borghi, Felice, additional, Giraudo, Giorgio, additional, Sena, Giuseppe, additional, Castaldo, Pasquale, additional, Cardamone, Eugenia, additional, Portale, Giuseppe, additional, Zuin, Matteo, additional, Spolverato, Ylenia, additional, Esposito, Marialusia, additional, Isernia, Roberta Maria, additional, Di Salvo, Maria, additional, Manunza, Romina, additional, Esposito, Giuseppe, additional, Agus, Marcello, additional, Asti, Emanuele Luigi Giuseppe, additional, Bernardi, Daniele Tiziano, additional, Tonucci, Tommaso Panici, additional, Luppi, Davide, additional, Casadei, Massimiliano, additional, Bonilauri, Stefano, additional, Pezzolla, Angela, additional, Panebianco, Annunziata, additional, Laforgia, Rita, additional, De Luca, Maurizio, additional, Zese, Monica, additional, Parini, Dario, additional, Jovine, Elio, additional, De Sario, Giuseppina, additional, Lombardi, Raffaele, additional, Aprea, Giovanni, additional, Palomba, Giuseppe, additional, Capuano, Marianna, additional, Argenio, Giulio, additional, Orio, Gianluca, additional, Armellino, Mariano Fortunato, additional, Troian, Marina, additional, Guerra, Martina, additional, Nagliati, Carlo, additional, Biloslavo, Alan, additional, Germani, Paola, additional, Aizza, Giada, additional, Monsellato, Igor, additional, Chahrour, Ali Chaouki, additional, Anania, Gabriele, additional, Bombardini, Cristina, additional, Bagolini, Francesco, additional, Sganga, Gabriele, additional, Fransvea, Pietro, additional, Bianchi, Valentina, additional, Boati, Paolo, additional, Ferrara, Francesco, additional, Palmieri, Francesco, additional, Cianci, Pasquale, additional, Gattulli, Domenico, additional, Restini, Enrico, additional, Cillara, Nicola, additional, Cannavera, Alessandro, additional, Nita, Gabriela Elisa, additional, Sarnari, Jlenia, additional, Roscio, Francesco, additional, Clerici, Federico, additional, Scandroglio, Ildo, additional, Berti, Stefano, additional, Cadeo, Alessandro, additional, Filippelli, Alice, additional, Conti, Luigi, additional, Grassi, Carmine, additional, Cattaneo, Gaetano Maria, additional, Pighin, Marina, additional, Papis, Davide, additional, Gambino, Giovanni, additional, Bertino, Vanessa, additional, Schifano, Domenico, additional, Prando, Daniela, additional, Fogato, Luisella, additional, Cavallo, Fabio, additional, Ansaloni, Luca, additional, Picheo, Roberto, additional, Pontarolo, Nicholas, additional, Depalma, Norma, additional, Spampinato, Marcello, additional, D’Ugo, Stefano, additional, Lepre, Luca, additional, Capponi, Michela Giulii, additional, Campa, Rossella Domenica, additional, Sarro, Giuliano, additional, Dinuzzi, Vincenza Paola, additional, Olmi, Stefano, additional, Uccelli, Matteo, additional, Ferrari, Davide, additional, Inama, Marco, additional, Moretto, Gianluigi, additional, Fontana, Michele, additional, Favi, Francesco, additional, Picariello, Erika, additional, Rampini, Alessia, additional, Barberis, Andrea, additional, Azzinnaro, Antonio, additional, Oliva, Alba, additional, Totaro, Luigi, additional, Benzoni, Ilaria, additional, Ranieri, Valerio, additional, Capolupo, Gabriella Teresa, additional, Carannante, Filippo, additional, Caricato, Marco, additional, Ronconi, Maurizio, additional, Casiraghi, Silvia, additional, Casole, Giovanni, additional, Pantalone, Desire, additional, Alemanno, Giovanni, additional, Scheiterle, Maximilian, additional, Ceresoli, Marco, additional, Cereda, Marco, additional, Fumagalli, Chiara, additional, Zanzi, Federico, additional, Bolzon, Stefano, additional, Guerra, Enrico, additional, Lecchi, Francesca, additional, Cellerino, Paola, additional, Ardito, Antonella, additional, Scaramuzzo, Rosa, additional, Balla, Andrea, additional, Lepiane, Pasquale, additional, Tartaglia, Nicola, additional, Ambrosi, Antonio, additional, Pavone, Giovanna, additional, Palini, Gian Marco, additional, Veneroni, Simone, additional, Garulli, Gianluca, additional, Ricci, Claudio, additional, Torre, Beatrice, additional, Russo, Iris Shari, additional, Rottoli, Matteo, additional, Tanzanu, Marta, additional, Belvedere, Angela, additional, Milone, Marco, additional, Manigrasso, Michele, additional, De Palma, Giovanni Domenico, additional, Piccoli, Micaela, additional, Pattacini, Gianmaria Casoni, additional, Magnone, Stefano, additional, Bertoli, Paolo, additional, Pisano, Michele, additional, Massucco, Paolo, additional, Palisi, Marco, additional, Luzzi, Andrea-Pierre, additional, Fleres, Francesco, additional, Clarizia, Guglielmo, additional, Spolini, Alessandro, additional, Kobe, Yoshiro, additional, Toma, Takayuki, additional, Shimamura, Fumihiko, additional, Parker, Robert, additional, Ranketi, Sinkeet, additional, Mitei, Mercy, additional, Svagzdys, Saulius, additional, Pauzas, Henrikas, additional, Zilinskas, Justas, additional, Poskus, Tomas, additional, Kryzauskas, Marius, additional, Jakubauskas, Matas, additional, Zakaria, Andee Dzulkarnaen, additional, Zakaria, Zaidi, additional, Wong, Michael Pak-Kai, additional, Jusoh, Asri Che, additional, Zakaria, Muhammad Nazreen, additional, Cruz, Daniel Rios, additional, Elizalde, Aurea Barbara Rodriguez, additional, Reynaud, Alejandro Bañon, additional, Hernandez, Edgard Efren Lozada, additional, Monroy, Jose maria Victor Palomo, additional, Hinojosa-Ugarte, Diego, additional, Quiodettis, Martha, additional, Du Bois, María Esther, additional, Latorraca, José, additional, Major, Piotr, additional, Pędziwiatr, Michał, additional, Pisarska-Adamczyk, Magdalena, additional, Walędziak, Maciej, additional, Kwiatkowski, Andrzej, additional, Czyżykowski, Łukasz, additional, da Costa, Silvia Dantas, additional, Pereira, Bela, additional, Ferreira, Ana Rita Oliveira, additional, Almeida, Filipe, additional, Rocha, Ricardo, additional, Carneiro, Carla, additional, Perez, Diego Pita, additional, Carvas, João, additional, Rocha, Catarina, additional, Ferreira, Cátia, additional, Marques, Rita, additional, Fernandes, Urânia, additional, Leao, Pedro, additional, Goulart, André, additional, Pereira, Rita Gonçalves, additional, Patrocínio, Sara Daniela Direito, additional, de Mendonça, Nuno Gonçalo Gonçalves, additional, Manso, Maria Isabel Cerqueira, additional, Morais, Henrique Manuel Cardoso, additional, Cardoso, Paulo Sebastião, additional, Calu, Valentin, additional, Miron, Adrian, additional, Toma, Elena Adelina, additional, Gachabayov, Mahir, additional, Abdullaev, Abakar, additional, Litvin, Andrey, additional, Nechay, Taras, additional, Tyagunov, Alexander, additional, Yuldashev, Anvar, additional, Bradley, Alison, additional, Wilson, Michael, additional, Panyko, Arpád, additional, Látečková, Zuzana, additional, Lacko, Vladimír, additional, Lesko, Dusan, additional, Soltes, Marek, additional, Radonak, Jozef, additional, Turrado-Rodriguez, Victor, additional, Termes-Serra, Roser, additional, Morales-Sevillano, Xavier, additional, Lapolla, Pierfrancesco, additional, Mingoli, Andrea, additional, Brachini, Gioia, additional, Degiuli, Maurizio, additional, Sofia, Silvia, additional, Reddavid, Rossella, additional, de Manzoni Garberini, Andrea, additional, Buffone, Angelica, additional, del Pozo, Eduardo Perea, additional, Aparicio-Sánchez, Daniel, additional, Dos Barbeito, Sandra, additional, Estaire-Gómez, Mercedes, additional, Vitón-Herrero, Rebeca, additional, de los Ángeles Gil Olarte-Marquez, Mª, additional, Gil-Martínez, José, additional, Alconchel, Felipe, additional, Nicolás-López, Tatiana, additional, Rahy-Martin, Aida Cristina, additional, Pelloni, María, additional, Bañolas-Suarez, Raquel, additional, Mendoza-Moreno, Fernando, additional, Nisa, Francisca García-Moreno, additional, Díez-Alonso, Manuel, additional, Rodas, María Elisa Valle, additional, Agundez, María Carmona, additional, Andrés, María Inmaculada Pérez, additional, Moreira, Claudia Cristina Lopes, additional, Perez, Aintzane Lizarazu, additional, Ponce, Iñigo Augusto, additional, González-Castillo, Ana María, additional, Membrilla-Fernández, Estela, additional, Salvans, Silvia, additional, Serradilla-Martín, Mario, additional, Pardo, Pablo Sancho, additional, Rivera-Alonso, Daniel, additional, Dziakova, Jana, additional, Huguet, Jose Mugüerza, additional, Valle, Naila Pagès, additional, Ruiz, Enrique Colás, additional, Valcárcel, Cristina Rey, additional, Moreno, Cristina Ruiz, additional, Salazar, Yeniffer Tatiana Moreno, additional, García, Juan Jesús Rubio, additional, Micó, Silvia Sevila, additional, López, Joaquín Ruiz, additional, Farré, Silvia Pérez, additional, Gomez, Maite Santamaria, additional, Petit, Nuria Mestres, additional, Titos-García, Alberto, additional, Aranda-Narváez, Jose Manuel, additional, Romacho-López, Laura, additional, Sánchez-Guillén, Luis, additional, Aranaz-Ostariz, Veronica, additional, Bosch-Ramírez, Marina, additional, Martínez-Pérez, Aleix, additional, Martínez-López, Elías, additional, Sebastián-Tomás, Juan Carlos, additional, Jimenez-Riera, Granada, additional, Jimenez-Vega, Javier, additional, Cuellar, Jose Aurelio Navas, additional, Campos-Serra, Andrea, additional, Muñoz-Campaña, Anna, additional, Gràcia-Roman, Raquel, additional, Alegre, Javier Martínez, additional, Pinto, Francisca Lima, additional, O’Sullivan, Sara Nuñez, additional, Antona, Francisco Blanco, additional, Jiménez, Beatriz Muñoz, additional, López-Sánchez, Jaime, additional, Carmona, Zahira Gómez, additional, Fernández, Rocio Torres, additional, Sierra, Isabel Blesa, additional, de León, Laura Román García, additional, Moreno, Verónica Polaino, additional, Iglesias, Eva, additional, Cumplido, Paola Lora, additional, Bravo, Altea Arango, additional, Simó, Ignacio Rey, additional, Domínguez, Carlota López, additional, Caamaño, Aloia Guerreiro, additional, Lozano, Rafael Calleja, additional, Martínez, Manuel Durán, additional, Torres, Álvaro Naranjo, additional, de Quiros, Javier Tomas Morales Bernaldo, additional, Pellino, Gianluca, additional, Cloquell, Miriam Moratal, additional, Moller, Elsa García, additional, Jalal-Eldin, Sami, additional, Abdoun, Ahmed K., additional, Hamid, Hytham K. S., additional, Lohsiriwat, Varut, additional, Mongkhonsupphawan, Aitsariya, additional, Baraket, Oussama, additional, Ayed, Karim, additional, Abbassi, Imed, additional, Ali, Ali Ben, additional, Ammar, Houssem, additional, Kchaou, Ali, additional, Tlili, Ahmed, additional, Zribi, Imen, additional, Colak, Elif, additional, Polat, Suleyman, additional, Koylu, Zehra Alan, additional, Guner, Ali, additional, Usta, Mehmet Arif, additional, Reis, Murat Emre, additional, Mantoglu, Baris, additional, Gonullu, Emre, additional, Akin, Emrah, additional, Altintoprak, Fatih, additional, Bayhan, Zulfu, additional, Firat, Necattin, additional, Isik, Arda, additional, Memis, Ufuk, additional, Bayrak, Mehmet, additional, Altıntaş, Yasemin, additional, Kara, Yasin, additional, Bozkurt, Mehmet Abdussamet, additional, Kocataş, Ali, additional, Das, Koray, additional, Seker, Ahmet, additional, Ozer, Nazmi, additional, Atici, Semra Demirli, additional, Tuncer, Korhan, additional, Kaya, Tayfun, additional, Ozkan, Zeynep, additional, Ilhan, Onur, additional, Agackiran, Ibrahim, additional, Uzunoglu, Mustafa Yener, additional, Demirbas, Eren, additional, Altinel, Yuksel, additional, Meric, Serhat, additional, Hacım, Nadir Adnan, additional, Uymaz, Derya Salim, additional, Omarov, Nail, additional, Balık, Emre, additional, Tebala, Giovanni D., additional, Khalil, Hany, additional, Rana, Mridul, additional, Khan, Mansoor, additional, Florence, Charlotte, additional, Swaminathan, Christie, additional, Leo, Cosimo Alex, additional, Liasis, Lampros, additional, Watfah, Josef, additional, Trostchansky, Ivan, additional, Delgado, Edward, additional, Pontillo, Marcelo, additional, Latifi, Rifat, additional, Coimbra, Raul, additional, Edwards, Sara, additional, Lopez, Ana, additional, Velmahos, George, additional, Dorken, Ander, additional, Gebran, Anthony, additional, Palmer, Amanda, additional, Oury, Jeffrey, additional, Bardes, James M., additional, Seng, Sirivan Suon, additional, Coffua, Lauren S., additional, Ratnasekera, Asanthi, additional, Egodage, Tanya, additional, Echeverria-Rosario, Karla, additional, Armento, Isabella, additional, Napolitano, Lena M., additional, Sangji, Naveen F., additional, Hemmila, Mark, additional, Quick, Jacob A., additional, Austin, Tyler R., additional, Hyman, Theodore S., additional, Curtiss, William, additional, McClure, Amanda, additional, Cairl, Nicholas, additional, Biffl, Walter L., additional, Truong, Hung P., additional, Schaffer, Kathryn, additional, Reames, Summer, additional, Banchini, Filippo, additional, Capelli, Patrizio, additional, Coccolini, Federico, additional, Sartelli, Massimo, additional, Bravi, Francesca, additional, Vallicelli, Carlo, additional, Agnoletti, Vanni, additional, Baiocchi, Gian Luca, additional, and Catena, Fausto, additional

