93 results on '"Achilli A."'
Search Results
2. Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing
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Chen, Ningbo, primary, Xia, Xiaoting, additional, Hanif, Quratulain, additional, Zhang, Fengwei, additional, Dang, Ruihua, additional, Huang, Bizhi, additional, Lyu, Yang, additional, Luo, Xiaoyu, additional, Zhang, Hucai, additional, Yan, Huixuan, additional, Wang, Shikang, additional, Wang, Fuwen, additional, Chen, Jialei, additional, Guan, Xiwen, additional, Liu, Yangkai, additional, Li, Shuang, additional, Jin, Liangliang, additional, Wang, Pengfei, additional, Sun, Luyang, additional, Zhang, Jicai, additional, Liu, Jianyong, additional, Qu, Kaixing, additional, Cao, Yanhong, additional, Sun, Junli, additional, Liao, Yuying, additional, Xiao, Zhengzhong, additional, Cai, Ming, additional, Mu, Lan, additional, Siddiki, Amam Zonaed, additional, Asif, Muhammad, additional, Mansoor, Shahid, additional, Babar, Masroor Ellahi, additional, Hussain, Tanveer, additional, Silva, Gamamada Liyanage Lalanie Pradeepa, additional, Gorkhali, Neena Amatya, additional, Terefe, Endashaw, additional, Belay, Gurja, additional, Tijjani, Abdulfatai, additional, Zegeye, Tsadkan, additional, Gebre, Mebrate Genet, additional, Ma, Yun, additional, Wang, Yu, additional, Huang, Yongzhen, additional, Lan, Xianyong, additional, Chen, Hong, additional, Migliore, Nicola Rambaldi, additional, Colombo, Giulia, additional, Semino, Ornella, additional, Achilli, Alessandro, additional, Sinding, Mikkel-Holger S., additional, Lenstra, Johannes A., additional, Cheng, Haijian, additional, Lu, Wenfa, additional, Hanotte, Olivier, additional, Han, Jianlin, additional, Jiang, Yu, additional, and Lei, Chuzhao, additional
- Published
- 2023
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3. Underactuated embedded constraints gripper for grasping in toxic environments
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Achilli, Gabriele Maria, primary, Logozzo, Silvia, additional, Malvezzi, Monica, additional, and Valigi, Maria Cristina, additional
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- 2023
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4. Mid-term oncological outcomes after complete versus conventional mesocolic excision for right-sided colon cancer: a propensity score matching analysis
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Alessandro Giani, Camillo Leonardo Bertoglio, Michele Mazzola, Irene Giusti, Pietro Achilli, Pietro Carnevali, Matteo Origi, Carmelo Magistro, and Giovanni Ferrari
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Kidney Neoplasms ,Cohort Studies ,Postoperative Complications ,Treatment Outcome ,Colonic Neoplasms ,Humans ,Lymph Node Excision ,Laparoscopy ,Surgery ,Propensity Score ,Carcinoma, Renal Cell ,Colectomy ,Mesocolon ,Retrospective Studies - Abstract
The correct extent of mesocolic dissection for right-sided colon cancer (RCC) is still under debate. Complete mesocolic excision (CME) has not gained wide diffusion, mainly due to its technical complexity and unclear oncological superiority. This study aims to evaluate oncological outcomes of CME compared with non-complete mesocolic excision (NCME) during resection for I-III stage RCC.Prospectively collected data of patients who underwent surgery between 2010 and 2018 were retrospectively analysed. 1:1 Propensity score matching (PSM) was used to balance baseline characteristics of CME and NCME patients. The primary endpoint of the study was local recurrence-free survival (LRFS). The two groups were also compared in terms of short-term outcomes, distant recurrence-free survival, disease-free survival, and overall survival.Of the 444 patients included in the study, 292 were correctly matched after PSM, 146 in each group. The median follow-up was 45 months (IQR 33-63). Conversion rate, complications, and 90-day mortality were comparable in both groups. The median number of lymph nodes harvested was higher in CME patients (23 vs 19, p = 0.034). 3-year LRFS rates for CME patients was 100% and 95.6% for NCME (log-rank p = 0.028). At 3 years, there were no differences between the groups in terms of overall survival, distant recurrence-free survival, and disease-free survival.Our PSM cohort study shows that CME is safe, provides a higher number of lymph nodes harvested, and is associated with better local recurrence-free survival.
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- 2022
5. High prevalence of sensitization to non-specific lipid transfer protein in adult patients with primary eosinophilic gastrointestinal disorders in Italy: a single center series
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Carlo Maria Rossi, Marco Vincenzo Lenti, Giovanna Achilli, Stefania Merli, Aurelio Mauro, Andrea Anderloni, and Antonio Di Sabatino
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Immunology ,Immunology and Allergy ,Molecular Biology - Published
- 2022
6. High prevalence of sensitization to non-specific lipid transfer protein in adult patients with primary eosinophilic gastrointestinal disorders in Italy: a single center series
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Rossi, Carlo Maria, primary, Lenti, Marco Vincenzo, additional, Achilli, Giovanna, additional, Merli, Stefania, additional, Mauro, Aurelio, additional, Anderloni, Andrea, additional, and Di Sabatino, Antonio, additional
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- 2022
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7. Population structure, allelic variation at Rht-B1 and Ppd-A1 loci and its effects on agronomic traits in Argentinian durum wheat
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Ana Laura Achilli, Pablo Federico Roncallo, Adelina Olga Larsen, Susanne Dreisigacker, and Viviana Echenique
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Phenotype ,Multidisciplinary ,Genotype ,Edible Grain ,Genes, Plant ,Alleles ,Triticum - Abstract
Exploring the genetic variability in yield and yield-related traits is essential to continue improving genetic gains. Fifty-nine Argentinian durum wheat cultivars were analyzed for important agronomic traits in three field experiments. The collection was genotyped with 3565 genome-wide SNPs and functional markers in order to determine the allelic variation at Rht-B1 and Ppd-A1 genes. Population structure analyses revealed the presence of three main groups, composed by old, modern and genotypes with European or CIMMYT ancestry. The photoperiod sensitivity Ppd-A1b allele showed higher frequency (75%) than the insensitivity one Ppd-A1a (GS105). The semi-dwarfism Rht-B1b and the Ppd-A1a (GS105) alleles were associated with increases in harvest index and decreases in plant height, grain protein content and earlier heading date, although only the varieties carrying the Rht-B1 variants showed differences in grain yield. Out of the two main yield components, grain number per plant was affected by allelic variants at Rht-B1 and Ppd-A1 loci, while no differences were observed in thousand kernel weight. The increases in grain number per spike associated with Rht-B1b were attributed to a higher grain number per spikelet, whereas Ppd-A1a (GS105) was associated with higher grain number per spikelet, but also with lower spikelets per spike.