Published
2024
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6. Comparison between computed tomography and magnetic resonance imaging in detecting multiple myeloma lesions in the skull: A systematic review

Author

Rocha, Thaiza Goncalves, primary, de Oliveira, Carla Barros, additional, de Magalhães Filho, Roberto José Pessoa, additional, Maiolino, Angelo, additional, Magno, Marcela Baraúna, additional, da Silva Barbirato, Davi, additional, Villoria, Eduardo Murad, additional, Maia, Lucianne Cople, additional, Torres, Sandra Regina, additional, and Visconti, Maria Augusta, additional

Published
2023
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9. Host fecal DNA specific methylation signatures mark gut dysbiosis and inflammation in children affected by autism spectrum disorder

Author

Cuomo, Mariella, primary, Coretti, Lorena, additional, Costabile, Davide, additional, Della Monica, Rosa, additional, De Riso, Giulia, additional, Buonaiuto, Michela, additional, Trio, Federica, additional, Bravaccio, Carmela, additional, Visconti, Roberta, additional, Berni Canani, Roberto, additional, Chiariotti, Lorenzo, additional, and Lembo, Francesca, additional

Published
2023
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11. Robert L. Pressey (1953–2023)

Author

Adams, Vanessa M., primary, Álvarez-Romero, Jorge G., additional, Ban, Natalie C., additional, Mills, Morena, additional, and Visconti, Piero, additional

Published
2023
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12. Targeted inhibition of the methyltransferase SETD8 synergizes with the Wee1 inhibitor adavosertib in restraining glioblastoma growth

Author

Della Monica, Rosa, primary, Buonaiuto, Michela, additional, Cuomo, Mariella, additional, Pagano, Cristina, additional, Trio, Federica, additional, Costabile, Davide, additional, de Riso, Giulia, additional, Cicala, Francesca Sveva, additional, Raia, Maddalena, additional, Franca, Raduan Ahmed, additional, Del Basso De Caro, Marialaura, additional, Sorrentino, Domenico, additional, Navarra, Giovanna, additional, Coppola, Laura, additional, Tripodi, Lorella, additional, Pastore, Lucio, additional, Hench, Juergen, additional, Frank, Stephan, additional, Schonauer, Claudio, additional, Catapano, Giuseppe, additional, Bifulco, Maurizio, additional, Chiariotti, Lorenzo, additional, and Visconti, Roberta, additional

Published
2023
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14. A mid-term follow-up with a lung ultrasonographic score correlates with the severity of COVID-19 acute phase

Author

Tiziano Perrone, Francesco Falaschi, Federica Meloni, Alessia Ballesio, Umberto Sabatini, Marco Vincenzo Lenti, Federica Melazzini, Sara Lettieri, Stefano Novati, Sara Cutti, Carola Maria Marioli, Catherine Klersy, Raffaele Bruno, Luigi Oltrona Visconti, and Antonio Di Sabatino

Subjects
Emergency Medicine, Internal Medicine
Abstract

Lung ultrasound (LUS) has rapidly emerged in COVID-19 diagnosis and for the follow-up during the acute phase. LUS is not yet used routinely in lung damage follow-up after COVID-19 infection. We investigated the correlation between LUS score, and clinical and laboratory parameters of severity of SARS-COV-2 damage during hospitalization and at follow-up visit. Observational retrospective study including all the patients discharged from the COVID-19 wards, who attended the post-COVID outpatient clinic of the IRCCS Policlinico San Matteo in April-June 2020. 115 patients were enrolled. Follow-up visits with LUS score measurements were at a median of 38 days (IQR 28-48) after discharge. LUS scores were associated with the length of hospitalization (p 0.001), patients' age (p = 0.036), use of non-invasive ventilation (CPAP p 0.001 or HFNC p = 0.018), administration of corticosteroids therapy (p = 0.030), and laboratory parameters during the acute phase (WBC p 0.001, LDH p 0.001, CRP p 0.001, D-dimer p = 0.008, IL-6 p = 0.045), and inversely correlated with lymphocyte count (p = 0.007). We found correlation between LUS score and both LDH (p = 0.001) and the antibody anti-SARS-CoV-2 titers (p value = 0.008). Most of these finding were confirmed by dichothomizing the LUS score (≤ 9 or 9 points). We found a significantly higher LUS score at the follow-up in the patients with persistent dyspnea (7.00, IQR 3.00-11.00) when compared to eupnoeic patients (3.00, IQR 0-7.00 p 0.001). LUS score at follow-up visit correlates with more severe lung disease. These findings support the hypothesis that ultrasound could be a valid tool in the follow-up medium-term COVID-19 lung damage.

Published
2022
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19. Capacity of countries to reduce biological invasions

Author

Guillaume Latombe, Hanno Seebens, Bernd Lenzner, Franck Courchamp, Stefan Dullinger, Marina Golivets, Ingolf Kühn, Brian Leung, Núria Roura-Pascual, Emma Cebrian, Wayne Dawson, Christophe Diagne, Jonathan M. Jeschke, Cristian Pérez-Granados, Dietmar Moser, Anna Turbelin, Piero Visconti, Franz Essl, University of Vienna [Vienna], University of Edinburgh, Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Goethe-Universität Frankfurt am Main-Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Leibniz Association-Leibniz Association, Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Martin-Luther-University Halle-Wittenberg, Department of Geobotany and Botanical Garden, Martin-Luther-Universität Halle Wittenberg (MLU), McGill University = Université McGill [Montréal, Canada], Universitat de Girona [Girona], Universitat de Girona (UdG), Departament de Ciencies Ambientals, Centre d'Estudis Avançats de Blanes (CEAB), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Aquatic Ecology, Durham University, Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Freie Universität Berlin, Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Universidad de Alicante, International Institute for Applied Systems Analysis [Laxenburg] (IIASA), This research was funded through the 2017-2018 Belmont Forum and BiodivERsA joint call for research proposals, under the BiodivScen ERA-Net COFUND programme, and with the funding organisations FWF (project no I 4011-B32–GL, BeL, SD, DM, FE), MCIN/AEI/https://doi.org/10.13039/501100011033 (PCI2018-092966–NRP, CPG, EC), BMBF (16LC1807C–MG, IK, 16LC1807A–HS, 16LC1807B–JMJ) and ANR (NR-18-EBI4-0004–FC, CB, CD, AT)., Universidad de Alicante. Departamento de Ecología, Ecología y Conservación de Poblaciones y Comunidades Animales (ECPCA), Department of Botany and Biodiversity Research, Institute of Biology/Geobotany and Botanical Garden, German Centre for Integrative Biodiversity Research (iDiv), Institute of Biology, Freie Universität Berlin, Berlin, Germany, Departamento de Ecología, Universidad de Alicante, Alicante, Spain, This research was funded through the 2017-2018 Belmont Forum and BiodivERsA joint call for research proposals, under the BiodivScen ERA-Net COFUND programme, and with the funding organisations FWF (project no I 4011-B32-GL, BeL, SD, DM, FE), MCIN/AEI/https://doi.org/10.13039/501100011033 (PCI2018-092966NRP, CPG, EC), BMBF (16LC1807C-MG, IK, 16LC1807A-HS, 16LC1807B-JMJ) and ANR (ANR-18-EBI4-0004-FC, CB, CD, AT).Document Information, and ANR-18-EBI4-0004,AlienScenarios,Developing and applying scenarios of biological invasions for the 21st century(2018)

Subjects
Governance, Global and Planetary Change, Established alien species, Health (social science), Sociology and Political Science, Ecology, [SDV]Life Sciences [q-bio], Geography, Planning and Development, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, Management, Monitoring, Policy and Law, Lifestyle, Environmental performance, Scenarios, [SDE]Environmental Sciences, Trade, Innovation, Nature and Landscape Conservation
Abstract

Este artículo contiene 19 páginas, 4 figuras, 2 tablas., The extent and impacts of biological invasions on biodiversity are largely shaped by an array of socio-economic and environmental factors, which exhibit high variation among countries. Yet, a global analysis of how these factors vary across countries is currently lacking. Here, we investigate how five broad, country-specific socio-economic and environmental indices (Governance, Trade, Environmental Performance, Lifestyle and Education, Innovation) explain country-level (1) established alien species (EAS) richness of eight taxonomic groups, and (2) proactive or reactive capacity to prevent and manage biological invasions and their impacts. These indices underpin many aspects of the invasion process, including the introduction, establishment, spread and management of alien species. They are also general enough to enable a global comparison across countries, and are therefore essential for defining future scenarios for biological invasions. Models including Trade, Governance, Lifestyle and Education, or a combination of these, best explained EAS richness across taxonomic groups and national proactive or reactive capacity. Historical (1996 or averaged over 1996–2015) levels of Governance and Trade better explained both EAS richness and the capacity of countries to manage invasions than more recent (2015) levels, revealing a historical legacy with important implications for the future of biological invasions. Using Governance and Trade to define a two-dimensional socio-economic space in which the position of a country captures its capacity to address issues of biological invasions, we identified four main clusters of countries in 2015. Most countries had an increase in Trade over the past 25 years, but trajectories were more geographically heterogeneous for Governance. Declines in levels of Governance are concerning as they may be responsible for larger levels of invasions in the future. By identifying the factors influencing EAS richness and the regions most susceptible to changes in these factors, our results provide novel insights to integrate biological invasions into scenarios of biodiversity change to better inform decision-making for policy and the management of biological invasions., This research was funded through the 2017-2018 Belmont Forum and BiodivERsA joint call for research proposals, under the BiodivScen ERA-Net COFUND programme, and with the funding organisations FWF (project no I 4011-B32–GL, BeL, SD, DM, FE), MCIN/AEI/https:// doi. org/ 10. 13039/ 50110 00110 33 (PCI2018-092966– NRP, CPG, EC), BMBF (16LC1807C–MG, IK; 16LC1807A–HS; 16LC1807B–JMJ) and ANR (NR-18-EBI4-0004–FC, CB, CD, AT).

Published
2022
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20. Difference in the neurocognitive functions of WLWH and MLWH in an Italian cohort of people living with HIV

Author

Valentina Delle Donne, Valentina Massaroni, Nicoletta Ciccarelli, Francesca Lombardi, Alberto Borghetti, Arturo Ciccullo, Alex Dusina, Damiano Farinacci, Ganmaria Baldin, Elena Visconti, Enrica Tamburrini, and Simona Di Giambenedetto

Subjects
Male, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, HIV Infections, Cohort Studies, Cellular and Molecular Neuroscience, Cross-Sectional Studies, Anti-Retroviral Agents, Neurology, HIV · HIV-associated neurocognitive disorders · Sex differences · Neurocognition · Cognition evaluation, Virology, Humans, Female, Neurology (clinical), Retrospective Studies
Abstract

Based on the available literature, women living with HIV (WLWH) seem to show greater cognitive and emotional disadvantages than men living with HIV (MLWH). Our aim was to compare the cognitive performance of MLWH and WLWH in an Italian cohort of People Living With HIV (PLWH) and to analyse factors potentially contributing to sex differences in cognitive function. We ran a retrospective, cross-sectional analysis of a monocentric dataset of PLWH who were administered a standardized neuropsychological test battery (SNB) during routine clinical care. We enrolled 161 Italian PLWH who are on combined antiretroviral therapy (cART): 114 (70.8%) MLWH and 47 (29.2%) WLWH.Global cognitive performance (composite z score) (GCP) was significantly higher in MLWH than WLWH [mean 0.19 (SD 0.85) vs − 0.13 (SD 0.96); p = 0.039]. Moreover, WLWH obtained significantly higher scores on the Zung Depression Scale than MLWH [mean 41.8 (SD 10.9) vs 36.7 (SD 9.2); p = 0.003]. However, there was no statistically significant direct effect between male sex and better GCP (p = 0.692) in the context of a mediation model. On the contrary, the associations between male sex and better GCP were mediated by higher level of education (a*b = + 0.15, Bootstrap CI95 = 0.05 and 0.27) and a lower Zung depression score (a*b = + 0.10, Bootstrap CI95 = 0.02 and 0.21).In conclusion, the global cognitive performance of WLWH is lower than that of MLWH. However, other demographic and clinical factors besides sex might help explain differences in their neurocognitive functions and make it possible for us to monitor them and identify those patients most in need.