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- 2022
8. Laparoscopic right hemicolectomy for hepatic flexure adenocarcinoma with complete mesocolic excision and 3D-CT vascular reconstruction
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Giusti, I., primary, Carnevali, P., additional, Bertoglio, C. L., additional, Giani, A., additional, Achilli, P., additional, Grimaldi, S., additional, Origi, M., additional, Mazzola, M., additional, Magistro, C., additional, and Ferrari, G., additional
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- 2022
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9. Population structure, allelic variation at Rht-B1 and Ppd-A1 loci and its effects on agronomic traits in Argentinian durum wheat
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Achilli, Ana Laura, primary, Roncallo, Pablo Federico, additional, Larsen, Adelina Olga, additional, Dreisigacker, Susanne, additional, and Echenique, Viviana, additional
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- 2022
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10. Mid-term oncological outcomes after complete versus conventional mesocolic excision for right-sided colon cancer: a propensity score matching analysis
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Giani, Alessandro, primary, Bertoglio, Camillo Leonardo, additional, Mazzola, Michele, additional, Giusti, Irene, additional, Achilli, Pietro, additional, Carnevali, Pietro, additional, Origi, Matteo, additional, Magistro, Carmelo, additional, and Ferrari, Giovanni, additional
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- 2022
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11. Robotic surgery for rectal cancer as a platform to build on: review of current evidence
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David W. Larson, Pietro Achilli, and Fabian Grass
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Laparoscopic surgery ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Operative Time ,03 medical and health sciences ,0302 clinical medicine ,Robotic Surgical Procedures ,medicine ,Humans ,Robotic surgery ,Laparoscopy ,Digestive System Surgical Procedures ,Quality of Health Care ,medicine.diagnostic_test ,business.industry ,General surgery ,Margins of Excision ,Cancer ,Workload ,Health Care Costs ,General Medicine ,Length of Stay ,medicine.disease ,Total mesorectal excision ,Colorectal surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Colorectal Neoplasms ,business ,Learning Curve - Abstract
Laparoscopy in colorectal surgery reduces the rate of postoperative complications, shortens the length of stay in hospital, and improves the quality of patient care. Despite these established benefits, the technical challenges of rectal resection for cancer have resulted in most operations being performed through open surgery in the USA. Moreover, controversy in the current literature questions the oncologic safety of a laparoscopic approach for rectal cancer. How then can surgeons innovate to overcome the technical challenges while preserving the critical oncological outcomes of high-quality rectal cancer surgery? Robotics may be a platform that allows us to overcome the technical challenges in the pelvis while maintaining both oncological outcomes and the benefits of a minimally invasive technique. Current evidence suggests that the quality of total mesorectal excision, the rates of circumferential margin involvement, and postoperative outcomes are comparable between robotic and laparoscopic surgery. While a robotic approach demonstrates lower conversion rates and reduced surgeon workload, the operative time is longer and initial costs are higher; however, time and future science will determine its true benefits. We review the current state of robotic surgery and its impact on rectal cancer surgery.
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- 2020
12. Biomolecular insights into North African-related ancestry, mobility and diet in eleventh-century Al-Andalus
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Anna Olivieri, Ali Madour, Tarek Shoeib, Martin B. Richards, João Guimarães, Marina Silva, Gonzalo Oteo-García, Pierre Justeau, Pedro Soares, António Brehm, Antònia Flaquer, Krista McGrath, Douglas J. Clarke, Antonio Torroni, Antonio Salas, Alessandro Achilli, Francesca Gandini, Peter Ditchfield, Alessandro Fichera, Alexandra Rosa, Katharina Dulias, Teresa Rito, Jarosław Bryk, Alberto Gómez-Carballa, Michelle Alexander, Bobby Yau, Amparo Barrachina, Vicente Palomar, Maria Pala, Ceiridwen J. Edwards, M. George B. Foody, Rui Martiniano, Matthew von Tersch, Apollo - University of Cambridge Repository, and Universidade do Minho
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Humanidades::História e Arqueologia ,Population genetics ,Immigration ,Eleventh ,Africa, Northern ,Peninsula ,Phylogeny ,media_common ,education.field_of_study ,Multidisciplinary ,geography.geographical_feature_category ,article ,Islam ,GF ,FOS: Sociology ,Phylogeography ,Archaeology ,631/181/19 ,GN ,Medicine ,Genetic Background ,media_common.quotation_subject ,Science ,Human Migration ,Population ,Ancient history ,Evolutionary genetics ,Mosaic ,631/181/27 ,QH301 ,Humans ,631/181/457 ,education ,QH426 ,geography ,Ciências Naturais::Ciências Biológicas ,Science & Technology ,Genome, Human ,QH ,History, Medieval ,QR ,Diet ,Ancient DNA ,Genetics, Population ,631/181/2474 ,Spain ,Anthropology - Abstract
Supplementary Information: The online version contains supplementary material available at https://doi.org/ 10.1038/s41598-021-95996-3., Sequence data for UE2298/MS060 can be downloaded from the European Nucleotide Archive (accession number: PRJEB47085). Newly reported present-day mtDNA sequences are deposited into GenBank (MZ920249 - MZ921390). Additional requests should be addressed to: marina.silva@crick.ac.uk; gonzalo.oteo-garcia@hud. ac.uk; m.b.richards@hud.ac.uk., Historical records document medieval immigration from North Africa to Iberia to create Islamic al-Andalus. Here, we present a low-coverage genome of an eleventh century CE man buried in an Islamic necropolis in Segorbe, near Valencia, Spain. Uniparental lineages indicate North African ancestry, but at the autosomal level he displays a mosaic of North African and European-like ancestries, distinct from any present-day population. Altogether, the genome-wide evidence, stable isotope results and the age of the burial indicate that his ancestry was ultimately a result of admixture between recently arrived Amazigh people (Berbers) and the population inhabiting the Peninsula prior to the Islamic conquest. We detect differences between our sample and a previously published group of contemporary individuals from Valencia, exemplifying how detailed, small-scale aDNA studies can illuminate fine-grained regional and temporal differences. His genome demonstrates how ancient DNA studies can capture portraits of past genetic variation that have been erased by later demographic shifts-in this case, most likely the seventeenth century CE expulsion of formerly Islamic communities as tolerance dissipated following the Reconquista by the Catholic kingdoms of the north., We thank the Museo Municipal de Arqueologia y Etnologia de Segorbe for granting access to their collections and the Conselleria d'Educacio, Investigacio, Cultura i Esport de la Generalitat Valenciana for granting the permissions for the study. We thank Lara Cassidy, Valeria Mattiangeli and Dan Bradley for valuable advice and technical support. Part of this work was delivered via the BBSRC National Capability in Genomics and Single Cell Analysis (BBS/E/T/000PR9816) at Earlham Institute by members of the Genomics Pipelines and Core Bioinformatics Groups. We wish to acknowledge the use of the Orion High Performance Computing cluster at the School of Applied Sciences, University of Huddersfield. M.S., G.O.G., A.Fi., P.J., M.G.B.F., K.D., B.Y. were supported by a Leverhulme Doctoral Scholarship awarded to M.B.R. and M.P. P.S., M.B.R., and M.P. acknowledge FCT (Fundacao para a Ciencia e a Tecnologia) support through project PTDC/EPH-ARQ/4164/2014, partially funded by FEDER funds (COMPETE 2020 project 016899). P.S., A.Br., A.R. and T.R. acknowledge FCT support through project PTDC/SOC-ANT/30316/2017. P.S. acknowledges the "Contrato-Programa" UIDB/04050/2020 and contract CEECINST/0007772018 funded by FCT I.P. A.A., A.O., and A.T. acknowledge the support of the Italian Ministry of Education, University and Research for the projects "Dipartimenti di Eccellenza" Program (2018-2022) -Department of Biology and Biotechnology "L. Spallanzani," University of Pavia and PRIN2017 20174BTC4R. The KORA research platform (KORA, Cooperative Research in the Region of Augsburg) was initiated and financed by the Helmholtz Zentrum Munchen -German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria. Furthermore, KORA research was supported within the Munich Center of Health Sciences (MC Health), LudwigMaximilians-Universitat, as part of LMUinnovativ.
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- 2021
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13. Laparoscopic right hemicolectomy for hepatic flexure adenocarcinoma with complete mesocolic excision and 3D-CT vascular reconstruction
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I. Giusti, P. Carnevali, C. L. Bertoglio, A. Giani, P. Achilli, S. Grimaldi, M. Origi, M. Mazzola, C. Magistro, and G. Ferrari
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Gastroenterology ,Surgery - Published
- 2022
14. Biomolecular insights into North African-related ancestry, mobility and diet in eleventh-century Al-Andalus
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Silva, Marina, primary, Oteo-García, Gonzalo, additional, Martiniano, Rui, additional, Guimarães, João, additional, von Tersch, Matthew, additional, Madour, Ali, additional, Shoeib, Tarek, additional, Fichera, Alessandro, additional, Justeau, Pierre, additional, Foody, M. George B., additional, McGrath, Krista, additional, Barrachina, Amparo, additional, Palomar, Vicente, additional, Dulias, Katharina, additional, Yau, Bobby, additional, Gandini, Francesca, additional, Clarke, Douglas J., additional, Rosa, Alexandra, additional, Brehm, António, additional, Flaquer, Antònia, additional, Rito, Teresa, additional, Olivieri, Anna, additional, Achilli, Alessandro, additional, Torroni, Antonio, additional, Gómez-Carballa, Alberto, additional, Salas, Antonio, additional, Bryk, Jaroslaw, additional, Ditchfield, Peter W., additional, Alexander, Michelle, additional, Pala, Maria, additional, Soares, Pedro A., additional, Edwards, Ceiridwen J., additional, and Richards, Martin B., additional
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- 2021
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15. Completely intracorporeal anastomosis in robotic left colonic and rectal surgery: technique and 30-day outcomes
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Achilli, Pietro, primary, Perry, William, additional, Grass, Fabian, additional, Abd El Aziz, Mohamed A., additional, Kelley, Scott R., additional, Larson, David W., additional, and Behm, Kevin T., additional
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- 2021
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16. Linkage disequilibrium patterns, population structure and diversity analysis in a worldwide durum wheat collection including Argentinian genotypes
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Roncallo, Pablo Federico, primary, Larsen, Adelina Olga, additional, Achilli, Ana Laura, additional, Pierre, Carolina Saint, additional, Gallo, Cristian Andrés, additional, Dreisigacker, Susanne, additional, and Echenique, Viviana, additional
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- 2021
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17. Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy
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Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, de Andreis, Federica Borrelli, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,030204 cardiovascular system & hematology ,Single Center ,Tertiary referral hospital ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,Medicine ,cardiovascular diseases ,Mean platelet volume ,biology ,SARS-CoV-2 ,business.industry ,Pulmonary embolism ,C-reactive protein ,Anticoagulants ,Thrombosis ,equipment and supplies ,medicine.disease ,Im - Original ,030220 oncology & carcinogenesis ,biology.protein ,Emergency Medicine ,Observational study ,business - Abstract
Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score > 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p p p = 0.002 and p = 0.005, respectively). No significant difference was found in d-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.