Published
2022
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23. Using the IUCN Red List to map threats to terrestrial vertebrates at global scale

Author

Jonas Geldmann, Mike Harfoot, Piero Visconti, Carolina Hazin, Nick J. B. Isaac, Stuart H. M. Butchart, Craig Hilton-Taylor, Charlotte L. Outhwaite, Maria P. Dias, Michael R. Hoffmann, Lars Iversen, Alison Johnston, Andrew Balmford, Neil D. Burgess, University of St Andrews. Statistics, Harfoot, Michael B. J. [0000-0003-2598-8652], Johnston, Alison [0000-0001-8221-013X], Butchart, Stuart H. M. [0000-0002-1140-4049], Dias, Maria P. [0000-0002-7281-4391], Hilton-Taylor, Craig [0000-0003-1163-1425], Hoffmann, Michael [0000-0003-4785-2254], Isaac, Nick J. B. [0000-0002-4869-8052], Outhwaite, Charlotte L. [0000-0001-9997-6780], Visconti, Piero [0000-0001-6823-2826], Geldmann, Jonas [0000-0002-1191-7610], Apollo - University of Cambridge Repository, Harfoot, Michael BJ [0000-0003-2598-8652], Butchart, Stuart HM [0000-0002-1140-4049], Dias, Maria P [0000-0002-7281-4391], Isaac, Nick JB [0000-0002-4869-8052], and Outhwaite, Charlotte L [0000-0001-9997-6780]

Subjects
Conservation of Natural Resources, QH301 Biology, Biodiversity, Climate change, Last, Conservation, Ecology and Environment, Article, Invasive species, Environmental impact, QH301, Invasion, Worlds, Anthropocene, 704/172/4081, SDG 13 - Climate Action, Animals, Humans, Hunting, IUCN Red List, QA Mathematics, QA, Ecology, Evolution, Behavior and Systematics, SDG 15 - Life on Land, Diversity, Land, GE, Ecology, Conservation biology, Anthropogenic Effects, Endangered Species, Logging, DAS, Impact, Geography, Progress, Vertebrates, Spatial ecology, 631/158/672, GE Environmental Sciences, Global biodiversity
Abstract

The Anthropocene is characterized by unparalleled human impact on other species, potentially ushering in the sixth mass extinction. Yet mitigation efforts remain hampered by limited information on the spatial patterns and intensity of the threats driving global biodiversity loss. Here we use expert-derived information from the International Union for Conservation of Nature Red List on threats to 23,271 species, representing all terrestrial amphibians, birds and mammals, to generate global maps of the six major threats to these groups: agriculture, hunting and trapping, logging, pollution, invasive species, and climate change. Our results show that agriculture and logging are pervasive in the tropics and that hunting and trapping is the most geographically widespread threat to mammals and birds. Additionally, current representations of human pressure underestimate the overall pressure on biodiversity, due to the exclusion of threats such as hunting and climate change. Alarmingly, this is particularly the case in areas of the highest biodiversity importance., Red List information is used to generate global maps of the likelihood of impacts on terrestrial vertebrates exerted by agriculture, hunting and trapping, logging, pollution, invasive species and climate change.

Published
2021
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24. Quinpi: Integrating Conservation Laws with CWENO Implicit Methods

Author

G. Puppo, M. Semplice, and G. Visconti

Subjects
Computational Mathematics, Essentially non-oscillatory schemes, Finite volumes, Implicit schemes, WENO and CWENO reconstructions, Applied Mathematics, FOS: Mathematics, Computer Science::Mathematical Software, Numerical Analysis (math.NA), Mathematics - Numerical Analysis, 65M08, 65M20, 35L65, 65L04, Computer Science::Digital Libraries
Abstract

Many interesting applications of hyperbolic systems of equations are stiff, and require the time step to satisfy restrictive stability conditions. One way to avoid small time steps is to use implicit time integration. Implicit integration is quite straightforward for first-order schemes. High order schemes instead also need to control spurious oscillations, which requires limiting in space and time also in the linear case. We propose a framework to simplify considerably the application of high order non-oscillatory schemes through the introduction of a low order implicit predictor, which is used both to set up the nonlinear weights of a standard high order space reconstruction, and to achieve limiting in time. In this preliminary work, we concentrate on the case of a third-order scheme, based on diagonally implicit Runge Kutta ($$\mathsf {DIRK}$$ DIRK ) integration in time and central weighted essentially non-oscillatory ($$\mathsf {CWENO}$$ CWENO ) reconstruction in space. The numerical tests involve linear and nonlinear scalar conservation laws.

Published
2022
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26. Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma

Author

Visconti, Alessia, primary, Rossi, Niccolò, additional, Deriš, Helena, additional, Lee, Karla A, additional, Hanić, Maja, additional, Trbojević-Akmačić, Irena, additional, Thomas, Andrew M., additional, Bolte, Laura A., additional, Björk, Johannes R., additional, Hooiveld-Noeken, Jahlisa S., additional, Board, Ruth, additional, Harland, Mark, additional, Newton-Bishop, Julia, additional, Harries, Mark, additional, Sacco, Joseph J., additional, Lorigan, Paul, additional, Shaw, Heather M., additional, de Vries, Elisabeth G.E., additional, Fehrmann, Rudolf S.N., additional, Weersma, Rinse K., additional, Spector, Tim D., additional, Nathan, Paul, additional, Hospers, Geke A. P., additional, Sasieni, Peter, additional, Bataille, Veronique, additional, Lauc, Gordan, additional, and Falchi, Mario, additional

Published
2023
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28. The person-to-person transmission landscape of the gut and oral microbiomes

Author

Valles-Colomer, Mireia, primary, Blanco-Míguez, Aitor, additional, Manghi, Paolo, additional, Asnicar, Francesco, additional, Dubois, Leonard, additional, Golzato, Davide, additional, Armanini, Federica, additional, Cumbo, Fabio, additional, Huang, Kun D., additional, Manara, Serena, additional, Masetti, Giulia, additional, Pinto, Federica, additional, Piperni, Elisa, additional, Punčochář, Michal, additional, Ricci, Liviana, additional, Zolfo, Moreno, additional, Farrant, Olivia, additional, Goncalves, Adriana, additional, Selma-Royo, Marta, additional, Binetti, Ana G., additional, Becerra, Jimmy E., additional, Han, Bei, additional, Lusingu, John, additional, Amuasi, John, additional, Amoroso, Loredana, additional, Visconti, Alessia, additional, Steves, Claire M., additional, Falchi, Mario, additional, Filosi, Michele, additional, Tett, Adrian, additional, Last, Anna, additional, Xu, Qian, additional, Qin, Nan, additional, Qin, Huanlong, additional, May, Jürgen, additional, Eibach, Daniel, additional, Corrias, Maria Valeria, additional, Ponzoni, Mirco, additional, Pasolli, Edoardo, additional, Spector, Tim D., additional, Domenici, Enrico, additional, Collado, Maria Carmen, additional, and Segata, Nicola, additional

Published
2023
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29. The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