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- 2020
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18. Mitochondrial genomes from modern and ancient Turano-Mongolian cattle reveal an ancient diversity of taurine maternal lineages in East Asia
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Xia, Xiao-Ting, primary, Achilli, Alessandro, additional, Lenstra, Johannes A., additional, Tong, Bin, additional, Ma, Yun, additional, Huang, Yong-Zhen, additional, Han, Jian-Lin, additional, Sun, Zhou-Yong, additional, Chen, Hong, additional, Lei, Chu-Zhao, additional, Hu, Song-Mei, additional, and Chen, Ning-Bo, additional
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- 2021
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19. Author Correction: Uncovering the sources of DNA found on the Turin Shroud
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Barcaccia, Gianni, primary, Galla, Giulio, additional, Achilli, Alessandro, additional, Olivieri, Anna, additional, and Torroni, Antonio, additional
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- 2021
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20. Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy
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Lenti, Marco Vincenzo, Borrelli de Andreis, Federica, Pellegrino, Ivan, Klersy, Catherine, Merli, Stefania, Miceli, Emanuela, Aronico, Nicola, Mengoli, Caterina, Di Stefano, Michele, Cococcia, Sara, Santacroce, Giovanni, Soriano, Simone, Melazzini, Federica, Delliponti, Mariangela, Baldanti, Fausto, Triarico, Antonio, Corazza, Gino Roberto, Pinzani, Massimo, Di Sabatino, Antonio, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Derosa, Giuseppe, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mugellini, Amedeo, Muggia, Chiara, Noris, Patrizia, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Torello Vjera, Francesca, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Freddi, Giulia, Frigerio, Chiara, Fumoso, Federica, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Savioli, Jessica, Spataro, Carmine, and Stefani, Debora
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Adult ,Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Pneumonia, Viral ,030204 cardiovascular system & hematology ,Acute respiratory failure ,Chronic liver disease ,Hepatitis ,03 medical and health sciences ,0302 clinical medicine ,Intensive care ,Internal medicine ,Patients' Rooms ,medicine ,Internal Medicine ,Humans ,030212 general & internal medicine ,Pandemics ,Aged ,Retrospective Studies ,Aged, 80 and over ,Liver injury ,medicine.diagnostic_test ,business.industry ,COVID-19 ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Im - Original ,Coronavirus ,Hospitalization ,Severe acute respiratory syndrome ,Italy ,Liver ,Emergency Medicine ,Female ,Liver function ,Coronavirus Infections ,business ,Liver function tests ,Liver Failure - Abstract
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO2/FiO2
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- 2020
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21. Cattle mitogenome variation reveals a post-glacial expansion of haplogroup P and an early incorporation into northeast Asian domestic herds
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Mannen, Hideyuki, primary, Yonezawa, Takahiro, additional, Murata, Kako, additional, Noda, Aoi, additional, Kawaguchi, Fuki, additional, Sasazaki, Shinji, additional, Olivieri, Anna, additional, Achilli, Alessandro, additional, and Torroni, Antonio, additional
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- 2020
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22. The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains
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Modi, Alessandra, primary, Lancioni, Hovirag, additional, Cardinali, Irene, additional, Capodiferro, Marco R., additional, Rambaldi Migliore, Nicola, additional, Hussein, Abir, additional, Strobl, Christina, additional, Bodner, Martin, additional, Schnaller, Lisa, additional, Xavier, Catarina, additional, Rizzi, Ermanno, additional, Bonomi Ponzi, Laura, additional, Vai, Stefania, additional, Raveane, Alessandro, additional, Cavadas, Bruno, additional, Semino, Ornella, additional, Torroni, Antonio, additional, Olivieri, Anna, additional, Lari, Martina, additional, Pereira, Luisa, additional, Parson, Walther, additional, Caramelli, David, additional, and Achilli, Alessandro, additional
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- 2020
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23. An underestimated “false negative COVID cholecystitis” in Northern Italy and the contagion of a surgical ward: it can happen everywhere
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Giulio, Mari, primary, Achilli, Pietro, additional, and Dario, Maggioni, additional
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- 2020
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24. Robotic surgery for rectal cancer as a platform to build on: review of current evidence
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Achilli, Pietro, primary, Grass, Fabian, additional, and Larson, David W., additional
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- 2020
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25. Preoperative immunonutrition in frail patients with colorectal cancer: an intervention to improve postoperative outcomes
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Achilli, Pietro, primary, Mazzola, Michele, additional, Bertoglio, Camillo Leonardo, additional, Magistro, Carmelo, additional, Origi, Matteo, additional, Carnevali, Pietro, additional, Gervasi, Federico, additional, Mastellone, Carmen, additional, Guanziroli, Nicoletta, additional, Corradi, Ettore, additional, and Ferrari, Giovanni, additional
- Published
- 2019
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26. Radiosynthesis of Gold/Albumin Core/shell Nanoparticles for Biomedical Applications
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Mariano Grasselli, Constanza Yanel Flores, and Estefania Achilli
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Nanotecnología ,0301 basic medicine ,Materials science ,Nanostructure ,NANOSTRUCTURE ,Mechanical Engineering ,Radiosynthesis ,Albumin ,Nanoparticle ,RADIATION EFFECTS ,INGENIERÍAS Y TECNOLOGÍAS ,Nano-materiales ,Condensed Matter Physics ,03 medical and health sciences ,030104 developmental biology ,Mechanics of Materials ,Colloidal gold ,Microscopy ,AU ,General Materials Science ,Fourier transform infrared spectroscopy ,Plasmon ,Nuclear chemistry - Abstract
Gold/albumin core/shell nanoparticles (Au/AlbNPs) was prepared by a novel aggregation/crosslinking technique and characterized by several spectroscopic and microscopy methods. Albumin, in presence of gold nanoparticles (AuNPs), is aggregated by the addition of ethanol and further stabilized by radiation-induced crosslinking using a 60Co source. Nanoconstructs are characterized to determine size, morphology and optical characteristics. The Au/AlbNPs were prepared in different ethanol and albumins concentrations. Results showed that it is possible to obtain Au/AlbNPs using ethanol 30 %v/v, albumin in different concentrations and an irradiation dose of 10 kGy. Au/AlbNP plasmon peak shifted to 530 nm, keeping the typical plasmon peak shape. The size of Au/AlbNPs is approximately double respect to the naked AuNPs and they show core/shell type morphology. The main amide peaks of albumin in FTIR spectrum can be found in the spectrum of nanoconstructs. Fil: Flores, Constanza Yanel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de la Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB; Argentina Fil: Achilli, Estefanía Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de la Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB; Argentina Fil: Grasselli, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de la Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología-Universidad Nacional de Quilmes - GBEyB; Argentina
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- 2017
27. An underestimated 'false negative COVID cholecystitis' in Northern Italy and the contagion of a surgical ward: it can happen everywhere
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Mari Giulio, Pietro Achilli, and Maggioni Dario
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Infectious disease transmission ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,General surgery ,False Negative Reactions ,medicine.disease ,Surgery ,Northern italy ,medicine ,Cholecystitis ,business ,Letter to the Editor ,Viral etiology - Published
- 2020
28. Correction to: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy
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Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, Borrelli de Andreis, Federica, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina
- Subjects
Adult ,Male ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,MEDLINE ,Tertiary referral hospital ,Single Center ,Statistics, Nonparametric ,Tertiary Care Centers ,Prevalence ,Internal Medicine ,medicine ,Humans ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Aged ,Retrospective Studies ,Aged, 80 and over ,Academic Medical Centers ,Task force ,business.industry ,Correction ,COVID-19 ,Venous Thromboembolism ,Middle Aged ,Northern italy ,Italy ,Emergency medicine ,Emergency Medicine ,Female ,business ,Venous thromboembolism - Abstract
Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p 0.0001) or lactate dehydrogenase (LDH) (p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p 0.0001). Platelet-to-lymphocyte ratio significantly correlated with CRP (p 0.0001). The majority of VTE patients was male and younger compared to non-VTE patients (p = 0.002 and p = 0.005, respectively). No significant difference was found in D-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.