Author

De Simone, Belinda, primary, Abu-Zidan, Fikri M., additional, Chouillard, Elie, additional, Di Saverio, Salomone, additional, Sartelli, Massimo, additional, Podda, Mauro, additional, Gomes, Carlos Augusto, additional, Moore, Ernest E., additional, Moug, Susan J., additional, Ansaloni, Luca, additional, Kluger, Yoram, additional, Coccolini, Federico, additional, Landaluce-Olavarria, Aitor, additional, Estraviz-Mateos, Begoña, additional, Uriguen-Etxeberria, Ana, additional, Giordano, Alessio, additional, Luna, Alfonso Palmieri, additional, Amín, Luz Adriana Hernández, additional, Hernández, Adriana María Palmieri, additional, Shabana, Amanda, additional, Dzulkarnaen, Zakaria Andee, additional, Othman, Muhammad Asyraf, additional, Sani, Mohamad Ikhwan, additional, Balla, Andrea, additional, Scaramuzzo, Rosa, additional, Lepiane, Pasquale, additional, Bottari, Andrea, additional, Staderini, Fabio, additional, Cianchi, Fabio, additional, Cavallaro, Andrea, additional, Zanghì, Antonio, additional, Cappellani, Alessandro, additional, Campagnacci, Roberto, additional, Maurizi, Angela, additional, Martinotti, Mario, additional, Ruggieri, Annamaria, additional, Jusoh, Asri Che, additional, Rahman, Karim Abdul, additional, Zulkifli, Anis Suraya M., additional, Petronio, Barbara, additional, Matías-García, Belén, additional, Quiroga-Valcárcel, Ana, additional, Mendoza-Moreno, Fernando, additional, Atanasov, Boyko, additional, Campanile, Fabio Cesare, additional, Vecchioni, Ilaria, additional, Cardinali, Luca, additional, Travaglini, Grazia, additional, Sebastiani, Elisa, additional, Chooklin, Serge, additional, Chuklin, Serhii, additional, Cianci, Pasquale, additional, Restini, Enrico, additional, Capuzzolo, Sabino, additional, Currò, Giuseppe, additional, Filippo, Rosalinda, additional, Rispoli, Michele, additional, Aparicio-Sánchez, Daniel, additional, Muñóz-Cruzado, Virginia Durán, additional, Barbeito, Sandra Dios, additional, Delibegovic, Samir, additional, Kesetovic, Amar, additional, Sasia, Diego, additional, Borghi, Felice, additional, Giraudo, Giorgio, additional, Visconti, Diego, additional, Doria, Emanuele, additional, Santarelli, Mauro, additional, Luppi, Davide, additional, Bonilauri, Stefano, additional, Grossi, Ugo, additional, Zanus, Giacomo, additional, Sartori, Alberto, additional, Piatto, Giacomo, additional, De Luca, Maurizio, additional, Vita, Domenico, additional, Conti, Luigi, additional, Capelli, Patrizio, additional, Cattaneo, Gaetano Maria, additional, Marinis, Athanasios, additional, Vederaki, Styliani-Aikaterini, additional, Bayrak, Mehmet, additional, Altıntas, Yasemin, additional, Uzunoglu, Mustafa Yener, additional, Demirbas, Iskender Eren, additional, Altinel, Yuksel, additional, Meric, Serhat, additional, Aktimur, Yunus Emre, additional, Uymaz, Derya Salim, additional, Omarov, Nail, additional, Azamat, Ibrahim, additional, Lostoridis, Eftychios, additional, Nagorni, Eleni-Aikaterini, additional, Pujante, Antonio, additional, Anania, Gabriele, additional, Bombardini, Cristina, additional, Bagolini, Francesco, additional, Gonullu, Emre, additional, Mantoglu, Baris, additional, Capoglu, Recayi, additional, Cappato, Stefano, additional, Muzio, Elena, additional, Colak, Elif, additional, Polat, Suleyman, additional, Koylu, Zehra Alan, additional, Altintoprak, Fatih, additional, Bayhan, Zülfü, additional, Akin, Emrah, additional, Andolfi, Enrico, additional, Rezart, Sulce, additional, Kim, Jae Il, additional, Jung, Sung Won, additional, Shin, Yong Chan, additional, Enciu, Octavian, additional, Toma, Elena Adelina, additional, Medas, Fabio, additional, Canu, Gian Luigi, additional, Cappellacci, Federico, additional, D’Acapito, Fabrizio, additional, Ercolani, Giorgio, additional, Solaini, Leonardo, additional, Roscio, Francesco, additional, Clerici, Federico, additional, Gelmini, Roberta, additional, Serra, Francesco, additional, Rossi, Elena Giulia, additional, Fleres, Francesco, additional, Clarizia, Guglielmo, additional, Spolini, Alessandro, additional, Ferrara, Francesco, additional, Nita, Gabriela, additional, Sarnari, Jlenia, additional, Gachabayov, Mahir, additional, Abdullaev, Abakar, additional, Poillucci, Gaetano, additional, Palini, Gian Marco, additional, Veneroni, Simone, additional, Garulli, Gianluca, additional, Piccoli, Micaela, additional, Pattacini, Gianmaria Casoni, additional, Pecchini, Francesca, additional, Argenio, Giulio, additional, Armellino, Mariano Fortunato, additional, Brisinda, Giuseppe, additional, Tedesco, Silvia, additional, Fransvea, Pietro, additional, Ietto, Giuseppe, additional, Franchi, Caterina, additional, Carcano, Giulio, additional, Martines, Gennaro, additional, Trigiante, Giuseppe, additional, Negro, Giulia, additional, Vega, Gustavo Machain, additional, González, Agustín Rodríguez, additional, Ojeda, Leonardo, additional, Piccolo, Gaetano, additional, Bondurri, Andrea, additional, Maffioli, Anna, additional, Guerci, Claudio, additional, Sin, Boo Han, additional, Zuhdi, Zamri, additional, Azman, Azlanudin, additional, Mousa, Hussam, additional, al Bahri, Shadi, additional, Augustin, Goran, additional, Romic, Ivan, additional, Moric, Trpimir, additional, Nikolopoulos, Ioannis, additional, Andreuccetti, Jacopo, additional, Pignata, Giusto, additional, D’Alessio, Rossella, additional, Kenig, Jakub, additional, Skorus, Urszula, additional, Fraga, Gustavo Pereira, additional, Hirano, Elcio Shiyoiti, additional, de Lima Bertuol, Jackson Vinícius, additional, Isik, Arda, additional, Kurnaz, Eray, additional, Asghar, Mohammad Sohail, additional, Afzal, Ameer, additional, Akbar, Ali, additional, Nikolouzakis, Taxiarchis Konstantinos, additional, Lasithiotakis, Konstantinos, additional, Chrysos, Emmanuel, additional, Das, Koray, additional, Özer, Nazmi, additional, Seker, Ahmet, additional, Ibrahim, Mohamed, additional, Hamid, Hytham K. S., additional, Babiker, Ahmed, additional, Bouliaris, Konstantinos, additional, Koukoulis, George, additional, Kolla, Chrysoula-Christina, additional, Lucchi, Andrea, additional, Agostinelli, Laura, additional, Taddei, Antonio, additional, Fortuna, Laura, additional, Agostini, Carlotta, additional, Licari, Leo, additional, Viola, Simona, additional, Callari, Cosimo, additional, Laface, Letizia, additional, Abate, Emmanuele, additional, Casati, Massimiliano, additional, Anastasi, Alessandro, additional, Canonico, Giuseppe, additional, Gabellini, Linda, additional, Tosi, Lorenzo, additional, Guariniello, Anna, additional, Zanzi, Federico, additional, Bains, Lovenish, additional, Sydorchuk, Larysa, additional, Iftoda, Oksana, additional, Sydorchuk, Andrii, additional, Malerba, Michele, additional, Costanzo, Federico, additional, Galleano, Raffaele, additional, Monteleone, Michela, additional, Costanzi, Andrea, additional, Riva, Carlo, additional, Walędziak, Maciej, additional, Kwiatkowski, Andrzej, additional, Czyżykowski, Łukasz, additional, Major, Piotr, additional, Strzałka, Marcin, additional, Matyja, Maciej, additional, Natkaniec, Michal, additional, Valenti, Maria Rosaria, additional, Di Vita, Maria Domenica Pia, additional, Sotiropoulou, Maria, additional, Kapiris, Stylianos, additional, Massalou, Damien, additional, Veroux, Massimiliano, additional, Volpicelli, Alessio, additional, Gioco, Rossella, additional, Uccelli, Matteo, additional, Bonaldi, Marta, additional, Olmi, Stefano, additional, Nardi, Matteo, additional, Livadoti, Giada, additional, Mesina, Cristian, additional, Dumitrescu, Theodor Viorel, additional, Ciorbagiu, Mihai Calin, additional, Ammendola, Michele, additional, Ammerata, Giorgio, additional, Romano, Roberto, additional, Slavchev, Mihail, additional, Misiakos, Evangelos P., additional, Pikoulis, Emmanouil, additional, Papaconstantinou, Dimitrios, additional, Elbahnasawy, Mohamed, additional, Abdel-elsalam, Sherief, additional, Felsenreich, Daniel M., additional, Jedamzik, Julia, additional, Michalopoulos, Nikolaos V., additional, Sidiropoulos, Theodoros A., additional, Papadoliopoulou, Maria, additional, Cillara, Nicola, additional, Deserra, Antonello, additional, Cannavera, Alessandro, additional, Negoi, Ionuţ, additional, Schizas, Dimitrios, additional, Syllaios, Athanasios, additional, Vagios, Ilias, additional, Gourgiotis, Stavros, additional, Dai, Nick, additional, Gurung, Rekha, additional, Norrey, Marcus, additional, Pesce, Antonio, additional, Feo, Carlo Vittorio, additional, Fabbri, Nicolo’, additional, Machairas, Nikolaos, additional, Dorovinis, Panagiotis, additional, Keramida, Myrto D., additional, Mulita, Francesk, additional, Verras, Georgios Ioannis, additional, Vailas, Michail, additional, Yalkin, Omer, additional, Iflazoglu, Nidal, additional, Yigit, Direnc, additional, Baraket, Oussama, additional, Ayed, Karim, additional, Ghalloussi, Mohamed hedi, additional, Patias, Parmenion, additional, Ntokos, Georgios, additional, Rahim, Razrim, additional, Bala, Miklosh, additional, Kedar, Asaf, additional, Sawyer, Robert G., additional, Trinh, Anna, additional, Miller, Kelsey, additional, Sydorchuk, Ruslan, additional, Knut, Ruslan, additional, Plehutsa, Oleksandr, additional, Liman, Rumeysa Kevser, additional, Ozkan, Zeynep, additional, Kader, Saleh Abdel, additional, Gupta, Sanjay, additional, Gureh, Monika, additional, Saeidi, Sara, additional, Aliakbarian, Mohsen, additional, Dalili, Amin, additional, Shoko, Tomohisa, additional, Kojima, Mitsuaki, additional, Nakamoto, Raira, additional, Atici, Semra Demirli, additional, Tuncer, Gizem Kilinc, additional, Kaya, Tayfun, additional, Delis, Spiros G., additional, Rossi, Stefano, additional, Picardi, Biagio, additional, del Monte, Simone Rossi, additional, Triantafyllou, Tania, additional, Theodorou, Dimitrios, additional, Pintar, Tadeja, additional, Salobir, Jure, additional, Manatakis, Dimitrios K., additional, Tasis, Nikolaos, additional, Acheimastos, Vasileios, additional, Ioannidis, Orestis, additional, Loutzidou, Lydia, additional, Symeonidis, Savvas, additional, de Sá, Tiago Correia, additional, Rocha, Mónica, additional, Guagni, Tommaso, additional, Pantalone, Desiré, additional, Maltinti, Gherardo, additional, Khokha, Vladimir, additional, Abdel-elsalam, Wafaa, additional, Ghoneim, Basma, additional, López-Ruiz, José Antonio, additional, Kara, Yasin, additional, Zainudin, Syaza, additional, Hayati, Firdaus, additional, Azizan, Nornazirah, additional, Khei, Victoria Tan Phooi, additional, Yi, Rebecca Choy Xin, additional, Sellappan, Harivinthan, additional, Demetrashvili, Zaza, additional, Lekiashvili, Nika, additional, Tvaladze, Ana, additional, Froiio, Caterina, additional, Bernardi, Daniele, additional, Bonavina, Luigi, additional, Gil-Olarte, Angeles, additional, Grassia, Sebastiano, additional, Romero-Vargas, Estela, additional, Bianco, Francesco, additional, Gumbs, Andrew A., additional, Dogjani, Agron, additional, Agresta, Ferdinando, additional, Litvin, Andrey, additional, Balogh, Zsolt J., additional, Gendrikson, George, additional, Martino, Costanza, additional, Damaskos, Dimitrios, additional, Pararas, Nikolaos, additional, Kirkpatrick, Andrew, additional, Kurtenkov, Mikhail, additional, Gomes, Felipe Couto, additional, Pisanu, Adolfo, additional, Nardello, Oreste, additional, Gambarini, Fabrizio, additional, Aref, Hager, additional, Angelis, Nicola de’, additional, Agnoletti, Vanni, additional, Biondi, Antonio, additional, Vacante, Marco, additional, Griggio, Giulia, additional, Tutino, Roberta, additional, Massani, Marco, additional, Bisetto, Giovanni, additional, Occhionorelli, Savino, additional, Andreotti, Dario, additional, Lacavalla, Domenico, additional, Biffl, Walter L., additional, and Catena, Fausto, additional