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- 2021
29. Linking cell function with perfusion: insights from the transcatheter delivery of bone marrow-derived CD133+ cells in ischemic refractory cardiomyopathy trial (RECARDIO)
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Paolo Scacciatella, Piergiuseppe Agostoni, Giuseppe Gaipa, Giulio Pompilio, Erica Rurali, Alberto Bestetti, Daniela Belotti, Corrado Carbucicchio, Fabrizio Celeste, Alice Bonomi, Valentina Catto, Felice Achilli, Lorenza Michela Biava, Matteo Parma, Stefano Righetti, Beatrice Bassetti, Maurizio Arosio, and Elisa Gambini
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Male ,0301 basic medicine ,Becaplermin ,Myocardial Ischemia ,Cardiomyopathy ,Gene Expression ,Medicine (miscellaneous) ,030204 cardiovascular system & hematology ,Ventricular Dysfunction, Left ,0302 clinical medicine ,lcsh:QD415-436 ,AC133 Antigen ,Prospective Studies ,Prospective cohort study ,Chemokine CCL5 ,Bone Marrow Transplantation ,lcsh:R5-920 ,Ejection fraction ,Hepatocyte Growth Factor ,Canadian Cardiovascular Society ,Treatment Outcome ,medicine.anatomical_structure ,Cardiology ,Molecular Medicine ,Patient Safety ,Cardiomyopathies ,lcsh:Medicine (General) ,Perfusion ,medicine.medical_specialty ,Ischemia ,Bone Marrow Cells ,Transplantation, Autologous ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Angina Pectoris ,lcsh:Biochemistry ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Humans ,Aged ,Tomography, Emission-Computed, Single-Photon ,Interleukin-6 ,business.industry ,Research ,Cell Biology ,medicine.disease ,Transplantation ,030104 developmental biology ,Bone marrow ,business ,Endocardium - Abstract
Background Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we evaluated the safety and preliminary efficacy of transcatheter delivery of autologous BM-derived advanced therapy medicinal product CD133+ cells (ATMP-CD133) in RA patients, correlating perfusion outcome with cell function. Methods In the phase I “Endocavitary Injection of Bone Marrow Derived CD133+ Cells in Ischemic Refractory Cardiomyopathy” (RECARDIO) trial, a total of 10 patients with left ventricular (LV) dysfunction (ejection fraction ≤ 45%) and evidence of reversible ischemia, as assessed by single-photon emission computed tomography (SPECT), underwent BM aspiration and fluoroscopy-based percutaneous endomyocardial delivery of ATMP-CD133. Patients were evaluated at 6 and 12 months for safety and preliminary efficacy endpoints. ATMP-CD133 samples were used for in vitro correlations. Results Patients were treated safely with a mean number of 6.57 ± 3.45 × 106 ATMP-CD133. At 6-month follow-up, myocardial perfusion at SPECT was significantly ameliorated in terms of changes in summed stress (from 18.2 ± 8.6 to 13.8 ± 7.8, p = 0.05) and difference scores (from 12.0 ± 5.3 to 6.1 ± 4.0, p = 0.02) and number of segments with inducible ischemia (from 7.3 ± 2.2 to 4.0 ± 2.7, p = 0.003). Similarly, Canadian Cardiovascular Society and New York Heart Association classes significantly improved at follow-up vs baseline (p ≤ 0.001 and p = 0.007, respectively). Changes in summed stress score changes positively correlated with ATMP-CD133 release of proangiogenic cytokines HGF and PDGF-bb (r = 0.80, p = 0.009 and r = 0.77, p = 0.01, respectively) and negatively with the proinflammatory cytokines RANTES (r = − 0.79, p = 0.01) and IL-6 (r = − 0.76, p = 0.02). Conclusion Results of the RECARDIO trial suggested safety and efficacy in terms of clinical and perfusion outcomes in patients with RA and LV dysfunction. The observed link between myocardial perfusion improvements and ATMP-CD133 secretome may represent a proof of concept for further mechanistic investigations. Trial registration ClinicalTrials.gov, NCT02059681. Registered 11 February 2014.
- Published
- 2018
30. Challenges and opportunities at the nexus of energy, water, and food: A perspective from the southwest United States
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R. Clayton Shallcross, Shane A. Snyder, Kimberly L. Ogden, Neal R. Armstrong, Andrea Achilli, and Erin L. Armstrong
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Sustainable development ,Renewable Energy, Sustainability and the Environment ,business.industry ,Energy (esotericism) ,Energy Engineering and Power Technology ,02 engineering and technology ,010501 environmental sciences ,021001 nanoscience & nanotechnology ,01 natural sciences ,Electronic, Optical and Magnetic Materials ,Unit (housing) ,Water resources ,Electricity generation ,Mechanics of Materials ,Agriculture ,Production (economics) ,0210 nano-technology ,business ,Environmental planning ,Nexus (standard) ,0105 earth and related environmental sciences - Abstract
Large regions of the United States (and the world) face “situational scarcities” of water that arises from energy extraction and use, agricultural practices, expanding urban populations, and poorly integrated water policies. Creating “fit-for-purpose” water from suboptimal sources will require new materials and a new understanding of the separation of contaminants from complex aqueous media. We review here scientific, technological, and societal challenges at the nexus of energy, water, and food. We focus on specific examples of energy and water stress in the southwestern United States and technological routes to new sources of water. Situational scarcities of water are increasing worldwide because of the reliance on uncertain water sources, coupled with expanding populations, expanded agricultural uses of water, and water and energy use policies that have not always been effectively integrated. This review is framed using the outcomes of recent National Science Foundation workshops focusing on the Energy/Water/Food Nexus and from other recent U.S. Department of Energy workshops focused on the Energy/Water nexus. Water-stressed regions, even after extensive conservation measures, may need new supplies of water that come from less than optimal sources. A basic understanding of the separation of water from complex aqueous solutions along with new materials, distributed and publically accepted technologies and unit operations, underpin the future production of “fit-for-purpose” water. Regional test beds are required that are small and provide for simultaneous control of a number of variables, yet large enough to approximate real communities. Solutions to these problems represent opportunities for innovation and creation of economically viable, resilient communities.