Published
2022
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32. A mid-term follow-up with a lung ultrasonographic score correlates with the severity of COVID-19 acute phase

Author

Perrone, Tiziano, primary, Falaschi, Francesco, additional, Meloni, Federica, additional, Ballesio, Alessia, additional, Sabatini, Umberto, additional, Lenti, Marco Vincenzo, additional, Melazzini, Federica, additional, Lettieri, Sara, additional, Novati, Stefano, additional, Cutti, Sara, additional, Marioli, Carola Maria, additional, Klersy, Catherine, additional, Bruno, Raffaele, additional, Oltrona Visconti, Luigi, additional, and Di Sabatino, Antonio, additional

Published
2022
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33. Barriers associated with emergency medical service activation in patients with ST-segment elevation acute coronary syndromes

Author

Enrico, Baldi, Rita, Camporotondo, Massimiliano, Gnecchi, Rossana, Totaro, Stefania, Guida, Ilaria, Costantino, Alessandra, Repetto, Simone, Savastano, Maria Clara, Sacchi, Carola, Bollato, Federica, Giglietta, Luigi, Oltrona Visconti, Sergio, Leonardi, and Leonardo, Pignalosa

Subjects
Emergency Medical Services, Acute coronary syndrome, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Disease, EM - Original, Emergency Medical System, STEACS, Percutaneous Coronary Intervention, Internal Medicine, medicine, Humans, ST segment, In patient, Prospective Studies, Acute Coronary Syndrome, Emergency medical system, Cardiovascular History, business.industry, Primary percutaneous coronary intervention, Percutaneous coronary intervention, Arrhythmias, Cardiac, medicine.disease, Northern italy, Emergency medicine, Emergency Medicine, Emergency Service, Hospital, business, Barriers
Abstract

Many ST-segment elevation acute coronary syndrome (STEACS) patients fail to activate the Emergency Medical System (EMS), with possible dramatic consequences. Prior studies focusing on barriers to EMS activation included patients with any acute coronary syndrome (ACS) without representation of southern European populations. We aimed to investigate the barriers to EMS call for patients diagnosed for STEACS in Italy. A prospective, single-center, survey administered to all patients treated with primary percutaneous coronary intervention for STEACS in a tertiary hospital in northern Italy from 01/06/2018 to 31/05/2020. The questionnaire was filled out by 293 patients. Of these, 191 (65.2%) activated the EMS after symptoms onset. The main reasons for failing to contact EMS were the perception that the symptoms were unrelated to an important health problem (45.5%) and that a private vehicle is faster than EMS to reach the hospital (34.7%). Patients who called a private doctor after symptoms onset did not call EMS more frequently than those who did not and 30% of the patients who did not call the EMS would still act in the same way if a new episode occurred. Previous history of cardiovascular disease was the only predictor of EMS call. Information campaigns are urgently needed to increase EMS activation in case of suspected STEACS and should be primary focused on patients without cardiovascular history, on the misperception that a private vehicle is faster than EMS activation, and on the fact that cardiac arrest occurs early and may be prevented by EMS activation. Supplementary Information The online version contains supplementary material available at 10.1007/s11739-021-02894-7.

Published
2021
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34. Lipobrachiopexy: Cosmetic Outcomes and Limb Lymphatic Function of a Novel Brachioplasty Technique in Massive Weight Loss Patients

Author

Marzia Salgarello, Giuseppe Visconti, and Alessandro Bianchi

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine.disease, Surgery, Plastic surgery, medicine.anatomical_structure, Lymphedema, Otorhinolaryngology, Liposuction, medicine.artery, medicine, Deformity, Upper limb, Brachioplasty, medicine.symptom, Brachial artery, business
Abstract

Many types of brachioplasty techniques have been described in the literature, and the main focus has been scar aesthetics, reproducibility and safety. Little attention has been given to other two aspects of the procedure: overall aesthetic with a focus on the torso-brachial angle and on the lymphatic distress related to the procedure. In this paper, we described a novel technique of brachioplasty called lipobrachiopexy, a lymph-sparing procedure which includes tendon suspension suture to improve cosmetics . Over 18 months, 22 consecutive patients underwent bilateral lipobrachioplasty with circumferential liposuction sparing brachial artery perforators, J-scar dermolipectomy and superficial fascia suspension to the pectoralis major tendon. Aesthetic outcomes, lymphatic function, sensory function and patient’s satisfaction were evaluated at 1-year follow-up. The correction of the bat wing deformity and the shape of the transition of the upper arm to the chest was evaluated by quantifying the torso-brachial angle using Photoshop. Lymphatic function was analysed pre-operatively at 1, 6 and 12 months after surgery by indocyanine green lymphography (PDE, Hamamatsu Photonics, Japan). An average of 447.5 cc (range, 350–550 cc) of fat was aspirated for each side. No major complications were experienced. Patients’ and surgeons’ satisfaction was high to very high in all cases. The lymphatic function was found preserved, with the same physiological linear patterns and tracer progression pre-operatively and 1 year after surgery. The torso-brachial angles showed significant improvements (86.7 ± 14.7–100.7 ± 10.2 right side and 85.4 ± 16.3–101.5 ± 9.9 left side). Lipobrachiopexy is a safe and effective technique that adds to the recent trends in brachioplasty, a reestablishment of the brachial fascial systems and addressing the anatomical etiological factor of the bat wing deformity. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Published
2021
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38. Reply to: The risks of overstating the climate benefits of ecosystem restoration