- Published
- 2018
31. Analysis of the human Y-chromosome haplogroup Q characterizes ancient population movements in Eurasia and the Americas
- Author
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Grugni, Viola, primary, Raveane, Alessandro, additional, Ongaro, Linda, additional, Battaglia, Vincenza, additional, Trombetta, Beniamino, additional, Colombo, Giulia, additional, Capodiferro, Marco Rosario, additional, Olivieri, Anna, additional, Achilli, Alessandro, additional, Perego, Ugo A., additional, Motta, Jorge, additional, Tribaldos, Maribel, additional, Woodward, Scott R., additional, Ferretti, Luca, additional, Cruciani, Fulvio, additional, Torroni, Antonio, additional, and Semino, Ornella, additional
- Published
- 2019
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32. GeVn complexes for silicon-based room-temperature single-atom nanoelectronics
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Achilli, Simona, primary, Manini, Nicola, additional, Onida, Giovanni, additional, Shinada, Takahiro, additional, Tanii, Takashi, additional, and Prati, Enrico, additional
- Published
- 2018
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33. Linking cell function with perfusion: insights from the transcatheter delivery of bone marrow-derived CD133+ cells in ischemic refractory cardiomyopathy trial (RECARDIO)
- Author
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Bassetti, Beatrice, primary, Carbucicchio, Corrado, additional, Catto, Valentina, additional, Gambini, Elisa, additional, Rurali, Erica, additional, Bestetti, Alberto, additional, Gaipa, Giuseppe, additional, Belotti, Daniela, additional, Celeste, Fabrizio, additional, Parma, Matteo, additional, Righetti, Stefano, additional, Biava, Lorenza, additional, Arosio, Maurizio, additional, Bonomi, Alice, additional, Agostoni, Piergiuseppe, additional, Scacciatella, Paolo, additional, Achilli, Felice, additional, and Pompilio, Giulio, additional
- Published
- 2018
- Full Text
- View/download PDF
34. Challenges and opportunities at the nexus of energy, water, and food: A perspective from the southwest United States
- Author
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Armstrong, Neal R., primary, Shallcross, R. Clayton, additional, Ogden, Kimberly, additional, Snyder, Shane, additional, Achilli, Andrea, additional, and Armstrong, Erin L., additional
- Published
- 2018
- Full Text
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35. Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report
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Achilli, Pietro, primary, Guttadauro, Angelo, additional, Bonfanti, Paolo, additional, Terragni, Sabina, additional, Fumagalli, Luca, additional, Cioffi, Ugo, additional, Gabrielli, Francesco, additional, De Simone, Matilde, additional, and Chiarelli, Marco, additional
- Published
- 2017
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36. Bulgarians vs the other European populations: a mitochondrial DNA perspective
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Desislava Nesheva, Anna Olivieri, Ornella Semino, Antonio Torroni, Vincenza Battaglia, Sena Karachanak, Alessandro Achilli, Valeria Carossa, Yordan Yordanov, Viola Grugni, Baharak Hooshiar Kashani, Angel S. Galabov, Draga Toncheva, and Maria Pala
- Subjects
Mitochondrial DNA ,Population ,Biology ,DNA, Mitochondrial ,Human mitochondrial genetics ,Haplogroup ,Pathology and Forensic Medicine ,mtDNA ,population genetics ,Ethnicity ,Humans ,Bulgaria ,education ,Genetics ,education.field_of_study ,Haplotype ,Sequence Analysis, DNA ,Haplogroup L3 ,DNA Fingerprinting ,Europe ,Eastern european ,Genetics, Population ,Haplotypes ,Evolutionary biology ,Polymorphism, Restriction Fragment Length ,Human mitochondrial DNA haplogroup - Abstract
To define the matrilineal relationships between Bulgarians and other European populations, we have evaluated the mitochondrial DNA (mtDNA) variation in a sample of 855 Bulgarian subjects from the mtDNA perspective. The molecular survey was performed by sequencing ∼750 bp of the control region, which resulted in 557 different haplotypes, and by a subsequent restriction fragment length polymorphism analysis to confirm haplogroup/subhaplogroup affiliation. The classification was carried out according to the most updated criteria as reported by van Oven and Kayser (Hum Mutat 30:386-394, 2009), allowing the identification of 45 mitochondrial clades. The observed pattern of mtDNA variation indicates that the Bulgarian mitochondrial pool is geographically homogeneous across the country, and that is characterized by an overall extremely high frequency of western Eurasian lineages. In the principal component analysis, Bulgarians locate in an intermediate position between Eastern European and Mediterranean populations, which is in agreement with historical events. Thus, while the Mediterranean legacy could be attributed to the Thracians, indigenous people that firstly inhabited the Balkans, the Eastern contribution is likely due to the Proto-Bulgarians originating from the Middle East and to the Slavs migrating from northeast Europe.
- Published
- 2011
37. Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients
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Ruggeri, Clarissa, primary, Gioffré, Sonia, additional, Achilli, Felice, additional, Colombo, Gualtiero I., additional, and D’Alessandra, Yuri, additional
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- 2017
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38. Radiosynthesis of Gold/Albumin Core/shell Nanoparticles for Biomedical Applications
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Flores, Constanza Y., primary, Achilli, Estefania, additional, and Grasselli, Mariano, additional
- Published
- 2017
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39. Whole Mitogenomes Reveal the History of Swamp Buffalo: Initially Shaped by Glacial Periods and Eventually Modelled by Domestication
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Wang, S., primary, Chen, N., additional, Capodiferro, M. R., additional, Zhang, T., additional, Lancioni, H., additional, Zhang, H., additional, Miao, Y., additional, Chanthakhoun, V., additional, Wanapat, M., additional, Yindee, M., additional, Zhang, Y., additional, Lu, H., additional, Caporali, L., additional, Dang, R., additional, Huang, Y., additional, Lan, X., additional, Plath, M., additional, Chen, H., additional, Lenstra, J. A., additional, Achilli, A., additional, and Lei, C., additional
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- 2017
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40. Origin and spread of human mitochondrial DNA haplogroup U7
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Sahakyan, Hovhannes, primary, Hooshiar Kashani, Baharak, additional, Tamang, Rakesh, additional, Kushniarevich, Alena, additional, Francis, Amirtharaj, additional, Costa, Marta D, additional, Pathak, Ajai Kumar, additional, Khachatryan, Zaruhi, additional, Sharma, Indu, additional, van Oven, Mannis, additional, Parik, Jüri, additional, Hovhannisyan, Hrant, additional, Metspalu, Ene, additional, Pennarun, Erwan, additional, Karmin, Monika, additional, Tamm, Erika, additional, Tambets, Kristiina, additional, Bahmanimehr, Ardeshir, additional, Reisberg, Tuuli, additional, Reidla, Maere, additional, Achilli, Alessandro, additional, Olivieri, Anna, additional, Gandini, Francesca, additional, Perego, Ugo A., additional, Al-Zahery, Nadia, additional, Houshmand, Massoud, additional, Sanati, Mohammad Hossein, additional, Soares, Pedro, additional, Rai, Ekta, additional, Šarac, Jelena, additional, Šarić, Tena, additional, Sharma, Varun, additional, Pereira, Luisa, additional, Fernandes, Veronica, additional, Černý, Viktor, additional, Farjadian, Shirin, additional, Singh, Deepankar Pratap, additional, Azakli, Hülya, additional, Üstek, Duran, additional, Ekomasova, Natalia, additional, Kutuev, Ildus, additional, Litvinov, Sergei, additional, Bermisheva, Marina, additional, Khusnutdinova, Elza K., additional, Rai, Niraj, additional, Singh, Manvendra, additional, Singh, Vijay Kumar, additional, Reddy, Alla G., additional, Tolk, Helle-Viivi, additional, Cvjetan, Svjetlana, additional, Lauc, Lovorka Barac, additional, Rudan, Pavao, additional, Michalodimitrakis, Emmanuel N., additional, Anagnou, Nicholas P., additional, Pappa, Kalliopi I., additional, Golubenko, Maria V., additional, Orekhov, Vladimir, additional, Borinskaya, Svetlana A, additional, Kaldma, Katrin, additional, Schauer, Monica A., additional, Simionescu, Maya, additional, Gusar, Vladislava, additional, Grechanina, Elena, additional, Govindaraj, Periyasamy, additional, Voevoda, Mikhail, additional, Damba, Larissa, additional, Sharma, Swarkar, additional, Singh, Lalji, additional, Semino, Ornella, additional, Behar, Doron M., additional, Yepiskoposyan, Levon, additional, Richards, Martin B., additional, Metspalu, Mait, additional, Kivisild, Toomas, additional, Thangaraj, Kumarasamy, additional, Endicott, Phillip, additional, Chaubey, Gyaneshwer, additional, Torroni, Antonio, additional, and Villems, Richard, additional
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- 2017
- Full Text
- View/download PDF
41. High rate of starvation-associated mutagenesis in Ung− yeast caused by the overproduction of human activation-induced deaminase
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Angela Lucaccioni, Youri I. Pavlov, Alessandro Achilli, and Nora Babudri
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biology ,Adenine ,Mutagenesis ,starvation-associated mutagenesis ,Saccharomyces cerevisiae ,General Medicine ,Base excision repair ,Molecular biology ,Insertional mutagenesis ,DNA glycosylase ,Cytidine Deaminase ,Uracil-DNA glycosylase ,Genetics ,Activation-induced (cytidine) deaminase ,biology.protein ,Humans ,DNA mismatch repair ,Uracil-DNA Glycosidase ,Site-directed mutagenesis - Abstract
We examined the role of Saccharomyces cerevisiae uracil DNA glycosylase in the suppression of mutagenesis in non-dividing, adenine-starved cells expressing human activation-induced deaminase (AID) gene. Our aim was to further understand the mechanisms preventing starvation-associated mutagenesis in yeast and to explore the consequences of AID gene expression in non-proliferating eukaryotic cells. Genetic control of starvation-induced mutagenesis in many aspects is similar to the control of spontaneous logarithmic phase mutagenesis. Low DNA polymerase fidelity, defects of mismatch repair or post-replication repair lead to the elevation of mutagenesis. Less is known about the role of uracil in DNA. In yeast, the UNG1 gene codes for a uracil DNA glycosylase, which removes uracil from DNA, thus preventing an accumulation of mutations. The UNG1 gene is constitutively expressed at low levels throughout the cell cycle and peaks in late G1/early S phase. We have shown that the wild-type UNG1 allele protects from AID-induced mutations in starved cells to the same extent as it does in logarithmic growth phase cells. This finding implies that the first step in uracil removal by base excision repair (BER) is similar in these two conditions and provides the first data for understanding the role of BER in starvation-associated mutagenesis.
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- 2007
42. Influence of phase transitions on the second harmonic generation in metal nanoparticles
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A. Stella, Marco Allione, S. Achilli, A. M. Malvezzi, Richard Kofman, P. Cheyssac, and Maddalena Patrini
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Phase transition ,Materials science ,business.industry ,Mie scattering ,Optical physics ,Physics::Optics ,Nonlinear optics ,Second-harmonic generation ,Molecular physics ,Atomic and Molecular Physics, and Optics ,Optics ,High harmonic generation ,Wetting ,Surface plasmon resonance ,business - Abstract
In this work we use nonlinear optical properties of Ga nanoparticles monolayers of different average sizes embedded in dielectric matrices to investigate the liquid-solid phase transitions in these materials. Ga nanoparticles, formed by exploiting the partial wetting of liquid Ga over a SiOx surface are irradiated with fs laser pulses from a Ti:sapphire source. The resulting Second Harmonic (SH) generated in the reflection and transmission directions is measured along the phase transitions by cooling the sample from 320 K down to liquid nitrogen temperature. Hysteresis cycles are observed in the nonlinear transmission, which exhibit a strong amplification from the solid to liquid values as compared to the linear optical results. A simple model for SH generation, based on Mie scattering calculations which includes the effect of surface plasmon resonance provides a fair key for the interpretation of the observed effects.
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- 2003
43. Reduction of nitroblue tetrazolium to formazan by folic acid
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Stefania Grandi, Giampaolo Minetti, Cesare Balduini, Annarita Ciana, and Cesare Achilli
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chemistry.chemical_classification ,General Chemical Engineering ,Carboxylic acid ,Electron donor ,General Chemistry ,Glutamic acid ,Biochemistry ,Industrial and Manufacturing Engineering ,Amino acid ,chemistry.chemical_compound ,chemistry ,Folic acid ,Materials Chemistry ,Moiety ,Formazan ,Nuclear chemistry ,Carbodiimide - Abstract
The reduction of nitroblue tetrazolium (NBT) to formazan by folic acid, N-(4-aminobenzoyl) glutamic acid, and other amino acids was studied in this paper. The reduction involves only one of the two tetrazolium rings of NBT. The reaction is considerably more rapid with folic acid and N-(4-aminobenzoyl) glutamic acid than with the other amino acids under study. The electron donor moiety appears to be the carboxylic acid in the alpha position. N-ethyl-N(3-dimethylaminopropyl) carbodiimide notably increases the rate of the reaction and promotes the reduction of both tetrazolium rings. c 2013 Institute of Chemistry, Slovak Academy of Sciences
- Published
- 2014
44. Energy expenditure and nutritional adequacy of rehabilitation paraplegics with asymptomatic bacteriuria and pressure sores
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G Fizzotti, C Pistarini, Ornella Pastoris, Federica Boschi, Roberto Aquilani, Mariana Catapano, M. P. Achilli, S. Moroni, A Contardi, and Manuela Verri
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Bacteriuria ,Pressure sores ,medicine.medical_treatment ,Nutritional Status ,urologic and male genital diseases ,Asymptomatic ,Blood Urea Nitrogen ,otorhinolaryngologic diseases ,medicine ,Humans ,Muscle, Skeletal ,Asymptomatic bacteriuria ,Aged ,Paraplegia ,Pressure Ulcer ,Rehabilitation ,business.industry ,Nutritional status ,General Medicine ,Middle Aged ,bacterial infections and mycoses ,medicine.disease ,female genital diseases and pregnancy complications ,stomatognathic diseases ,Neurology ,Energy expenditure ,Creatinine ,Physical therapy ,Female ,Neurology (clinical) ,medicine.symptom ,Energy Intake ,Energy Metabolism ,business - Abstract
To measure resting energy expenditure (REE) in a group of people with postacute paraplegia, quantify the impact of asymptomatic bacteriuria and pressure sore(s) on patients' metabolic rate, and estimate the adequacy of patients' nutritional intakes to preserve patients' protein levels.Ten males with post-acute paraplegia aged 42.1+/-18.7 years. We evaluated: height, body mass index (BMI), resting energy expenditure (REE), total daily calorie requirement (E), 24-h urine creatinine excretion (Cru), creatinine index (CI), and nitrogen balance (NB).Subjects with paraplegia showed high erythrocyte sedimentation rates. As a group, they had normal resting calorie consumption when REE was normalized for unit of urine creatinine (REE/Cru), it was higher in patients than in controls. Six of the 10 patients had a low calorie intake: of these only three had a negative nitrogen balance.In conclusion, the resting energy expenditure of the subjects with significant bacteriuria and pressure sore(s) of 23.7 kcal/kg/day suggests that a large portion of patients may have an inadequate calorie protein intake to preserve their nutritional status. The clinical significance of this study is that 28.5 kcal/kg/day may be the lower calorie threshold to meet the metabolic demands of people with apyretic paraplegia with bacteriuria and pressure sore(s).