Author

Strassburg, Bernardo B. N., primary, Iribarrem, Alvaro, additional, Beyer, Hawthorne L., additional, Cordeiro, Carlos Leandro, additional, Crouzeilles, Renato, additional, Jakovac, Catarina, additional, Junqueira, André Braga, additional, Lacerda, Eduardo, additional, Latawiec, Agnieszka E., additional, Balmford, Andrew, additional, Brooks, Thomas M., additional, Butchart, Stuart H. M., additional, Chazdon, Robin L., additional, Erb, Karl-Heinz, additional, Brancalion, Pedro, additional, Buchanan, Graeme, additional, Cooper, David, additional, Díaz, Sandra, additional, Donald, Paul F., additional, Kapos, Valerie, additional, Leclère, David, additional, Miles, Lera, additional, Obersteiner, Michael, additional, Plutzar, Christoph, additional, Scaramuzza, Carlos Alberto de M., additional, Scarano, Fabio R., additional, and Visconti, Piero, additional

Published
2022
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39. Effects of central tendency measures on term weighting in textual information retrieval

Author

Andrea Visconti, Hooman Tahayori, and Farzad Ghahramani

Subjects
Normalization (statistics), 0209 industrial biotechnology, Computer science, Computational intelligence, 02 engineering and technology, computer.software_genre, Theoretical Computer Science, Term (time), Textual information, News aggregator, Weighting, 020901 industrial engineering & automation, Simple (abstract algebra), 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Geometry and Topology, Data mining, Document retrieval, computer, Software
Abstract

It has become evident that term weighting has a significant effect on relevant document retrieval for which various methods are proposed. However, the main question that arises is which weighting method is the best? In this paper, it is shown that proper aggregation of weights generated by carefully selected basic weighting methods improves retrieval of the relevant documents with respect to the user’s needs. Toward this aim, it is shown that even using simple central tendency measures such as average, median or mid-range over an appropriate subset of basic weighting methods provides term weight that not only outperforms using each basic weighting method but also results in more effective weights in comparison with recently proposed complicated weighting methods. Based on exploiting the proposed method on various datasets, we have studied the effects of normalization of the basic weights, normalization of the vector lengths, the use of different components in the term frequency factor, etc. Results reveal the criteria for selecting an appropriate subset of basic weighting methods that would be fed to the aggregator in order to achieve higher retrieval precision.

Published
2021
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40. Sensitivity of soil electromagnetic induction measurements to salinity, water content, clay, organic matter and bulk density

Author

Fernando Visconti and José Miguel de Paz

Subjects
Salinity, N01 Agricultural engineering, P34 Soil biology, 0211 other engineering and technologies, Soil science, 02 engineering and technology, Electrical resistivity and conductivity, Linear regression, Organic matter, Texture, Sensitivity (control systems), P33 Soil chemistry and physics, Water content, 021101 geological & geomatics engineering, chemistry.chemical_classification, 04 agricultural and veterinary sciences, Bulk density, Electromagnetic induction, chemistry, 040103 agronomy & agriculture, P10 Water resources and management, P30 Soil science and management, 0401 agriculture, forestry, and fisheries, Environmental science, Precision agriculture, Sensitivity analysis, General Agricultural and Biological Sciences
Abstract

Observed variations in the ground electrical conductivity (σb*) measurements obtained with EMI instruments depend on several soil proxies that infuence crop growth and development such as salinity (σe), contents of water (θw), clay (wc) and organic matter (wom) and bulk density (ρb). However, the relative contributions of all these to σb* are unknown. This knowledge is needed to improve the planning and interpretation of σb* data for precision agriculture applications. Recently, a semi-empirical model has been developed to relate σb* measurements taken with an EM38 device to σe, θw, wc, wom and ρb and also soil temperature (t). In this work this model was subjected to a global sensitivity analysis (GSA) based on the soil data obtained during two surveys carried out, one in summer and the other in autumn, in an ample irrigated area in SE Spain. On the basis of the multiple linear regression meta-models developed for the σb* measurements, these were found to linearly respond to the soil properties (R2 between 0.92 and 0.96) and thus, the GSA could be based on their standardised regression coefcients. According to these, the soil characteristics explain the following percentages of variance in σb* (PV): 30–34 (σe), 8–20 (θw), 32–47 (wc), 0.6–2.6 (wom), 5.7–7.5 (ρb) and 0.3–0.4 (t) with changes from the summer to the autumn season of − 4, − 12 and+15 in the PV explained by the most infuential properties, respectively, σe, θw and wc. The results of the GSA will help the planning and interpretation of σb* measurements for improving crop management.

Published
2021
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41. Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

Author

Lorenzo Visconti, Stefano Gianni, Romano Silvestri, Giuseppe La Regina, Antonio Coluccia, Livia Pagano, Marianna Bufano, Angelo Toto, Caterina Nardella, Francesca Malagrinò, Marianna Nalli, Nardella, C., Visconti, L., Malagrino, Francesca., Pagano, L., Bufano, M., Nalli, M., Coluccia, A., La Regina, G., Silvestri, R., Gianni, S., and Toto, A.

Subjects
PDZ Domain, Inhibitor, QH301-705.5, Immunology, Protein domain, PDZ domain, PDZ Domains, Ligand, Review, Computational biology, Protein–protein interactions, Biology, Ligands, General Biochemistry, Genetics and Molecular Biology, Protein–protein interaction, Neoplasms, Cell polarity, medicine, Humans, Biology (General), Ecology, Evolution, Behavior and Systematics, Binding selectivity, Inhibitors, Protein, Applied Mathematics, Small molecules, Neurodegeneration, Proteins, medicine.disease, Virus Diseases, Modeling and Simulation, Neoplasm, Signal transduction, General Agricultural and Biological Sciences, inhibitors, small molecules, protein–protein interactions, Small molecule, Function (biology), Human, Protein Binding
Abstract

The interaction between proteins is a fundamental event for cellular life that is generally mediated by specialized protein domains or modules. PDZ domains are the largest class of protein–protein interaction modules, involved in several cellular pathways such as signal transduction, cell–cell junctions, cell polarity and adhesion, and protein trafficking. Because of that, dysregulation of PDZ domain function often causes the onset of pathologies, thus making this family of domains an interesting pharmaceutical target. In this review article we provide an overview of the structural and functional features of PDZ domains and their involvement in the cellular and molecular pathways at the basis of different human pathologies. We also discuss some of the strategies that have been developed with the final goal to hijack or inhibit the interaction of PDZ domains with their ligands. Because of the generally low binding selectivity of PDZ domain and the scarce efficiency of small molecules in inhibiting PDZ binding, this task resulted particularly difficult to pursue and still demands increasing experimental efforts in order to become completely feasible and successful in vivo.

Published
2021
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42. Model-driven engineering city spaces via bidirectional model transformations

Author

Zhenjiang Hu, Christos Tsigkanos, Carlo Ghezzi, and Ennio Visconti

Subjects
Theoretical computer science, Computer science, Special Section Paper, CityGML, 020207 software engineering, Context (language use), 02 engineering and technology, Digital twins, 01 natural sciences, Domain (software engineering), Development (topology), Bidirectional model transformations, Modeling and Simulation, Informatics, 0103 physical sciences, Physical space, Synchronization (computer science), 0202 electrical engineering, electronic engineering, information engineering, Model-driven engineering, Model-driven architecture, 010306 general physics, computer, Software, computer.programming_language
Abstract

Engineering cyber-physical systems inhabiting contemporary urban spatial environments demands software engineering facilities to support design and operation. Tools and approaches in civil engineering and architectural informatics produce artifacts that are geometrical or geographical representations describing physical spaces. The models we consider conform to the CityGML standard; although relying on international standards and accessible in machine-readable formats, such physical space descriptions often lack semantic information that can be used to support analyses. In our context, analysis as commonly understood in software engineering refers to reasoning on properties of an abstracted model—in this case a city design. We support model-based development, firstly by providing a way to derive analyzable models from CityGML descriptions, and secondly, we ensure that changes performed are propagated correctly. Essentially, a digital twin of a city is kept synchronized, in both directions, with the information from the actual city. Specifically, our formal programming technique and accompanying technical framework assure that relevant information added, or changes applied to the domain (resp. analyzable) model are reflected back in the analyzable (resp. domain) model automatically and coherently. The technique developed is rooted in the theory of bidirectional transformations, which guarantees that synchronization between models is consistent and well behaved. Produced models can bootstrap graph-theoretic, spatial or dynamic analyses. We demonstrate that bidirectional transformations can be achieved in practice on real city models.

Published
2021
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43. Why you cannot even hope to use Ore algebras in Cryptography

Author

Michela Ceria, Teo Mora, and Andrea Visconti

Subjects
Discrete mathematics, Polynomial, Ring (mathematics), Algebra and Number Theory, Reduction (recursion theory), business.industry, Applied Mathematics, Order (ring theory), Cryptography, Buchberger reduction, Theory of computation, Multivariate Ore extensions, Key exchange, business, Mathematics
Abstract

We adapt tag-variables and Buchberger reduction in order, given two elements, $$pg\in R$$ into an effective ring R, to express g as the evaluation of a polynomial $$f(X)\in R[X]$$ at p, $$g=f(p)$$ . As a by-product, we present also an attack to a couple of Cryptographical protocols.