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- 2001
45. Textile Organic Electrochemical Transistors as a Platform for Wearable Biosensors
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Gualandi, I., primary, Marzocchi, M., additional, Achilli, A., additional, Cavedale, D., additional, Bonfiglio, A., additional, and Fraboni, B., additional
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- 2016
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46. Mapping human dispersals into the Horn of Africa from Arabian Ice Age refugia using mitogenomes
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Gandini, Francesca, primary, Achilli, Alessandro, additional, Pala, Maria, additional, Bodner, Martin, additional, Brandini, Stefania, additional, Huber, Gabriela, additional, Egyed, Balazs, additional, Ferretti, Luca, additional, Gómez-Carballa, Alberto, additional, Salas, Antonio, additional, Scozzari, Rosaria, additional, Cruciani, Fulvio, additional, Coppa, Alfredo, additional, Parson, Walther, additional, Semino, Ornella, additional, Soares, Pedro, additional, Torroni, Antonio, additional, Richards, Martin B., additional, and Olivieri, Anna, additional
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- 2016
- Full Text
- View/download PDF
47. Continuous versus cyclic oral contraceptives for endometriosis: any conclusive evidence?
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Chiara Achilli, Chiara Di Tucci, Pierluigi Benedetti Panici, and Ludovico Muzii
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endometriosis ,medicine.medical_specialty ,Endometriosis ,MEDLINE ,law.invention ,oral ,Randomized controlled trial ,Obstetrics and gynaecology ,law ,medicine ,humans ,medicine (all) ,Gynecology ,business.industry ,General surgery ,Obstetrics and Gynecology ,Contraceptives ,Conclusive evidence ,General Medicine ,medicine.disease ,Continuous treatment ,Regimen ,female ,Family planning ,obstetrics and gynecology ,business ,Contraceptives, Oral - Abstract
Ludovico Muzii Phone0039 06 4940550Emailludovico.muzii@uniroma1.itChiara di Tucci Chiara Achilli Pierluigi Benedetti Panici Department of Obstetrics and Gynecology,“Sapienza” University ofRome,Viale del Policlinico 155,00161Rome,ItalyThis comment refers to the article available at doi:10.1007/s0040401536411 and an author’s reply to this comment is available atdoi:10.1007/s0040401537804.Dear Editor,We read with interest the paper recently published by Zorbas et al. [1].The paper is a systematic review on the use of a continuous versus a cyclicoral contraceptive (OC) schedule after surgery for endometriosis excision.The authors conclude that a continuous OC regimen seems to offersignificant advantages compared to a cyclic regimen. The authors shouldbe commended for their effort to bring new evidences on the issue ofpostoperative management of patients operated for endometriosis.Furthermore, the conclusions of the review seem reasonable, and in fact acontinuous OC schedule is often preferred in the clinical setting.However, in our opinion, there are several issues that limit the conclusionof the study. First of all, the electronic search was incomplete, since onlytwo randomized clinical trials (RCTs) were identified [2, 3], whereas a1,*1111
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- 2015
48. Whole mitochondrial genomes unveil the impact of domestication on goat matrilineal variability
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Colli, Licia, primary, Lancioni, Hovirag, additional, Cardinali, Irene, additional, Olivieri, Anna, additional, Capodiferro, Marco Rosario, additional, Pellecchia, Marco, additional, Rzepus, Marcin, additional, Zamani, Wahid, additional, Naderi, Saeid, additional, Gandini, Francesca, additional, Vahidi, Seyed Mohammad Farhad, additional, Agha, Saif, additional, Randi, Ettore, additional, Battaglia, Vincenza, additional, Sardina, Maria Teresa, additional, Portolano, Baldassare, additional, Rezaei, Hamid Reza, additional, Lymberakis, Petros, additional, Boyer, Frédéric, additional, Coissac, Eric, additional, Pompanon, François, additional, Taberlet, Pierre, additional, Ajmone Marsan, Paolo, additional, and Achilli, Alessandro, additional
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- 2015
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49. Uncovering the sources of DNA found on the Turin Shroud
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Barcaccia, Gianni, primary, Galla, Giulio, additional, Achilli, Alessandro, additional, Olivieri, Anna, additional, and Torroni, Antonio, additional
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- 2015
- Full Text
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50. Speciation of selected minor and major elements in oil ash I. Operationally defined chemical associations and aqueous speciation
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A. Bianchi, U. de Robertis, I. Gács, A. Zoboli, and M. Achilli
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Environmental Engineering ,Chemistry ,Ecological Modeling ,media_common.quotation_subject ,Ion chromatography ,Vanadium ,chemistry.chemical_element ,Fractionation ,Pollution ,Speciation ,chemistry.chemical_compound ,Chromium ,Nitric acid ,Environmental chemistry ,Environmental Chemistry ,Composition (visual arts) ,Sample preparation ,Water Science and Technology ,media_common - Abstract
This study is focused on the speciation of selected elements in oil ash. Our efforts weredirected primarily to obtain information on the various forms of vanadium, chromium and nickel.One sample was characterized via its total composition and via its capacity for releasing variouselements. The latter was estimated by hot water and nitric acid extractions. A rapid cold waterextraction technique has been developed and utilized for sample preparation prior to aqueousspeciation by high pressure ion chromatography (HPIC).
- Published
- 1997
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