Published
2021
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44. Author Correction: Global priority areas for ecosystem restoration

Author

Strassburg, Bernardo B. N., primary, Iribarrem, Alvaro, additional, Beyer, Hawthorne L., additional, Cordeiro, Carlos Leandro, additional, Crouzeilles, Renato, additional, Jakovac, Catarina C., additional, Braga Junqueira, André, additional, Lacerda, Eduardo, additional, Latawiec, Agnieszka E., additional, Balmford, Andrew, additional, Brooks, Thomas M., additional, Butchart, Stuart H. M., additional, Chazdon, Robin L., additional, Erb, Karl-Heinz, additional, Brancalion, Pedro, additional, Buchanan, Graeme, additional, Cooper, David, additional, Díaz, Sandra, additional, Donald, Paul F., additional, Kapos, Valerie, additional, Leclère, David, additional, Miles, Lera, additional, Obersteiner, Michael, additional, Plutzar, Christoph, additional, de M. Scaramuzza, Carlos Alberto, additional, Scarano, Fabio R., additional, and Visconti, Piero, additional

Published
2022
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46. Capacity of countries to reduce biological invasions

Author

Latombe, Guillaume, primary, Seebens, Hanno, additional, Lenzner, Bernd, additional, Courchamp, Franck, additional, Dullinger, Stefan, additional, Golivets, Marina, additional, Kühn, Ingolf, additional, Leung, Brian, additional, Roura-Pascual, Núria, additional, Cebrian, Emma, additional, Dawson, Wayne, additional, Diagne, Christophe, additional, Jeschke, Jonathan M., additional, Pérez-Granados, Cristian, additional, Moser, Dietmar, additional, Turbelin, Anna, additional, Visconti, Piero, additional, and Essl, Franz, additional

Published
2022
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47. Reply to: Restoration prioritization must be informed by marginalized people

Author

Strassburg, Bernardo B. N., primary, Iribarrem, Alvaro, additional, Beyer, Hawthorne L., additional, Cordeiro, Carlos Leandro, additional, Crouzeilles, Renato, additional, Jakovac, Catarina, additional, Junqueira, André Braga, additional, Lacerda, Eduardo, additional, Latawiec, Agnieszka E., additional, Balmford, Andrew, additional, Brooks, Thomas M., additional, Butchart, Stuart H. M., additional, Chazdon, Robin L., additional, Erb, Karl-Heinz, additional, Brancalion, Pedro, additional, Buchanan, Graeme, additional, Cooper, David, additional, Díaz, Sandra, additional, Donald, Paul F., additional, Kapos, Valerie, additional, Leclère, David, additional, Miles, Lera, additional, Obersteiner, Michael, additional, Plutzar, Christoph, additional, Scaramuzza, Carlos Alberto de Mattos, additional, Scarano, Fabio R., additional, and Visconti, Piero, additional

Published
2022
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48. Difference in the neurocognitive functions of WLWH and MLWH in an Italian cohort of people living with HIV

Author

Donne, Valentina Delle, primary, Massaroni, Valentina, additional, Ciccarelli, Nicoletta, additional, Lombardi, Francesca, additional, Borghetti, Alberto, additional, Ciccullo, Arturo, additional, Dusina, Alex, additional, Farinacci, Damiano, additional, Baldin, Ganmaria, additional, Visconti, Elena, additional, Tamburrini, Enrica, additional, and Di Giambenedetto, Simona, additional

Published
2022
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49. Post-ROSC peripheral perfusion index discriminates 30-day survival after out-of-hospital cardiac arrest

Author

Antonella De Pirro, Luigi Oltrona Visconti, Enrico Baldi, Rosa Fracchia, Francesca Romana Gentile, Simone Savastano, Laura Frigerio, Fabio Sciutti, Alessandra Palo, Roberto Primi, Enrico Contri, and Sara Compagnoni

Subjects
Adult, Male, Resuscitation, medicine.medical_specialty, Perfusion index, 030204 cardiovascular system & hematology, Out of hospital cardiac arrest, 03 medical and health sciences, 0302 clinical medicine, Peripheral perfusion, Predictive Value of Tests, Internal medicine, Internal Medicine, medicine, Humans, Registries, 030212 general & internal medicine, Aged, Retrospective Studies, Proportional hazards model, business.industry, Middle Aged, Prognosis, Cardiopulmonary Resuscitation, Perfusion Index, Survival Rate, Blood pressure, Emergency Medicine, Cardiology, Bystander cpr, Female, business, Perfusion, Out-of-Hospital Cardiac Arrest
Abstract

Prognostication after an out-of-hospital cardiac arrest (OHCA) remains a challenge. The peripheral-derived perfusion index (PI) is a simple and non-invasive way to assess perfusion. We sought to assess whether the PI was able to discriminate the prognosis of patients resuscitated from an OHCA. All the reports generated by the manual monitor/defibrillator (Corpuls 3 by GS Elektromedizinische Gerate G. Stemple GmbH, Germany) used for all the OHCAs who achieved ROSC treated by our Emergency Medical Service from January 2015 to December 2018 were reviewed. The mean PI value of each minute after ROSC was automatically provided by the device and the mean value of 30 min of monitoring (MPI30) was calculated. Pre-hospital data were collected according to the Utstein 2014 recommendations. Among 1,909 resuscitation attempts, ROSC was achieved in 346 and it was possible to calculate an MPI30 in 164. MPI30 was higher in the patients who survived at 30 days [1.6 (95% CI 1.2–2.1) vs 1 (95% CI 0.8–1.3), p = 0.0017]. At the multivariable Cox regression model, after correction for shockable rhythm, witnessed status, bystander CPR, age, and blood pressure, MPI30 was found to be an independent predictor of both 30-day mortality [RR 0.83 (95% CI 0.69–0.99), p = 0.036] and 30-day mortality or poor neurologic outcome [RR 0.85 (95% CI 0.72–0.99), p = 0.04]. Overall 30-day survival with good neurologic outcome was significantly different in the three tertiles [T1: 0.1–0.8; T2: 0.9–1.8 and T3: 1.82–7.8, log-rank p = 0.007]. The post-ROSC peripheral perfusion index was found to be an independent predictor of 30-day mortality or poor neurologic outcome. It could help prognostication in OHCA patients.

Published
2020
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50. Transaxillary Nipple-Sparing Mastectomy and Direct-to-Implant Breast Reconstruction Using a Simplified Endoscopic Approach: Indications, Cosmetic Outcomes and Technical Refinements

Author

Riccardo Masetti, Liliana Barone-Adesi, Giorgia Garganese, Giuseppe Visconti, Alessandro Bianchi, Marzia Salgarello, and Gianluca Franceschini

Subjects
medicine.medical_specialty, Settore MED/18 - CHIRURGIA GENERALE, Breast surgery, medicine.medical_treatment, 030230 surgery, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, Breast cancer, Endoscopic breast implant, 0302 clinical medicine, Patient satisfaction, law, Breast implant, medicine, business.industry, Endoscopic breast surgery, Axillary breast surgery, medicine.disease, Surgery, Plastic surgery, Otorhinolaryngology, business, Breast reconstruction, Mastectomy
Abstract

The increasing demand for further aesthetic outcome improvement in implant-based breast reconstruction after nipple-sparing mastectomy (NSM) leads to major novelties, including endoscopic and robotic NSM with the aim to limit scar visibility. In this paper, we report our experience with a novel and simplified surgical approach—single-axillary-incision non-endoscopic NSM and node surgery followed by an endoscopic DTI breast reconstruction—by focusing on reconstructive indications, technical refinements and aesthetic outcomes. Between June 2016 and October 2019, 14 women underwent this novel technique using definitive anatomical silicone gel filled, totaling 20 breasts. Reconstructive evaluation methods were clinically and photography-based assessment. Breast-Q has been used to quantify patient satisfaction. Feasibility and safety data are also provided. The average follow-up time was 11 months (range 3–42 months). No local–regional recurrence occurred during follow-up. Median operation time was 340 min; mean hospital stay was 4.1 days. The average mastectomy specimen weight was on average 139 g (ranging from 98 to 182 g). The average implant volume for the reconstructed side was 306 cc (ranging from 165 to 550 cc). Patients’ satisfaction was high to very high. Authors’ experience suggests that non-endoscopic transaxillary NSM, node surgery and endoscopic direct-to-implant breast reconstruction is a valid, oncological safe, aesthetically sound scarless option in breast cancer patients with small to moderate breast size. It should represent the incision of choice in patient with previous breast surgery with scars that may compromise flap/NAC vascularity using traditional NSM incisions. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Published
2020
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